DnaJ domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WS81_LEIDO

TriTrypDb:

LdBPK_120710.1 , LdCL_120018900 , LDHU3_12.1410

Length:

608

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WS81

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WS81

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0006458	'de novo' protein folding	3	1
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010033	response to organic substance	3	1
GO:0010243	response to organonitrogen compound	4	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0030433	ubiquitin-dependent ERAD pathway	6	1
GO:0033554	cellular response to stress	3	1
GO:0034976	response to endoplasmic reticulum stress	4	1
GO:0035966	response to topologically incorrect protein	3	1
GO:0035967	cellular response to topologically incorrect protein	4	1
GO:0036503	ERAD pathway	5	1
GO:0042221	response to chemical	2	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0050896	response to stimulus	1	1
GO:0051084	'de novo' post-translational protein folding	4	1
GO:0051085	chaperone cofactor-dependent protein refolding	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0051716	cellular response to stimulus	2	1
GO:0051788	response to misfolded protein	4	1
GO:0061077	chaperone-mediated protein folding	3	1
GO:0070887	cellular response to chemical stimulus	3	1
GO:0071218	cellular response to misfolded protein	5	1
GO:0071310	cellular response to organic substance	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901698	response to nitrogen compound	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0030544	Hsp70 protein binding	4	1
GO:0031072	heat shock protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	414	418	PF00656	0.733
CLV_NRD_NRD_1	132	134	PF00675	0.796
CLV_NRD_NRD_1	175	177	PF00675	0.632
CLV_NRD_NRD_1	21	23	PF00675	0.479
CLV_NRD_NRD_1	25	27	PF00675	0.474
CLV_NRD_NRD_1	307	309	PF00675	0.706
CLV_NRD_NRD_1	487	489	PF00675	0.553
CLV_NRD_NRD_1	60	62	PF00675	0.497
CLV_PCSK_FUR_1	173	177	PF00082	0.624
CLV_PCSK_FUR_1	58	62	PF00082	0.276
CLV_PCSK_KEX2_1	132	134	PF00082	0.796
CLV_PCSK_KEX2_1	175	177	PF00082	0.632
CLV_PCSK_KEX2_1	21	23	PF00082	0.411
CLV_PCSK_KEX2_1	25	27	PF00082	0.411
CLV_PCSK_KEX2_1	307	309	PF00082	0.713
CLV_PCSK_KEX2_1	350	352	PF00082	0.584
CLV_PCSK_KEX2_1	487	489	PF00082	0.525
CLV_PCSK_KEX2_1	58	60	PF00082	0.411
CLV_PCSK_PC1ET2_1	350	352	PF00082	0.584
CLV_PCSK_PC7_1	21	27	PF00082	0.276
CLV_PCSK_SKI1_1	26	30	PF00082	0.415
CLV_PCSK_SKI1_1	282	286	PF00082	0.580
CLV_PCSK_SKI1_1	323	327	PF00082	0.558
CLV_PCSK_SKI1_1	332	336	PF00082	0.510
CLV_PCSK_SKI1_1	386	390	PF00082	0.539
DEG_SPOP_SBC_1	207	211	PF00917	0.634
DEG_SPOP_SBC_1	369	373	PF00917	0.563
DOC_ANK_TNKS_1	145	152	PF00023	0.649
DOC_CYCLIN_RxL_1	21	34	PF00134	0.479
DOC_CYCLIN_RxL_1	4	12	PF00134	0.393
DOC_MAPK_gen_1	21	31	PF00069	0.411
DOC_MAPK_gen_1	297	305	PF00069	0.590
DOC_PP4_FxxP_1	103	106	PF00568	0.722
DOC_PP4_FxxP_1	189	192	PF00568	0.731
DOC_PP4_FxxP_1	464	467	PF00568	0.632
DOC_USP7_MATH_1	141	145	PF00917	0.827
DOC_USP7_MATH_1	205	209	PF00917	0.668
DOC_USP7_MATH_1	245	249	PF00917	0.750
DOC_USP7_MATH_1	369	373	PF00917	0.563
DOC_USP7_MATH_1	465	469	PF00917	0.778
DOC_USP7_MATH_1	489	493	PF00917	0.509
DOC_USP7_MATH_1	507	511	PF00917	0.634
DOC_USP7_MATH_1	593	597	PF00917	0.781
DOC_USP7_MATH_1	69	73	PF00917	0.761
DOC_WW_Pin1_4	104	109	PF00397	0.688
DOC_WW_Pin1_4	201	206	PF00397	0.737
DOC_WW_Pin1_4	344	349	PF00397	0.615
DOC_WW_Pin1_4	497	502	PF00397	0.736
DOC_WW_Pin1_4	544	549	PF00397	0.494
DOC_WW_Pin1_4	584	589	PF00397	0.667
LIG_14-3-3_CanoR_1	181	189	PF00244	0.708
LIG_14-3-3_CanoR_1	220	224	PF00244	0.682
LIG_14-3-3_CanoR_1	244	254	PF00244	0.593
LIG_14-3-3_CanoR_1	323	328	PF00244	0.688
LIG_14-3-3_CanoR_1	332	341	PF00244	0.714
LIG_14-3-3_CanoR_1	4	10	PF00244	0.432
LIG_14-3-3_CanoR_1	460	467	PF00244	0.591
LIG_14-3-3_CanoR_1	488	496	PF00244	0.588
LIG_14-3-3_CanoR_1	93	103	PF00244	0.569
LIG_AP2alpha_2	455	457	PF02296	0.684
LIG_APCC_ABBA_1	29	34	PF00400	0.393
LIG_BRCT_BRCA1_1	208	212	PF00533	0.746
LIG_eIF4E_1	24	30	PF01652	0.411
LIG_FHA_1	151	157	PF00498	0.758
LIG_FHA_1	6	12	PF00498	0.523
LIG_FHA_2	111	117	PF00498	0.664
LIG_FHA_2	317	323	PF00498	0.584
LIG_FHA_2	372	378	PF00498	0.728
LIG_GBD_Chelix_1	520	528	PF00786	0.456
LIG_Integrin_RGD_1	474	476	PF01839	0.648
LIG_LIR_Apic_2	188	192	PF02991	0.731
LIG_LIR_Apic_2	324	330	PF02991	0.601
LIG_LIR_Apic_2	462	467	PF02991	0.633
LIG_LIR_Gen_1	67	74	PF02991	0.564
LIG_LIR_Nem_3	3	9	PF02991	0.354
LIG_LIR_Nem_3	67	73	PF02991	0.561
LIG_PCNA_yPIPBox_3	525	538	PF02747	0.483
LIG_RPA_C_Fungi	233	245	PF08784	0.555
LIG_SH2_CRK	6	10	PF00017	0.411
LIG_SH2_SRC	50	53	PF00017	0.509
LIG_SH2_STAP1	50	54	PF00017	0.411
LIG_SH2_STAT3	277	280	PF00017	0.683
LIG_SH2_STAT5	277	280	PF00017	0.683
LIG_SH2_STAT5	327	330	PF00017	0.557
LIG_SH2_STAT5	499	502	PF00017	0.655
LIG_SH2_STAT5	555	558	PF00017	0.498
LIG_SH3_1	585	591	PF00018	0.616
LIG_SH3_2	197	202	PF14604	0.595
LIG_SH3_3	190	196	PF00018	0.644
LIG_SH3_3	197	203	PF00018	0.680
LIG_SH3_3	585	591	PF00018	0.661
LIG_SH3_3	77	83	PF00018	0.715
LIG_SH3_3	98	104	PF00018	0.726
LIG_TRAF2_1	113	116	PF00917	0.769
LIG_TRAF2_1	258	261	PF00917	0.698
LIG_TRAF2_1	598	601	PF00917	0.567
MOD_CDC14_SPxK_1	347	350	PF00782	0.565
MOD_CDK_SPK_2	544	549	PF00069	0.508
MOD_CDK_SPxK_1	344	350	PF00069	0.570
MOD_CDK_SPxxK_3	344	351	PF00069	0.573
MOD_CK1_1	161	167	PF00069	0.657
MOD_CK1_1	201	207	PF00069	0.687
MOD_CK1_1	208	214	PF00069	0.690
MOD_CK1_1	228	234	PF00069	0.715
MOD_CK1_1	313	319	PF00069	0.682
MOD_CK1_1	343	349	PF00069	0.667
MOD_CK1_1	364	370	PF00069	0.798
MOD_CK1_1	570	576	PF00069	0.509
MOD_CK1_1	72	78	PF00069	0.723
MOD_CK2_1	110	116	PF00069	0.767
MOD_CK2_1	182	188	PF00069	0.661
MOD_CK2_1	246	252	PF00069	0.800
MOD_CK2_1	316	322	PF00069	0.593
MOD_CK2_1	371	377	PF00069	0.706
MOD_CK2_1	409	415	PF00069	0.637
MOD_CK2_1	507	513	PF00069	0.570
MOD_CK2_1	516	522	PF00069	0.546
MOD_CK2_1	559	565	PF00069	0.495
MOD_CK2_1	594	600	PF00069	0.817
MOD_CK2_1	68	74	PF00069	0.564
MOD_GlcNHglycan	143	146	PF01048	0.754
MOD_GlcNHglycan	184	187	PF01048	0.772
MOD_GlcNHglycan	188	192	PF01048	0.736
MOD_GlcNHglycan	249	252	PF01048	0.661
MOD_GlcNHglycan	292	295	PF01048	0.678
MOD_GlcNHglycan	311	315	PF01048	0.482
MOD_GlcNHglycan	417	421	PF01048	0.769
MOD_GlcNHglycan	428	431	PF01048	0.590
MOD_GlcNHglycan	437	440	PF01048	0.696
MOD_GlcNHglycan	445	448	PF01048	0.571
MOD_GlcNHglycan	461	464	PF01048	0.760
MOD_GlcNHglycan	569	572	PF01048	0.459
MOD_GSK3_1	201	208	PF00069	0.792
MOD_GSK3_1	212	219	PF00069	0.548
MOD_GSK3_1	225	232	PF00069	0.688
MOD_GSK3_1	340	347	PF00069	0.705
MOD_GSK3_1	355	362	PF00069	0.716
MOD_GSK3_1	364	371	PF00069	0.717
MOD_GSK3_1	539	546	PF00069	0.424
MOD_GSK3_1	589	596	PF00069	0.725
MOD_GSK3_1	68	75	PF00069	0.715
MOD_N-GLC_1	156	161	PF02516	0.752
MOD_N-GLC_1	343	348	PF02516	0.687
MOD_N-GLC_1	364	369	PF02516	0.645
MOD_N-GLC_2	160	162	PF02516	0.780
MOD_NEK2_1	118	123	PF00069	0.658
MOD_NEK2_1	212	217	PF00069	0.734
MOD_NEK2_1	340	345	PF00069	0.611
MOD_NEK2_1	443	448	PF00069	0.699
MOD_NEK2_1	516	521	PF00069	0.644
MOD_NEK2_1	556	561	PF00069	0.572
MOD_NEK2_1	73	78	PF00069	0.597
MOD_PIKK_1	161	167	PF00454	0.609
MOD_PIKK_1	214	220	PF00454	0.774
MOD_PIKK_1	229	235	PF00454	0.643
MOD_PKA_2	219	225	PF00069	0.692
MOD_PKA_2	228	234	PF00069	0.623
MOD_PKA_2	290	296	PF00069	0.607
MOD_PKA_2	316	322	PF00069	0.604
MOD_PKA_2	393	399	PF00069	0.601
MOD_PKA_2	459	465	PF00069	0.641
MOD_PKA_2	534	540	PF00069	0.658
MOD_PKB_1	236	244	PF00069	0.679
MOD_Plk_1	252	258	PF00069	0.641
MOD_Plk_1	321	327	PF00069	0.697
MOD_Plk_1	396	402	PF00069	0.626
MOD_Plk_1	73	79	PF00069	0.526
MOD_Plk_2-3	150	156	PF00069	0.667
MOD_Plk_2-3	252	258	PF00069	0.810
MOD_Plk_4	219	225	PF00069	0.786
MOD_Plk_4	323	329	PF00069	0.588
MOD_Plk_4	527	533	PF00069	0.612
MOD_ProDKin_1	104	110	PF00069	0.688
MOD_ProDKin_1	201	207	PF00069	0.736
MOD_ProDKin_1	344	350	PF00069	0.616
MOD_ProDKin_1	497	503	PF00069	0.733
MOD_ProDKin_1	544	550	PF00069	0.489
MOD_ProDKin_1	584	590	PF00069	0.673
MOD_SUMO_for_1	258	261	PF00179	0.698
TRG_ENDOCYTIC_2	6	9	PF00928	0.415
TRG_ER_diArg_1	174	176	PF00400	0.622
TRG_ER_diArg_1	20	22	PF00400	0.439
TRG_ER_diArg_1	236	239	PF00400	0.669
TRG_ER_diArg_1	24	26	PF00400	0.430
TRG_ER_diArg_1	307	309	PF00400	0.731
TRG_ER_diArg_1	487	489	PF00400	0.579
TRG_ER_diArg_1	58	61	PF00400	0.439
TRG_Pf-PMV_PEXEL_1	238	243	PF00026	0.567
TRG_Pf-PMV_PEXEL_1	482	486	PF00026	0.600
TRG_Pf-PMV_PEXEL_1	488	493	PF00026	0.562
TRG_Pf-PMV_PEXEL_1	7	12	PF00026	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC79	Leptomonas seymouri	36%	100%
A4H6Z1	Leishmania braziliensis	61%	100%
E9AGH2	Leishmania infantum	100%	100%
E9AP11	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QGH8	Leishmania major	83%	100%