Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7WRY4_LEIDO

TriTrypDb:

LdBPK_120440.1 , LdCL_120010000 , LDHU3_12.0620

Length:

609

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WRY4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WRY4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	256	260	PF00656	0.721
CLV_C14_Caspase3-7	323	327	PF00656	0.686
CLV_C14_Caspase3-7	33	37	PF00656	0.629
CLV_C14_Caspase3-7	445	449	PF00656	0.606
CLV_C14_Caspase3-7	591	595	PF00656	0.714
CLV_NRD_NRD_1	218	220	PF00675	0.665
CLV_NRD_NRD_1	395	397	PF00675	0.798
CLV_PCSK_FUR_1	393	397	PF00082	0.708
CLV_PCSK_KEX2_1	218	220	PF00082	0.757
CLV_PCSK_KEX2_1	392	394	PF00082	0.761
CLV_PCSK_KEX2_1	395	397	PF00082	0.760
CLV_PCSK_PC1ET2_1	392	394	PF00082	0.695
DEG_APCC_DBOX_1	472	480	PF00400	0.791
DEG_SPOP_SBC_1	512	516	PF00917	0.634
DOC_CKS1_1	559	564	PF01111	0.697
DOC_CYCLIN_yClb3_PxF_3	329	335	PF00134	0.602
DOC_PP1_RVXF_1	350	356	PF00149	0.706
DOC_USP7_MATH_1	153	157	PF00917	0.668
DOC_USP7_MATH_1	16	20	PF00917	0.749
DOC_USP7_MATH_1	166	170	PF00917	0.603
DOC_USP7_MATH_1	203	207	PF00917	0.733
DOC_USP7_MATH_1	242	246	PF00917	0.728
DOC_USP7_MATH_1	286	290	PF00917	0.754
DOC_USP7_MATH_1	40	44	PF00917	0.806
DOC_USP7_MATH_1	512	516	PF00917	0.733
DOC_USP7_MATH_1	551	555	PF00917	0.755
DOC_USP7_MATH_1	583	587	PF00917	0.770
DOC_USP7_MATH_1	590	594	PF00917	0.471
DOC_USP7_MATH_1	72	76	PF00917	0.687
DOC_WW_Pin1_4	196	201	PF00397	0.677
DOC_WW_Pin1_4	23	28	PF00397	0.756
DOC_WW_Pin1_4	238	243	PF00397	0.615
DOC_WW_Pin1_4	36	41	PF00397	0.561
DOC_WW_Pin1_4	558	563	PF00397	0.673
DOC_WW_Pin1_4	76	81	PF00397	0.727
DOC_WW_Pin1_4	89	94	PF00397	0.633
LIG_14-3-3_CanoR_1	218	224	PF00244	0.772
LIG_14-3-3_CanoR_1	393	399	PF00244	0.773
LIG_14-3-3_CanoR_1	441	450	PF00244	0.714
LIG_14-3-3_CanoR_1	521	526	PF00244	0.671
LIG_14-3-3_CanoR_1	542	550	PF00244	0.626
LIG_BIR_III_2	326	330	PF00653	0.599
LIG_BIR_III_4	448	452	PF00653	0.603
LIG_BRCT_BRCA1_1	207	211	PF00533	0.766
LIG_BRCT_BRCA1_1	46	50	PF00533	0.803
LIG_BRCT_BRCA1_1	90	94	PF00533	0.660
LIG_EVH1_2	526	530	PF00568	0.646
LIG_FHA_1	118	124	PF00498	0.661
LIG_FHA_1	421	427	PF00498	0.770
LIG_FHA_1	483	489	PF00498	0.665
LIG_FHA_1	559	565	PF00498	0.702
LIG_FHA_1	573	579	PF00498	0.548
LIG_FHA_1	80	86	PF00498	0.828
LIG_FHA_2	31	37	PF00498	0.580
LIG_FHA_2	321	327	PF00498	0.754
LIG_FHA_2	451	457	PF00498	0.706
LIG_FHA_2	572	578	PF00498	0.817
LIG_LIR_Apic_2	236	242	PF02991	0.721
LIG_LIR_Apic_2	381	386	PF02991	0.715
LIG_LIR_Gen_1	105	112	PF02991	0.628
LIG_LIR_Gen_1	334	343	PF02991	0.699
LIG_LIR_Gen_1	39	49	PF02991	0.672
LIG_LIR_Gen_1	51	62	PF02991	0.677
LIG_LIR_Nem_3	105	109	PF02991	0.629
LIG_LIR_Nem_3	334	338	PF02991	0.710
LIG_LIR_Nem_3	39	44	PF02991	0.645
LIG_LIR_Nem_3	51	57	PF02991	0.608
LIG_MYND_1	329	333	PF01753	0.599
LIG_Pex14_2	94	98	PF04695	0.613
LIG_SH2_CRK	309	313	PF00017	0.597
LIG_SH2_CRK	383	387	PF00017	0.714
LIG_SH2_CRK	54	58	PF00017	0.692
LIG_SH2_NCK_1	309	313	PF00017	0.597
LIG_SH2_NCK_1	54	58	PF00017	0.692
LIG_SH2_STAT5	239	242	PF00017	0.746
LIG_SH2_STAT5	309	312	PF00017	0.598
LIG_SH2_STAT5	383	386	PF00017	0.709
LIG_SH3_3	194	200	PF00018	0.731
LIG_SH3_3	21	27	PF00018	0.795
LIG_SH3_3	271	277	PF00018	0.634
LIG_SH3_3	327	333	PF00018	0.752
LIG_SH3_3	338	344	PF00018	0.559
LIG_SH3_3	444	450	PF00018	0.706
LIG_SH3_3	58	64	PF00018	0.686
LIG_SH3_3	584	590	PF00018	0.742
LIG_SUMO_SIM_par_1	573	579	PF11976	0.740
LIG_TRAF2_1	20	23	PF00917	0.634
LIG_TRAF2_1	596	599	PF00917	0.697
LIG_TYR_ITSM	50	57	PF00017	0.692
LIG_WRC_WIRS_1	109	114	PF05994	0.730
MOD_CK1_1	111	117	PF00069	0.560
MOD_CK1_1	125	131	PF00069	0.695
MOD_CK1_1	212	218	PF00069	0.720
MOD_CK1_1	225	231	PF00069	0.557
MOD_CK1_1	245	251	PF00069	0.654
MOD_CK1_1	268	274	PF00069	0.617
MOD_CK1_1	314	320	PF00069	0.716
MOD_CK1_1	45	51	PF00069	0.743
MOD_CK1_1	469	475	PF00069	0.783
MOD_CK1_1	510	516	PF00069	0.687
MOD_CK1_1	543	549	PF00069	0.775
MOD_CK1_1	55	61	PF00069	0.685
MOD_CK1_1	558	564	PF00069	0.701
MOD_CK1_1	568	574	PF00069	0.587
MOD_CK1_1	79	85	PF00069	0.743
MOD_CK1_1	88	94	PF00069	0.609
MOD_CK1_1	97	103	PF00069	0.537
MOD_CK2_1	16	22	PF00069	0.751
MOD_CK2_1	398	404	PF00069	0.741
MOD_CK2_1	512	518	PF00069	0.634
MOD_CK2_1	564	570	PF00069	0.698
MOD_CK2_1	592	598	PF00069	0.704
MOD_Cter_Amidation	393	396	PF01082	0.586
MOD_GlcNHglycan	114	117	PF01048	0.665
MOD_GlcNHglycan	155	158	PF01048	0.838
MOD_GlcNHglycan	168	171	PF01048	0.599
MOD_GlcNHglycan	173	177	PF01048	0.753
MOD_GlcNHglycan	18	21	PF01048	0.765
MOD_GlcNHglycan	207	210	PF01048	0.684
MOD_GlcNHglycan	211	214	PF01048	0.680
MOD_GlcNHglycan	224	227	PF01048	0.536
MOD_GlcNHglycan	244	247	PF01048	0.576
MOD_GlcNHglycan	253	256	PF01048	0.771
MOD_GlcNHglycan	270	273	PF01048	0.842
MOD_GlcNHglycan	398	401	PF01048	0.794
MOD_GlcNHglycan	416	419	PF01048	0.566
MOD_GlcNHglycan	44	47	PF01048	0.773
MOD_GlcNHglycan	444	447	PF01048	0.772
MOD_GlcNHglycan	473	476	PF01048	0.710
MOD_GlcNHglycan	523	526	PF01048	0.779
MOD_GlcNHglycan	537	540	PF01048	0.679
MOD_GlcNHglycan	57	60	PF01048	0.653
MOD_GlcNHglycan	570	573	PF01048	0.654
MOD_GlcNHglycan	579	583	PF01048	0.661
MOD_GlcNHglycan	594	597	PF01048	0.695
MOD_GlcNHglycan	69	72	PF01048	0.586
MOD_GlcNHglycan	87	90	PF01048	0.758
MOD_GSK3_1	107	114	PF00069	0.774
MOD_GSK3_1	130	137	PF00069	0.672
MOD_GSK3_1	155	162	PF00069	0.676
MOD_GSK3_1	172	179	PF00069	0.746
MOD_GSK3_1	203	210	PF00069	0.768
MOD_GSK3_1	213	220	PF00069	0.649
MOD_GSK3_1	238	245	PF00069	0.672
MOD_GSK3_1	294	301	PF00069	0.752
MOD_GSK3_1	307	314	PF00069	0.533
MOD_GSK3_1	316	323	PF00069	0.682
MOD_GSK3_1	36	43	PF00069	0.693
MOD_GSK3_1	394	401	PF00069	0.805
MOD_GSK3_1	44	51	PF00069	0.608
MOD_GSK3_1	478	485	PF00069	0.598
MOD_GSK3_1	507	514	PF00069	0.680
MOD_GSK3_1	540	547	PF00069	0.705
MOD_GSK3_1	551	558	PF00069	0.533
MOD_GSK3_1	564	571	PF00069	0.754
MOD_GSK3_1	578	585	PF00069	0.776
MOD_GSK3_1	588	595	PF00069	0.724
MOD_GSK3_1	72	79	PF00069	0.732
MOD_GSK3_1	85	92	PF00069	0.597
MOD_N-GLC_1	112	117	PF02516	0.814
MOD_N-GLC_1	314	319	PF02516	0.733
MOD_NEK2_1	107	112	PF00069	0.610
MOD_NEK2_1	231	236	PF00069	0.741
MOD_NEK2_1	398	403	PF00069	0.824
MOD_NEK2_1	44	49	PF00069	0.644
MOD_NEK2_1	544	549	PF00069	0.800
MOD_NEK2_1	564	569	PF00069	0.706
MOD_NEK2_1	578	583	PF00069	0.524
MOD_NEK2_1	94	99	PF00069	0.788
MOD_OFUCOSY	484	490	PF10250	0.730
MOD_PIKK_1	176	182	PF00454	0.739
MOD_PIKK_1	231	237	PF00454	0.817
MOD_PIKK_1	294	300	PF00454	0.824
MOD_PKA_2	143	149	PF00069	0.699
MOD_PKA_2	203	209	PF00069	0.692
MOD_PKA_2	217	223	PF00069	0.660
MOD_PKA_2	275	281	PF00069	0.674
MOD_PKA_2	394	400	PF00069	0.801
MOD_PKA_2	9	15	PF00069	0.614
MOD_Plk_1	420	426	PF00069	0.755
MOD_Plk_1	572	578	PF00069	0.740
MOD_Plk_2-3	30	36	PF00069	0.587
MOD_Plk_4	102	108	PF00069	0.766
MOD_Plk_4	114	120	PF00069	0.668
MOD_Plk_4	159	165	PF00069	0.729
MOD_Plk_4	265	271	PF00069	0.634
MOD_Plk_4	555	561	PF00069	0.801
MOD_ProDKin_1	196	202	PF00069	0.681
MOD_ProDKin_1	23	29	PF00069	0.757
MOD_ProDKin_1	238	244	PF00069	0.614
MOD_ProDKin_1	36	42	PF00069	0.559
MOD_ProDKin_1	558	564	PF00069	0.677
MOD_ProDKin_1	76	82	PF00069	0.727
MOD_ProDKin_1	89	95	PF00069	0.635
MOD_SUMO_for_1	405	408	PF00179	0.674
MOD_SUMO_rev_2	25	34	PF00179	0.763
MOD_SUMO_rev_2	399	407	PF00179	0.710
MOD_SUMO_rev_2	428	435	PF00179	0.700
TRG_DiLeu_BaEn_4	465	471	PF01217	0.640
TRG_ENDOCYTIC_2	54	57	PF00928	0.693
TRG_ER_diArg_1	393	396	PF00400	0.571
TRG_ER_diArg_1	7	10	PF00400	0.687
TRG_NLS_MonoExtC_3	391	396	PF00514	0.566

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H6W9	Leishmania braziliensis	53%	100%
E9AGD6	Leishmania infantum	100%	100%
E9ANX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QGP4	Leishmania major	83%	100%