Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7WSA2_LEIDO

TriTrypDb:

LdBPK_120860.1 , LdCL_120020700 , LDHU3_12.1660

Length:

639

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WSA2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WSA2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	634	638	PF00656	0.641
CLV_NRD_NRD_1	1	3	PF00675	0.675
CLV_NRD_NRD_1	10	12	PF00675	0.617
CLV_NRD_NRD_1	118	120	PF00675	0.707
CLV_NRD_NRD_1	138	140	PF00675	0.491
CLV_NRD_NRD_1	190	192	PF00675	0.682
CLV_NRD_NRD_1	44	46	PF00675	0.699
CLV_NRD_NRD_1	609	611	PF00675	0.558
CLV_NRD_NRD_1	617	619	PF00675	0.474
CLV_NRD_NRD_1	87	89	PF00675	0.676
CLV_PCSK_FUR_1	116	120	PF00082	0.708
CLV_PCSK_FUR_1	615	619	PF00082	0.538
CLV_PCSK_KEX2_1	116	118	PF00082	0.704
CLV_PCSK_KEX2_1	138	140	PF00082	0.611
CLV_PCSK_KEX2_1	190	192	PF00082	0.682
CLV_PCSK_KEX2_1	44	46	PF00082	0.699
CLV_PCSK_KEX2_1	609	611	PF00082	0.575
CLV_PCSK_KEX2_1	615	617	PF00082	0.483
CLV_PCSK_KEX2_1	87	89	PF00082	0.676
CLV_PCSK_PC7_1	112	118	PF00082	0.584
CLV_PCSK_SKI1_1	488	492	PF00082	0.636
CLV_PCSK_SKI1_1	576	580	PF00082	0.692
CLV_PCSK_SKI1_1	610	614	PF00082	0.527
CLV_PCSK_SKI1_1	82	86	PF00082	0.627
CLV_PCSK_SKI1_1	88	92	PF00082	0.583
DEG_COP1_1	194	204	PF00400	0.567
DEG_COP1_1	347	354	PF00400	0.642
DEG_Nend_UBRbox_1	1	4	PF02207	0.649
DEG_SCF_FBW7_1	445	452	PF00400	0.616
DEG_SCF_FBW7_1	577	583	PF00400	0.690
DEG_SPOP_SBC_1	148	152	PF00917	0.566
DOC_CKS1_1	219	224	PF01111	0.636
DOC_CKS1_1	346	351	PF01111	0.669
DOC_CKS1_1	36	41	PF01111	0.680
DOC_CKS1_1	446	451	PF01111	0.686
DOC_CKS1_1	543	548	PF01111	0.545
DOC_CKS1_1	577	582	PF01111	0.693
DOC_MAPK_DCC_7	198	206	PF00069	0.565
DOC_MAPK_gen_1	87	93	PF00069	0.672
DOC_MAPK_MEF2A_6	198	206	PF00069	0.565
DOC_PP2B_LxvP_1	101	104	PF13499	0.598
DOC_PP2B_LxvP_1	406	409	PF13499	0.590
DOC_PP4_FxxP_1	254	257	PF00568	0.602
DOC_PP4_FxxP_1	368	371	PF00568	0.567
DOC_USP7_MATH_1	104	108	PF00917	0.680
DOC_USP7_MATH_1	162	166	PF00917	0.652
DOC_USP7_MATH_1	173	177	PF00917	0.566
DOC_USP7_MATH_1	31	35	PF00917	0.642
DOC_USP7_MATH_1	311	315	PF00917	0.644
DOC_USP7_MATH_1	371	375	PF00917	0.652
DOC_USP7_MATH_1	465	469	PF00917	0.572
DOC_USP7_MATH_1	559	563	PF00917	0.688
DOC_USP7_MATH_1	580	584	PF00917	0.735
DOC_USP7_MATH_1	587	591	PF00917	0.714
DOC_USP7_MATH_1	63	67	PF00917	0.532
DOC_WW_Pin1_4	13	18	PF00397	0.702
DOC_WW_Pin1_4	169	174	PF00397	0.612
DOC_WW_Pin1_4	204	209	PF00397	0.616
DOC_WW_Pin1_4	215	220	PF00397	0.561
DOC_WW_Pin1_4	239	244	PF00397	0.550
DOC_WW_Pin1_4	332	337	PF00397	0.822
DOC_WW_Pin1_4	345	350	PF00397	0.642
DOC_WW_Pin1_4	35	40	PF00397	0.683
DOC_WW_Pin1_4	354	359	PF00397	0.682
DOC_WW_Pin1_4	396	401	PF00397	0.650
DOC_WW_Pin1_4	434	439	PF00397	0.635
DOC_WW_Pin1_4	445	450	PF00397	0.647
DOC_WW_Pin1_4	460	465	PF00397	0.670
DOC_WW_Pin1_4	478	483	PF00397	0.637
DOC_WW_Pin1_4	53	58	PF00397	0.521
DOC_WW_Pin1_4	542	547	PF00397	0.661
DOC_WW_Pin1_4	557	562	PF00397	0.547
DOC_WW_Pin1_4	576	581	PF00397	0.526
LIG_14-3-3_CanoR_1	2	7	PF00244	0.567
LIG_14-3-3_CanoR_1	247	257	PF00244	0.592
LIG_14-3-3_CanoR_1	345	349	PF00244	0.647
LIG_14-3-3_CanoR_1	420	426	PF00244	0.643
LIG_14-3-3_CanoR_1	47	53	PF00244	0.653
LIG_14-3-3_CanoR_1	486	491	PF00244	0.575
LIG_14-3-3_CanoR_1	506	513	PF00244	0.693
LIG_14-3-3_CanoR_1	535	539	PF00244	0.652
LIG_14-3-3_CanoR_1	553	558	PF00244	0.520
LIG_14-3-3_CanoR_1	87	93	PF00244	0.672
LIG_BRCT_BRCA1_1	213	217	PF00533	0.570
LIG_CSL_BTD_1	333	336	PF09270	0.635
LIG_CSL_BTD_1	377	380	PF09270	0.674
LIG_DLG_GKlike_1	2	10	PF00625	0.627
LIG_FHA_1	104	110	PF00498	0.635
LIG_FHA_1	201	207	PF00498	0.660
LIG_FHA_1	346	352	PF00498	0.694
LIG_FHA_1	446	452	PF00498	0.664
LIG_FHA_1	63	69	PF00498	0.611
LIG_FHA_1	94	100	PF00498	0.602
LIG_FHA_2	156	162	PF00498	0.630
LIG_FHA_2	275	281	PF00498	0.657
LIG_FHA_2	360	366	PF00498	0.686
LIG_FHA_2	527	533	PF00498	0.566
LIG_LIR_Apic_2	251	257	PF02991	0.607
LIG_LIR_Apic_2	332	337	PF02991	0.614
LIG_LIR_Apic_2	365	371	PF02991	0.574
LIG_LIR_Gen_1	327	338	PF02991	0.584
LIG_LIR_Nem_3	178	183	PF02991	0.594
LIG_LIR_Nem_3	327	333	PF02991	0.562
LIG_LYPXL_yS_3	360	363	PF13949	0.663
LIG_PDZ_Class_3	634	639	PF00595	0.647
LIG_Pex14_2	330	334	PF04695	0.562
LIG_SH2_CRK	180	184	PF00017	0.566
LIG_SH2_STAT5	567	570	PF00017	0.576
LIG_SH3_1	574	580	PF00018	0.649
LIG_SH3_2	39	44	PF14604	0.684
LIG_SH3_3	14	20	PF00018	0.607
LIG_SH3_3	202	208	PF00018	0.617
LIG_SH3_3	216	222	PF00018	0.542
LIG_SH3_3	228	234	PF00018	0.614
LIG_SH3_3	333	339	PF00018	0.666
LIG_SH3_3	346	352	PF00018	0.600
LIG_SH3_3	355	361	PF00018	0.598
LIG_SH3_3	36	42	PF00018	0.682
LIG_SH3_3	54	60	PF00018	0.513
LIG_SH3_3	540	546	PF00018	0.608
LIG_SH3_3	574	580	PF00018	0.649
LIG_SH3_4	82	89	PF00018	0.629
LIG_SUMO_SIM_anti_2	96	103	PF11976	0.519
LIG_SUMO_SIM_par_1	202	207	PF11976	0.616
LIG_TRAF2_1	225	228	PF00917	0.662
MOD_CDC14_SPxK_1	560	563	PF00782	0.632
MOD_CDK_SPK_2	561	566	PF00069	0.589
MOD_CDK_SPxK_1	557	563	PF00069	0.668
MOD_CK1_1	165	171	PF00069	0.679
MOD_CK1_1	172	178	PF00069	0.612
MOD_CK1_1	207	213	PF00069	0.614
MOD_CK1_1	218	224	PF00069	0.541
MOD_CK1_1	266	272	PF00069	0.805
MOD_CK1_1	293	299	PF00069	0.627
MOD_CK1_1	326	332	PF00069	0.626
MOD_CK1_1	347	353	PF00069	0.669
MOD_CK1_1	374	380	PF00069	0.703
MOD_CK1_1	398	404	PF00069	0.660
MOD_CK1_1	428	434	PF00069	0.656
MOD_CK1_1	48	54	PF00069	0.678
MOD_CK1_1	508	514	PF00069	0.665
MOD_CK1_1	547	553	PF00069	0.628
MOD_CK1_1	569	575	PF00069	0.697
MOD_CK1_1	58	64	PF00069	0.598
MOD_CK1_1	590	596	PF00069	0.746
MOD_CK2_1	108	114	PF00069	0.693
MOD_CK2_1	155	161	PF00069	0.631
MOD_CK2_1	173	179	PF00069	0.512
MOD_CK2_1	267	273	PF00069	0.634
MOD_CK2_1	274	280	PF00069	0.600
MOD_CK2_1	391	397	PF00069	0.610
MOD_CK2_1	48	54	PF00069	0.607
MOD_CK2_1	526	532	PF00069	0.567
MOD_DYRK1A_RPxSP_1	576	580	PF00069	0.627
MOD_GlcNHglycan	130	133	PF01048	0.803
MOD_GlcNHglycan	144	147	PF01048	0.545
MOD_GlcNHglycan	174	178	PF01048	0.542
MOD_GlcNHglycan	197	201	PF01048	0.799
MOD_GlcNHglycan	213	216	PF01048	0.556
MOD_GlcNHglycan	244	247	PF01048	0.634
MOD_GlcNHglycan	298	301	PF01048	0.595
MOD_GlcNHglycan	311	314	PF01048	0.612
MOD_GlcNHglycan	320	323	PF01048	0.631
MOD_GlcNHglycan	467	470	PF01048	0.681
MOD_GlcNHglycan	493	496	PF01048	0.645
MOD_GlcNHglycan	507	510	PF01048	0.572
MOD_GlcNHglycan	538	541	PF01048	0.646
MOD_GlcNHglycan	549	552	PF01048	0.623
MOD_GlcNHglycan	582	585	PF01048	0.642
MOD_GlcNHglycan	592	595	PF01048	0.606
MOD_GlcNHglycan	603	606	PF01048	0.478
MOD_GlcNHglycan	96	99	PF01048	0.618
MOD_GSK3_1	104	111	PF00069	0.592
MOD_GSK3_1	165	172	PF00069	0.687
MOD_GSK3_1	196	203	PF00069	0.666
MOD_GSK3_1	207	214	PF00069	0.558
MOD_GSK3_1	242	249	PF00069	0.628
MOD_GSK3_1	252	259	PF00069	0.590
MOD_GSK3_1	260	267	PF00069	0.608
MOD_GSK3_1	290	297	PF00069	0.607
MOD_GSK3_1	31	38	PF00069	0.649
MOD_GSK3_1	311	318	PF00069	0.726
MOD_GSK3_1	325	332	PF00069	0.594
MOD_GSK3_1	350	357	PF00069	0.680
MOD_GSK3_1	359	366	PF00069	0.643
MOD_GSK3_1	391	398	PF00069	0.613
MOD_GSK3_1	430	437	PF00069	0.603
MOD_GSK3_1	445	452	PF00069	0.619
MOD_GSK3_1	459	466	PF00069	0.572
MOD_GSK3_1	48	55	PF00069	0.583
MOD_GSK3_1	486	493	PF00069	0.627
MOD_GSK3_1	507	514	PF00069	0.631
MOD_GSK3_1	515	522	PF00069	0.546
MOD_GSK3_1	534	541	PF00069	0.642
MOD_GSK3_1	553	560	PF00069	0.531
MOD_GSK3_1	576	583	PF00069	0.610
MOD_GSK3_1	58	65	PF00069	0.597
MOD_GSK3_1	601	608	PF00069	0.544
MOD_GSK3_1	7	14	PF00069	0.648
MOD_GSK3_1	89	96	PF00069	0.617
MOD_N-GLC_1	260	265	PF02516	0.549
MOD_N-GLC_1	434	439	PF02516	0.580
MOD_N-GLC_1	569	574	PF02516	0.697
MOD_N-GLC_1	630	635	PF02516	0.596
MOD_NEK2_1	1	6	PF00069	0.521
MOD_NEK2_1	196	201	PF00069	0.805
MOD_NEK2_1	260	265	PF00069	0.626
MOD_NEK2_1	290	295	PF00069	0.640
MOD_NEK2_1	363	368	PF00069	0.641
MOD_NEK2_1	52	57	PF00069	0.581
MOD_NEK2_2	181	186	PF00069	0.519
MOD_PIKK_1	162	168	PF00454	0.697
MOD_PIKK_1	425	431	PF00454	0.696
MOD_PK_1	486	492	PF00069	0.573
MOD_PKA_1	11	17	PF00069	0.594
MOD_PKA_1	2	8	PF00069	0.647
MOD_PKA_2	1	7	PF00069	0.572
MOD_PKA_2	142	148	PF00069	0.675
MOD_PKA_2	246	252	PF00069	0.564
MOD_PKA_2	293	299	PF00069	0.627
MOD_PKA_2	318	324	PF00069	0.781
MOD_PKA_2	344	350	PF00069	0.669
MOD_PKA_2	419	425	PF00069	0.666
MOD_PKA_2	48	54	PF00069	0.607
MOD_PKA_2	505	511	PF00069	0.687
MOD_PKA_2	519	525	PF00069	0.646
MOD_PKA_2	534	540	PF00069	0.505
MOD_PKA_2	86	92	PF00069	0.671
MOD_PKB_1	45	53	PF00069	0.706
MOD_Plk_1	196	202	PF00069	0.566
MOD_Plk_1	630	636	PF00069	0.610
MOD_Plk_4	200	206	PF00069	0.657
MOD_Plk_4	329	335	PF00069	0.639
MOD_Plk_4	359	365	PF00069	0.785
MOD_Plk_4	374	380	PF00069	0.603
MOD_Plk_4	48	54	PF00069	0.585
MOD_Plk_4	519	525	PF00069	0.689
MOD_ProDKin_1	13	19	PF00069	0.701
MOD_ProDKin_1	169	175	PF00069	0.611
MOD_ProDKin_1	204	210	PF00069	0.615
MOD_ProDKin_1	215	221	PF00069	0.564
MOD_ProDKin_1	239	245	PF00069	0.547
MOD_ProDKin_1	332	338	PF00069	0.823
MOD_ProDKin_1	345	351	PF00069	0.643
MOD_ProDKin_1	35	41	PF00069	0.682
MOD_ProDKin_1	354	360	PF00069	0.683
MOD_ProDKin_1	396	402	PF00069	0.652
MOD_ProDKin_1	434	440	PF00069	0.637
MOD_ProDKin_1	445	451	PF00069	0.647
MOD_ProDKin_1	460	466	PF00069	0.668
MOD_ProDKin_1	478	484	PF00069	0.637
MOD_ProDKin_1	53	59	PF00069	0.518
MOD_ProDKin_1	542	548	PF00069	0.659
MOD_ProDKin_1	557	563	PF00069	0.548
MOD_ProDKin_1	576	582	PF00069	0.517
TRG_DiLeu_BaLyEn_6	286	291	PF01217	0.576
TRG_ENDOCYTIC_2	180	183	PF00928	0.570
TRG_ENDOCYTIC_2	360	363	PF00928	0.663
TRG_ER_diArg_1	116	119	PF00400	0.705
TRG_ER_diArg_1	137	139	PF00400	0.670
TRG_ER_diArg_1	189	191	PF00400	0.670
TRG_ER_diArg_1	44	47	PF00400	0.702
TRG_ER_diArg_1	485	488	PF00400	0.625
TRG_ER_diArg_1	574	577	PF00400	0.672
TRG_ER_diArg_1	615	618	PF00400	0.540
TRG_Pf-PMV_PEXEL_1	385	389	PF00026	0.568
TRG_Pf-PMV_PEXEL_1	610	614	PF00026	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
E9AGJ0	Leishmania infantum	98%	100%
E9AIN8	Leishmania braziliensis	50%	97%
E9AP28	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4QGG1	Leishmania major	84%	100%