Proteasome_regulatory_ATPase_subunittcc1l8.3_puta tive/GeneDB:LmjF.12.0210

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome regulatory ATPase subunittcc1l8.3, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WRY0_LEIDO

TriTrypDb:

LdBPK_120190.1 , LdCL_120007200 , LDHU3_12.0300

Length:

411

Annotations

LeishMANIAdb annotations

A large and likely artifical grouping of protease domain carrying proteins related to proteasomal proteases. Only a tiny subgroup (the AFG3-related mitochondrail proteins) seem to have a TM segment.. Localization: Cytoplasmic (by homology) / Mitochondrial (by homology)

Annotations by Jardim et al.

Proteasome, proteasome regulatory ATPase subunittcc1l8.3 LINJ.12.0190

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 4
Forrest at al. (procyclic)	yes	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000502	proteasome complex	3	10
GO:0005737	cytoplasm	2	11
GO:0032991	protein-containing complex	1	11
GO:0110165	cellular anatomical entity	1	11
GO:0140535	intracellular protein-containing complex	2	10
GO:1902494	catalytic complex	2	10
GO:1905368	peptidase complex	3	10
GO:1905369	endopeptidase complex	4	10
GO:0008540	proteasome regulatory particle, base subcomplex	2	1

Expansion

Sequence features

A0A3S7WRY0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WRY0

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009056	catabolic process	2	11
GO:0009057	macromolecule catabolic process	4	11
GO:0019538	protein metabolic process	3	11
GO:0030163	protein catabolic process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901565	organonitrogen compound catabolic process	4	11
GO:1901575	organic substance catabolic process	3	11
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0016887	ATP hydrolysis activity	7	11
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0036402	proteasome-activating activity	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140657	ATP-dependent activity	1	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.604
CLV_C14_Caspase3-7	257	261	PF00656	0.342
CLV_C14_Caspase3-7	286	290	PF00656	0.360
CLV_C14_Caspase3-7	86	90	PF00656	0.537
CLV_NRD_NRD_1	236	238	PF00675	0.360
CLV_NRD_NRD_1	320	322	PF00675	0.342
CLV_NRD_NRD_1	330	332	PF00675	0.443
CLV_NRD_NRD_1	379	381	PF00675	0.342
CLV_PCSK_FUR_1	331	335	PF00082	0.431
CLV_PCSK_KEX2_1	265	267	PF00082	0.344
CLV_PCSK_KEX2_1	330	332	PF00082	0.443
CLV_PCSK_KEX2_1	333	335	PF00082	0.428
CLV_PCSK_KEX2_1	72	74	PF00082	0.523
CLV_PCSK_PC1ET2_1	265	267	PF00082	0.342
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.447
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.523
CLV_PCSK_SKI1_1	192	196	PF00082	0.367
CLV_PCSK_SKI1_1	204	208	PF00082	0.342
CLV_PCSK_SKI1_1	240	244	PF00082	0.342
CLV_PCSK_SKI1_1	30	34	PF00082	0.604
CLV_PCSK_SKI1_1	334	338	PF00082	0.433
CLV_PCSK_SKI1_1	41	45	PF00082	0.453
DOC_CYCLIN_RxL_1	24	37	PF00134	0.484
DOC_CYCLIN_RxL_1	330	341	PF00134	0.431
DOC_MAPK_FxFP_2	325	328	PF00069	0.360
DOC_MAPK_gen_1	213	222	PF00069	0.413
DOC_MAPK_gen_1	315	325	PF00069	0.342
DOC_MAPK_gen_1	330	337	PF00069	0.428
DOC_MAPK_gen_1	380	387	PF00069	0.443
DOC_MAPK_gen_1	72	79	PF00069	0.511
DOC_MAPK_MEF2A_6	113	122	PF00069	0.557
DOC_MAPK_MEF2A_6	170	177	PF00069	0.434
DOC_MAPK_MEF2A_6	247	255	PF00069	0.342
DOC_MAPK_MEF2A_6	275	284	PF00069	0.342
DOC_MAPK_MEF2A_6	343	352	PF00069	0.460
DOC_MAPK_MEF2A_6	72	81	PF00069	0.464
DOC_MAPK_RevD_3	251	266	PF00069	0.342
DOC_MAPK_RevD_3	365	381	PF00069	0.342
DOC_PP1_RVXF_1	319	326	PF00149	0.342
DOC_PP1_RVXF_1	331	338	PF00149	0.430
DOC_PP4_FxxP_1	325	328	PF00568	0.342
DOC_USP7_MATH_1	118	122	PF00917	0.519
DOC_USP7_MATH_1	2	6	PF00917	0.631
DOC_USP7_MATH_1	26	30	PF00917	0.574
DOC_USP7_MATH_1	7	11	PF00917	0.585
DOC_USP7_UBL2_3	113	117	PF12436	0.519
DOC_USP7_UBL2_3	20	24	PF12436	0.667
DOC_USP7_UBL2_3	68	72	PF12436	0.519
DOC_WW_Pin1_4	344	349	PF00397	0.459
LIG_14-3-3_CanoR_1	106	112	PF00244	0.508
LIG_BIR_II_1	1	5	PF00653	0.676
LIG_BRCT_BRCA1_1	100	104	PF00533	0.600
LIG_BRCT_BRCA1_1	251	255	PF00533	0.405
LIG_FHA_1	140	146	PF00498	0.546
LIG_FHA_1	203	209	PF00498	0.342
LIG_FHA_1	292	298	PF00498	0.342
LIG_FHA_1	55	61	PF00498	0.471
LIG_FHA_2	153	159	PF00498	0.495
LIG_FHA_2	269	275	PF00498	0.342
LIG_FHA_2	284	290	PF00498	0.342
LIG_FHA_2	355	361	PF00498	0.360
LIG_FHA_2	400	406	PF00498	0.553
LIG_LIR_Apic_2	324	328	PF02991	0.342
LIG_LIR_Gen_1	101	111	PF02991	0.506
LIG_LIR_Gen_1	153	164	PF02991	0.459
LIG_LIR_Gen_1	218	227	PF02991	0.360
LIG_LIR_Gen_1	303	314	PF02991	0.342
LIG_LIR_Gen_1	34	43	PF02991	0.575
LIG_LIR_Nem_3	101	107	PF02991	0.506
LIG_LIR_Nem_3	153	159	PF02991	0.465
LIG_LIR_Nem_3	218	222	PF02991	0.360
LIG_LIR_Nem_3	303	309	PF02991	0.342
LIG_LIR_Nem_3	31	36	PF02991	0.608
LIG_LIR_Nem_3	392	398	PF02991	0.432
LIG_LIR_Nem_3	404	410	PF02991	0.544
LIG_MLH1_MIPbox_1	100	104	PF16413	0.600
LIG_NRBOX	280	286	PF00104	0.342
LIG_PCNA_yPIPBox_3	275	285	PF02747	0.342
LIG_PCNA_yPIPBox_3	41	52	PF02747	0.443
LIG_Pex14_2	227	231	PF04695	0.474
LIG_SH2_CRK	197	201	PF00017	0.425
LIG_SH2_CRK	395	399	PF00017	0.457
LIG_SH2_NCK_1	156	160	PF00017	0.456
LIG_SH2_NCK_1	183	187	PF00017	0.473
LIG_SH2_PTP2	384	387	PF00017	0.438
LIG_SH2_STAT5	103	106	PF00017	0.508
LIG_SH2_STAT5	355	358	PF00017	0.420
LIG_SH2_STAT5	384	387	PF00017	0.438
LIG_SH3_3	170	176	PF00018	0.446
LIG_SH3_3	353	359	PF00018	0.360
LIG_SH3_3	382	388	PF00018	0.438
LIG_SUMO_SIM_anti_2	142	150	PF11976	0.645
LIG_SUMO_SIM_par_1	280	286	PF11976	0.360
LIG_TRAF2_1	67	70	PF00917	0.483
LIG_TYR_ITIM	154	159	PF00017	0.454
LIG_UBA3_1	107	113	PF00899	0.519
LIG_WW_3	189	193	PF00397	0.444
MOD_CK1_1	261	267	PF00069	0.342
MOD_CK1_1	5	11	PF00069	0.657
MOD_CK1_1	96	102	PF00069	0.536
MOD_CK2_1	28	34	PF00069	0.489
MOD_CK2_1	354	360	PF00069	0.360
MOD_CK2_1	399	405	PF00069	0.561
MOD_GlcNHglycan	14	17	PF01048	0.682
MOD_GlcNHglycan	362	365	PF01048	0.360
MOD_GlcNHglycan	63	67	PF01048	0.542
MOD_GlcNHglycan	9	12	PF01048	0.671
MOD_GlcNHglycan	95	98	PF01048	0.362
MOD_GSK3_1	1	8	PF00069	0.720
MOD_GSK3_1	141	148	PF00069	0.640
MOD_GSK3_1	399	406	PF00069	0.575
MOD_N-GLC_1	118	123	PF02516	0.356
MOD_N-GLC_1	146	151	PF02516	0.595
MOD_N-GLC_1	344	349	PF02516	0.459
MOD_N-GLC_2	129	131	PF02516	0.306
MOD_NEK2_1	1	6	PF00069	0.668
MOD_NEK2_1	124	129	PF00069	0.604
MOD_NEK2_1	291	296	PF00069	0.369
MOD_NEK2_2	28	33	PF00069	0.468
MOD_PIKK_1	283	289	PF00454	0.360
MOD_PIKK_1	98	104	PF00454	0.600
MOD_PKA_2	212	218	PF00069	0.427
MOD_Plk_1	118	124	PF00069	0.600
MOD_Plk_1	139	145	PF00069	0.544
MOD_Plk_1	152	158	PF00069	0.474
MOD_Plk_1	403	409	PF00069	0.701
MOD_Plk_4	202	208	PF00069	0.347
MOD_Plk_4	215	221	PF00069	0.375
MOD_Plk_4	249	255	PF00069	0.385
MOD_Plk_4	47	53	PF00069	0.646
MOD_ProDKin_1	344	350	PF00069	0.456
MOD_SUMO_for_1	61	64	PF00179	0.512
MOD_SUMO_for_1	67	70	PF00179	0.471
MOD_SUMO_rev_2	37	46	PF00179	0.597
MOD_SUMO_rev_2	64	74	PF00179	0.521
TRG_DiLeu_BaEn_1	56	61	PF01217	0.553
TRG_DiLeu_BaEn_4	34	40	PF01217	0.581
TRG_ENDOCYTIC_2	156	159	PF00928	0.459
TRG_ENDOCYTIC_2	183	186	PF00928	0.471
TRG_ENDOCYTIC_2	36	39	PF00928	0.583
TRG_ENDOCYTIC_2	384	387	PF00928	0.438
TRG_ENDOCYTIC_2	395	398	PF00928	0.441
TRG_Pf-PMV_PEXEL_1	230	234	PF00026	0.342
TRG_Pf-PMV_PEXEL_1	279	283	PF00026	0.342
TRG_Pf-PMV_PEXEL_1	30	34	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4E9	Leptomonas seymouri	42%	100%
A0A0N0P5B8	Leptomonas seymouri	37%	93%
A0A0N0P7K1	Leptomonas seymouri	44%	100%
A0A0N1IGY9	Leptomonas seymouri	93%	99%
A0A0N1IM81	Leptomonas seymouri	48%	94%
A0A0N1PAS8	Leptomonas seymouri	45%	94%
A0A0S4IJE6	Bodo saltans	43%	94%
A0A0S4ITX1	Bodo saltans	44%	93%
A0A0S4IY28	Bodo saltans	45%	100%
A0A0S4JCD0	Bodo saltans	52%	100%
A0A0S4JDU3	Bodo saltans	40%	100%
A0A0S4JSD8	Bodo saltans	86%	100%
A0A1X0NMZ3	Trypanosomatidae	49%	94%
A0A1X0NNS1	Trypanosomatidae	84%	99%
A0A1X0NT86	Trypanosomatidae	44%	93%
A0A1X0NUX3	Trypanosomatidae	45%	94%
A0A1X0P1T5	Trypanosomatidae	45%	100%
A0A1X0P8T7	Trypanosomatidae	43%	100%
A0A3Q8IJS0	Leishmania donovani	44%	100%
A0A3R7LUG9	Trypanosoma rangeli	36%	93%
A0A3R7N4Y5	Trypanosoma rangeli	41%	100%
A0A3S5H547	Leishmania donovani	44%	100%
A0A3S7WSK7	Leishmania donovani	48%	100%
A0A3S7WX14	Leishmania donovani	39%	100%
A0A3S7WX46	Leishmania donovani	45%	94%
A0A422NDS9	Trypanosoma rangeli	45%	94%
A0A422NLD8	Trypanosoma rangeli	49%	94%
A0A422NMN6	Trypanosoma rangeli	42%	100%
A0A422NUD9	Trypanosoma rangeli	86%	100%
A0LU46	Acidothermus cellulolyticus (strain ATCC 43068 / DSM 8971 / 11B)	36%	70%
A1A0U4	Bifidobacterium adolescentis (strain ATCC 15703 / DSM 20083 / NCTC 11814 / E194a)	42%	80%
A1R6Q4	Paenarthrobacter aurescens (strain TC1)	36%	68%
A1UHT0	Mycobacterium sp. (strain KMS)	38%	67%
A3CV35	Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)	45%	100%
A3Q196	Mycobacterium sp. (strain JLS)	38%	67%
A4FBX6	Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338)	35%	69%
A4G0S4	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	44%	100%
A4H3L6	Leishmania braziliensis	43%	100%
A4H6T6	Leishmania braziliensis	99%	100%
A4H795	Leishmania braziliensis	48%	100%
A4HCA3	Leishmania braziliensis	45%	100%
A4HCA7	Leishmania braziliensis	38%	100%
A4HME8	Leishmania braziliensis	33%	100%
A4HPV3	Leishmania braziliensis	45%	100%
A4HVN7	Leishmania infantum	48%	100%
A4HZT4	Leishmania infantum	45%	100%
A4HZT9	Leishmania infantum	39%	100%
A4IE38	Leishmania infantum	44%	100%
A4X741	Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)	36%	69%
A6UQT3	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	45%	100%
A6VHR1	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	44%	100%
A6W963	Kineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216)	36%	71%
A7I8B8	Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)	46%	94%
A8M2A0	Salinispora arenicola (strain CNS-205)	36%	69%
A9A916	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	44%	100%
B1VDV2	Corynebacterium urealyticum (strain ATCC 43042 / DSM 7109)	38%	76%
B1W303	Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)	35%	70%
B2GIP2	Kocuria rhizophila (strain ATCC 9341 / DSM 348 / NBRC 103217 / DC2201)	38%	72%
B3DRN4	Bifidobacterium longum (strain DJO10A)	37%	79%
B6YXR2	Thermococcus onnurineus (strain NA1)	47%	100%
B7GUP3	Bifidobacterium longum subsp. infantis (strain ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12)	37%	79%
B8GGN4	Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)	44%	100%
B8H8L3	Pseudarthrobacter chlorophenolicus (strain ATCC 700700 / DSM 12829 / CIP 107037 / JCM 12360 / KCTC 9906 / NCIMB 13794 / A6)	36%	70%
C0ZZV2	Rhodococcus erythropolis (strain PR4 / NBRC 100887)	36%	70%
C3MRF1	Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)	44%	100%
C3MY47	Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)	44%	100%
C3MZI6	Sulfolobus islandicus (strain M.16.27)	44%	100%
C3N7K8	Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)	44%	100%
C3NFW6	Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)	45%	100%
C3PGA0	Corynebacterium aurimucosum (strain ATCC 700975 / DSM 44827 / CIP 107346 / CN-1)	34%	78%
C4KIR6	Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)	44%	100%
C5A6P8	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	48%	100%
C5BVA6	Beutenbergia cavernae (strain ATCC BAA-8 / DSM 12333 / NBRC 16432)	36%	73%
C6WIC8	Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / JCM 3225 / NBRC 14064 / NCIMB 13271 / NRRL B-12336 / IMRU 3971 / 101)	37%	69%
C7LYP4	Acidimicrobium ferrooxidans (strain DSM 10331 / JCM 15462 / NBRC 103882 / ICP)	37%	71%
C7MCZ0	Brachybacterium faecium (strain ATCC 43885 / DSM 4810 / JCM 11609 / LMG 19847 / NBRC 14762 / NCIMB 9860 / 6-10)	38%	77%
C7PVU9	Catenulispora acidiphila (strain DSM 44928 / JCM 14897 / NBRC 102108 / NRRL B-24433 / ID139908)	35%	69%
C7R400	Jonesia denitrificans (strain ATCC 14870 / DSM 20603 / BCRC 15368 / CIP 55.134 / JCM 11481 / NBRC 15587 / NCTC 10816 / Prevot 55134)	35%	75%
C8XAR0	Nakamurella multipartita (strain ATCC 700099 / DSM 44233 / CIP 104796 / JCM 9543 / NBRC 105858 / Y-104)	38%	69%
C9ZNL6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
C9ZQC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	83%	100%
C9ZRM0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	94%
C9ZRM8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	92%
D0A259	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
D0A4A2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
D0A6K9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	94%
D0LDS6	Gordonia bronchialis (strain ATCC 25592 / DSM 43247 / BCRC 13721 / JCM 3198 / KCTC 3076 / NBRC 16047 / NCTC 10667)	37%	68%
D1BHU2	Sanguibacter keddieii (strain ATCC 51767 / DSM 10542 / NCFB 3025 / ST-74)	35%	71%
D1BS23	Xylanimonas cellulosilytica (strain DSM 15894 / CECT 5975 / LMG 20990 / XIL07)	37%	76%
D2ATX1	Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)	35%	70%
D2Q9C6	Bifidobacterium dentium (strain ATCC 27534 / DSM 20436 / JCM 1195 / Bd1)	40%	78%
D2S6D9	Geodermatophilus obscurus (strain ATCC 25078 / DSM 43160 / JCM 3152 / KCC A-0152 / KCTC 9177 / NBRC 13315 / NRRL B-3577 / G-20)	37%	69%
D4GUJ7	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	44%	100%
E9ACJ9	Leishmania major	44%	100%
E9AG43	Leishmania infantum	44%	100%
E9AGB0	Leishmania infantum	100%	100%
E9AJT7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9ANU8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
E9APD3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E9ATM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AVN9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AVP4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
O04019	Arabidopsis thaliana	39%	97%
O14126	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	94%
O16368	Caenorhabditis elegans	51%	93%
O17071	Caenorhabditis elegans	41%	100%
O18413	Drosophila melanogaster	45%	100%
O23894	Brassica campestris	41%	97%
O26824	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	43%	100%
O28303	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	46%	100%
O42586	Xenopus laevis	43%	100%
O42587	Xenopus laevis	43%	97%
O42931	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	43%	94%
O50202	Rhodococcus erythropolis	36%	70%
O57940	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	47%	100%
O64982	Prunus persica	46%	97%
O74445	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	100%
O74894	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	66%	100%
O76371	Caenorhabditis elegans	41%	96%
O88685	Mus musculus	40%	93%
P0DKJ9	Oryza sativa subsp. japonica	43%	96%
P0DKK0	Oryza sativa subsp. japonica	43%	96%
P17980	Homo sapiens	40%	94%
P33297	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	95%
P33298	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	63%	96%
P33299	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	45%	88%
P34123	Dictyostelium discoideum	66%	100%
P34124	Dictyostelium discoideum	47%	100%
P35998	Homo sapiens	45%	95%
P36612	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	50%	92%
P40327	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	48%	94%
P41836	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	44%	100%
P43686	Homo sapiens	69%	98%
P46465	Oryza sativa subsp. japonica	41%	96%
P46466	Oryza sativa subsp. japonica	49%	92%
P46470	Xenopus laevis	45%	89%
P46471	Mus musculus	45%	95%
P46472	Xenopus laevis	45%	95%
P46502	Caenorhabditis elegans	69%	99%
P46507	Manduca sexta	67%	99%
P48601	Drosophila melanogaster	51%	94%
P53549	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	43%	94%
P54775	Mus musculus	69%	98%
P54776	Solanum lycopersicum	39%	97%
P54778	Solanum tuberosum	70%	100%
P54814	Manduca sexta	45%	100%
P62191	Homo sapiens	50%	93%
P62192	Mus musculus	50%	93%
P62193	Rattus norvegicus	50%	93%
P62194	Bos taurus	46%	100%
P62195	Homo sapiens	46%	100%
P62196	Mus musculus	46%	100%
P62197	Sus scrofa	46%	100%
P62198	Rattus norvegicus	46%	100%
P62333	Homo sapiens	40%	100%
P62334	Mus musculus	40%	100%
P62335	Ictidomys tridecemlineatus	40%	100%
P78578	Aspergillus niger	66%	97%
P85200	Helianthus annuus	71%	99%
Q01939	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	44%	100%
Q0W257	Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)	44%	99%
Q18787	Caenorhabditis elegans	42%	94%
Q1B795	Mycobacterium sp. (strain MCS)	38%	67%
Q25544	Naegleria fowleri	43%	99%
Q2FQ56	Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)	47%	100%
Q2KIW6	Bos taurus	40%	100%
Q3T030	Bos taurus	69%	98%
Q41365	Spinacia oleracea	46%	96%
Q47NX7	Thermobifida fusca (strain YX)	38%	70%
Q4Q0X8	Leishmania major	44%	100%
Q4QBT5	Leishmania major	39%	100%
Q4QBU0	Leishmania major	45%	100%
Q4QG45	Leishmania major	48%	100%
Q4QGS2	Leishmania major	100%	100%
Q4R4R0	Macaca fascicularis	45%	95%
Q4R7L3	Macaca fascicularis	69%	98%
Q54PJ1	Dictyostelium discoideum	41%	100%
Q54PN7	Dictyostelium discoideum	39%	98%
Q55BV5	Dictyostelium discoideum	51%	94%
Q58576	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	49%	96%
Q5E9F9	Bos taurus	45%	95%
Q5JHS5	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	50%	100%
Q5R8D7	Pongo abelii	44%	95%
Q5UT56	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	40%	100%
Q5YUW4	Nocardia farcinica (strain IFM 10152)	36%	70%
Q63347	Rattus norvegicus	44%	95%
Q63569	Rattus norvegicus	40%	94%
Q63570	Rattus norvegicus	69%	98%
Q6LWR0	Methanococcus maripaludis (strain S2 / LL)	44%	100%
Q828J2	Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)	36%	70%
Q86JA1	Dictyostelium discoideum	44%	96%
Q8FTE3	Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)	37%	78%
Q8G3G6	Bifidobacterium longum (strain NCC 2705)	37%	79%
Q8PY58	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	46%	98%
Q8SQI9	Encephalitozoon cuniculi (strain GB-M1)	65%	100%
Q8SQK0	Encephalitozoon cuniculi (strain GB-M1)	47%	100%
Q8SR13	Encephalitozoon cuniculi (strain GB-M1)	40%	100%
Q8SRH0	Encephalitozoon cuniculi (strain GB-M1)	49%	97%
Q8TI88	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	45%	98%
Q8TX03	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	48%	94%
Q8U4H3	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	47%	100%
Q90732	Gallus gallus	49%	93%
Q94BQ2	Arabidopsis thaliana	45%	98%
Q975U2	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	44%	100%
Q980M1	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	44%	100%
Q9C5U3	Arabidopsis thaliana	45%	98%
Q9HNP9	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	47%	100%
Q9HRW6	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	40%	100%
Q9MAK9	Arabidopsis thaliana	42%	100%
Q9RJ58	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	35%	70%
Q9SEI2	Arabidopsis thaliana	41%	97%
Q9SEI3	Arabidopsis thaliana	41%	100%
Q9SEI4	Arabidopsis thaliana	68%	100%
Q9SL67	Arabidopsis thaliana	49%	93%
Q9SSB4	Arabidopsis thaliana	38%	89%
Q9SSB5	Arabidopsis thaliana	46%	96%
Q9SZD4	Arabidopsis thaliana	49%	93%
Q9V287	Pyrococcus abyssi (strain GE5 / Orsay)	47%	100%
Q9WZ49	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	38%	67%
Q9XTT9	Caenorhabditis elegans	45%	99%
Q9YAC7	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	46%	100%
V5AV12	Trypanosoma cruzi	49%	94%
V5B5D2	Trypanosoma cruzi	33%	84%
V5B5X1	Trypanosoma cruzi	44%	94%
V5B5X6	Trypanosoma cruzi	36%	93%
V5BKL6	Trypanosoma cruzi	43%	100%
V5BSS5	Trypanosoma cruzi	42%	100%