Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 18

Species:

Leishmania donovani

UniProt:

A0A3S7WRX5_LEIDO

TriTrypDb:

LdBPK_120500.1 , LdCL_120010700 , LDHU3_12.0760

Length:

167

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	1
GO:0016020	membrane	2	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WRX5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WRX5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	144	146	PF00675	0.658
CLV_NRD_NRD_1	45	47	PF00675	0.616
CLV_PCSK_KEX2_1	133	135	PF00082	0.615
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.615
CLV_PCSK_SKI1_1	3	7	PF00082	0.602
DOC_PP1_RVXF_1	100	107	PF00149	0.570
DOC_PP1_RVXF_1	78	85	PF00149	0.516
DOC_USP7_UBL2_3	153	157	PF12436	0.608
DOC_USP7_UBL2_3	19	23	PF12436	0.588
DOC_WW_Pin1_4	106	111	PF00397	0.710
DOC_WW_Pin1_4	121	126	PF00397	0.624
DOC_WW_Pin1_4	148	153	PF00397	0.717
LIG_14-3-3_CanoR_1	143	152	PF00244	0.568
LIG_14-3-3_CanoR_1	7	17	PF00244	0.599
LIG_BRCT_BRCA1_1	17	21	PF00533	0.611
LIG_BRCT_BRCA1_2	17	23	PF00533	0.571
LIG_LIR_Gen_1	155	165	PF02991	0.622
LIG_LIR_Nem_3	155	161	PF02991	0.629
LIG_NRP_CendR_1	164	167	PF00754	0.545
LIG_Pex14_2	17	21	PF04695	0.540
LIG_Pex14_2	9	13	PF04695	0.540
LIG_SH3_3	115	121	PF00018	0.582
LIG_SH3_3	146	152	PF00018	0.530
LIG_SH3_3	156	162	PF00018	0.679
LIG_SH3_3	67	73	PF00018	0.614
LIG_WRC_WIRS_1	10	15	PF05994	0.533
LIG_WW_1	162	165	PF00397	0.611
LIG_WW_3	161	165	PF00397	0.601
MOD_CDK_SPK_2	148	153	PF00069	0.628
MOD_CK1_1	11	17	PF00069	0.702
MOD_CK1_1	35	41	PF00069	0.598
MOD_CK1_1	50	56	PF00069	0.574
MOD_Cter_Amidation	131	134	PF01082	0.615
MOD_GlcNHglycan	35	38	PF01048	0.735
MOD_GlcNHglycan	50	53	PF01048	0.583
MOD_GlcNHglycan	65	68	PF01048	0.569
MOD_GSK3_1	11	18	PF00069	0.549
MOD_GSK3_1	144	151	PF00069	0.705
MOD_GSK3_1	35	42	PF00069	0.670
MOD_NEK2_1	1	6	PF00069	0.573
MOD_NEK2_1	144	149	PF00069	0.578
MOD_NEK2_1	32	37	PF00069	0.634
MOD_NEK2_1	9	14	PF00069	0.596
MOD_NEK2_2	39	44	PF00069	0.641
MOD_PIKK_1	144	150	PF00454	0.575
MOD_PKA_2	144	150	PF00069	0.575
MOD_Plk_4	39	45	PF00069	0.633
MOD_ProDKin_1	106	112	PF00069	0.709
MOD_ProDKin_1	121	127	PF00069	0.624
MOD_ProDKin_1	148	154	PF00069	0.720
MOD_SUMO_for_1	152	155	PF00179	0.626
MOD_SUMO_rev_2	151	159	PF00179	0.622

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JMJ7	Bodo saltans	46%	100%
E9AGE2	Leishmania infantum	99%	100%
E9ANY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QGN8	Leishmania major	93%	100%