Methyltransferase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative methyltransferase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WS96_LEIDO

TriTrypDb:

LdCL_120021450

Length:

320

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3S7WS96

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WS96

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	4
GO:0032259	methylation	2	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0008168	methyltransferase activity	4	4
GO:0016740	transferase activity	2	4
GO:0016741	transferase activity, transferring one-carbon groups	3	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	62	66	PF00656	0.502
CLV_PCSK_SKI1_1	255	259	PF00082	0.382
DEG_SCF_FBW7_1	239	245	PF00400	0.347
DOC_CKS1_1	239	244	PF01111	0.355
DOC_CKS1_1	51	56	PF01111	0.306
DOC_CYCLIN_RxL_1	119	128	PF00134	0.388
DOC_PP1_RVXF_1	120	127	PF00149	0.178
DOC_PP4_FxxP_1	163	166	PF00568	0.178
DOC_USP7_MATH_1	130	134	PF00917	0.178
DOC_USP7_MATH_1	166	170	PF00917	0.388
DOC_USP7_MATH_1	201	205	PF00917	0.444
DOC_USP7_MATH_1	237	241	PF00917	0.542
DOC_USP7_MATH_1	298	302	PF00917	0.508
DOC_WW_Pin1_4	134	139	PF00397	0.388
DOC_WW_Pin1_4	235	240	PF00397	0.527
DOC_WW_Pin1_4	250	255	PF00397	0.328
DOC_WW_Pin1_4	294	299	PF00397	0.449
DOC_WW_Pin1_4	50	55	PF00397	0.309
LIG_14-3-3_CanoR_1	157	166	PF00244	0.248
LIG_BIR_III_4	56	60	PF00653	0.429
LIG_BRCT_BRCA1_1	159	163	PF00533	0.178
LIG_eIF4E_1	55	61	PF01652	0.532
LIG_FHA_1	256	262	PF00498	0.442
LIG_FHA_1	277	283	PF00498	0.502
LIG_FHA_1	30	36	PF00498	0.527
LIG_FHA_1	65	71	PF00498	0.298
LIG_FHA_2	223	229	PF00498	0.388
LIG_FHA_2	290	296	PF00498	0.459
LIG_FHA_2	51	57	PF00498	0.308
LIG_GBD_Chelix_1	113	121	PF00786	0.388
LIG_LIR_Apic_2	160	166	PF02991	0.178
LIG_LIR_Gen_1	263	274	PF02991	0.322
LIG_LIR_Gen_1	279	287	PF02991	0.467
LIG_LIR_Gen_1	53	61	PF02991	0.322
LIG_LIR_Nem_3	18	23	PF02991	0.435
LIG_LIR_Nem_3	247	252	PF02991	0.432
LIG_LIR_Nem_3	263	269	PF02991	0.155
LIG_LIR_Nem_3	279	283	PF02991	0.424
LIG_LIR_Nem_3	53	58	PF02991	0.425
LIG_NRBOX	116	122	PF00104	0.354
LIG_Pex14_1	248	252	PF04695	0.339
LIG_SH2_CRK	26	30	PF00017	0.466
LIG_SH2_CRK	55	59	PF00017	0.521
LIG_SH2_NCK_1	214	218	PF00017	0.239
LIG_SH2_NCK_1	280	284	PF00017	0.463
LIG_SH2_NCK_1	55	59	PF00017	0.521
LIG_SH2_STAP1	21	25	PF00017	0.427
LIG_SH2_STAP1	214	218	PF00017	0.354
LIG_SH2_STAT5	252	255	PF00017	0.352
LIG_SH2_STAT5	26	29	PF00017	0.415
LIG_SH3_3	2	8	PF00018	0.505
LIG_SH3_3	236	242	PF00018	0.360
LIG_SH3_3	280	286	PF00018	0.457
LIG_SH3_3	48	54	PF00018	0.453
LIG_SH3_3	80	86	PF00018	0.388
LIG_SUMO_SIM_anti_2	203	209	PF11976	0.388
LIG_SUMO_SIM_par_1	219	225	PF11976	0.354
LIG_TYR_ITSM	51	58	PF00017	0.312
MOD_CDK_SPK_2	250	255	PF00069	0.321
MOD_CK1_1	133	139	PF00069	0.388
MOD_CK1_1	203	209	PF00069	0.388
MOD_CK1_1	224	230	PF00069	0.408
MOD_CK1_1	238	244	PF00069	0.347
MOD_CK1_1	30	36	PF00069	0.488
MOD_CK2_1	150	156	PF00069	0.392
MOD_CK2_1	222	228	PF00069	0.388
MOD_CK2_1	289	295	PF00069	0.443
MOD_GlcNHglycan	109	112	PF01048	0.354
MOD_GlcNHglycan	159	162	PF01048	0.280
MOD_GlcNHglycan	175	178	PF01048	0.409
MOD_GSK3_1	130	137	PF00069	0.373
MOD_GSK3_1	197	204	PF00069	0.388
MOD_GSK3_1	238	245	PF00069	0.547
MOD_GSK3_1	24	31	PF00069	0.378
MOD_GSK3_1	294	301	PF00069	0.379
MOD_GSK3_1	59	66	PF00069	0.503
MOD_N-GLC_1	157	162	PF02516	0.178
MOD_NEK2_1	221	226	PF00069	0.301
MOD_NEK2_1	28	33	PF00069	0.462
MOD_NEK2_1	3	8	PF00069	0.429
MOD_Plk_1	130	136	PF00069	0.388
MOD_Plk_1	40	46	PF00069	0.452
MOD_Plk_2-3	150	156	PF00069	0.388
MOD_Plk_4	24	30	PF00069	0.496
MOD_ProDKin_1	134	140	PF00069	0.388
MOD_ProDKin_1	235	241	PF00069	0.524
MOD_ProDKin_1	250	256	PF00069	0.331
MOD_ProDKin_1	294	300	PF00069	0.437
MOD_ProDKin_1	50	56	PF00069	0.303
TRG_DiLeu_BaLyEn_6	217	222	PF01217	0.354
TRG_ENDOCYTIC_2	26	29	PF00928	0.448
TRG_ENDOCYTIC_2	280	283	PF00928	0.420
TRG_ENDOCYTIC_2	55	58	PF00928	0.529
TRG_ER_diArg_1	92	95	PF00400	0.178
TRG_Pf-PMV_PEXEL_1	157	162	PF00026	0.354
TRG_Pf-PMV_PEXEL_1	259	263	PF00026	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCI3	Leptomonas seymouri	51%	97%
A0A0S4JFN7	Bodo saltans	36%	100%
P0C5J1	Homo sapiens	25%	97%
Q96G04	Homo sapiens	26%	97%