Carboxypeptidase_putative/GeneDB:LmjF.13.0090/Gen eDB:LmjF.14.0180/GeneDB:LmjF.33.2540/GeneDB:LmjF.36.6260

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

metallo-peptidase, Clan MA(E) Family M32

Species:

Leishmania donovani

UniProt:

A0A3S7WSA3_LEIDO

TriTrypDb:

LdBPK_130090.1 , LdCL_130005900 , LDHU3_13.0120

Length:

503

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 3
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 2
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 9

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 24
NetGPI	no	yes: 0, no: 24

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A0A3S7WSA3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WSA3

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	25
GO:0006518	peptide metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	25
GO:0008152	metabolic process	1	25
GO:0019538	protein metabolic process	3	25
GO:0043170	macromolecule metabolic process	3	25
GO:0043603	amide metabolic process	3	1
GO:0044238	primary metabolic process	2	25
GO:0071704	organic substance metabolic process	2	25
GO:1901564	organonitrogen compound metabolic process	3	25

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	25
GO:0004180	carboxypeptidase activity	5	25
GO:0004181	metallocarboxypeptidase activity	6	25
GO:0008233	peptidase activity	3	25
GO:0008235	metalloexopeptidase activity	5	25
GO:0008237	metallopeptidase activity	4	25
GO:0008238	exopeptidase activity	4	25
GO:0016787	hydrolase activity	2	25
GO:0016853	isomerase activity	2	2
GO:0140096	catalytic activity, acting on a protein	2	25

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	138	140	PF00675	0.197
CLV_NRD_NRD_1	496	498	PF00675	0.316
CLV_NRD_NRD_1	86	88	PF00675	0.280
CLV_PCSK_KEX2_1	138	140	PF00082	0.197
CLV_PCSK_KEX2_1	496	498	PF00082	0.289
CLV_PCSK_KEX2_1	86	88	PF00082	0.296
CLV_PCSK_SKI1_1	171	175	PF00082	0.446
CLV_PCSK_SKI1_1	258	262	PF00082	0.343
CLV_PCSK_SKI1_1	290	294	PF00082	0.440
CLV_PCSK_SKI1_1	61	65	PF00082	0.359

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IZ28	Bodo saltans	45%	100%
A0A1X0NY67	Trypanosomatidae	53%	99%
A0A1X0P441	Trypanosomatidae	56%	100%
A0A1X0P598	Trypanosomatidae	57%	100%
A0A3Q8IBW2	Leishmania donovani	53%	100%
A0A3Q8IJY8	Leishmania donovani	49%	100%
A0A3Q8IU74	Leishmania donovani	55%	100%
A0A422P042	Trypanosoma rangeli	54%	100%
A0A422P4R1	Trypanosoma rangeli	54%	100%
A4H716	Leishmania braziliensis	81%	100%

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