Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WRY8_LEIDO

TriTrypDb:

LdBPK_120400.1 , LdCL_120009600 , LDHU3_12.0580

Length:

651

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WRY8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WRY8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	146	150	PF00656	0.514
CLV_C14_Caspase3-7	208	212	PF00656	0.765
CLV_C14_Caspase3-7	264	268	PF00656	0.767
CLV_C14_Caspase3-7	333	337	PF00656	0.720
CLV_C14_Caspase3-7	366	370	PF00656	0.760
CLV_C14_Caspase3-7	484	488	PF00656	0.552
CLV_NRD_NRD_1	276	278	PF00675	0.735
CLV_NRD_NRD_1	3	5	PF00675	0.619
CLV_NRD_NRD_1	408	410	PF00675	0.634
CLV_NRD_NRD_1	471	473	PF00675	0.549
CLV_NRD_NRD_1	508	510	PF00675	0.675
CLV_NRD_NRD_1	625	627	PF00675	0.664
CLV_NRD_NRD_1	629	631	PF00675	0.670
CLV_NRD_NRD_1	644	646	PF00675	0.651
CLV_NRD_NRD_1	72	74	PF00675	0.560
CLV_NRD_NRD_1	75	77	PF00675	0.577
CLV_PCSK_FUR_1	403	407	PF00082	0.638
CLV_PCSK_FUR_1	626	630	PF00082	0.786
CLV_PCSK_KEX2_1	12	14	PF00082	0.595
CLV_PCSK_KEX2_1	2	4	PF00082	0.641
CLV_PCSK_KEX2_1	226	228	PF00082	0.632
CLV_PCSK_KEX2_1	276	278	PF00082	0.735
CLV_PCSK_KEX2_1	402	404	PF00082	0.636
CLV_PCSK_KEX2_1	405	407	PF00082	0.639
CLV_PCSK_KEX2_1	408	410	PF00082	0.643
CLV_PCSK_KEX2_1	470	472	PF00082	0.540
CLV_PCSK_KEX2_1	508	510	PF00082	0.686
CLV_PCSK_KEX2_1	627	629	PF00082	0.673
CLV_PCSK_KEX2_1	644	646	PF00082	0.651
CLV_PCSK_KEX2_1	71	73	PF00082	0.528
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.595
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.641
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.632
CLV_PCSK_PC1ET2_1	402	404	PF00082	0.607
CLV_PCSK_PC1ET2_1	627	629	PF00082	0.673
CLV_PCSK_PC7_1	403	409	PF00082	0.634
CLV_PCSK_PC7_1	68	74	PF00082	0.521
CLV_PCSK_SKI1_1	3	7	PF00082	0.621
CLV_PCSK_SKI1_1	390	394	PF00082	0.690
CLV_PCSK_SKI1_1	458	462	PF00082	0.560
CLV_PCSK_SKI1_1	52	56	PF00082	0.459
CLV_PCSK_SKI1_1	645	649	PF00082	0.655
DEG_APCC_DBOX_1	469	477	PF00400	0.615
DEG_Nend_UBRbox_1	1	4	PF02207	0.599
DEG_SCF_FBW7_1	230	236	PF00400	0.736
DEG_SPOP_SBC_1	235	239	PF00917	0.628
DEG_SPOP_SBC_1	448	452	PF00917	0.719
DOC_CDC14_PxL_1	118	126	PF14671	0.633
DOC_CDC14_PxL_1	565	573	PF14671	0.665
DOC_CKS1_1	230	235	PF01111	0.735
DOC_MAPK_gen_1	316	323	PF00069	0.628
DOC_USP7_MATH_1	205	209	PF00917	0.714
DOC_USP7_MATH_1	233	237	PF00917	0.790
DOC_USP7_MATH_1	281	285	PF00917	0.660
DOC_USP7_MATH_1	326	330	PF00917	0.626
DOC_USP7_MATH_1	355	359	PF00917	0.506
DOC_USP7_MATH_1	446	450	PF00917	0.802
DOC_USP7_MATH_1	463	467	PF00917	0.376
DOC_USP7_MATH_1	527	531	PF00917	0.742
DOC_USP7_MATH_1	540	544	PF00917	0.711
DOC_USP7_MATH_1	592	596	PF00917	0.720
DOC_USP7_MATH_1	80	84	PF00917	0.627
DOC_USP7_MATH_1	90	94	PF00917	0.557
DOC_WW_Pin1_4	122	127	PF00397	0.650
DOC_WW_Pin1_4	156	161	PF00397	0.642
DOC_WW_Pin1_4	229	234	PF00397	0.780
DOC_WW_Pin1_4	236	241	PF00397	0.735
DOC_WW_Pin1_4	279	284	PF00397	0.770
DOC_WW_Pin1_4	322	327	PF00397	0.622
DOC_WW_Pin1_4	328	333	PF00397	0.617
DOC_WW_Pin1_4	392	397	PF00397	0.753
DOC_WW_Pin1_4	444	449	PF00397	0.723
DOC_WW_Pin1_4	453	458	PF00397	0.545
DOC_WW_Pin1_4	474	479	PF00397	0.660
DOC_WW_Pin1_4	551	556	PF00397	0.741
DOC_WW_Pin1_4	608	613	PF00397	0.717
LIG_14-3-3_CanoR_1	142	148	PF00244	0.543
LIG_14-3-3_CanoR_1	16	24	PF00244	0.580
LIG_14-3-3_CanoR_1	247	255	PF00244	0.681
LIG_14-3-3_CanoR_1	306	310	PF00244	0.777
LIG_14-3-3_CanoR_1	379	384	PF00244	0.556
LIG_14-3-3_CanoR_1	390	395	PF00244	0.629
LIG_14-3-3_CanoR_1	481	489	PF00244	0.519
LIG_14-3-3_CanoR_1	535	540	PF00244	0.678
LIG_14-3-3_CanoR_1	547	553	PF00244	0.731
LIG_Actin_WH2_2	466	483	PF00022	0.517
LIG_APCC_ABBA_1	383	388	PF00400	0.729
LIG_BRCT_BRCA1_1	255	259	PF00533	0.690
LIG_BRCT_BRCA1_1	27	31	PF00533	0.595
LIG_BRCT_BRCA1_1	284	288	PF00533	0.768
LIG_BRCT_BRCA1_1	544	548	PF00533	0.782
LIG_deltaCOP1_diTrp_1	252	259	PF00928	0.723
LIG_EVH1_2	160	164	PF00568	0.507
LIG_FHA_1	157	163	PF00498	0.545
LIG_FHA_1	189	195	PF00498	0.641
LIG_FHA_1	457	463	PF00498	0.670
LIG_FHA_1	475	481	PF00498	0.424
LIG_FHA_1	559	565	PF00498	0.767
LIG_FHA_2	247	253	PF00498	0.749
LIG_FHA_2	262	268	PF00498	0.568
LIG_FHA_2	289	295	PF00498	0.603
LIG_FHA_2	340	346	PF00498	0.714
LIG_FHA_2	482	488	PF00498	0.531
LIG_FHA_2	582	588	PF00498	0.635
LIG_LIR_Gen_1	291	300	PF02991	0.570
LIG_LIR_Gen_1	39	50	PF02991	0.452
LIG_LIR_Nem_3	168	173	PF02991	0.482
LIG_LIR_Nem_3	256	262	PF02991	0.719
LIG_LIR_Nem_3	291	295	PF02991	0.611
LIG_LIR_Nem_3	39	45	PF02991	0.458
LIG_MYND_1	122	126	PF01753	0.607
LIG_NRBOX	129	135	PF00104	0.555
LIG_Pex14_2	288	292	PF04695	0.772
LIG_SH2_CRK	187	191	PF00017	0.546
LIG_SH2_CRK	42	46	PF00017	0.434
LIG_SH2_SRC	498	501	PF00017	0.540
LIG_SH2_STAT3	394	397	PF00017	0.754
LIG_SH2_STAT5	173	176	PF00017	0.496
LIG_SH3_1	227	233	PF00018	0.738
LIG_SH3_3	199	205	PF00018	0.765
LIG_SH3_3	227	233	PF00018	0.738
LIG_SH3_3	320	326	PF00018	0.594
LIG_SH3_3	451	457	PF00018	0.608
LIG_SH3_3	585	591	PF00018	0.754
LIG_SUMO_SIM_anti_2	305	314	PF11976	0.600
LIG_TRAF2_1	291	294	PF00917	0.596
MOD_CDK_SPK_2	236	241	PF00069	0.694
MOD_CDK_SPK_2	453	458	PF00069	0.717
MOD_CDK_SPxxK_3	474	481	PF00069	0.641
MOD_CK1_1	148	154	PF00069	0.541
MOD_CK1_1	192	198	PF00069	0.774
MOD_CK1_1	236	242	PF00069	0.728
MOD_CK1_1	27	33	PF00069	0.706
MOD_CK1_1	282	288	PF00069	0.678
MOD_CK1_1	305	311	PF00069	0.599
MOD_CK1_1	34	40	PF00069	0.579
MOD_CK1_1	425	431	PF00069	0.619
MOD_CK1_1	449	455	PF00069	0.702
MOD_CK1_1	456	462	PF00069	0.525
MOD_CK1_1	521	527	PF00069	0.675
MOD_CK1_1	611	617	PF00069	0.739
MOD_CK1_1	85	91	PF00069	0.583
MOD_CK2_1	246	252	PF00069	0.758
MOD_CK2_1	288	294	PF00069	0.622
MOD_CK2_1	339	345	PF00069	0.732
MOD_CK2_1	581	587	PF00069	0.626
MOD_CK2_1	80	86	PF00069	0.612
MOD_DYRK1A_RPxSP_1	229	233	PF00069	0.734
MOD_DYRK1A_RPxSP_1	453	457	PF00069	0.604
MOD_GlcNHglycan	149	153	PF01048	0.546
MOD_GlcNHglycan	165	168	PF01048	0.554
MOD_GlcNHglycan	18	21	PF01048	0.564
MOD_GlcNHglycan	191	194	PF01048	0.796
MOD_GlcNHglycan	220	223	PF01048	0.692
MOD_GlcNHglycan	255	258	PF01048	0.667
MOD_GlcNHglycan	284	287	PF01048	0.762
MOD_GlcNHglycan	33	36	PF01048	0.587
MOD_GlcNHglycan	369	373	PF01048	0.730
MOD_GlcNHglycan	374	378	PF01048	0.551
MOD_GlcNHglycan	444	447	PF01048	0.610
MOD_GlcNHglycan	544	547	PF01048	0.786
MOD_GlcNHglycan	82	85	PF01048	0.701
MOD_GSK3_1	188	195	PF00069	0.609
MOD_GSK3_1	218	225	PF00069	0.732
MOD_GSK3_1	229	236	PF00069	0.668
MOD_GSK3_1	23	30	PF00069	0.699
MOD_GSK3_1	261	268	PF00069	0.705
MOD_GSK3_1	305	312	PF00069	0.754
MOD_GSK3_1	322	329	PF00069	0.642
MOD_GSK3_1	442	449	PF00069	0.709
MOD_GSK3_1	542	549	PF00069	0.763
MOD_GSK3_1	556	563	PF00069	0.649
MOD_GSK3_1	80	87	PF00069	0.679
MOD_N-GLC_1	205	210	PF02516	0.754
MOD_N-GLC_1	355	360	PF02516	0.628
MOD_N-GLC_1	409	414	PF02516	0.579
MOD_N-GLC_1	518	523	PF02516	0.702
MOD_N-GLC_2	344	346	PF02516	0.607
MOD_NEK2_1	18	23	PF00069	0.568
MOD_NEK2_1	255	260	PF00069	0.745
MOD_NEK2_1	265	270	PF00069	0.684
MOD_NEK2_1	31	36	PF00069	0.588
MOD_NEK2_1	461	466	PF00069	0.495
MOD_NEK2_1	480	485	PF00069	0.503
MOD_NEK2_1	548	553	PF00069	0.614
MOD_PIKK_1	461	467	PF00454	0.500
MOD_PKA_2	246	252	PF00069	0.662
MOD_PKA_2	265	271	PF00069	0.497
MOD_PKA_2	305	311	PF00069	0.599
MOD_PKA_2	480	486	PF00069	0.515
MOD_PKA_2	493	499	PF00069	0.570
MOD_PKA_2	534	540	PF00069	0.796
MOD_PKA_2	546	552	PF00069	0.634
MOD_PKB_1	407	415	PF00069	0.654
MOD_Plk_1	205	211	PF00069	0.758
MOD_Plk_1	355	361	PF00069	0.726
MOD_Plk_1	46	52	PF00069	0.450
MOD_Plk_1	518	524	PF00069	0.669
MOD_Plk_1	85	91	PF00069	0.432
MOD_Plk_4	205	211	PF00069	0.725
MOD_Plk_4	27	33	PF00069	0.550
MOD_Plk_4	355	361	PF00069	0.657
MOD_Plk_4	46	52	PF00069	0.450
MOD_Plk_4	54	60	PF00069	0.445
MOD_Plk_4	560	566	PF00069	0.649
MOD_ProDKin_1	122	128	PF00069	0.649
MOD_ProDKin_1	156	162	PF00069	0.637
MOD_ProDKin_1	229	235	PF00069	0.781
MOD_ProDKin_1	236	242	PF00069	0.734
MOD_ProDKin_1	279	285	PF00069	0.770
MOD_ProDKin_1	322	328	PF00069	0.622
MOD_ProDKin_1	392	398	PF00069	0.751
MOD_ProDKin_1	444	450	PF00069	0.720
MOD_ProDKin_1	453	459	PF00069	0.537
MOD_ProDKin_1	474	480	PF00069	0.648
MOD_ProDKin_1	551	557	PF00069	0.742
MOD_ProDKin_1	608	614	PF00069	0.718
TRG_DiLeu_BaLyEn_6	475	480	PF01217	0.644
TRG_ENDOCYTIC_2	42	45	PF00928	0.437
TRG_ER_diArg_1	184	187	PF00400	0.548
TRG_ER_diArg_1	227	230	PF00400	0.739
TRG_ER_diArg_1	3	5	PF00400	0.619
TRG_ER_diArg_1	403	406	PF00400	0.652
TRG_ER_diArg_1	407	409	PF00400	0.616
TRG_ER_diArg_1	469	472	PF00400	0.534
TRG_ER_diArg_1	508	510	PF00400	0.787
TRG_ER_diArg_1	626	629	PF00400	0.786
TRG_ER_diArg_1	71	73	PF00400	0.554
TRG_NLS_Bipartite_1	626	645	PF00514	0.662
TRG_NLS_MonoCore_2	401	406	PF00514	0.639
TRG_NLS_MonoCore_2	626	631	PF00514	0.784
TRG_NLS_MonoExtC_3	225	230	PF00514	0.623
TRG_NLS_MonoExtC_3	401	406	PF00514	0.672
TRG_NLS_MonoExtC_3	639	644	PF00514	0.754
TRG_NLS_MonoExtC_3	72	77	PF00514	0.605
TRG_NLS_MonoExtN_4	626	631	PF00514	0.669
TRG_NLS_MonoExtN_4	640	645	PF00514	0.655
TRG_NLS_MonoExtN_4	71	77	PF00514	0.528
TRG_Pf-PMV_PEXEL_1	347	351	PF00026	0.593

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2D5	Leptomonas seymouri	38%	100%
A4H6V9	Leishmania braziliensis	69%	100%
E9AGD2	Leishmania infantum	100%	100%
E9ANX2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QGP8	Leishmania major	87%	100%