LisH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WRY5_LEIDO

TriTrypDb:

LdBPK_120600.1 , LdCL_120011700 , LDHU3_12.0930

Length:

617

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WRY5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WRY5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004843	cysteine-type deubiquitinase activity	5	7
GO:0008233	peptidase activity	3	7
GO:0008234	cysteine-type peptidase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0019783	ubiquitin-like protein peptidase activity	4	7
GO:0101005	deubiquitinase activity	5	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1990380	K48-linked deubiquitinase activity	6	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.493
CLV_C14_Caspase3-7	281	285	PF00656	0.661
CLV_NRD_NRD_1	172	174	PF00675	0.583
CLV_NRD_NRD_1	180	182	PF00675	0.494
CLV_NRD_NRD_1	190	192	PF00675	0.500
CLV_NRD_NRD_1	235	237	PF00675	0.681
CLV_NRD_NRD_1	245	247	PF00675	0.658
CLV_NRD_NRD_1	288	290	PF00675	0.695
CLV_NRD_NRD_1	40	42	PF00675	0.436
CLV_NRD_NRD_1	606	608	PF00675	0.591
CLV_NRD_NRD_1	610	612	PF00675	0.591
CLV_PCSK_FUR_1	180	184	PF00082	0.477
CLV_PCSK_KEX2_1	118	120	PF00082	0.680
CLV_PCSK_KEX2_1	180	182	PF00082	0.537
CLV_PCSK_KEX2_1	188	190	PF00082	0.594
CLV_PCSK_KEX2_1	235	237	PF00082	0.634
CLV_PCSK_KEX2_1	244	246	PF00082	0.497
CLV_PCSK_KEX2_1	288	290	PF00082	0.752
CLV_PCSK_KEX2_1	40	42	PF00082	0.436
CLV_PCSK_KEX2_1	610	612	PF00082	0.587
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.661
CLV_PCSK_PC1ET2_1	182	184	PF00082	0.480
CLV_PCSK_PC1ET2_1	188	190	PF00082	0.506
CLV_PCSK_PC1ET2_1	244	246	PF00082	0.660
CLV_PCSK_SKI1_1	147	151	PF00082	0.477
CLV_PCSK_SKI1_1	191	195	PF00082	0.455
CLV_PCSK_SKI1_1	289	293	PF00082	0.721
CLV_PCSK_SKI1_1	328	332	PF00082	0.535
CLV_PCSK_SKI1_1	506	510	PF00082	0.516
CLV_PCSK_SKI1_1	610	614	PF00082	0.595
CLV_PCSK_SKI1_1	68	72	PF00082	0.451
DEG_SPOP_SBC_1	355	359	PF00917	0.635
DEG_SPOP_SBC_1	86	90	PF00917	0.653
DOC_MAPK_gen_1	439	447	PF00069	0.606
DOC_MAPK_gen_1	604	614	PF00069	0.591
DOC_MAPK_MEF2A_6	607	616	PF00069	0.588
DOC_MAPK_MEF2A_6	68	75	PF00069	0.462
DOC_PP2B_LxvP_1	71	74	PF13499	0.462
DOC_PP2B_PxIxI_1	477	483	PF00149	0.553
DOC_USP7_MATH_1	149	153	PF00917	0.628
DOC_USP7_MATH_1	277	281	PF00917	0.583
DOC_USP7_MATH_1	353	357	PF00917	0.747
DOC_USP7_MATH_1	415	419	PF00917	0.686
DOC_USP7_MATH_1	472	476	PF00917	0.729
DOC_USP7_MATH_1	5	9	PF00917	0.545
DOC_USP7_MATH_1	500	504	PF00917	0.777
DOC_USP7_MATH_1	510	514	PF00917	0.628
DOC_USP7_MATH_1	534	538	PF00917	0.688
DOC_USP7_MATH_1	558	562	PF00917	0.711
DOC_USP7_MATH_1	586	590	PF00917	0.746
DOC_USP7_MATH_1	603	607	PF00917	0.489
DOC_USP7_MATH_1	84	88	PF00917	0.588
DOC_USP7_UBL2_3	174	178	PF12436	0.548
DOC_USP7_UBL2_3	182	186	PF12436	0.494
DOC_USP7_UBL2_3	604	608	PF12436	0.668
DOC_WW_Pin1_4	413	418	PF00397	0.631
DOC_WW_Pin1_4	530	535	PF00397	0.732
DOC_WW_Pin1_4	541	546	PF00397	0.615
DOC_WW_Pin1_4	550	555	PF00397	0.787
LIG_14-3-3_CanoR_1	15	21	PF00244	0.357
LIG_14-3-3_CanoR_1	189	194	PF00244	0.495
LIG_14-3-3_CanoR_1	288	294	PF00244	0.745
LIG_14-3-3_CanoR_1	390	396	PF00244	0.619
LIG_14-3-3_CanoR_1	439	448	PF00244	0.695
LIG_14-3-3_CanoR_1	457	467	PF00244	0.638
LIG_14-3-3_CanoR_1	59	67	PF00244	0.432
LIG_Actin_WH2_2	31	46	PF00022	0.505
LIG_AP2alpha_2	319	321	PF02296	0.537
LIG_BRCT_BRCA1_1	415	419	PF00533	0.671
LIG_BRCT_BRCA1_1	463	467	PF00533	0.675
LIG_BRCT_BRCA1_1	543	547	PF00533	0.630
LIG_BRCT_BRCA1_1	588	592	PF00533	0.629
LIG_FHA_1	11	17	PF00498	0.652
LIG_FHA_1	296	302	PF00498	0.686
LIG_FHA_1	356	362	PF00498	0.574
LIG_FHA_2	149	155	PF00498	0.412
LIG_FHA_2	279	285	PF00498	0.712
LIG_FHA_2	578	584	PF00498	0.676
LIG_FHA_2	95	101	PF00498	0.432
LIG_LIR_Apic_2	413	417	PF02991	0.616
LIG_LIR_Gen_1	159	166	PF02991	0.539
LIG_LIR_Nem_3	111	115	PF02991	0.561
LIG_LIR_Nem_3	159	163	PF02991	0.585
LIG_PCNA_yPIPBox_3	31	44	PF02747	0.392
LIG_SH2_CRK	414	418	PF00017	0.619
LIG_SH2_NCK_1	230	234	PF00017	0.641
LIG_SH2_NCK_1	414	418	PF00017	0.606
LIG_SH2_STAP1	160	164	PF00017	0.462
LIG_SH2_STAP1	504	508	PF00017	0.669
LIG_SH3_3	90	96	PF00018	0.649
LIG_SH3_4	604	611	PF00018	0.670
LIG_SUMO_SIM_anti_2	24	30	PF11976	0.379
LIG_SxIP_EBH_1	439	451	PF03271	0.637
LIG_TRAF2_1	165	168	PF00917	0.452
LIG_WRC_WIRS_1	47	52	PF05994	0.604
MOD_CK1_1	111	117	PF00069	0.683
MOD_CK1_1	212	218	PF00069	0.633
MOD_CK1_1	231	237	PF00069	0.623
MOD_CK1_1	248	254	PF00069	0.630
MOD_CK1_1	287	293	PF00069	0.624
MOD_CK1_1	295	301	PF00069	0.653
MOD_CK1_1	324	330	PF00069	0.504
MOD_CK1_1	356	362	PF00069	0.733
MOD_CK1_1	370	376	PF00069	0.757
MOD_CK1_1	461	467	PF00069	0.751
MOD_CK1_1	476	482	PF00069	0.488
MOD_CK1_1	537	543	PF00069	0.545
MOD_CK1_1	548	554	PF00069	0.737
MOD_CK1_1	578	584	PF00069	0.676
MOD_CK1_1	87	93	PF00069	0.560
MOD_CK2_1	129	135	PF00069	0.509
MOD_CK2_1	148	154	PF00069	0.470
MOD_CK2_1	18	24	PF00069	0.465
MOD_CK2_1	207	213	PF00069	0.650
MOD_CK2_1	309	315	PF00069	0.720
MOD_CK2_1	5	11	PF00069	0.504
MOD_CK2_1	577	583	PF00069	0.651
MOD_CK2_1	603	609	PF00069	0.588
MOD_CK2_1	94	100	PF00069	0.444
MOD_Cter_Amidation	116	119	PF01082	0.618
MOD_Cter_Amidation	242	245	PF01082	0.661
MOD_GlcNHglycan	241	244	PF01048	0.657
MOD_GlcNHglycan	247	250	PF01048	0.605
MOD_GlcNHglycan	252	255	PF01048	0.555
MOD_GlcNHglycan	281	284	PF01048	0.656
MOD_GlcNHglycan	289	292	PF01048	0.766
MOD_GlcNHglycan	294	297	PF01048	0.752
MOD_GlcNHglycan	323	326	PF01048	0.558
MOD_GlcNHglycan	372	375	PF01048	0.655
MOD_GlcNHglycan	395	398	PF01048	0.732
MOD_GlcNHglycan	419	422	PF01048	0.703
MOD_GlcNHglycan	423	426	PF01048	0.768
MOD_GlcNHglycan	450	453	PF01048	0.577
MOD_GlcNHglycan	464	467	PF01048	0.670
MOD_GlcNHglycan	468	471	PF01048	0.740
MOD_GlcNHglycan	475	478	PF01048	0.544
MOD_GlcNHglycan	485	488	PF01048	0.632
MOD_GlcNHglycan	512	515	PF01048	0.761
MOD_GlcNHglycan	536	539	PF01048	0.711
MOD_GlcNHglycan	541	544	PF01048	0.556
MOD_GlcNHglycan	560	563	PF01048	0.629
MOD_GlcNHglycan	566	569	PF01048	0.592
MOD_GlcNHglycan	580	583	PF01048	0.462
MOD_GlcNHglycan	588	591	PF01048	0.610
MOD_GlcNHglycan	89	92	PF01048	0.577
MOD_GSK3_1	101	108	PF00069	0.472
MOD_GSK3_1	309	316	PF00069	0.668
MOD_GSK3_1	413	420	PF00069	0.753
MOD_GSK3_1	458	465	PF00069	0.714
MOD_GSK3_1	466	473	PF00069	0.616
MOD_GSK3_1	500	507	PF00069	0.665
MOD_GSK3_1	515	522	PF00069	0.580
MOD_GSK3_1	530	537	PF00069	0.577
MOD_GSK3_1	541	548	PF00069	0.622
MOD_GSK3_1	574	581	PF00069	0.611
MOD_GSK3_1	582	589	PF00069	0.577
MOD_GSK3_1	82	89	PF00069	0.597
MOD_N-GLC_1	255	260	PF02516	0.535
MOD_N-GLC_1	410	415	PF02516	0.611
MOD_N-GLC_1	534	539	PF02516	0.557
MOD_NEK2_1	16	21	PF00069	0.459
MOD_NEK2_1	321	326	PF00069	0.595
MOD_NEK2_1	419	424	PF00069	0.702
MOD_NEK2_1	43	48	PF00069	0.460
MOD_NEK2_1	440	445	PF00069	0.647
MOD_NEK2_1	459	464	PF00069	0.787
MOD_NEK2_1	515	520	PF00069	0.654
MOD_NEK2_1	539	544	PF00069	0.637
MOD_NEK2_1	575	580	PF00069	0.601
MOD_PIKK_1	341	347	PF00454	0.589
MOD_PK_1	441	447	PF00069	0.615
MOD_PKA_1	189	195	PF00069	0.452
MOD_PKA_1	245	251	PF00069	0.653
MOD_PKA_2	105	111	PF00069	0.503
MOD_PKA_2	189	195	PF00069	0.587
MOD_PKA_2	245	251	PF00069	0.653
MOD_PKA_2	287	293	PF00069	0.741
MOD_PKA_2	43	49	PF00069	0.538
MOD_PKA_2	510	516	PF00069	0.682
MOD_PKA_2	575	581	PF00069	0.601
MOD_PKA_2	77	83	PF00069	0.559
MOD_PKB_1	334	342	PF00069	0.556
MOD_Plk_1	255	261	PF00069	0.530
MOD_Plk_1	368	374	PF00069	0.549
MOD_Plk_1	504	510	PF00069	0.667
MOD_Plk_1	534	540	PF00069	0.602
MOD_Plk_1	57	63	PF00069	0.453
MOD_Plk_2-3	129	135	PF00069	0.517
MOD_Plk_2-3	207	213	PF00069	0.648
MOD_Plk_2-3	313	319	PF00069	0.698
MOD_Plk_4	476	482	PF00069	0.585
MOD_Plk_4	94	100	PF00069	0.444
MOD_ProDKin_1	413	419	PF00069	0.634
MOD_ProDKin_1	530	536	PF00069	0.733
MOD_ProDKin_1	541	547	PF00069	0.617
MOD_ProDKin_1	550	556	PF00069	0.584
TRG_DiLeu_BaEn_1	159	164	PF01217	0.540
TRG_DiLeu_BaEn_1	222	227	PF01217	0.552
TRG_DiLeu_BaEn_1	24	29	PF01217	0.408
TRG_ENDOCYTIC_2	112	115	PF00928	0.569
TRG_ENDOCYTIC_2	160	163	PF00928	0.481
TRG_ER_diArg_1	180	183	PF00400	0.480
TRG_ER_diArg_1	189	191	PF00400	0.496
TRG_ER_diArg_1	235	237	PF00400	0.634
TRG_ER_diArg_1	245	247	PF00400	0.658
TRG_ER_diArg_1	610	612	PF00400	0.574
TRG_NLS_MonoCore_2	180	185	PF00514	0.477
TRG_NLS_MonoExtC_3	181	186	PF00514	0.453
TRG_NLS_MonoExtN_4	178	185	PF00514	0.445
TRG_NLS_MonoExtN_4	241	248	PF00514	0.628
TRG_Pf-PMV_PEXEL_1	137	141	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	191	195	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	245	250	PF00026	0.654
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.440
TRG_Pf-PMV_PEXEL_1	64	69	PF00026	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2E7	Leptomonas seymouri	40%	97%
A4H6X8	Leishmania braziliensis	70%	99%
E9AGF2	Leishmania infantum	98%	100%
E9ANZ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QGM8	Leishmania major	88%	100%