RanBP2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WS83_LEIDO

TriTrypDb:

LdBPK_120840.1 , LdCL_120020500 , LDHU3_12.1640

Length:

439

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 3, no: 5
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WS83

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WS83

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.798
CLV_C14_Caspase3-7	320	324	PF00656	0.502
CLV_C14_Caspase3-7	425	429	PF00656	0.528
CLV_NRD_NRD_1	153	155	PF00675	0.597
CLV_NRD_NRD_1	157	159	PF00675	0.589
CLV_NRD_NRD_1	161	163	PF00675	0.603
CLV_NRD_NRD_1	337	339	PF00675	0.448
CLV_NRD_NRD_1	387	389	PF00675	0.473
CLV_NRD_NRD_1	412	414	PF00675	0.780
CLV_NRD_NRD_1	422	424	PF00675	0.657
CLV_PCSK_KEX2_1	152	154	PF00082	0.612
CLV_PCSK_KEX2_1	157	159	PF00082	0.587
CLV_PCSK_KEX2_1	161	163	PF00082	0.600
CLV_PCSK_KEX2_1	262	264	PF00082	0.527
CLV_PCSK_KEX2_1	337	339	PF00082	0.448
CLV_PCSK_KEX2_1	389	391	PF00082	0.535
CLV_PCSK_KEX2_1	412	414	PF00082	0.772
CLV_PCSK_KEX2_1	421	423	PF00082	0.626
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.527
CLV_PCSK_PC1ET2_1	389	391	PF00082	0.434
CLV_PCSK_PC7_1	153	159	PF00082	0.629
CLV_PCSK_SKI1_1	129	133	PF00082	0.638
CLV_PCSK_SKI1_1	21	25	PF00082	0.568
CLV_PCSK_SKI1_1	350	354	PF00082	0.331
CLV_PCSK_SKI1_1	390	394	PF00082	0.505
CLV_PCSK_SKI1_1	412	416	PF00082	0.767
DEG_Nend_Nbox_1	1	3	PF02207	0.684
DEG_SPOP_SBC_1	145	149	PF00917	0.609
DEG_SPOP_SBC_1	427	431	PF00917	0.525
DOC_ANK_TNKS_1	272	279	PF00023	0.380
DOC_CYCLIN_RxL_1	387	397	PF00134	0.346
DOC_CYCLIN_yCln2_LP_2	392	398	PF00134	0.464
DOC_MAPK_gen_1	327	336	PF00069	0.374
DOC_MAPK_gen_1	388	396	PF00069	0.518
DOC_MAPK_JIP1_4	390	396	PF00069	0.472
DOC_MAPK_MEF2A_6	21	30	PF00069	0.479
DOC_MAPK_MEF2A_6	388	396	PF00069	0.534
DOC_MAPK_NFAT4_5	21	29	PF00069	0.412
DOC_PP2B_LxvP_1	392	395	PF13499	0.468
DOC_PP2B_PxIxI_1	306	312	PF00149	0.361
DOC_USP7_MATH_1	145	149	PF00917	0.616
DOC_USP7_MATH_1	17	21	PF00917	0.486
DOC_USP7_MATH_1	184	188	PF00917	0.561
DOC_USP7_MATH_1	250	254	PF00917	0.443
DOC_USP7_MATH_1	37	41	PF00917	0.546
DOC_USP7_MATH_1	405	409	PF00917	0.603
DOC_WW_Pin1_4	241	246	PF00397	0.393
DOC_WW_Pin1_4	394	399	PF00397	0.416
DOC_WW_Pin1_4	88	93	PF00397	0.621
LIG_14-3-3_CanoR_1	183	189	PF00244	0.530
LIG_BRCT_BRCA1_1	204	208	PF00533	0.465
LIG_BRCT_BRCA1_1	280	284	PF00533	0.260
LIG_DCNL_PONY_1	1	4	PF03556	0.678
LIG_FHA_1	134	140	PF00498	0.763
LIG_FHA_1	174	180	PF00498	0.644
LIG_FHA_1	293	299	PF00498	0.399
LIG_FHA_1	358	364	PF00498	0.462
LIG_FHA_1	79	85	PF00498	0.658
LIG_FHA_2	115	121	PF00498	0.627
LIG_FHA_2	163	169	PF00498	0.541
LIG_FHA_2	303	309	PF00498	0.368
LIG_FHA_2	318	324	PF00498	0.529
LIG_LIR_Gen_1	192	201	PF02991	0.448
LIG_LIR_Gen_1	205	216	PF02991	0.441
LIG_LIR_Gen_1	217	226	PF02991	0.488
LIG_LIR_Gen_1	40	49	PF02991	0.666
LIG_LIR_Gen_1	63	71	PF02991	0.548
LIG_LIR_LC3C_4	397	401	PF02991	0.409
LIG_LIR_Nem_3	205	211	PF02991	0.468
LIG_LIR_Nem_3	212	218	PF02991	0.406
LIG_LIR_Nem_3	40	45	PF02991	0.678
LIG_NRBOX	25	31	PF00104	0.510
LIG_Pex14_1	375	379	PF04695	0.348
LIG_RPA_C_Fungi	333	345	PF08784	0.378
LIG_SH2_CRK	280	284	PF00017	0.349
LIG_SH2_SRC	367	370	PF00017	0.343
LIG_SH2_STAP1	237	241	PF00017	0.416
LIG_SH2_STAP1	280	284	PF00017	0.453
LIG_SH2_STAT3	369	372	PF00017	0.413
LIG_SH2_STAT3	379	382	PF00017	0.429
LIG_SH2_STAT5	226	229	PF00017	0.342
LIG_SH2_STAT5	335	338	PF00017	0.389
LIG_SH2_STAT5	367	370	PF00017	0.343
LIG_SH3_1	11	17	PF00018	0.636
LIG_SH3_2	89	94	PF14604	0.545
LIG_SH3_3	11	17	PF00018	0.636
LIG_SH3_3	230	236	PF00018	0.421
LIG_SH3_3	392	398	PF00018	0.474
LIG_SH3_3	86	92	PF00018	0.618
LIG_SH3_3	97	103	PF00018	0.793
LIG_SUMO_SIM_par_1	28	35	PF11976	0.573
LIG_SUMO_SIM_par_1	397	404	PF11976	0.371
LIG_TRAF2_1	71	74	PF00917	0.515
LIG_WRC_WIRS_1	61	66	PF05994	0.522
MOD_CDC14_SPxK_1	91	94	PF00782	0.553
MOD_CDK_SPK_2	241	246	PF00069	0.453
MOD_CDK_SPxK_1	88	94	PF00069	0.547
MOD_CK1_1	144	150	PF00069	0.727
MOD_CK1_1	202	208	PF00069	0.510
MOD_CK1_1	253	259	PF00069	0.477
MOD_CK1_1	40	46	PF00069	0.627
MOD_CK1_1	404	410	PF00069	0.661
MOD_CK1_1	431	437	PF00069	0.519
MOD_CK1_1	53	59	PF00069	0.527
MOD_CK2_1	114	120	PF00069	0.602
MOD_CK2_1	355	361	PF00069	0.420
MOD_Cter_Amidation	260	263	PF01082	0.455
MOD_Cter_Amidation	419	422	PF01082	0.564
MOD_GlcNHglycan	109	112	PF01048	0.636
MOD_GlcNHglycan	143	146	PF01048	0.592
MOD_GlcNHglycan	162	165	PF01048	0.614
MOD_GlcNHglycan	179	182	PF01048	0.645
MOD_GlcNHglycan	402	406	PF01048	0.478
MOD_GlcNHglycan	407	410	PF01048	0.584
MOD_GlcNHglycan	54	58	PF01048	0.616
MOD_GSK3_1	101	108	PF00069	0.734
MOD_GSK3_1	112	119	PF00069	0.657
MOD_GSK3_1	121	128	PF00069	0.672
MOD_GSK3_1	129	136	PF00069	0.716
MOD_GSK3_1	140	147	PF00069	0.712
MOD_GSK3_1	160	167	PF00069	0.510
MOD_GSK3_1	173	180	PF00069	0.556
MOD_GSK3_1	249	256	PF00069	0.410
MOD_GSK3_1	40	47	PF00069	0.561
MOD_GSK3_1	401	408	PF00069	0.597
MOD_GSK3_1	422	429	PF00069	0.707
MOD_LATS_1	114	120	PF00433	0.685
MOD_LATS_1	160	166	PF00433	0.599
MOD_N-GLC_1	141	146	PF02516	0.530
MOD_NEK2_1	127	132	PF00069	0.677
MOD_NEK2_1	179	184	PF00069	0.618
MOD_NEK2_1	199	204	PF00069	0.540
MOD_NEK2_1	249	254	PF00069	0.388
MOD_NEK2_1	28	33	PF00069	0.574
MOD_NEK2_1	302	307	PF00069	0.336
MOD_NEK2_2	330	335	PF00069	0.444
MOD_PIKK_1	189	195	PF00454	0.438
MOD_PIKK_1	37	43	PF00454	0.604
MOD_PK_1	422	428	PF00069	0.538
MOD_PKA_1	412	418	PF00069	0.805
MOD_PKA_1	422	428	PF00069	0.656
MOD_PKA_2	160	166	PF00069	0.720
MOD_PKA_2	253	259	PF00069	0.481
MOD_PKA_2	267	273	PF00069	0.263
MOD_PKA_2	412	418	PF00069	0.724
MOD_PKA_2	422	428	PF00069	0.609
MOD_Plk_1	17	23	PF00069	0.590
MOD_Plk_1	427	433	PF00069	0.542
MOD_Plk_2-3	355	361	PF00069	0.442
MOD_Plk_4	28	34	PF00069	0.553
MOD_Plk_4	294	300	PF00069	0.361
MOD_Plk_4	330	336	PF00069	0.364
MOD_Plk_4	44	50	PF00069	0.488
MOD_ProDKin_1	241	247	PF00069	0.391
MOD_ProDKin_1	394	400	PF00069	0.417
MOD_ProDKin_1	88	94	PF00069	0.625
TRG_DiLeu_BaEn_1	339	344	PF01217	0.381
TRG_DiLeu_BaEn_2	17	23	PF01217	0.561
TRG_ENDOCYTIC_2	218	221	PF00928	0.425
TRG_ENDOCYTIC_2	280	283	PF00928	0.357
TRG_ER_diArg_1	152	154	PF00400	0.605
TRG_ER_diArg_1	272	275	PF00400	0.435
TRG_ER_diArg_1	336	338	PF00400	0.555
TRG_ER_diArg_1	387	390	PF00400	0.424
TRG_ER_diArg_1	412	414	PF00400	0.759
TRG_ER_diArg_1	421	423	PF00400	0.636
TRG_NLS_MonoExtC_3	9	14	PF00514	0.556
TRG_NLS_MonoExtN_4	8	14	PF00514	0.552
TRG_Pf-PMV_PEXEL_1	214	219	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7W8	Leptomonas seymouri	58%	97%
A0A3R7L7Q9	Trypanosoma rangeli	34%	98%
A4H706	Leishmania braziliensis	75%	100%
E9AGI8	Leishmania infantum	100%	100%
E9AP26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QGG3	Leishmania major	94%	100%
V5DFZ8	Trypanosoma cruzi	34%	99%