Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WS94_LEIDO

TriTrypDb:

LdBPK_120930.1 , LdCL_120021400 , LDHU3_12.1750

Length:

438

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WS94

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WS94

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	146	148	PF00675	0.724
CLV_NRD_NRD_1	179	181	PF00675	0.791
CLV_NRD_NRD_1	254	256	PF00675	0.481
CLV_NRD_NRD_1	419	421	PF00675	0.708
CLV_PCSK_FUR_1	144	148	PF00082	0.610
CLV_PCSK_FUR_1	177	181	PF00082	0.544
CLV_PCSK_KEX2_1	146	148	PF00082	0.713
CLV_PCSK_KEX2_1	179	181	PF00082	0.714
CLV_PCSK_KEX2_1	256	258	PF00082	0.541
CLV_PCSK_KEX2_1	418	420	PF00082	0.723
CLV_PCSK_KEX2_1	88	90	PF00082	0.399
CLV_PCSK_PC1ET2_1	256	258	PF00082	0.610
CLV_PCSK_PC1ET2_1	88	90	PF00082	0.399
CLV_PCSK_SKI1_1	146	150	PF00082	0.602
DEG_COP1_1	175	185	PF00400	0.531
DEG_SCF_FBW7_1	278	284	PF00400	0.560
DEG_SCF_FBW7_1	316	322	PF00400	0.625
DOC_CDC14_PxL_1	372	380	PF14671	0.560
DOC_CKS1_1	1	6	PF01111	0.585
DOC_CKS1_1	119	124	PF01111	0.691
DOC_CKS1_1	140	145	PF01111	0.679
DOC_CKS1_1	278	283	PF01111	0.691
DOC_CKS1_1	305	310	PF01111	0.647
DOC_CKS1_1	316	321	PF01111	0.526
DOC_CYCLIN_yCln2_LP_2	378	384	PF00134	0.549
DOC_CYCLIN_yCln2_LP_2	99	105	PF00134	0.557
DOC_MAPK_gen_1	130	138	PF00069	0.639
DOC_MAPK_MEF2A_6	371	380	PF00069	0.482
DOC_PP1_RVXF_1	422	429	PF00149	0.605
DOC_PP2B_LxvP_1	138	141	PF13499	0.783
DOC_PP2B_LxvP_1	302	305	PF13499	0.532
DOC_PP2B_LxvP_1	378	381	PF13499	0.449
DOC_PP4_FxxP_1	428	431	PF00568	0.593
DOC_USP7_MATH_1	126	130	PF00917	0.767
DOC_USP7_MATH_1	15	19	PF00917	0.611
DOC_USP7_MATH_1	167	171	PF00917	0.710
DOC_USP7_MATH_1	238	242	PF00917	0.617
DOC_USP7_MATH_1	262	266	PF00917	0.595
DOC_USP7_MATH_1	281	285	PF00917	0.624
DOC_USP7_MATH_1	294	298	PF00917	0.492
DOC_USP7_MATH_1	327	331	PF00917	0.630
DOC_USP7_MATH_1	429	433	PF00917	0.702
DOC_USP7_UBL2_3	157	161	PF12436	0.662
DOC_WW_Pin1_4	11	16	PF00397	0.684
DOC_WW_Pin1_4	112	117	PF00397	0.592
DOC_WW_Pin1_4	118	123	PF00397	0.512
DOC_WW_Pin1_4	136	141	PF00397	0.729
DOC_WW_Pin1_4	18	23	PF00397	0.634
DOC_WW_Pin1_4	201	206	PF00397	0.709
DOC_WW_Pin1_4	223	228	PF00397	0.661
DOC_WW_Pin1_4	274	279	PF00397	0.591
DOC_WW_Pin1_4	304	309	PF00397	0.649
DOC_WW_Pin1_4	312	317	PF00397	0.577
DOC_WW_Pin1_4	394	399	PF00397	0.581
DOC_WW_Pin1_4	411	416	PF00397	0.668
DOC_WW_Pin1_4	427	432	PF00397	0.638
DOC_WW_Pin1_4	98	103	PF00397	0.512
LIG_14-3-3_CanoR_1	132	137	PF00244	0.785
LIG_14-3-3_CanoR_1	146	152	PF00244	0.628
LIG_14-3-3_CanoR_1	163	171	PF00244	0.755
LIG_14-3-3_CanoR_1	177	183	PF00244	0.721
LIG_14-3-3_CanoR_1	223	227	PF00244	0.669
LIG_14-3-3_CanoR_1	26	35	PF00244	0.336
LIG_14-3-3_CanoR_1	320	324	PF00244	0.610
LIG_14-3-3_CanoR_1	343	348	PF00244	0.481
LIG_14-3-3_CanoR_1	362	372	PF00244	0.482
LIG_14-3-3_CanoR_1	379	385	PF00244	0.439
LIG_14-3-3_CanoR_1	401	405	PF00244	0.658
LIG_14-3-3_CanoR_1	418	426	PF00244	0.713
LIG_14-3-3_CterR_2	435	438	PF00244	0.587
LIG_BIR_II_1	1	5	PF00653	0.632
LIG_BIR_III_1	1	5	PF00653	0.587
LIG_BIR_III_3	1	5	PF00653	0.587
LIG_BIR_III_4	310	314	PF00653	0.517
LIG_FHA_1	132	138	PF00498	0.708
LIG_FHA_1	223	229	PF00498	0.727
LIG_FHA_1	316	322	PF00498	0.563
LIG_FHA_1	386	392	PF00498	0.518
LIG_FHA_2	305	311	PF00498	0.622
LIG_FHA_2	312	318	PF00498	0.537
LIG_LIR_Apic_2	288	294	PF02991	0.721
LIG_LIR_Apic_2	427	431	PF02991	0.759
LIG_LIR_Gen_1	241	251	PF02991	0.573
LIG_LIR_Gen_1	296	305	PF02991	0.608
LIG_LIR_Gen_1	52	61	PF02991	0.463
LIG_LIR_Gen_1	70	80	PF02991	0.399
LIG_LIR_Nem_3	184	189	PF02991	0.519
LIG_LIR_Nem_3	241	246	PF02991	0.498
LIG_LIR_Nem_3	296	302	PF02991	0.598
LIG_LIR_Nem_3	52	57	PF02991	0.403
LIG_LIR_Nem_3	69	75	PF02991	0.382
LIG_MYND_1	227	231	PF01753	0.504
LIG_MYND_3	103	107	PF01753	0.593
LIG_NRBOX	31	37	PF00104	0.497
LIG_SH2_CRK	291	295	PF00017	0.632
LIG_SH2_CRK	73	77	PF00017	0.424
LIG_SH2_NCK_1	291	295	PF00017	0.600
LIG_SH2_NCK_1	352	356	PF00017	0.521
LIG_SH2_SRC	337	340	PF00017	0.480
LIG_SH2_SRC	352	355	PF00017	0.583
LIG_SH2_SRC	73	76	PF00017	0.475
LIG_SH2_STAP1	73	77	PF00017	0.483
LIG_SH2_STAT5	279	282	PF00017	0.661
LIG_SH2_STAT5	298	301	PF00017	0.591
LIG_SH2_STAT5	337	340	PF00017	0.470
LIG_SH2_STAT5	347	350	PF00017	0.437
LIG_SH2_STAT5	51	54	PF00017	0.406
LIG_SH2_STAT5	97	100	PF00017	0.531
LIG_SH3_1	113	119	PF00018	0.577
LIG_SH3_2	119	124	PF14604	0.691
LIG_SH3_3	113	119	PF00018	0.774
LIG_SH3_3	120	126	PF00018	0.666
LIG_SH3_3	137	143	PF00018	0.661
LIG_SH3_3	206	212	PF00018	0.607
LIG_SH3_3	225	231	PF00018	0.659
LIG_SH3_3	275	281	PF00018	0.652
LIG_SH3_3	302	308	PF00018	0.611
LIG_SH3_3	313	319	PF00018	0.593
LIG_SH3_3	370	376	PF00018	0.534
LIG_SH3_3	423	429	PF00018	0.574
LIG_SUMO_SIM_par_1	133	139	PF11976	0.688
LIG_SUMO_SIM_par_1	28	37	PF11976	0.553
LIG_WW_1	334	337	PF00397	0.435
LIG_WW_3	121	125	PF00397	0.690
MOD_CDC14_SPxK_1	204	207	PF00782	0.659
MOD_CDC14_SPxK_1	430	433	PF00782	0.645
MOD_CDK_SPK_2	139	144	PF00069	0.655
MOD_CDK_SPK_2	18	23	PF00069	0.546
MOD_CDK_SPK_2	277	282	PF00069	0.589
MOD_CDK_SPK_2	315	320	PF00069	0.653
MOD_CDK_SPxK_1	118	124	PF00069	0.692
MOD_CDK_SPxK_1	201	207	PF00069	0.659
MOD_CDK_SPxK_1	427	433	PF00069	0.668
MOD_CDK_SPxxK_3	139	146	PF00069	0.680
MOD_CDK_SPxxK_3	394	401	PF00069	0.535
MOD_CDK_SPxxK_3	411	418	PF00069	0.510
MOD_CK1_1	11	17	PF00069	0.603
MOD_CK1_1	114	120	PF00069	0.701
MOD_CK1_1	139	145	PF00069	0.654
MOD_CK1_1	150	156	PF00069	0.598
MOD_CK1_1	175	181	PF00069	0.738
MOD_CK1_1	18	24	PF00069	0.584
MOD_CK1_1	214	220	PF00069	0.751
MOD_CK1_1	222	228	PF00069	0.723
MOD_CK1_1	232	238	PF00069	0.703
MOD_CK1_1	241	247	PF00069	0.559
MOD_CK1_1	315	321	PF00069	0.671
MOD_CK1_1	397	403	PF00069	0.626
MOD_CK1_1	427	433	PF00069	0.710
MOD_CK2_1	112	118	PF00069	0.637
MOD_CK2_1	13	19	PF00069	0.664
MOD_CK2_1	311	317	PF00069	0.540
MOD_GlcNHglycan	174	177	PF01048	0.599
MOD_GlcNHglycan	213	216	PF01048	0.731
MOD_GlcNHglycan	234	237	PF01048	0.682
MOD_GlcNHglycan	365	368	PF01048	0.626
MOD_GSK3_1	107	114	PF00069	0.671
MOD_GSK3_1	11	18	PF00069	0.670
MOD_GSK3_1	126	133	PF00069	0.765
MOD_GSK3_1	211	218	PF00069	0.713
MOD_GSK3_1	219	226	PF00069	0.709
MOD_GSK3_1	277	284	PF00069	0.616
MOD_GSK3_1	300	307	PF00069	0.679
MOD_GSK3_1	311	318	PF00069	0.642
MOD_GSK3_1	343	350	PF00069	0.498
MOD_GSK3_1	353	360	PF00069	0.459
MOD_GSK3_1	49	56	PF00069	0.554
MOD_N-GLC_1	49	54	PF02516	0.404
MOD_NEK2_1	106	111	PF00069	0.589
MOD_NEK2_1	357	362	PF00069	0.541
MOD_NEK2_1	49	54	PF00069	0.441
MOD_NEK2_1	57	62	PF00069	0.431
MOD_NEK2_2	238	243	PF00069	0.488
MOD_PIKK_1	229	235	PF00454	0.816
MOD_PK_1	147	153	PF00069	0.616
MOD_PK_1	406	412	PF00069	0.596
MOD_PKA_1	199	205	PF00069	0.692
MOD_PKA_1	418	424	PF00069	0.521
MOD_PKA_2	131	137	PF00069	0.692
MOD_PKA_2	162	168	PF00069	0.635
MOD_PKA_2	178	184	PF00069	0.687
MOD_PKA_2	215	221	PF00069	0.711
MOD_PKA_2	222	228	PF00069	0.646
MOD_PKA_2	25	31	PF00069	0.370
MOD_PKA_2	319	325	PF00069	0.609
MOD_PKA_2	361	367	PF00069	0.600
MOD_PKA_2	400	406	PF00069	0.704
MOD_PKA_2	418	424	PF00069	0.652
MOD_PKB_1	130	138	PF00069	0.639
MOD_Plk_1	106	112	PF00069	0.595
MOD_Plk_1	268	274	PF00069	0.653
MOD_Plk_1	406	412	PF00069	0.596
MOD_Plk_4	132	138	PF00069	0.706
MOD_Plk_4	181	187	PF00069	0.519
MOD_Plk_4	238	244	PF00069	0.615
MOD_Plk_4	294	300	PF00069	0.524
MOD_ProDKin_1	11	17	PF00069	0.681
MOD_ProDKin_1	112	118	PF00069	0.593
MOD_ProDKin_1	136	142	PF00069	0.726
MOD_ProDKin_1	18	24	PF00069	0.628
MOD_ProDKin_1	201	207	PF00069	0.712
MOD_ProDKin_1	223	229	PF00069	0.662
MOD_ProDKin_1	274	280	PF00069	0.591
MOD_ProDKin_1	304	310	PF00069	0.654
MOD_ProDKin_1	312	318	PF00069	0.573
MOD_ProDKin_1	394	400	PF00069	0.583
MOD_ProDKin_1	411	417	PF00069	0.668
MOD_ProDKin_1	427	433	PF00069	0.639
MOD_ProDKin_1	98	104	PF00069	0.522
MOD_SUMO_rev_2	192	201	PF00179	0.622
MOD_SUMO_rev_2	83	90	PF00179	0.407
TRG_DiLeu_BaLyEn_6	28	33	PF01217	0.499
TRG_ENDOCYTIC_2	51	54	PF00928	0.376
TRG_ENDOCYTIC_2	73	76	PF00928	0.381
TRG_ER_diArg_1	143	146	PF00400	0.709
TRG_ER_diArg_1	177	180	PF00400	0.729
TRG_ER_diArg_1	255	258	PF00400	0.558
TRG_ER_diArg_1	418	420	PF00400	0.715
TRG_ER_diArg_1	433	436	PF00400	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6F0	Leptomonas seymouri	49%	91%
A0A3R7KKI7	Trypanosoma rangeli	30%	97%
C9ZI49	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	94%
E9AGJ7	Leishmania infantum	99%	100%
E9AIN1	Leishmania braziliensis	62%	100%
E9AP34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QGF4	Leishmania major	85%	100%