Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7WS06_LEIDO

TriTrypDb:

LdBPK_120510.1 , LdCL_120010800 , LDHU3_12.0780

Length:

499

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WS06

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WS06

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	210	214	PF00656	0.616
CLV_NRD_NRD_1	119	121	PF00675	0.463
CLV_NRD_NRD_1	156	158	PF00675	0.461
CLV_NRD_NRD_1	18	20	PF00675	0.449
CLV_PCSK_KEX2_1	119	121	PF00082	0.463
CLV_PCSK_KEX2_1	18	20	PF00082	0.449
CLV_PCSK_KEX2_1	491	493	PF00082	0.517
CLV_PCSK_PC1ET2_1	491	493	PF00082	0.517
CLV_PCSK_PC7_1	487	493	PF00082	0.514
CLV_PCSK_SKI1_1	119	123	PF00082	0.477
CLV_PCSK_SKI1_1	467	471	PF00082	0.520
CLV_PCSK_SKI1_1	64	68	PF00082	0.376
CLV_Separin_Metazoa	413	417	PF03568	0.637
CLV_Separin_Metazoa	468	472	PF03568	0.527
DEG_APCC_KENBOX_2	270	274	PF00400	0.686
DEG_SCF_FBW7_1	166	173	PF00400	0.583
DEG_SPOP_SBC_1	170	174	PF00917	0.684
DOC_CYCLIN_RxL_1	467	477	PF00134	0.483
DOC_MAPK_FxFP_2	422	425	PF00069	0.619
DOC_MAPK_gen_1	145	153	PF00069	0.455
DOC_PP4_FxxP_1	296	299	PF00568	0.660
DOC_PP4_FxxP_1	422	425	PF00568	0.619
DOC_USP7_MATH_1	170	174	PF00917	0.731
DOC_USP7_MATH_1	189	193	PF00917	0.631
DOC_USP7_MATH_1	198	202	PF00917	0.611
DOC_USP7_MATH_1	207	211	PF00917	0.680
DOC_USP7_MATH_1	232	236	PF00917	0.650
DOC_USP7_MATH_1	310	314	PF00917	0.632
DOC_USP7_MATH_1	334	338	PF00917	0.728
DOC_USP7_MATH_1	347	351	PF00917	0.778
DOC_USP7_MATH_1	389	393	PF00917	0.635
DOC_USP7_MATH_1	456	460	PF00917	0.556
DOC_USP7_UBL2_3	143	147	PF12436	0.463
DOC_USP7_UBL2_3	271	275	PF12436	0.687
DOC_WW_Pin1_4	166	171	PF00397	0.579
DOC_WW_Pin1_4	213	218	PF00397	0.730
DOC_WW_Pin1_4	233	238	PF00397	0.505
DOC_WW_Pin1_4	255	260	PF00397	0.730
DOC_WW_Pin1_4	295	300	PF00397	0.640
DOC_WW_Pin1_4	364	369	PF00397	0.660
DOC_WW_Pin1_4	371	376	PF00397	0.602
LIG_14-3-3_CanoR_1	19	25	PF00244	0.475
LIG_14-3-3_CanoR_1	244	248	PF00244	0.669
LIG_14-3-3_CanoR_1	338	348	PF00244	0.736
LIG_14-3-3_CanoR_1	384	390	PF00244	0.622
LIG_14-3-3_CanoR_1	64	74	PF00244	0.382
LIG_AP2alpha_2	420	422	PF02296	0.621
LIG_BRCT_BRCA1_1	171	175	PF00533	0.662
LIG_CSL_BTD_1	318	321	PF09270	0.637
LIG_EVH1_1	424	428	PF00568	0.624
LIG_FHA_1	135	141	PF00498	0.463
LIG_FHA_1	385	391	PF00498	0.597
LIG_FHA_1	69	75	PF00498	0.437
LIG_FHA_2	112	118	PF00498	0.477
LIG_FHA_2	447	453	PF00498	0.625
LIG_LIR_Apic_2	226	231	PF02991	0.638
LIG_LIR_Apic_2	295	299	PF02991	0.657
LIG_LIR_Apic_2	420	425	PF02991	0.619
LIG_LIR_Gen_1	25	34	PF02991	0.371
LIG_LIR_Gen_1	436	442	PF02991	0.690
LIG_LIR_Gen_1	9	17	PF02991	0.464
LIG_LIR_Nem_3	25	30	PF02991	0.508
LIG_LIR_Nem_3	436	441	PF02991	0.695
LIG_LIR_Nem_3	488	493	PF02991	0.511
LIG_NRBOX	469	475	PF00104	0.483
LIG_SH2_CRK	222	226	PF00017	0.642
LIG_SH2_CRK	228	232	PF00017	0.593
LIG_SH2_CRK	438	442	PF00017	0.728
LIG_SH2_CRK	490	494	PF00017	0.520
LIG_SH2_STAP1	27	31	PF00017	0.448
LIG_SH2_STAP1	385	389	PF00017	0.680
LIG_SH2_STAT5	385	388	PF00017	0.696
LIG_SH3_3	231	237	PF00018	0.533
LIG_SH3_3	253	259	PF00018	0.801
LIG_SH3_3	314	320	PF00018	0.633
LIG_SH3_3	422	428	PF00018	0.624
LIG_SH3_CIN85_PxpxPR_1	421	426	PF14604	0.626
LIG_SUMO_SIM_anti_2	313	319	PF11976	0.601
LIG_TRAF2_1	102	105	PF00917	0.529
LIG_TRAF2_1	48	51	PF00917	0.415
LIG_UBA3_1	469	476	PF00899	0.481
LIG_WRC_WIRS_1	293	298	PF05994	0.599
MOD_CDK_SPxxK_3	213	220	PF00069	0.632
MOD_CDK_SPxxK_3	299	306	PF00069	0.650
MOD_CK1_1	168	174	PF00069	0.714
MOD_CK1_1	212	218	PF00069	0.692
MOD_CK1_1	235	241	PF00069	0.651
MOD_CK1_1	245	251	PF00069	0.587
MOD_CK1_1	289	295	PF00069	0.697
MOD_CK1_1	3	9	PF00069	0.545
MOD_CK1_1	333	339	PF00069	0.817
MOD_CK1_1	341	347	PF00069	0.599
MOD_CK1_1	371	377	PF00069	0.644
MOD_CK1_1	81	87	PF00069	0.538
MOD_CK2_1	111	117	PF00069	0.476
MOD_CK2_1	198	204	PF00069	0.567
MOD_CK2_1	233	239	PF00069	0.651
MOD_CK2_1	255	261	PF00069	0.657
MOD_CK2_1	266	272	PF00069	0.617
MOD_CK2_1	3	9	PF00069	0.523
MOD_CK2_1	427	433	PF00069	0.575
MOD_CK2_1	45	51	PF00069	0.405
MOD_GlcNHglycan	124	129	PF01048	0.471
MOD_GlcNHglycan	209	212	PF01048	0.681
MOD_GlcNHglycan	299	302	PF01048	0.612
MOD_GlcNHglycan	312	315	PF01048	0.572
MOD_GlcNHglycan	331	335	PF01048	0.723
MOD_GlcNHglycan	349	352	PF01048	0.676
MOD_GlcNHglycan	387	390	PF01048	0.725
MOD_GlcNHglycan	429	432	PF01048	0.630
MOD_GlcNHglycan	452	456	PF01048	0.627
MOD_GlcNHglycan	458	461	PF01048	0.517
MOD_GlcNHglycan	75	78	PF01048	0.503
MOD_GlcNHglycan	80	83	PF01048	0.498
MOD_GlcNHglycan	91	94	PF01048	0.473
MOD_GSK3_1	107	114	PF00069	0.494
MOD_GSK3_1	164	171	PF00069	0.700
MOD_GSK3_1	209	216	PF00069	0.663
MOD_GSK3_1	242	249	PF00069	0.707
MOD_GSK3_1	288	295	PF00069	0.701
MOD_GSK3_1	326	333	PF00069	0.775
MOD_GSK3_1	334	341	PF00069	0.785
MOD_GSK3_1	364	371	PF00069	0.662
MOD_GSK3_1	385	392	PF00069	0.803
MOD_GSK3_1	436	443	PF00069	0.703
MOD_GSK3_1	447	454	PF00069	0.546
MOD_GSK3_1	84	91	PF00069	0.620
MOD_NEK2_1	107	112	PF00069	0.376
MOD_NEK2_1	243	248	PF00069	0.671
MOD_NEK2_1	45	50	PF00069	0.401
MOD_NEK2_1	78	83	PF00069	0.631
MOD_NEK2_1	89	94	PF00069	0.599
MOD_PIKK_1	198	204	PF00454	0.741
MOD_PIKK_1	215	221	PF00454	0.592
MOD_PIKK_1	336	342	PF00454	0.682
MOD_PIKK_1	391	397	PF00454	0.640
MOD_PIKK_1	45	51	PF00454	0.417
MOD_PKA_2	107	113	PF00069	0.409
MOD_PKA_2	134	140	PF00069	0.464
MOD_PKA_2	243	249	PF00069	0.669
MOD_PKA_2	383	389	PF00069	0.620
MOD_PKA_2	78	84	PF00069	0.533
MOD_PKA_2	96	102	PF00069	0.444
MOD_Plk_1	275	281	PF00069	0.635
MOD_Plk_1	289	295	PF00069	0.557
MOD_Plk_1	3	9	PF00069	0.523
MOD_Plk_1	84	90	PF00069	0.535
MOD_Plk_2-3	266	272	PF00069	0.617
MOD_Plk_4	223	229	PF00069	0.625
MOD_Plk_4	292	298	PF00069	0.663
MOD_Plk_4	433	439	PF00069	0.789
MOD_ProDKin_1	166	172	PF00069	0.583
MOD_ProDKin_1	213	219	PF00069	0.728
MOD_ProDKin_1	233	239	PF00069	0.508
MOD_ProDKin_1	255	261	PF00069	0.729
MOD_ProDKin_1	295	301	PF00069	0.639
MOD_ProDKin_1	364	370	PF00069	0.662
MOD_ProDKin_1	371	377	PF00069	0.602
TRG_ENDOCYTIC_2	21	24	PF00928	0.476
TRG_ENDOCYTIC_2	27	30	PF00928	0.436
TRG_ENDOCYTIC_2	438	441	PF00928	0.736
TRG_ENDOCYTIC_2	490	493	PF00928	0.518
TRG_ER_diArg_1	118	120	PF00400	0.458
TRG_ER_diArg_1	17	19	PF00400	0.450
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	471	475	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	491	495	PF00026	0.394

Homologs


Protein	Taxonomy	Sequence identity	Coverage
E9AGE3	Leishmania infantum	99%	100%
E9ANY3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QGN7	Leishmania major	90%	100%