CCR4-NOT transcription complex subunit 2, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CCR4-NOT transcription complex subunit 2, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WRX6_LEIDO

TriTrypDb:

LdBPK_120300.1 , LdCL_120008600 , LDHU3_12.0470

Length:

564

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0030015	CCR4-NOT core complex	3	5
GO:0032991	protein-containing complex	1	5
GO:0140535	intracellular protein-containing complex	2	5
GO:0000932	P-body	5	1
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WRX6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WRX6

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	5
GO:0009889	regulation of biosynthetic process	4	5
GO:0010468	regulation of gene expression	5	5
GO:0010556	regulation of macromolecule biosynthetic process	5	5
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	5
GO:0019222	regulation of metabolic process	3	5
GO:0031323	regulation of cellular metabolic process	4	5
GO:0031326	regulation of cellular biosynthetic process	5	5
GO:0050789	regulation of biological process	2	5
GO:0050794	regulation of cellular process	3	5
GO:0051171	regulation of nitrogen compound metabolic process	4	5
GO:0051252	regulation of RNA metabolic process	5	5
GO:0060255	regulation of macromolecule metabolic process	4	5
GO:0065007	biological regulation	1	5
GO:0080090	regulation of primary metabolic process	4	5
GO:1903506	regulation of nucleic acid-templated transcription	7	5
GO:2001141	regulation of RNA biosynthetic process	6	5
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening	8	1
GO:0000956	nuclear-transcribed mRNA catabolic process	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006401	RNA catabolic process	5	1
GO:0006402	mRNA catabolic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010629	negative regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0048519	negative regulation of biological process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	342	346	PF00656	0.703
CLV_C14_Caspase3-7	471	475	PF00656	0.542
CLV_NRD_NRD_1	67	69	PF00675	0.739
CLV_PCSK_KEX2_1	449	451	PF00082	0.342
CLV_PCSK_KEX2_1	67	69	PF00082	0.739
CLV_PCSK_PC1ET2_1	449	451	PF00082	0.342
CLV_PCSK_SKI1_1	429	433	PF00082	0.432
CLV_PCSK_SKI1_1	477	481	PF00082	0.432
CLV_PCSK_SKI1_1	68	72	PF00082	0.743
DEG_COP1_1	322	329	PF00400	0.800
DOC_MAPK_gen_1	127	135	PF00069	0.742
DOC_MAPK_JIP1_4	403	409	PF00069	0.632
DOC_MAPK_MEF2A_6	312	320	PF00069	0.783
DOC_PP2B_LxvP_1	133	136	PF13499	0.752
DOC_PP2B_LxvP_1	49	52	PF13499	0.743
DOC_PP4_FxxP_1	25	28	PF00568	0.849
DOC_PP4_FxxP_1	393	396	PF00568	0.524
DOC_USP7_MATH_1	259	263	PF00917	0.792
DOC_USP7_MATH_1	268	272	PF00917	0.694
DOC_USP7_MATH_1	381	385	PF00917	0.716
DOC_USP7_MATH_1	544	548	PF00917	0.856
DOC_USP7_MATH_1	555	559	PF00917	0.675
DOC_USP7_MATH_1	560	564	PF00917	0.593
DOC_USP7_UBL2_3	308	312	PF12436	0.731
DOC_USP7_UBL2_3	401	405	PF12436	0.523
DOC_WW_Pin1_4	243	248	PF00397	0.845
DOC_WW_Pin1_4	320	325	PF00397	0.809
DOC_WW_Pin1_4	556	561	PF00397	0.852
LIG_14-3-3_CanoR_1	104	112	PF00244	0.737
LIG_14-3-3_CanoR_1	403	408	PF00244	0.637
LIG_BIR_II_1	1	5	PF00653	0.871
LIG_eIF4E_1	305	311	PF01652	0.718
LIG_FHA_1	321	327	PF00498	0.803
LIG_FHA_1	331	337	PF00498	0.588
LIG_FHA_1	353	359	PF00498	0.672
LIG_FHA_1	377	383	PF00498	0.706
LIG_FHA_1	480	486	PF00498	0.632
LIG_FHA_2	469	475	PF00498	0.542
LIG_FHA_2	59	65	PF00498	0.711
LIG_LIR_Apic_2	23	28	PF02991	0.855
LIG_LIR_Apic_2	386	391	PF02991	0.711
LIG_LIR_Apic_2	392	396	PF02991	0.427
LIG_LIR_Apic_2	397	402	PF02991	0.504
LIG_LIR_Gen_1	348	358	PF02991	0.678
LIG_LIR_Gen_1	411	420	PF02991	0.632
LIG_LIR_Gen_1	480	488	PF02991	0.632
LIG_LIR_Nem_3	348	354	PF02991	0.682
LIG_LIR_Nem_3	383	388	PF02991	0.723
LIG_LIR_Nem_3	411	415	PF02991	0.632
LIG_LIR_Nem_3	418	424	PF02991	0.550
LIG_LIR_Nem_3	480	486	PF02991	0.632
LIG_LIR_Nem_3	490	494	PF02991	0.516
LIG_MYND_1	236	240	PF01753	0.680
LIG_PCNA_yPIPBox_3	198	209	PF02747	0.754
LIG_SH2_CRK	399	403	PF00017	0.632
LIG_SH2_CRK	425	429	PF00017	0.632
LIG_SH2_PTP2	388	391	PF00017	0.701
LIG_SH2_SRC	325	328	PF00017	0.793
LIG_SH2_STAP1	385	389	PF00017	0.722
LIG_SH2_STAT3	176	179	PF00017	0.766
LIG_SH2_STAT5	325	328	PF00017	0.793
LIG_SH2_STAT5	388	391	PF00017	0.701
LIG_SH2_STAT5	422	425	PF00017	0.632
LIG_SH2_STAT5	483	486	PF00017	0.632
LIG_SH3_3	269	275	PF00018	0.835
LIG_SH3_3	310	316	PF00018	0.752
LIG_SH3_3	321	327	PF00018	0.624
LIG_SH3_3	329	335	PF00018	0.446
LIG_SH3_3	482	488	PF00018	0.632
LIG_SH3_4	401	408	PF00018	0.632
LIG_SUMO_SIM_anti_2	109	114	PF11976	0.716
LIG_TRAF2_1	516	519	PF00917	0.691
LIG_WRC_WIRS_1	409	414	PF05994	0.632
LIG_WW_2	316	319	PF00397	0.787
MOD_CK1_1	408	414	PF00069	0.632
MOD_CK1_1	558	564	PF00069	0.727
MOD_CK2_1	103	109	PF00069	0.754
MOD_CK2_1	325	331	PF00069	0.788
MOD_CK2_1	363	369	PF00069	0.693
MOD_CK2_1	461	467	PF00069	0.632
MOD_CK2_1	58	64	PF00069	0.712
MOD_GlcNHglycan	105	108	PF01048	0.738
MOD_GlcNHglycan	231	234	PF01048	0.749
MOD_GlcNHglycan	262	265	PF01048	0.805
MOD_GlcNHglycan	327	330	PF01048	0.792
MOD_GlcNHglycan	336	339	PF01048	0.632
MOD_GlcNHglycan	508	513	PF01048	0.666
MOD_GlcNHglycan	540	543	PF01048	0.826
MOD_GlcNHglycan	553	556	PF01048	0.612
MOD_GlcNHglycan	560	563	PF01048	0.735
MOD_GSK3_1	178	185	PF00069	0.762
MOD_GSK3_1	211	218	PF00069	0.692
MOD_GSK3_1	330	337	PF00069	0.650
MOD_GSK3_1	372	379	PF00069	0.704
MOD_GSK3_1	477	484	PF00069	0.632
MOD_GSK3_1	551	558	PF00069	0.779
MOD_N-GLC_1	149	154	PF02516	0.757
MOD_N-GLC_1	159	164	PF02516	0.533
MOD_N-GLC_1	260	265	PF02516	0.828
MOD_N-GLC_1	349	354	PF02516	0.680
MOD_N-GLC_1	556	561	PF02516	0.800
MOD_NEK2_1	228	233	PF00069	0.660
MOD_NEK2_1	349	354	PF00069	0.680
MOD_NEK2_1	373	378	PF00069	0.696
MOD_NEK2_1	466	471	PF00069	0.608
MOD_NEK2_1	479	484	PF00069	0.504
MOD_NEK2_1	58	63	PF00069	0.708
MOD_NEK2_2	481	486	PF00069	0.632
MOD_PIKK_1	178	184	PF00454	0.763
MOD_PIKK_1	193	199	PF00454	0.510
MOD_PIKK_1	28	34	PF00454	0.768
MOD_PIKK_1	339	345	PF00454	0.727
MOD_PIKK_1	358	364	PF00454	0.382
MOD_PIKK_1	493	499	PF00454	0.632
MOD_PIKK_1	522	528	PF00454	0.731
MOD_PKA_2	103	109	PF00069	0.754
MOD_Plk_1	159	165	PF00069	0.705
MOD_Plk_1	260	266	PF00069	0.849
MOD_Plk_1	349	355	PF00069	0.678
MOD_Plk_1	358	364	PF00069	0.539
MOD_Plk_1	416	422	PF00069	0.632
MOD_Plk_1	508	514	PF00069	0.671
MOD_Plk_2-3	461	467	PF00069	0.632
MOD_Plk_4	20	26	PF00069	0.857
MOD_Plk_4	223	229	PF00069	0.663
MOD_Plk_4	416	422	PF00069	0.632
MOD_Plk_4	461	467	PF00069	0.632
MOD_Plk_4	481	487	PF00069	0.400
MOD_ProDKin_1	243	249	PF00069	0.845
MOD_ProDKin_1	320	326	PF00069	0.808
MOD_ProDKin_1	556	562	PF00069	0.852
MOD_SUMO_for_1	415	418	PF00179	0.632
MOD_SUMO_rev_2	386	396	PF00179	0.696
TRG_DiLeu_BaEn_1	509	514	PF01217	0.677
TRG_ENDOCYTIC_2	387	390	PF00928	0.712
TRG_ENDOCYTIC_2	483	486	PF00928	0.632
TRG_ER_diArg_1	129	132	PF00400	0.738
TRG_NLS_MonoCore_2	399	404	PF00514	0.632
TRG_NLS_MonoExtC_3	399	404	PF00514	0.632
TRG_Pf-PMV_PEXEL_1	127	131	PF00026	0.740
TRG_Pf-PMV_PEXEL_1	339	343	PF00026	0.734
TRG_Pf-PMV_PEXEL_1	438	442	PF00026	0.432

Homologs


Protein	Taxonomy	Sequence identity	Coverage
E9AGC2	Leishmania infantum	99%	99%
E9ANW2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QGQ8	Leishmania major	95%	100%