Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WRY6_LEIDO

TriTrypDb:

LdBPK_120320.1 , LdCL_120008800 , LDHU3_12.0490

Length:

317

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A0A3S7WRY6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WRY6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	231	235	PF00656	0.793
CLV_NRD_NRD_1	215	217	PF00675	0.626
CLV_NRD_NRD_1	279	281	PF00675	0.532
CLV_NRD_NRD_1	86	88	PF00675	0.689
CLV_PCSK_KEX2_1	221	223	PF00082	0.568
CLV_PCSK_KEX2_1	279	281	PF00082	0.532
CLV_PCSK_KEX2_1	40	42	PF00082	0.414
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.591
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.425
CLV_PCSK_PC7_1	275	281	PF00082	0.596
CLV_PCSK_SKI1_1	47	51	PF00082	0.418
DEG_SPOP_SBC_1	163	167	PF00917	0.828
DOC_CYCLIN_yCln2_LP_2	110	116	PF00134	0.411
DOC_MAPK_gen_1	126	135	PF00069	0.704
DOC_MAPK_gen_1	87	95	PF00069	0.374
DOC_PP1_RVXF_1	45	52	PF00149	0.546
DOC_PP1_RVXF_1	89	96	PF00149	0.370
DOC_PP2B_LxvP_1	210	213	PF13499	0.803
DOC_USP7_MATH_1	162	166	PF00917	0.797
DOC_USP7_MATH_1	19	23	PF00917	0.505
DOC_USP7_MATH_1	2	6	PF00917	0.694
DOC_USP7_UBL2_3	217	221	PF12436	0.752
DOC_WW_Pin1_4	109	114	PF00397	0.411
DOC_WW_Pin1_4	169	174	PF00397	0.822
LIG_14-3-3_CanoR_1	10	16	PF00244	0.619
LIG_14-3-3_CanoR_1	53	61	PF00244	0.443
LIG_BRCT_BRCA1_1	98	102	PF00533	0.411
LIG_CaM_NSCaTE_8	51	58	PF13499	0.450
LIG_FHA_1	125	131	PF00498	0.639
LIG_FHA_1	176	182	PF00498	0.809
LIG_FHA_1	205	211	PF00498	0.667
LIG_FHA_1	286	292	PF00498	0.676
LIG_FHA_1	308	314	PF00498	0.725
LIG_FHA_2	229	235	PF00498	0.815
LIG_LIR_Nem_3	141	147	PF02991	0.623
LIG_LIR_Nem_3	197	202	PF02991	0.664
LIG_PCNA_yPIPBox_3	74	88	PF02747	0.460
LIG_PTB_Apo_2	103	110	PF02174	0.450
LIG_SH2_NCK_1	31	35	PF00017	0.590
LIG_SH2_STAP1	44	48	PF00017	0.690
LIG_SH2_STAT3	71	74	PF00017	0.449
LIG_SH3_2	113	118	PF14604	0.460
LIG_SH3_3	110	116	PF00018	0.306
LIG_SH3_3	167	173	PF00018	0.770
LIG_SH3_3	200	206	PF00018	0.720
LIG_TYR_ITIM	29	34	PF00017	0.588
LIG_UBA3_1	209	217	PF00899	0.734
MOD_CK1_1	12	18	PF00069	0.616
MOD_CK1_1	165	171	PF00069	0.798
MOD_CK1_1	263	269	PF00069	0.735
MOD_CK1_1	56	62	PF00069	0.512
MOD_CK2_1	264	270	PF00069	0.850
MOD_GlcNHglycan	12	15	PF01048	0.467
MOD_GlcNHglycan	147	150	PF01048	0.357
MOD_GlcNHglycan	253	256	PF01048	0.547
MOD_GlcNHglycan	257	260	PF01048	0.539
MOD_GlcNHglycan	266	269	PF01048	0.515
MOD_GlcNHglycan	5	8	PF01048	0.532
MOD_GlcNHglycan	55	58	PF01048	0.403
MOD_GlcNHglycan	98	101	PF01048	0.357
MOD_GSK3_1	165	172	PF00069	0.769
MOD_GSK3_1	190	197	PF00069	0.764
MOD_GSK3_1	249	256	PF00069	0.762
MOD_GSK3_1	260	267	PF00069	0.851
MOD_GSK3_1	49	56	PF00069	0.419
MOD_LATS_1	120	126	PF00433	0.658
MOD_N-GLC_1	3	8	PF02516	0.556
MOD_NEK2_1	124	129	PF00069	0.646
MOD_NEK2_1	98	103	PF00069	0.368
MOD_PIKK_1	204	210	PF00454	0.704
MOD_PIKK_1	215	221	PF00454	0.814
MOD_PIKK_1	243	249	PF00454	0.783
MOD_PKA_2	215	221	PF00069	0.770
MOD_PKA_2	9	15	PF00069	0.641
MOD_Plk_1	307	313	PF00069	0.721
MOD_Plk_4	194	200	PF00069	0.728
MOD_Plk_4	56	62	PF00069	0.464
MOD_ProDKin_1	109	115	PF00069	0.411
MOD_ProDKin_1	169	175	PF00069	0.825
MOD_SUMO_for_1	294	297	PF00179	0.719
TRG_DiLeu_BaLyEn_6	25	30	PF01217	0.662
TRG_DiLeu_BaLyEn_6	44	49	PF01217	0.463
TRG_DiLeu_BaLyEn_6	50	55	PF01217	0.432
TRG_ENDOCYTIC_2	31	34	PF00928	0.587
TRG_ER_diArg_1	278	280	PF00400	0.734
TRG_ER_diArg_1	81	84	PF00400	0.437
TRG_Pf-PMV_PEXEL_1	28	33	PF00026	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL14	Leptomonas seymouri	36%	95%
A4H6V2	Leishmania braziliensis	67%	100%
E9AGC4	Leishmania infantum	100%	100%
E9ANW4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QGQ6	Leishmania major	91%	100%