SET domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WS98_LEIDO

TriTrypDb:

LdBPK_120880.1 , LdCL_120020900 , LDHU3_12.1680

Length:

622

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WS98

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WS98

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0034968	histone lysine methylation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0005488	binding	1	5
GO:0008168	methyltransferase activity	4	1
GO:0008170	N-methyltransferase activity	5	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016278	lysine N-methyltransferase activity	6	1
GO:0016279	protein-lysine N-methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	1
GO:0042054	histone methyltransferase activity	4	1
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	226	230	PF00656	0.743
CLV_C14_Caspase3-7	513	517	PF00656	0.451
CLV_MEL_PAP_1	154	160	PF00089	0.570
CLV_NRD_NRD_1	291	293	PF00675	0.337
CLV_NRD_NRD_1	302	304	PF00675	0.378
CLV_NRD_NRD_1	449	451	PF00675	0.391
CLV_NRD_NRD_1	486	488	PF00675	0.572
CLV_PCSK_FUR_1	289	293	PF00082	0.173
CLV_PCSK_FUR_1	447	451	PF00082	0.459
CLV_PCSK_KEX2_1	291	293	PF00082	0.291
CLV_PCSK_KEX2_1	328	330	PF00082	0.362
CLV_PCSK_KEX2_1	449	451	PF00082	0.389
CLV_PCSK_KEX2_1	486	488	PF00082	0.480
CLV_PCSK_KEX2_1	580	582	PF00082	0.411
CLV_PCSK_PC1ET2_1	328	330	PF00082	0.362
CLV_PCSK_PC1ET2_1	580	582	PF00082	0.411
CLV_PCSK_SKI1_1	102	106	PF00082	0.423
CLV_PCSK_SKI1_1	334	338	PF00082	0.325
CLV_PCSK_SKI1_1	487	491	PF00082	0.546
CLV_PCSK_SKI1_1	580	584	PF00082	0.400
CLV_PCSK_SKI1_1	611	615	PF00082	0.500
DEG_APCC_DBOX_1	541	549	PF00400	0.355
DOC_CDC14_PxL_1	132	140	PF14671	0.520
DOC_CDC14_PxL_1	186	194	PF14671	0.537
DOC_CDC14_PxL_1	436	444	PF14671	0.510
DOC_CKS1_1	198	203	PF01111	0.502
DOC_CYCLIN_RxL_1	328	339	PF00134	0.525
DOC_CYCLIN_yClb1_LxF_4	542	548	PF00134	0.371
DOC_CYCLIN_yCln2_LP_2	198	204	PF00134	0.462
DOC_MAPK_DCC_7	187	195	PF00069	0.535
DOC_MAPK_gen_1	173	183	PF00069	0.531
DOC_MAPK_MEF2A_6	187	195	PF00069	0.535
DOC_PP2B_LxvP_1	305	308	PF13499	0.562
DOC_USP7_MATH_1	3	7	PF00917	0.742
DOC_USP7_MATH_1	354	358	PF00917	0.505
DOC_USP7_MATH_1	397	401	PF00917	0.566
DOC_WW_Pin1_4	164	169	PF00397	0.603
DOC_WW_Pin1_4	197	202	PF00397	0.485
DOC_WW_Pin1_4	268	273	PF00397	0.562
DOC_WW_Pin1_4	407	412	PF00397	0.545
LIG_14-3-3_CanoR_1	157	161	PF00244	0.548
LIG_14-3-3_CanoR_1	291	300	PF00244	0.565
LIG_14-3-3_CanoR_1	334	339	PF00244	0.583
LIG_14-3-3_CanoR_1	452	460	PF00244	0.553
LIG_14-3-3_CanoR_1	465	474	PF00244	0.335
LIG_14-3-3_CanoR_1	542	548	PF00244	0.371
LIG_AP2alpha_2	472	474	PF02296	0.540
LIG_APCC_ABBA_1	41	46	PF00400	0.530
LIG_BIR_III_4	617	621	PF00653	0.588
LIG_BRCT_BRCA1_1	113	117	PF00533	0.522
LIG_BRCT_BRCA1_1	356	360	PF00533	0.571
LIG_BRCT_BRCA1_1	5	9	PF00533	0.726
LIG_eIF4E_1	100	106	PF01652	0.514
LIG_FHA_1	149	155	PF00498	0.515
LIG_FHA_1	337	343	PF00498	0.560
LIG_FHA_1	36	42	PF00498	0.507
LIG_FHA_1	364	370	PF00498	0.527
LIG_FHA_1	423	429	PF00498	0.476
LIG_FHA_2	53	59	PF00498	0.497
LIG_LIR_Gen_1	313	323	PF02991	0.540
LIG_LIR_Gen_1	368	376	PF02991	0.578
LIG_LIR_Nem_3	309	314	PF02991	0.519
LIG_LIR_Nem_3	368	373	PF02991	0.578
LIG_LIR_Nem_3	454	460	PF02991	0.540
LIG_LIR_Nem_3	490	496	PF02991	0.491
LIG_LIR_Nem_3	546	552	PF02991	0.367
LIG_MYND_1	136	140	PF01753	0.566
LIG_MYND_3	135	139	PF01753	0.534
LIG_NRBOX	519	525	PF00104	0.419
LIG_NRBOX	562	568	PF00104	0.430
LIG_SH2_CRK	269	273	PF00017	0.581
LIG_SH2_CRK	316	320	PF00017	0.562
LIG_SH2_CRK	370	374	PF00017	0.525
LIG_SH2_CRK	549	553	PF00017	0.426
LIG_SH2_NCK_1	133	137	PF00017	0.525
LIG_SH2_NCK_1	370	374	PF00017	0.525
LIG_SH2_STAP1	37	41	PF00017	0.511
LIG_SH2_STAT3	36	39	PF00017	0.507
LIG_SH2_STAT3	438	441	PF00017	0.390
LIG_SH2_STAT5	269	272	PF00017	0.487
LIG_SH2_STAT5	37	40	PF00017	0.491
LIG_SH2_STAT5	370	373	PF00017	0.581
LIG_SH2_STAT5	438	441	PF00017	0.380
LIG_SH2_STAT5	458	461	PF00017	0.193
LIG_SH2_STAT5	536	539	PF00017	0.353
LIG_SH3_3	348	354	PF00018	0.562
LIG_SH3_3	380	386	PF00018	0.511
LIG_SUMO_SIM_anti_2	194	200	PF11976	0.547
LIG_SUMO_SIM_anti_2	610	617	PF11976	0.498
LIG_SUMO_SIM_par_1	191	197	PF11976	0.438
LIG_SUMO_SIM_par_1	333	339	PF11976	0.568
LIG_TRAF2_1	231	234	PF00917	0.781
LIG_TYR_ITIM	314	319	PF00017	0.562
LIG_TYR_ITSM	366	373	PF00017	0.581
LIG_UBA3_1	296	304	PF00899	0.566
LIG_UBA3_1	355	361	PF00899	0.581
LIG_WRC_WIRS_1	401	406	PF05994	0.562
MOD_CK1_1	109	115	PF00069	0.609
MOD_CK1_1	197	203	PF00069	0.422
MOD_CK1_1	259	265	PF00069	0.532
MOD_CK1_1	400	406	PF00069	0.502
MOD_CK1_1	525	531	PF00069	0.469
MOD_CK1_1	599	605	PF00069	0.453
MOD_CK2_1	138	144	PF00069	0.423
MOD_CK2_1	156	162	PF00069	0.484
MOD_CK2_1	52	58	PF00069	0.535
MOD_GlcNHglycan	120	123	PF01048	0.469
MOD_GlcNHglycan	385	389	PF01048	0.301
MOD_GlcNHglycan	5	8	PF01048	0.715
MOD_GlcNHglycan	600	604	PF01048	0.490
MOD_GlcNHglycan	61	64	PF01048	0.437
MOD_GSK3_1	112	119	PF00069	0.582
MOD_GSK3_1	256	263	PF00069	0.540
MOD_GSK3_1	496	503	PF00069	0.458
MOD_GSK3_1	518	525	PF00069	0.527
MOD_LATS_1	332	338	PF00433	0.525
MOD_N-GLC_1	405	410	PF02516	0.280
MOD_N-GLC_2	23	25	PF02516	0.549
MOD_NEK2_1	336	341	PF00069	0.581
MOD_NEK2_1	405	410	PF00069	0.484
MOD_NEK2_1	59	64	PF00069	0.455
MOD_NEK2_2	414	419	PF00069	0.584
MOD_NEK2_2	500	505	PF00069	0.445
MOD_PIKK_1	35	41	PF00454	0.467
MOD_PIKK_1	510	516	PF00454	0.574
MOD_PKA_1	291	297	PF00069	0.373
MOD_PKA_2	156	162	PF00069	0.551
MOD_PKA_2	291	297	PF00069	0.561
MOD_PKA_2	451	457	PF00069	0.524
MOD_PKB_1	289	297	PF00069	0.373
MOD_Plk_1	432	438	PF00069	0.472
MOD_Plk_2-3	156	162	PF00069	0.577
MOD_Plk_4	194	200	PF00069	0.492
MOD_Plk_4	365	371	PF00069	0.539
MOD_Plk_4	400	406	PF00069	0.476
MOD_Plk_4	543	549	PF00069	0.372
MOD_ProDKin_1	164	170	PF00069	0.605
MOD_ProDKin_1	197	203	PF00069	0.480
MOD_ProDKin_1	268	274	PF00069	0.562
MOD_ProDKin_1	407	413	PF00069	0.545
MOD_SUMO_for_1	253	256	PF00179	0.636
MOD_SUMO_for_1	360	363	PF00179	0.581
MOD_SUMO_for_1	582	585	PF00179	0.445
TRG_DiLeu_BaEn_1	194	199	PF01217	0.542
TRG_DiLeu_BaEn_1	519	524	PF01217	0.506
TRG_DiLeu_BaEn_2	454	460	PF01217	0.540
TRG_DiLeu_BaEn_4	364	370	PF01217	0.484
TRG_DiLeu_BaLyEn_6	149	154	PF01217	0.463
TRG_ENDOCYTIC_2	316	319	PF00928	0.551
TRG_ENDOCYTIC_2	370	373	PF00928	0.581
TRG_ENDOCYTIC_2	457	460	PF00928	0.536
TRG_ENDOCYTIC_2	549	552	PF00928	0.371
TRG_ER_diArg_1	289	292	PF00400	0.445
TRG_ER_diArg_1	447	450	PF00400	0.396
TRG_ER_diArg_1	504	507	PF00400	0.508
TRG_NES_CRM1_1	148	162	PF08389	0.491
TRG_NES_CRM1_1	557	570	PF08389	0.470
TRG_NLS_MonoExtC_3	579	585	PF00514	0.442
TRG_NLS_MonoExtN_4	578	584	PF00514	0.410
TRG_Pf-PMV_PEXEL_1	130	134	PF00026	0.468
TRG_Pf-PMV_PEXEL_1	152	156	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	291	295	PF00026	0.173
TRG_Pf-PMV_PEXEL_1	476	481	PF00026	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDV1	Leptomonas seymouri	62%	100%
A0A0S4IJK9	Bodo saltans	40%	100%
A0A1X0NMI4	Trypanosomatidae	44%	100%
A0A422NUZ8	Trypanosoma rangeli	46%	100%
C9ZI42	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	99%
E9AGJ2	Leishmania infantum	99%	100%
E9AIN6	Leishmania braziliensis	85%	100%
E9AP30	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QGF9	Leishmania major	93%	100%
V5DFZ1	Trypanosoma cruzi	43%	100%