CCR4-NOT transcription complex subunit 2, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CCR4-NOT transcription complex subunit 2, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WRX6_LEIDO

TriTrypDb:

LdBPK_120300.1 , LdCL_120008600 , LDHU3_12.0470

Length:

564

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

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Cellular components
Term	Name	Level	Count
GO:0000932	P-body	5	1
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0030015	CCR4-NOT core complex	3	5
GO:0032991	protein-containing complex	1	5
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1

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Expansion

Sequence features

A0A3S7WRX6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WRX6

Function

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Biological processes
Term	Name	Level	Count
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening	8	1
GO:0000956	nuclear-transcribed mRNA catabolic process	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006355	regulation of DNA-templated transcription	6	5
GO:0006401	RNA catabolic process	5	1
GO:0006402	mRNA catabolic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	342	346	PF00656	0.703
CLV_C14_Caspase3-7	471	475	PF00656	0.542
CLV_NRD_NRD_1	67	69	PF00675	0.739
CLV_PCSK_KEX2_1	449	451	PF00082	0.342
CLV_PCSK_KEX2_1	67	69	PF00082	0.739
CLV_PCSK_PC1ET2_1	449	451	PF00082	0.342
CLV_PCSK_SKI1_1	429	433	PF00082	0.432
CLV_PCSK_SKI1_1	477	481	PF00082	0.432
CLV_PCSK_SKI1_1	68	72	PF00082	0.743
DEG_COP1_1	322	329	PF00400	0.800

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
E9AGC2	Leishmania infantum	99%	99%
E9ANW2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QGQ8	Leishmania major	95%	100%

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