Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7WSA8_LEIDO

TriTrypDb:

LdBPK_130100.1 , LdCL_130006000 , LDHU3_13.0130

Length:

436

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WSA8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WSA8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	338	342	PF00656	0.652
CLV_NRD_NRD_1	197	199	PF00675	0.586
CLV_NRD_NRD_1	262	264	PF00675	0.657
CLV_NRD_NRD_1	308	310	PF00675	0.691
CLV_NRD_NRD_1	93	95	PF00675	0.633
CLV_PCSK_KEX2_1	261	263	PF00082	0.660
CLV_PCSK_KEX2_1	77	79	PF00082	0.589
CLV_PCSK_KEX2_1	93	95	PF00082	0.447
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.623
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.589
CLV_PCSK_SKI1_1	104	108	PF00082	0.515
CLV_PCSK_SKI1_1	122	126	PF00082	0.440
CLV_PCSK_SKI1_1	137	141	PF00082	0.418
CLV_PCSK_SKI1_1	286	290	PF00082	0.625
DEG_APCC_DBOX_1	103	111	PF00400	0.513
DEG_MDM2_SWIB_1	11	19	PF02201	0.640
DEG_SCF_FBW7_1	323	328	PF00400	0.675
DEG_SPOP_SBC_1	2	6	PF00917	0.676
DEG_SPOP_SBC_1	431	435	PF00917	0.642
DOC_CKS1_1	297	302	PF01111	0.638
DOC_CKS1_1	326	331	PF01111	0.690
DOC_MAPK_MEF2A_6	286	295	PF00069	0.666
DOC_PP2B_LxvP_1	350	353	PF13499	0.624
DOC_PP2B_PxIxI_1	218	224	PF00149	0.612
DOC_PP4_FxxP_1	59	62	PF00568	0.641
DOC_USP7_MATH_1	20	24	PF00917	0.626
DOC_USP7_MATH_1	284	288	PF00917	0.644
DOC_USP7_MATH_1	333	337	PF00917	0.659
DOC_USP7_MATH_1	62	66	PF00917	0.624
DOC_USP7_UBL2_3	77	81	PF12436	0.599
DOC_WW_Pin1_4	180	185	PF00397	0.587
DOC_WW_Pin1_4	206	211	PF00397	0.614
DOC_WW_Pin1_4	215	220	PF00397	0.570
DOC_WW_Pin1_4	261	266	PF00397	0.647
DOC_WW_Pin1_4	296	301	PF00397	0.747
DOC_WW_Pin1_4	321	326	PF00397	0.677
DOC_WW_Pin1_4	329	334	PF00397	0.636
DOC_WW_Pin1_4	345	350	PF00397	0.559
DOC_WW_Pin1_4	357	362	PF00397	0.573
DOC_WW_Pin1_4	367	372	PF00397	0.574
DOC_WW_Pin1_4	391	396	PF00397	0.649
DOC_WW_Pin1_4	405	410	PF00397	0.533
DOC_WW_Pin1_4	54	59	PF00397	0.694
LIG_14-3-3_CanoR_1	104	110	PF00244	0.545
LIG_14-3-3_CanoR_1	141	147	PF00244	0.566
LIG_14-3-3_CanoR_1	211	221	PF00244	0.719
LIG_14-3-3_CanoR_1	225	233	PF00244	0.582
LIG_14-3-3_CanoR_1	303	312	PF00244	0.691
LIG_14-3-3_CanoR_1	428	432	PF00244	0.688
LIG_Actin_WH2_2	127	143	PF00022	0.604
LIG_Actin_WH2_2	23	40	PF00022	0.524
LIG_BIR_II_1	1	5	PF00653	0.648
LIG_EVH1_1	350	354	PF00568	0.625
LIG_FHA_1	195	201	PF00498	0.624
LIG_FHA_1	216	222	PF00498	0.695
LIG_FHA_1	7	13	PF00498	0.534
LIG_FHA_1	84	90	PF00498	0.526
LIG_FHA_2	187	193	PF00498	0.657
LIG_FHA_2	244	250	PF00498	0.727
LIG_FHA_2	336	342	PF00498	0.652
LIG_GBD_Chelix_1	200	208	PF00786	0.644
LIG_LIR_Apic_2	56	62	PF02991	0.651
LIG_LIR_Gen_1	152	163	PF02991	0.594
LIG_LIR_Gen_1	32	40	PF02991	0.519
LIG_LIR_Gen_1	5	12	PF02991	0.653
LIG_LIR_Gen_1	67	76	PF02991	0.600
LIG_LIR_Nem_3	14	18	PF02991	0.545
LIG_LIR_Nem_3	152	158	PF02991	0.605
LIG_LIR_Nem_3	28	34	PF02991	0.446
LIG_LIR_Nem_3	393	399	PF02991	0.635
LIG_LIR_Nem_3	5	11	PF02991	0.661
LIG_LIR_Nem_3	67	72	PF02991	0.607
LIG_MYND_1	378	382	PF01753	0.643
LIG_Pex14_2	11	15	PF04695	0.648
LIG_Pex14_2	123	127	PF04695	0.615
LIG_Pex14_2	69	73	PF04695	0.601
LIG_REV1ctd_RIR_1	121	129	PF16727	0.536
LIG_SH2_CRK	34	38	PF00017	0.525
LIG_SH2_NCK_1	155	159	PF00017	0.525
LIG_SH2_SRC	155	158	PF00017	0.508
LIG_SH2_STAP1	155	159	PF00017	0.525
LIG_SH3_2	359	364	PF14604	0.648
LIG_SH3_2	368	373	PF14604	0.591
LIG_SH3_3	234	240	PF00018	0.741
LIG_SH3_3	292	298	PF00018	0.705
LIG_SH3_3	346	352	PF00018	0.637
LIG_SH3_3	353	359	PF00018	0.595
LIG_SH3_3	365	371	PF00018	0.524
LIG_SH3_3	403	409	PF00018	0.552
LIG_SH3_CIN85_PxpxPR_1	298	303	PF14604	0.641
LIG_SUMO_SIM_anti_2	254	260	PF11976	0.616
LIG_SUMO_SIM_par_1	254	260	PF11976	0.652
LIG_TRAF2_1	415	418	PF00917	0.684
LIG_WW_2	353	356	PF00397	0.630
LIG_WW_3	366	370	PF00397	0.634
MOD_CDC14_SPxK_1	264	267	PF00782	0.632
MOD_CDC14_SPxK_1	370	373	PF00782	0.641
MOD_CDC14_SPxK_1	394	397	PF00782	0.637
MOD_CDK_SPK_2	206	211	PF00069	0.614
MOD_CDK_SPK_2	298	303	PF00069	0.676
MOD_CDK_SPxK_1	261	267	PF00069	0.645
MOD_CDK_SPxK_1	325	331	PF00069	0.679
MOD_CDK_SPxK_1	367	373	PF00069	0.637
MOD_CDK_SPxK_1	391	397	PF00069	0.647
MOD_CDK_SPxxK_3	296	303	PF00069	0.640
MOD_CDK_SPxxK_3	357	364	PF00069	0.647
MOD_CDK_SPxxK_3	405	412	PF00069	0.612
MOD_CK1_1	206	212	PF00069	0.694
MOD_CK1_1	214	220	PF00069	0.624
MOD_CK1_1	226	232	PF00069	0.512
MOD_CK1_1	23	29	PF00069	0.472
MOD_CK1_1	271	277	PF00069	0.716
MOD_CK1_1	360	366	PF00069	0.647
MOD_CK1_1	408	414	PF00069	0.668
MOD_CK1_1	45	51	PF00069	0.692
MOD_CK1_1	54	60	PF00069	0.608
MOD_CK1_1	6	12	PF00069	0.559
MOD_CK2_1	1	7	PF00069	0.565
MOD_CK2_1	150	156	PF00069	0.615
MOD_CK2_1	243	249	PF00069	0.695
MOD_CK2_1	426	432	PF00069	0.649
MOD_CK2_1	46	52	PF00069	0.624
MOD_GlcNHglycan	144	147	PF01048	0.532
MOD_GlcNHglycan	205	208	PF01048	0.637
MOD_GlcNHglycan	22	26	PF01048	0.570
MOD_GlcNHglycan	226	229	PF01048	0.736
MOD_GlcNHglycan	286	289	PF01048	0.626
MOD_GlcNHglycan	31	34	PF01048	0.539
MOD_GlcNHglycan	343	346	PF01048	0.650
MOD_GlcNHglycan	386	389	PF01048	0.670
MOD_GlcNHglycan	413	416	PF01048	0.682
MOD_GlcNHglycan	45	48	PF01048	0.527
MOD_GlcNHglycan	52	56	PF01048	0.640
MOD_GSK3_1	2	9	PF00069	0.582
MOD_GSK3_1	211	218	PF00069	0.685
MOD_GSK3_1	219	226	PF00069	0.608
MOD_GSK3_1	257	264	PF00069	0.693
MOD_GSK3_1	280	287	PF00069	0.665
MOD_GSK3_1	298	305	PF00069	0.595
MOD_GSK3_1	317	324	PF00069	0.562
MOD_GSK3_1	325	332	PF00069	0.625
MOD_GSK3_1	341	348	PF00069	0.565
MOD_GSK3_1	372	379	PF00069	0.672
MOD_GSK3_1	380	387	PF00069	0.633
MOD_GSK3_1	42	49	PF00069	0.664
MOD_GSK3_1	426	433	PF00069	0.647
MOD_GSK3_1	54	61	PF00069	0.559
MOD_GSK3_1	88	95	PF00069	0.672
MOD_GSK3_1	96	103	PF00069	0.635
MOD_N-GLC_1	303	308	PF02516	0.650
MOD_NEK2_1	1	6	PF00069	0.682
MOD_NEK2_1	105	110	PF00069	0.425
MOD_NEK2_1	140	145	PF00069	0.555
MOD_NEK2_1	194	199	PF00069	0.636
MOD_NEK2_1	334	339	PF00069	0.656
MOD_NEK2_1	43	48	PF00069	0.556
MOD_NEK2_1	88	93	PF00069	0.619
MOD_PIKK_1	354	360	PF00454	0.640
MOD_PIKK_1	98	104	PF00454	0.641
MOD_PKA_2	140	146	PF00069	0.558
MOD_PKA_2	224	230	PF00069	0.662
MOD_PKA_2	302	308	PF00069	0.692
MOD_PKA_2	372	378	PF00069	0.663
MOD_PKA_2	384	390	PF00069	0.604
MOD_PKA_2	411	417	PF00069	0.681
MOD_PKA_2	427	433	PF00069	0.561
MOD_PKA_2	92	98	PF00069	0.633
MOD_Plk_1	83	89	PF00069	0.551
MOD_Plk_2-3	150	156	PF00069	0.498
MOD_Plk_4	105	111	PF00069	0.708
MOD_Plk_4	150	156	PF00069	0.615
MOD_Plk_4	169	175	PF00069	0.388
MOD_Plk_4	286	292	PF00069	0.702
MOD_ProDKin_1	180	186	PF00069	0.584
MOD_ProDKin_1	206	212	PF00069	0.617
MOD_ProDKin_1	215	221	PF00069	0.572
MOD_ProDKin_1	261	267	PF00069	0.645
MOD_ProDKin_1	296	302	PF00069	0.746
MOD_ProDKin_1	321	327	PF00069	0.678
MOD_ProDKin_1	329	335	PF00069	0.636
MOD_ProDKin_1	345	351	PF00069	0.555
MOD_ProDKin_1	357	363	PF00069	0.575
MOD_ProDKin_1	367	373	PF00069	0.578
MOD_ProDKin_1	391	397	PF00069	0.647
MOD_ProDKin_1	405	411	PF00069	0.537
MOD_ProDKin_1	54	60	PF00069	0.692
TRG_DiLeu_BaEn_1	14	19	PF01217	0.642
TRG_DiLeu_BaEn_1	190	195	PF01217	0.654
TRG_DiLeu_BaEn_2	6	12	PF01217	0.534
TRG_ENDOCYTIC_2	155	158	PF00928	0.524
TRG_ENDOCYTIC_2	34	37	PF00928	0.599
TRG_ENDOCYTIC_2	396	399	PF00928	0.627
TRG_ER_diArg_1	92	94	PF00400	0.638
TRG_NES_CRM1_1	152	165	PF08389	0.591
TRG_NLS_MonoExtC_3	260	265	PF00514	0.607
TRG_Pf-PMV_PEXEL_1	401	405	PF00026	0.616

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H717	Leishmania braziliensis	62%	100%
A4HVE6	Leishmania infantum	100%	100%
E9AP44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%