LisH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WS82_LEIDO

TriTrypDb:

LdBPK_130010.1 , LdCL_130005100 , LDHU3_13.0020

Length:

650

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	2
GO:0016604	nuclear body	2	2
GO:0016607	nuclear speck	3	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

A0A3S7WS82

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WS82

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	5
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	5
GO:0000398	mRNA splicing, via spliceosome	8	5
GO:0006139	nucleobase-containing compound metabolic process	3	5
GO:0006396	RNA processing	6	5
GO:0006397	mRNA processing	7	5
GO:0006725	cellular aromatic compound metabolic process	3	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	5
GO:0008380	RNA splicing	7	5
GO:0009987	cellular process	1	5
GO:0016070	RNA metabolic process	5	5
GO:0016071	mRNA metabolic process	6	5
GO:0034641	cellular nitrogen compound metabolic process	3	5
GO:0043170	macromolecule metabolic process	3	5
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	5
GO:0046483	heterocycle metabolic process	3	5
GO:0071704	organic substance metabolic process	2	5
GO:0090304	nucleic acid metabolic process	4	5
GO:1901360	organic cyclic compound metabolic process	3	5

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	257	259	PF00675	0.634
CLV_NRD_NRD_1	369	371	PF00675	0.508
CLV_NRD_NRD_1	75	77	PF00675	0.445
CLV_PCSK_KEX2_1	257	259	PF00082	0.631
CLV_PCSK_KEX2_1	369	371	PF00082	0.485
CLV_PCSK_SKI1_1	104	108	PF00082	0.606
CLV_PCSK_SKI1_1	146	150	PF00082	0.427
CLV_PCSK_SKI1_1	153	157	PF00082	0.383
CLV_PCSK_SKI1_1	20	24	PF00082	0.717
CLV_PCSK_SKI1_1	236	240	PF00082	0.511
CLV_PCSK_SKI1_1	96	100	PF00082	0.556
DEG_APCC_DBOX_1	515	523	PF00400	0.487
DEG_APCC_DBOX_1	75	83	PF00400	0.411
DEG_Nend_UBRbox_3	1	3	PF02207	0.724
DEG_ODPH_VHL_1	297	308	PF01847	0.554
DOC_CYCLIN_yCln2_LP_2	267	273	PF00134	0.558
DOC_CYCLIN_yCln2_LP_2	491	497	PF00134	0.538
DOC_MAPK_MEF2A_6	38	46	PF00069	0.420
DOC_PP1_RVXF_1	144	151	PF00149	0.272
DOC_PP1_RVXF_1	372	379	PF00149	0.478
DOC_PP2B_LxvP_1	267	270	PF13499	0.613
DOC_PP2B_LxvP_1	330	333	PF13499	0.422
DOC_PP4_MxPP_1	225	228	PF00568	0.504
DOC_USP7_MATH_1	106	110	PF00917	0.564
DOC_USP7_MATH_1	113	117	PF00917	0.470
DOC_USP7_MATH_1	15	19	PF00917	0.718
DOC_USP7_MATH_1	180	184	PF00917	0.543
DOC_USP7_MATH_1	343	347	PF00917	0.612
DOC_USP7_MATH_1	584	588	PF00917	0.608
DOC_USP7_MATH_1	94	98	PF00917	0.474
DOC_USP7_UBL2_3	104	108	PF12436	0.635
DOC_USP7_UBL2_3	96	100	PF12436	0.551
DOC_WW_Pin1_4	114	119	PF00397	0.647
DOC_WW_Pin1_4	21	26	PF00397	0.630
DOC_WW_Pin1_4	490	495	PF00397	0.431
DOC_WW_Pin1_4	502	507	PF00397	0.347
DOC_WW_Pin1_4	543	548	PF00397	0.581
LIG_14-3-3_CanoR_1	146	151	PF00244	0.507
LIG_14-3-3_CanoR_1	233	239	PF00244	0.397
LIG_14-3-3_CanoR_1	258	267	PF00244	0.537
LIG_14-3-3_CanoR_1	291	299	PF00244	0.590
LIG_14-3-3_CanoR_1	463	469	PF00244	0.462
LIG_14-3-3_CanoR_1	545	551	PF00244	0.436
LIG_14-3-3_CanoR_1	617	625	PF00244	0.406
LIG_14-3-3_CanoR_1	76	80	PF00244	0.461
LIG_Actin_RPEL_3	31	50	PF02755	0.549
LIG_BIR_III_4	14	18	PF00653	0.742
LIG_BRCT_BRCA1_1	124	128	PF00533	0.463
LIG_BRCT_BRCA1_1	506	510	PF00533	0.507
LIG_CSL_BTD_1	330	333	PF09270	0.381
LIG_CtBP_PxDLS_1	228	232	PF00389	0.633
LIG_EH1_1	453	461	PF00400	0.484
LIG_eIF4E_1	454	460	PF01652	0.459
LIG_FHA_1	169	175	PF00498	0.511
LIG_FHA_1	191	197	PF00498	0.481
LIG_FHA_1	230	236	PF00498	0.612
LIG_FHA_1	24	30	PF00498	0.668
LIG_FHA_1	332	338	PF00498	0.489
LIG_FHA_1	371	377	PF00498	0.487
LIG_FHA_1	381	387	PF00498	0.430
LIG_FHA_1	422	428	PF00498	0.535
LIG_FHA_1	432	438	PF00498	0.450
LIG_FHA_1	474	480	PF00498	0.386
LIG_FHA_1	482	488	PF00498	0.388
LIG_FHA_1	507	513	PF00498	0.433
LIG_FHA_1	576	582	PF00498	0.555
LIG_FHA_2	176	182	PF00498	0.526
LIG_FHA_2	35	41	PF00498	0.501
LIG_FHA_2	534	540	PF00498	0.582
LIG_FHA_2	551	557	PF00498	0.411
LIG_LIR_Gen_1	165	174	PF02991	0.316
LIG_LIR_Gen_1	242	253	PF02991	0.446
LIG_LIR_Gen_1	278	289	PF02991	0.541
LIG_LIR_Gen_1	292	302	PF02991	0.575
LIG_LIR_Gen_1	444	454	PF02991	0.470
LIG_LIR_Nem_3	165	170	PF02991	0.316
LIG_LIR_Nem_3	183	189	PF02991	0.557
LIG_LIR_Nem_3	211	217	PF02991	0.550
LIG_LIR_Nem_3	242	248	PF02991	0.441
LIG_LIR_Nem_3	278	284	PF02991	0.547
LIG_LIR_Nem_3	292	297	PF02991	0.567
LIG_LIR_Nem_3	444	450	PF02991	0.475
LIG_LIR_Nem_3	452	457	PF02991	0.497
LIG_NRBOX	169	175	PF00104	0.403
LIG_PCNA_yPIPBox_3	453	463	PF02747	0.411
LIG_Pex14_2	239	243	PF04695	0.575
LIG_Rb_pABgroove_1	386	394	PF01858	0.353
LIG_REV1ctd_RIR_1	148	156	PF16727	0.400
LIG_SH2_CRK	454	458	PF00017	0.464
LIG_SH2_GRB2like	214	217	PF00017	0.638
LIG_SH2_NCK_1	245	249	PF00017	0.493
LIG_SH2_STAP1	447	451	PF00017	0.530
LIG_SH2_STAP1	609	613	PF00017	0.554
LIG_SH2_STAT3	596	599	PF00017	0.758
LIG_SH2_STAT3	609	612	PF00017	0.344
LIG_SH2_STAT5	172	175	PF00017	0.414
LIG_SH2_STAT5	204	207	PF00017	0.420
LIG_SH2_STAT5	217	220	PF00017	0.564
LIG_SH2_STAT5	468	471	PF00017	0.344
LIG_SH2_STAT5	567	570	PF00017	0.387
LIG_SH2_STAT5	596	599	PF00017	0.693
LIG_SH2_STAT5	74	77	PF00017	0.558
LIG_SH3_3	220	226	PF00018	0.659
LIG_SH3_3	330	336	PF00018	0.478
LIG_SH3_3	339	345	PF00018	0.645
LIG_SH3_3	577	583	PF00018	0.727
LIG_SUMO_SIM_par_1	227	232	PF11976	0.639
LIG_SUMO_SIM_par_1	26	33	PF11976	0.565
LIG_SUMO_SIM_par_1	423	428	PF11976	0.506
LIG_SUMO_SIM_par_1	478	484	PF11976	0.407
LIG_SUMO_SIM_par_1	635	644	PF11976	0.475
LIG_TRAF2_1	85	88	PF00917	0.534
MOD_CK1_1	292	298	PF00069	0.470
MOD_CK1_1	380	386	PF00069	0.514
MOD_CK1_1	431	437	PF00069	0.478
MOD_CK1_1	490	496	PF00069	0.464
MOD_CK1_1	505	511	PF00069	0.291
MOD_CK1_1	546	552	PF00069	0.539
MOD_CK1_1	598	604	PF00069	0.636
MOD_CK1_1	90	96	PF00069	0.547
MOD_CK2_1	175	181	PF00069	0.537
MOD_CK2_1	34	40	PF00069	0.508
MOD_CK2_1	533	539	PF00069	0.556
MOD_CK2_1	550	556	PF00069	0.599
MOD_CK2_1	629	635	PF00069	0.487
MOD_CK2_1	86	92	PF00069	0.545
MOD_GlcNHglycan	108	111	PF01048	0.509
MOD_GlcNHglycan	17	20	PF01048	0.686
MOD_GlcNHglycan	267	270	PF01048	0.613
MOD_GlcNHglycan	285	289	PF01048	0.420
MOD_GlcNHglycan	317	320	PF01048	0.487
MOD_GlcNHglycan	393	396	PF01048	0.567
MOD_GlcNHglycan	558	561	PF01048	0.433
MOD_GlcNHglycan	56	59	PF01048	0.411
MOD_GlcNHglycan	591	594	PF01048	0.728
MOD_GlcNHglycan	646	649	PF01048	0.583
MOD_GlcNHglycan	8	11	PF01048	0.717
MOD_GlcNHglycan	92	95	PF01048	0.520
MOD_GSK3_1	100	107	PF00069	0.444
MOD_GSK3_1	168	175	PF00069	0.531
MOD_GSK3_1	204	211	PF00069	0.512
MOD_GSK3_1	259	266	PF00069	0.562
MOD_GSK3_1	280	287	PF00069	0.509
MOD_GSK3_1	289	296	PF00069	0.478
MOD_GSK3_1	30	37	PF00069	0.543
MOD_GSK3_1	331	338	PF00069	0.484
MOD_GSK3_1	421	428	PF00069	0.542
MOD_GSK3_1	469	476	PF00069	0.428
MOD_GSK3_1	481	488	PF00069	0.407
MOD_GSK3_1	498	505	PF00069	0.236
MOD_GSK3_1	535	542	PF00069	0.579
MOD_GSK3_1	546	553	PF00069	0.409
MOD_GSK3_1	625	632	PF00069	0.549
MOD_GSK3_1	640	647	PF00069	0.416
MOD_GSK3_1	86	93	PF00069	0.530
MOD_N-GLC_1	461	466	PF02516	0.421
MOD_N-GLC_1	539	544	PF02516	0.604
MOD_N-GLC_2	216	218	PF02516	0.706
MOD_N-GLC_2	222	224	PF02516	0.613
MOD_N-GLC_2	401	403	PF02516	0.451
MOD_NEK2_1	122	127	PF00069	0.429
MOD_NEK2_1	151	156	PF00069	0.425
MOD_NEK2_1	158	163	PF00069	0.393
MOD_NEK2_1	239	244	PF00069	0.460
MOD_NEK2_1	259	264	PF00069	0.354
MOD_NEK2_1	289	294	PF00069	0.488
MOD_NEK2_1	315	320	PF00069	0.465
MOD_NEK2_1	368	373	PF00069	0.360
MOD_NEK2_1	391	396	PF00069	0.573
MOD_NEK2_1	425	430	PF00069	0.550
MOD_NEK2_1	461	466	PF00069	0.481
MOD_NEK2_1	487	492	PF00069	0.399
MOD_NEK2_1	511	516	PF00069	0.377
MOD_NEK2_1	54	59	PF00069	0.411
MOD_NEK2_1	595	600	PF00069	0.659
MOD_NEK2_1	641	646	PF00069	0.565
MOD_NEK2_1	75	80	PF00069	0.541
MOD_NEK2_2	172	177	PF00069	0.397
MOD_NEK2_2	234	239	PF00069	0.490
MOD_NEK2_2	567	572	PF00069	0.342
MOD_NEK2_2	94	99	PF00069	0.540
MOD_PIKK_1	204	210	PF00454	0.478
MOD_PIKK_1	595	601	PF00454	0.754
MOD_PKA_2	260	266	PF00069	0.616
MOD_PKA_2	290	296	PF00069	0.559
MOD_PKA_2	368	374	PF00069	0.321
MOD_PKA_2	533	539	PF00069	0.542
MOD_PKA_2	575	581	PF00069	0.643
MOD_PKA_2	75	81	PF00069	0.462
MOD_Plk_1	158	164	PF00069	0.551
MOD_Plk_1	284	290	PF00069	0.531
MOD_Plk_1	86	92	PF00069	0.551
MOD_Plk_2-3	87	93	PF00069	0.594
MOD_Plk_4	146	152	PF00069	0.263
MOD_Plk_4	168	174	PF00069	0.506
MOD_Plk_4	24	30	PF00069	0.567
MOD_Plk_4	380	386	PF00069	0.437
MOD_Plk_4	455	461	PF00069	0.467
MOD_Plk_4	464	470	PF00069	0.503
MOD_Plk_4	487	493	PF00069	0.509
MOD_Plk_4	506	512	PF00069	0.226
MOD_ProDKin_1	114	120	PF00069	0.639
MOD_ProDKin_1	21	27	PF00069	0.620
MOD_ProDKin_1	490	496	PF00069	0.440
MOD_ProDKin_1	502	508	PF00069	0.348
MOD_ProDKin_1	543	549	PF00069	0.573
MOD_SUMO_for_1	623	626	PF00179	0.505
TRG_ENDOCYTIC_2	135	138	PF00928	0.517
TRG_ENDOCYTIC_2	245	248	PF00928	0.464
TRG_ENDOCYTIC_2	447	450	PF00928	0.535
TRG_ENDOCYTIC_2	454	457	PF00928	0.485
TRG_ER_diArg_1	256	258	PF00400	0.612
TRG_ER_diArg_1	368	370	PF00400	0.492
TRG_ER_diArg_1	571	574	PF00400	0.559
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2V3	Leptomonas seymouri	70%	97%
A0A1X0NHC6	Trypanosomatidae	40%	98%
A0A3R7RLK0	Trypanosoma rangeli	42%	98%
A4H709	Leishmania braziliensis	88%	100%
A4HVD7	Leishmania infantum	99%	100%
C9ZTR0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	87%
E9AP35	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QGF3	Leishmania major	92%	100%
V5BXX9	Trypanosoma cruzi	41%	98%