LeishMANIAdb
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Integral membrane protein conserved region (DUF2404), putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Integral membrane protein conserved region (DUF2404), putative
Gene product:
Putative integral membrane protein conserved region (DUF2404), putative
Species:
Leishmania donovani
UniProt:
A0A3S7WS71_LEIDO
TriTrypDb:
LdBPK_120760.1 , LdCL_120019500 , LDHU3_12.1520
Length:
947

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5
GO:0005783 endoplasmic reticulum 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

A0A3S7WS71
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WS71

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 3
GO:0006869 lipid transport 5 3
GO:0051179 localization 1 3
GO:0051234 establishment of localization 2 3
GO:0071702 organic substance transport 4 3
Molecular functions
Term Name Level Count
GO:0005488 binding 1 4
GO:0008289 lipid binding 2 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 379 383 PF00656 0.761
CLV_C14_Caspase3-7 388 392 PF00656 0.712
CLV_C14_Caspase3-7 399 403 PF00656 0.615
CLV_C14_Caspase3-7 404 408 PF00656 0.619
CLV_C14_Caspase3-7 711 715 PF00656 0.684
CLV_C14_Caspase3-7 768 772 PF00656 0.786
CLV_NRD_NRD_1 180 182 PF00675 0.349
CLV_NRD_NRD_1 412 414 PF00675 0.527
CLV_NRD_NRD_1 426 428 PF00675 0.522
CLV_NRD_NRD_1 503 505 PF00675 0.345
CLV_PCSK_KEX2_1 412 414 PF00082 0.519
CLV_PCSK_KEX2_1 426 428 PF00082 0.534
CLV_PCSK_KEX2_1 913 915 PF00082 0.547
CLV_PCSK_PC1ET2_1 913 915 PF00082 0.547
CLV_PCSK_SKI1_1 170 174 PF00082 0.524
CLV_PCSK_SKI1_1 203 207 PF00082 0.566
CLV_PCSK_SKI1_1 326 330 PF00082 0.441
CLV_PCSK_SKI1_1 34 38 PF00082 0.366
CLV_PCSK_SKI1_1 484 488 PF00082 0.300
CLV_PCSK_SKI1_1 571 575 PF00082 0.327
CLV_PCSK_SKI1_1 631 635 PF00082 0.406
CLV_PCSK_SKI1_1 636 640 PF00082 0.350
CLV_PCSK_SKI1_1 693 697 PF00082 0.387
CLV_PCSK_SKI1_1 759 763 PF00082 0.486
CLV_PCSK_SKI1_1 914 918 PF00082 0.494
CLV_PCSK_SKI1_1 922 926 PF00082 0.398
CLV_PCSK_SKI1_1 933 937 PF00082 0.375
CLV_PCSK_SKI1_1 95 99 PF00082 0.395
DEG_APCC_DBOX_1 503 511 PF00400 0.555
DEG_APCC_DBOX_1 769 777 PF00400 0.784
DEG_MDM2_SWIB_1 7 15 PF02201 0.331
DEG_SCF_FBW7_1 737 743 PF00400 0.774
DEG_SPOP_SBC_1 882 886 PF00917 0.747
DOC_CDC14_PxL_1 638 646 PF14671 0.546
DOC_CKS1_1 737 742 PF01111 0.776
DOC_CKS1_1 825 830 PF01111 0.689
DOC_CYCLIN_yClb5_NLxxxL_5 922 928 PF00134 0.699
DOC_MAPK_DCC_7 770 778 PF00069 0.757
DOC_MAPK_gen_1 167 177 PF00069 0.728
DOC_MAPK_gen_1 181 187 PF00069 0.530
DOC_MAPK_gen_1 504 512 PF00069 0.647
DOC_MAPK_gen_1 922 930 PF00069 0.624
DOC_MAPK_MEF2A_6 615 623 PF00069 0.541
DOC_MAPK_MEF2A_6 770 778 PF00069 0.757
DOC_PP1_RVXF_1 314 321 PF00149 0.573
DOC_PP4_FxxP_1 668 671 PF00568 0.572
DOC_USP7_MATH_1 146 150 PF00917 0.696
DOC_USP7_MATH_1 2 6 PF00917 0.268
DOC_USP7_MATH_1 232 236 PF00917 0.770
DOC_USP7_MATH_1 258 262 PF00917 0.678
DOC_USP7_MATH_1 275 279 PF00917 0.703
DOC_USP7_MATH_1 289 293 PF00917 0.715
DOC_USP7_MATH_1 369 373 PF00917 0.667
DOC_USP7_MATH_1 543 547 PF00917 0.565
DOC_USP7_MATH_1 669 673 PF00917 0.593
DOC_USP7_MATH_1 677 681 PF00917 0.632
DOC_USP7_MATH_1 722 726 PF00917 0.749
DOC_USP7_MATH_1 740 744 PF00917 0.671
DOC_USP7_MATH_1 764 768 PF00917 0.743
DOC_USP7_MATH_1 797 801 PF00917 0.715
DOC_USP7_MATH_1 816 820 PF00917 0.735
DOC_USP7_MATH_1 829 833 PF00917 0.791
DOC_USP7_MATH_1 876 880 PF00917 0.793
DOC_USP7_UBL2_3 925 929 PF12436 0.638
DOC_WW_Pin1_4 330 335 PF00397 0.779
DOC_WW_Pin1_4 673 678 PF00397 0.601
DOC_WW_Pin1_4 713 718 PF00397 0.732
DOC_WW_Pin1_4 733 738 PF00397 0.743
DOC_WW_Pin1_4 748 753 PF00397 0.643
DOC_WW_Pin1_4 821 826 PF00397 0.762
DOC_WW_Pin1_4 840 845 PF00397 0.813
DOC_WW_Pin1_4 87 92 PF00397 0.686
LIG_14-3-3_CanoR_1 233 241 PF00244 0.664
LIG_14-3-3_CanoR_1 34 40 PF00244 0.567
LIG_14-3-3_CanoR_1 342 350 PF00244 0.671
LIG_14-3-3_CanoR_1 451 456 PF00244 0.558
LIG_14-3-3_CanoR_1 544 551 PF00244 0.635
LIG_14-3-3_CanoR_1 571 577 PF00244 0.615
LIG_14-3-3_CanoR_1 636 644 PF00244 0.555
LIG_14-3-3_CanoR_1 742 746 PF00244 0.705
LIG_14-3-3_CanoR_1 850 859 PF00244 0.791
LIG_14-3-3_CanoR_1 914 924 PF00244 0.627
LIG_APCC_ABBA_1 492 497 PF00400 0.537
LIG_APCC_ABBA_1 654 659 PF00400 0.542
LIG_APCC_ABBA_1 661 666 PF00400 0.555
LIG_APCC_ABBAyCdc20_2 653 659 PF00400 0.542
LIG_BIR_II_1 1 5 PF00653 0.509
LIG_BRCT_BRCA1_1 165 169 PF00533 0.758
LIG_BRCT_BRCA1_1 249 253 PF00533 0.735
LIG_BRCT_BRCA1_1 354 358 PF00533 0.692
LIG_BRCT_BRCA1_1 482 486 PF00533 0.535
LIG_BRCT_BRCA1_1 566 570 PF00533 0.510
LIG_BRCT_BRCA1_1 605 609 PF00533 0.564
LIG_Clathr_ClatBox_1 121 125 PF01394 0.614
LIG_Clathr_ClatBox_1 590 594 PF01394 0.518
LIG_CSL_BTD_1 860 863 PF09270 0.722
LIG_EVH1_2 335 339 PF00568 0.693
LIG_FHA_1 24 30 PF00498 0.540
LIG_FHA_1 312 318 PF00498 0.638
LIG_FHA_1 345 351 PF00498 0.674
LIG_FHA_1 376 382 PF00498 0.797
LIG_FHA_1 594 600 PF00498 0.529
LIG_FHA_1 647 653 PF00498 0.636
LIG_FHA_1 825 831 PF00498 0.695
LIG_FHA_2 174 180 PF00498 0.610
LIG_FHA_2 189 195 PF00498 0.650
LIG_FHA_2 265 271 PF00498 0.762
LIG_FHA_2 397 403 PF00498 0.772
LIG_FHA_2 496 502 PF00498 0.631
LIG_LIR_Apic_2 106 110 PF02991 0.644
LIG_LIR_Apic_2 666 671 PF02991 0.573
LIG_LIR_Gen_1 130 137 PF02991 0.563
LIG_LIR_Gen_1 435 443 PF02991 0.674
LIG_LIR_Gen_1 450 459 PF02991 0.572
LIG_LIR_Gen_1 554 559 PF02991 0.530
LIG_LIR_Gen_1 680 689 PF02991 0.697
LIG_LIR_Nem_3 130 135 PF02991 0.543
LIG_LIR_Nem_3 435 439 PF02991 0.693
LIG_LIR_Nem_3 450 455 PF02991 0.567
LIG_LIR_Nem_3 463 468 PF02991 0.602
LIG_LIR_Nem_3 554 558 PF02991 0.570
LIG_LIR_Nem_3 567 572 PF02991 0.460
LIG_LIR_Nem_3 575 579 PF02991 0.609
LIG_LIR_Nem_3 680 684 PF02991 0.704
LIG_LYPXL_SIV_4 41 49 PF13949 0.579
LIG_MLH1_MIPbox_1 165 169 PF16413 0.758
LIG_MLH1_MIPbox_1 482 486 PF16413 0.535
LIG_MLH1_MIPbox_1 566 570 PF16413 0.510
LIG_MYND_1 844 848 PF01753 0.783
LIG_NRBOX 524 530 PF00104 0.611
LIG_NRBOX 923 929 PF00104 0.701
LIG_PCNA_PIPBox_1 648 657 PF02747 0.499
LIG_Pex14_2 481 485 PF04695 0.539
LIG_Pex14_2 7 11 PF04695 0.331
LIG_REV1ctd_RIR_1 166 174 PF16727 0.756
LIG_REV1ctd_RIR_1 567 575 PF16727 0.518
LIG_REV1ctd_RIR_1 70 78 PF16727 0.674
LIG_RPA_C_Fungi 829 841 PF08784 0.673
LIG_SH2_CRK 132 136 PF00017 0.578
LIG_SH2_CRK 576 580 PF00017 0.553
LIG_SH2_PTP2 42 45 PF00017 0.463
LIG_SH2_SRC 42 45 PF00017 0.431
LIG_SH2_STAP1 468 472 PF00017 0.564
LIG_SH2_STAT5 42 45 PF00017 0.446
LIG_SH2_STAT5 576 579 PF00017 0.546
LIG_SH2_STAT5 655 658 PF00017 0.396
LIG_SH3_1 841 847 PF00018 0.757
LIG_SH3_2 737 742 PF14604 0.631
LIG_SH3_3 537 543 PF00018 0.418
LIG_SH3_3 671 677 PF00018 0.471
LIG_SH3_3 734 740 PF00018 0.640
LIG_SH3_3 819 825 PF00018 0.707
LIG_SH3_3 841 847 PF00018 0.757
LIG_SUMO_SIM_anti_2 173 179 PF11976 0.518
LIG_SUMO_SIM_anti_2 496 504 PF11976 0.511
LIG_SUMO_SIM_par_1 119 125 PF11976 0.510
LIG_SUMO_SIM_par_1 589 594 PF11976 0.372
LIG_SUMO_SIM_par_1 774 780 PF11976 0.710
LIG_TYR_ITIM 574 579 PF00017 0.533
LIG_UBA3_1 455 460 PF00899 0.537
LIG_UBA3_1 499 505 PF00899 0.412
LIG_UBA3_1 647 653 PF00899 0.340
LIG_WRC_WIRS_1 478 483 PF05994 0.403
MOD_CDC14_SPxK_1 90 93 PF00782 0.696
MOD_CDK_SPK_2 673 678 PF00069 0.489
MOD_CDK_SPK_2 821 826 PF00069 0.607
MOD_CDK_SPxK_1 736 742 PF00069 0.737
MOD_CDK_SPxK_1 87 93 PF00069 0.699
MOD_CDK_SPxxK_3 713 720 PF00069 0.716
MOD_CK1_1 147 153 PF00069 0.726
MOD_CK1_1 154 160 PF00069 0.692
MOD_CK1_1 201 207 PF00069 0.647
MOD_CK1_1 222 228 PF00069 0.724
MOD_CK1_1 236 242 PF00069 0.605
MOD_CK1_1 271 277 PF00069 0.768
MOD_CK1_1 280 286 PF00069 0.616
MOD_CK1_1 292 298 PF00069 0.594
MOD_CK1_1 311 317 PF00069 0.584
MOD_CK1_1 338 344 PF00069 0.705
MOD_CK1_1 35 41 PF00069 0.542
MOD_CK1_1 377 383 PF00069 0.722
MOD_CK1_1 385 391 PF00069 0.636
MOD_CK1_1 538 544 PF00069 0.458
MOD_CK1_1 705 711 PF00069 0.756
MOD_CK1_1 736 742 PF00069 0.769
MOD_CK1_1 744 750 PF00069 0.640
MOD_CK1_1 753 759 PF00069 0.756
MOD_CK1_1 769 775 PF00069 0.567
MOD_CK1_1 800 806 PF00069 0.695
MOD_CK1_1 809 815 PF00069 0.549
MOD_CK1_1 824 830 PF00069 0.625
MOD_CK1_1 857 863 PF00069 0.766
MOD_CK1_1 877 883 PF00069 0.752
MOD_CK1_1 908 914 PF00069 0.592
MOD_CK1_1 915 921 PF00069 0.525
MOD_CK2_1 173 179 PF00069 0.518
MOD_CK2_1 188 194 PF00069 0.560
MOD_CK2_1 222 228 PF00069 0.759
MOD_CK2_1 264 270 PF00069 0.753
MOD_CK2_1 495 501 PF00069 0.572
MOD_GlcNHglycan 12 15 PF01048 0.391
MOD_GlcNHglycan 139 142 PF01048 0.620
MOD_GlcNHglycan 146 149 PF01048 0.605
MOD_GlcNHglycan 221 224 PF01048 0.787
MOD_GlcNHglycan 230 233 PF01048 0.660
MOD_GlcNHglycan 249 252 PF01048 0.463
MOD_GlcNHglycan 255 258 PF01048 0.636
MOD_GlcNHglycan 273 276 PF01048 0.725
MOD_GlcNHglycan 286 289 PF01048 0.565
MOD_GlcNHglycan 291 294 PF01048 0.512
MOD_GlcNHglycan 3 7 PF01048 0.382
MOD_GlcNHglycan 305 308 PF01048 0.665
MOD_GlcNHglycan 371 374 PF01048 0.592
MOD_GlcNHglycan 456 459 PF01048 0.430
MOD_GlcNHglycan 545 548 PF01048 0.445
MOD_GlcNHglycan 628 631 PF01048 0.512
MOD_GlcNHglycan 643 647 PF01048 0.425
MOD_GlcNHglycan 66 69 PF01048 0.620
MOD_GlcNHglycan 698 701 PF01048 0.669
MOD_GlcNHglycan 707 710 PF01048 0.619
MOD_GlcNHglycan 731 734 PF01048 0.654
MOD_GlcNHglycan 779 784 PF01048 0.666
MOD_GlcNHglycan 797 800 PF01048 0.721
MOD_GlcNHglycan 870 873 PF01048 0.674
MOD_GlcNHglycan 885 888 PF01048 0.668
MOD_GlcNHglycan 908 911 PF01048 0.611
MOD_GlcNHglycan 914 917 PF01048 0.585
MOD_GlcNHglycan 99 102 PF01048 0.428
MOD_GSK3_1 135 142 PF00069 0.658
MOD_GSK3_1 147 154 PF00069 0.619
MOD_GSK3_1 228 235 PF00069 0.665
MOD_GSK3_1 264 271 PF00069 0.707
MOD_GSK3_1 280 287 PF00069 0.550
MOD_GSK3_1 340 347 PF00069 0.649
MOD_GSK3_1 352 359 PF00069 0.627
MOD_GSK3_1 382 389 PF00069 0.789
MOD_GSK3_1 396 403 PF00069 0.574
MOD_GSK3_1 593 600 PF00069 0.386
MOD_GSK3_1 642 649 PF00069 0.407
MOD_GSK3_1 669 676 PF00069 0.492
MOD_GSK3_1 704 711 PF00069 0.624
MOD_GSK3_1 729 736 PF00069 0.773
MOD_GSK3_1 740 747 PF00069 0.636
MOD_GSK3_1 750 757 PF00069 0.588
MOD_GSK3_1 800 807 PF00069 0.756
MOD_GSK3_1 830 837 PF00069 0.736
MOD_GSK3_1 850 857 PF00069 0.680
MOD_GSK3_1 870 877 PF00069 0.780
MOD_GSK3_1 894 901 PF00069 0.651
MOD_GSK3_1 908 915 PF00069 0.611
MOD_GSK3_1 936 943 PF00069 0.732
MOD_GSK3_1 95 102 PF00069 0.507
MOD_N-GLC_1 188 193 PF02516 0.643
MOD_N-GLC_1 198 203 PF02516 0.604
MOD_N-GLC_1 268 273 PF02516 0.718
MOD_N-GLC_1 344 349 PF02516 0.738
MOD_N-GLC_1 386 391 PF02516 0.576
MOD_N-GLC_1 816 821 PF02516 0.747
MOD_N-GLC_1 868 873 PF02516 0.732
MOD_N-GLC_1 874 879 PF02516 0.637
MOD_N-GLC_1 895 900 PF02516 0.728
MOD_NEK2_1 137 142 PF00069 0.557
MOD_NEK2_1 168 173 PF00069 0.710
MOD_NEK2_1 188 193 PF00069 0.388
MOD_NEK2_1 198 203 PF00069 0.581
MOD_NEK2_1 23 28 PF00069 0.626
MOD_NEK2_1 247 252 PF00069 0.672
MOD_NEK2_1 253 258 PF00069 0.687
MOD_NEK2_1 268 273 PF00069 0.567
MOD_NEK2_1 303 308 PF00069 0.691
MOD_NEK2_1 32 37 PF00069 0.494
MOD_NEK2_1 328 333 PF00069 0.598
MOD_NEK2_1 358 363 PF00069 0.781
MOD_NEK2_1 495 500 PF00069 0.554
MOD_NEK2_1 529 534 PF00069 0.414
MOD_NEK2_1 572 577 PF00069 0.536
MOD_NEK2_1 593 598 PF00069 0.378
MOD_NEK2_1 754 759 PF00069 0.742
MOD_NEK2_1 830 835 PF00069 0.730
MOD_NEK2_1 883 888 PF00069 0.735
MOD_NEK2_2 151 156 PF00069 0.586
MOD_NEK2_2 308 313 PF00069 0.616
MOD_OFUCOSY 894 899 PF10250 0.728
MOD_PIKK_1 277 283 PF00454 0.617
MOD_PIKK_1 52 58 PF00454 0.526
MOD_PIKK_1 529 535 PF00454 0.411
MOD_PIKK_1 834 840 PF00454 0.778
MOD_PKA_1 912 918 PF00069 0.679
MOD_PKA_2 151 157 PF00069 0.586
MOD_PKA_2 163 169 PF00069 0.602
MOD_PKA_2 232 238 PF00069 0.581
MOD_PKA_2 369 375 PF00069 0.749
MOD_PKA_2 543 549 PF00069 0.548
MOD_PKA_2 702 708 PF00069 0.620
MOD_PKA_2 723 729 PF00069 0.672
MOD_PKA_2 741 747 PF00069 0.470
MOD_PKA_2 769 775 PF00069 0.713
MOD_PKA_2 854 860 PF00069 0.748
MOD_PKA_2 936 942 PF00069 0.728
MOD_Plk_1 188 194 PF00069 0.610
MOD_Plk_1 2 8 PF00069 0.303
MOD_Plk_1 264 270 PF00069 0.712
MOD_Plk_1 344 350 PF00069 0.772
MOD_Plk_1 396 402 PF00069 0.677
MOD_Plk_1 593 599 PF00069 0.377
MOD_Plk_1 816 822 PF00069 0.645
MOD_Plk_1 874 880 PF00069 0.656
MOD_Plk_2-3 396 402 PF00069 0.734
MOD_Plk_4 103 109 PF00069 0.408
MOD_Plk_4 127 133 PF00069 0.394
MOD_Plk_4 173 179 PF00069 0.585
MOD_Plk_4 188 194 PF00069 0.495
MOD_Plk_4 308 314 PF00069 0.666
MOD_Plk_4 44 50 PF00069 0.666
MOD_Plk_4 451 457 PF00069 0.438
MOD_Plk_4 477 483 PF00069 0.412
MOD_Plk_4 495 501 PF00069 0.412
MOD_Plk_4 564 570 PF00069 0.489
MOD_Plk_4 605 611 PF00069 0.503
MOD_Plk_4 669 675 PF00069 0.491
MOD_Plk_4 857 863 PF00069 0.756
MOD_ProDKin_1 330 336 PF00069 0.743
MOD_ProDKin_1 673 679 PF00069 0.485
MOD_ProDKin_1 713 719 PF00069 0.676
MOD_ProDKin_1 733 739 PF00069 0.686
MOD_ProDKin_1 748 754 PF00069 0.552
MOD_ProDKin_1 821 827 PF00069 0.716
MOD_ProDKin_1 840 846 PF00069 0.787
MOD_ProDKin_1 87 93 PF00069 0.608
MOD_SUMO_for_1 441 444 PF00179 0.513
MOD_SUMO_rev_2 159 169 PF00179 0.713
MOD_SUMO_rev_2 712 722 PF00179 0.758
TRG_DiLeu_BaEn_2 2 8 PF01217 0.344
TRG_ENDOCYTIC_2 132 135 PF00928 0.563
TRG_ENDOCYTIC_2 42 45 PF00928 0.463
TRG_ENDOCYTIC_2 576 579 PF00928 0.546
TRG_ENDOCYTIC_2 9 12 PF00928 0.331
TRG_ER_diArg_1 684 687 PF00400 0.508
TRG_ER_diLys_1 944 947 PF00400 0.773
TRG_Pf-PMV_PEXEL_1 326 330 PF00026 0.545
TRG_Pf-PMV_PEXEL_1 517 522 PF00026 0.529

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1ILD4 Leptomonas seymouri 45% 100%
E9AGI0 Leishmania infantum 100% 100%
E9AP16 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%
Q4QGH3 Leishmania major 88% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS