Semialdhyde_dh domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WRX1_LEIDO

TriTrypDb:

LdBPK_120340.1 , LdCL_120009000 , LDHU3_12.0520

Length:

416

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WRX1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WRX1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006913	nucleocytoplasmic transport	5	1
GO:0009987	cellular process	1	1
GO:0046907	intracellular transport	3	1
GO:0051169	nuclear transport	4	1
GO:0051170	import into nucleus	6	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.661
CLV_C14_Caspase3-7	155	159	PF00656	0.412
CLV_NRD_NRD_1	155	157	PF00675	0.423
CLV_NRD_NRD_1	370	372	PF00675	0.701
CLV_NRD_NRD_1	385	387	PF00675	0.596
CLV_PCSK_KEX2_1	108	110	PF00082	0.497
CLV_PCSK_KEX2_1	69	71	PF00082	0.636
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.603
CLV_PCSK_PC1ET2_1	69	71	PF00082	0.636
CLV_PCSK_SKI1_1	139	143	PF00082	0.415
CLV_PCSK_SKI1_1	163	167	PF00082	0.421
CLV_PCSK_SKI1_1	274	278	PF00082	0.475
CLV_PCSK_SKI1_1	306	310	PF00082	0.530
CLV_PCSK_SKI1_1	92	96	PF00082	0.464
DEG_SPOP_SBC_1	246	250	PF00917	0.479
DOC_USP7_MATH_1	107	111	PF00917	0.571
DOC_USP7_MATH_1	114	118	PF00917	0.608
DOC_USP7_MATH_1	228	232	PF00917	0.517
DOC_USP7_MATH_1	246	250	PF00917	0.255
DOC_USP7_MATH_1	261	265	PF00917	0.378
DOC_USP7_MATH_1	323	327	PF00917	0.372
DOC_USP7_UBL2_3	383	387	PF12436	0.590
DOC_WW_Pin1_4	187	192	PF00397	0.538
DOC_WW_Pin1_4	280	285	PF00397	0.535
DOC_WW_Pin1_4	370	375	PF00397	0.707
DOC_WW_Pin1_4	81	86	PF00397	0.518
LIG_14-3-3_CanoR_1	302	310	PF00244	0.622
LIG_14-3-3_CanoR_1	35	44	PF00244	0.439
LIG_14-3-3_CanoR_1	92	97	PF00244	0.441
LIG_14-3-3_CterR_2	413	416	PF00244	0.544
LIG_BRCT_BRCA1_1	248	252	PF00533	0.504
LIG_deltaCOP1_diTrp_1	97	105	PF00928	0.372
LIG_FHA_1	175	181	PF00498	0.442
LIG_FHA_1	232	238	PF00498	0.512
LIG_FHA_1	255	261	PF00498	0.472
LIG_FHA_1	8	14	PF00498	0.347
LIG_FHA_2	153	159	PF00498	0.408
LIG_FHA_2	164	170	PF00498	0.346
LIG_FHA_2	82	88	PF00498	0.483
LIG_LIR_Gen_1	146	152	PF02991	0.405
LIG_LIR_Gen_1	169	176	PF02991	0.323
LIG_LIR_Gen_1	249	260	PF02991	0.470
LIG_LIR_Gen_1	304	315	PF02991	0.518
LIG_LIR_Gen_1	42	52	PF02991	0.491
LIG_LIR_Gen_1	95	106	PF02991	0.371
LIG_LIR_Nem_3	136	141	PF02991	0.415
LIG_LIR_Nem_3	169	173	PF02991	0.327
LIG_LIR_Nem_3	248	254	PF02991	0.467
LIG_LIR_Nem_3	304	310	PF02991	0.551
LIG_LIR_Nem_3	42	47	PF02991	0.500
LIG_LIR_Nem_3	95	101	PF02991	0.367
LIG_PCNA_yPIPBox_3	24	37	PF02747	0.503
LIG_PDZ_Class_2	411	416	PF00595	0.528
LIG_Pex14_2	101	105	PF04695	0.367
LIG_SH2_CRK	138	142	PF00017	0.483
LIG_SH2_CRK	170	174	PF00017	0.346
LIG_SH2_CRK	183	187	PF00017	0.377
LIG_SH2_NCK_1	183	187	PF00017	0.473
LIG_SH2_SRC	170	173	PF00017	0.328
LIG_SH2_STAP1	170	174	PF00017	0.302
LIG_SH2_STAP1	44	48	PF00017	0.484
LIG_SH2_STAT3	20	23	PF00017	0.372
LIG_SH2_STAT5	172	175	PF00017	0.322
LIG_SH2_STAT5	379	382	PF00017	0.669
LIG_SH2_STAT5	398	401	PF00017	0.309
LIG_SUMO_SIM_anti_2	217	222	PF11976	0.555
LIG_SUMO_SIM_par_1	28	34	PF11976	0.356
MOD_CDC14_SPxK_1	190	193	PF00782	0.503
MOD_CDK_SPxK_1	187	193	PF00069	0.482
MOD_CDK_SPxxK_3	370	377	PF00069	0.554
MOD_CK1_1	161	167	PF00069	0.554
MOD_CK1_1	231	237	PF00069	0.507
MOD_CK1_1	244	250	PF00069	0.528
MOD_CK2_1	261	267	PF00069	0.462
MOD_CK2_1	341	347	PF00069	0.632
MOD_CK2_1	39	45	PF00069	0.568
MOD_CK2_1	58	64	PF00069	0.652
MOD_CK2_1	65	71	PF00069	0.640
MOD_CK2_1	81	87	PF00069	0.454
MOD_GlcNHglycan	116	119	PF01048	0.561
MOD_GlcNHglycan	160	163	PF01048	0.496
MOD_GlcNHglycan	183	186	PF01048	0.352
MOD_GlcNHglycan	231	234	PF01048	0.466
MOD_GlcNHglycan	325	328	PF01048	0.413
MOD_GlcNHglycan	343	346	PF01048	0.433
MOD_GSK3_1	187	194	PF00069	0.494
MOD_GSK3_1	240	247	PF00069	0.530
MOD_GSK3_1	323	330	PF00069	0.433
MOD_GSK3_1	405	412	PF00069	0.479
MOD_GSK3_1	77	84	PF00069	0.549
MOD_LATS_1	272	278	PF00433	0.536
MOD_LATS_1	298	304	PF00433	0.444
MOD_N-GLC_1	244	249	PF02516	0.392
MOD_NEK2_1	152	157	PF00069	0.402
MOD_NEK2_1	181	186	PF00069	0.396
MOD_NEK2_1	310	315	PF00069	0.567
MOD_NEK2_1	36	41	PF00069	0.440
MOD_PIKK_1	99	105	PF00454	0.554
MOD_PKA_1	108	114	PF00069	0.552
MOD_PKA_2	108	114	PF00069	0.614
MOD_PKA_2	301	307	PF00069	0.665
MOD_PKA_2	36	42	PF00069	0.418
MOD_Plk_1	191	197	PF00069	0.406
MOD_Plk_1	261	267	PF00069	0.434
MOD_Plk_1	361	367	PF00069	0.703
MOD_Plk_1	99	105	PF00069	0.488
MOD_Plk_2-3	262	268	PF00069	0.507
MOD_Plk_4	191	197	PF00069	0.455
MOD_Plk_4	247	253	PF00069	0.414
MOD_ProDKin_1	187	193	PF00069	0.548
MOD_ProDKin_1	280	286	PF00069	0.525
MOD_ProDKin_1	370	376	PF00069	0.702
MOD_ProDKin_1	81	87	PF00069	0.513
TRG_DiLeu_BaEn_4	99	105	PF01217	0.488
TRG_ENDOCYTIC_2	138	141	PF00928	0.377
TRG_ENDOCYTIC_2	147	150	PF00928	0.335
TRG_ENDOCYTIC_2	170	173	PF00928	0.328
TRG_ENDOCYTIC_2	44	47	PF00928	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6D9	Leptomonas seymouri	49%	100%
A0A1X0NR33	Trypanosomatidae	34%	100%
A0A422NA30	Trypanosoma rangeli	35%	100%
A4H6V4	Leishmania braziliensis	73%	99%
C9ZUI6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AGC6	Leishmania infantum	100%	100%
E9ANW6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	96%
Q4QGQ4	Leishmania major	94%	100%
V5BTJ4	Trypanosoma cruzi	36%	100%