Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WRW5_LEIDO

TriTrypDb:

LdBPK_120110.1 , LdCL_120006200 , LDHU3_12.0160

Length:

814

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WRW5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WRW5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.702
CLV_C14_Caspase3-7	399	403	PF00656	0.698
CLV_C14_Caspase3-7	645	649	PF00656	0.649
CLV_NRD_NRD_1	204	206	PF00675	0.727
CLV_NRD_NRD_1	270	272	PF00675	0.664
CLV_NRD_NRD_1	383	385	PF00675	0.525
CLV_NRD_NRD_1	404	406	PF00675	0.660
CLV_NRD_NRD_1	427	429	PF00675	0.587
CLV_NRD_NRD_1	460	462	PF00675	0.662
CLV_NRD_NRD_1	497	499	PF00675	0.724
CLV_NRD_NRD_1	764	766	PF00675	0.616
CLV_NRD_NRD_1	787	789	PF00675	0.700
CLV_PCSK_FUR_1	202	206	PF00082	0.651
CLV_PCSK_FUR_1	762	766	PF00082	0.601
CLV_PCSK_KEX2_1	116	118	PF00082	0.705
CLV_PCSK_KEX2_1	202	204	PF00082	0.730
CLV_PCSK_KEX2_1	261	263	PF00082	0.730
CLV_PCSK_KEX2_1	383	385	PF00082	0.525
CLV_PCSK_KEX2_1	427	429	PF00082	0.664
CLV_PCSK_KEX2_1	497	499	PF00082	0.728
CLV_PCSK_KEX2_1	543	545	PF00082	0.494
CLV_PCSK_KEX2_1	764	766	PF00082	0.694
CLV_PCSK_KEX2_1	771	773	PF00082	0.564
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.705
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.696
CLV_PCSK_PC1ET2_1	543	545	PF00082	0.475
CLV_PCSK_PC1ET2_1	771	773	PF00082	0.652
CLV_PCSK_PC7_1	257	263	PF00082	0.697
CLV_PCSK_PC7_1	379	385	PF00082	0.519
CLV_PCSK_SKI1_1	122	126	PF00082	0.701
CLV_PCSK_SKI1_1	127	131	PF00082	0.618
CLV_PCSK_SKI1_1	144	148	PF00082	0.428
CLV_PCSK_SKI1_1	228	232	PF00082	0.666
CLV_PCSK_SKI1_1	262	266	PF00082	0.622
CLV_PCSK_SKI1_1	35	39	PF00082	0.688
CLV_PCSK_SKI1_1	391	395	PF00082	0.657
CLV_PCSK_SKI1_1	444	448	PF00082	0.680
CLV_PCSK_SKI1_1	473	477	PF00082	0.670
CLV_PCSK_SKI1_1	543	547	PF00082	0.599
CLV_PCSK_SKI1_1	560	564	PF00082	0.552
CLV_PCSK_SKI1_1	609	613	PF00082	0.485
DEG_APCC_DBOX_1	238	246	PF00400	0.657
DEG_SPOP_SBC_1	795	799	PF00917	0.656
DOC_CYCLIN_RxL_1	529	540	PF00134	0.602
DOC_MAPK_gen_1	438	447	PF00069	0.610
DOC_MAPK_gen_1	769	775	PF00069	0.677
DOC_USP7_MATH_1	234	238	PF00917	0.510
DOC_USP7_MATH_1	264	268	PF00917	0.619
DOC_USP7_MATH_1	330	334	PF00917	0.699
DOC_USP7_MATH_1	596	600	PF00917	0.521
DOC_USP7_MATH_1	794	798	PF00917	0.698
DOC_USP7_MATH_1	84	88	PF00917	0.749
DOC_USP7_MATH_1	96	100	PF00917	0.612
DOC_USP7_UBL2_3	127	131	PF12436	0.700
DOC_USP7_UBL2_3	18	22	PF12436	0.646
DOC_USP7_UBL2_3	41	45	PF12436	0.704
DOC_WW_Pin1_4	653	658	PF00397	0.719
DOC_WW_Pin1_4	79	84	PF00397	0.670
LIG_14-3-3_CanoR_1	391	400	PF00244	0.397
LIG_14-3-3_CanoR_1	461	468	PF00244	0.485
LIG_14-3-3_CanoR_1	498	508	PF00244	0.544
LIG_14-3-3_CanoR_1	510	519	PF00244	0.416
LIG_14-3-3_CanoR_1	597	605	PF00244	0.617
LIG_14-3-3_CanoR_1	719	724	PF00244	0.534
LIG_14-3-3_CanoR_1	746	753	PF00244	0.609
LIG_14-3-3_CanoR_1	778	784	PF00244	0.667
LIG_14-3-3_CanoR_1	95	105	PF00244	0.609
LIG_Actin_WH2_2	238	253	PF00022	0.539
LIG_Actin_WH2_2	773	790	PF00022	0.462
LIG_BIR_II_1	1	5	PF00653	0.572
LIG_Clathr_ClatBox_1	672	676	PF01394	0.653
LIG_deltaCOP1_diTrp_1	701	706	PF00928	0.625
LIG_FHA_1	561	567	PF00498	0.737
LIG_FHA_1	708	714	PF00498	0.661
LIG_FHA_1	733	739	PF00498	0.707
LIG_FHA_1	747	753	PF00498	0.454
LIG_FHA_2	123	129	PF00498	0.698
LIG_FHA_2	454	460	PF00498	0.532
LIG_FHA_2	566	572	PF00498	0.731
LIG_FHA_2	577	583	PF00498	0.539
LIG_FHA_2	588	594	PF00498	0.548
LIG_FHA_2	627	633	PF00498	0.682
LIG_FHA_2	643	649	PF00498	0.474
LIG_FHA_2	713	719	PF00498	0.514
LIG_FHA_2	735	741	PF00498	0.706
LIG_FHA_2	797	803	PF00498	0.725
LIG_FHA_2	98	104	PF00498	0.662
LIG_LIR_Gen_1	159	166	PF02991	0.626
LIG_LIR_Gen_1	666	675	PF02991	0.600
LIG_LIR_Gen_1	701	709	PF02991	0.693
LIG_LIR_Nem_3	159	165	PF02991	0.627
LIG_LIR_Nem_3	666	672	PF02991	0.683
LIG_LIR_Nem_3	701	705	PF02991	0.534
LIG_PCNA_yPIPBox_3	329	338	PF02747	0.655
LIG_Pex14_1	702	706	PF04695	0.626
LIG_Pex14_2	162	166	PF04695	0.624
LIG_RPA_C_Fungi	493	505	PF08784	0.597
LIG_SH2_CRK	669	673	PF00017	0.675
LIG_SH2_CRK	695	699	PF00017	0.680
LIG_SH2_NCK_1	549	553	PF00017	0.505
LIG_SH2_NCK_1	695	699	PF00017	0.680
LIG_SH2_NCK_1	781	785	PF00017	0.585
LIG_SH2_STAP1	206	210	PF00017	0.714
LIG_SH2_STAP1	480	484	PF00017	0.510
LIG_SH2_STAP1	690	694	PF00017	0.672
LIG_SH2_STAT5	781	784	PF00017	0.545
LIG_SH3_3	77	83	PF00018	0.703
LIG_TRAF2_1	107	110	PF00917	0.631
LIG_TRAF2_1	146	149	PF00917	0.705
LIG_TRAF2_1	276	279	PF00917	0.775
LIG_TRAF2_1	343	346	PF00917	0.524
LIG_TRAF2_1	475	478	PF00917	0.599
LIG_TRAF2_1	493	496	PF00917	0.436
LIG_TRAF2_1	573	576	PF00917	0.728
MOD_CDC14_SPxK_1	656	659	PF00782	0.681
MOD_CDK_SPxK_1	653	659	PF00069	0.681
MOD_CK1_1	101	107	PF00069	0.690
MOD_CK1_1	599	605	PF00069	0.613
MOD_CK1_1	688	694	PF00069	0.590
MOD_CK1_1	708	714	PF00069	0.397
MOD_CK1_1	75	81	PF00069	0.621
MOD_CK1_1	779	785	PF00069	0.665
MOD_CK2_1	161	167	PF00069	0.689
MOD_CK2_1	253	259	PF00069	0.623
MOD_CK2_1	273	279	PF00069	0.657
MOD_CK2_1	379	385	PF00069	0.661
MOD_CK2_1	436	442	PF00069	0.647
MOD_CK2_1	449	455	PF00069	0.510
MOD_CK2_1	565	571	PF00069	0.682
MOD_CK2_1	576	582	PF00069	0.537
MOD_CK2_1	626	632	PF00069	0.685
MOD_CK2_1	712	718	PF00069	0.516
MOD_CK2_1	734	740	PF00069	0.707
MOD_CK2_1	796	802	PF00069	0.729
MOD_CK2_1	97	103	PF00069	0.671
MOD_GlcNHglycan	100	103	PF01048	0.746
MOD_GlcNHglycan	247	250	PF01048	0.608
MOD_GlcNHglycan	360	363	PF01048	0.642
MOD_GlcNHglycan	451	454	PF01048	0.588
MOD_GlcNHglycan	501	504	PF01048	0.587
MOD_GlcNHglycan	512	515	PF01048	0.573
MOD_GlcNHglycan	600	604	PF01048	0.729
MOD_GlcNHglycan	805	808	PF01048	0.765
MOD_GSK3_1	156	163	PF00069	0.671
MOD_GSK3_1	273	280	PF00069	0.597
MOD_GSK3_1	40	47	PF00069	0.592
MOD_GSK3_1	432	439	PF00069	0.648
MOD_GSK3_1	449	456	PF00069	0.461
MOD_GSK3_1	565	572	PF00069	0.655
MOD_GSK3_1	592	599	PF00069	0.652
MOD_GSK3_1	68	75	PF00069	0.751
MOD_GSK3_1	705	712	PF00069	0.624
MOD_GSK3_1	79	86	PF00069	0.724
MOD_GSK3_1	97	104	PF00069	0.565
MOD_N-GLC_1	732	737	PF02516	0.668
MOD_N-GLC_1	96	101	PF02516	0.788
MOD_NEK2_1	245	250	PF00069	0.602
MOD_NEK2_1	277	282	PF00069	0.577
MOD_NEK2_1	422	427	PF00069	0.625
MOD_NEK2_1	44	49	PF00069	0.552
MOD_NEK2_1	570	575	PF00069	0.527
MOD_NEK2_1	587	592	PF00069	0.644
MOD_NEK2_1	633	638	PF00069	0.575
MOD_NEK2_1	709	714	PF00069	0.728
MOD_NEK2_1	731	736	PF00069	0.707
MOD_NEK2_2	84	89	PF00069	0.713
MOD_PIKK_1	190	196	PF00454	0.478
MOD_PIKK_1	234	240	PF00454	0.511
MOD_PIKK_1	264	270	PF00454	0.817
MOD_PIKK_1	391	397	PF00454	0.582
MOD_PIKK_1	422	428	PF00454	0.613
MOD_PIKK_1	432	438	PF00454	0.532
MOD_PIKK_1	496	502	PF00454	0.507
MOD_PIKK_1	560	566	PF00454	0.736
MOD_PIKK_1	700	706	PF00454	0.698
MOD_PIKK_1	746	752	PF00454	0.609
MOD_PKA_1	131	137	PF00069	0.692
MOD_PKA_1	449	455	PF00069	0.577
MOD_PKA_2	312	318	PF00069	0.619
MOD_PKA_2	396	402	PF00069	0.694
MOD_PKA_2	460	466	PF00069	0.487
MOD_PKA_2	496	502	PF00069	0.604
MOD_PKA_2	576	582	PF00069	0.719
MOD_PKA_2	587	593	PF00069	0.545
MOD_PKA_2	596	602	PF00069	0.404
MOD_PKB_1	558	566	PF00069	0.736
MOD_Plk_1	122	128	PF00069	0.672
MOD_Plk_1	277	283	PF00069	0.595
MOD_Plk_1	436	442	PF00069	0.621
MOD_Plk_1	664	670	PF00069	0.573
MOD_Plk_1	700	706	PF00069	0.620
MOD_Plk_1	795	801	PF00069	0.692
MOD_Plk_2-3	255	261	PF00069	0.604
MOD_Plk_2-3	796	802	PF00069	0.729
MOD_Plk_4	161	167	PF00069	0.703
MOD_Plk_4	396	402	PF00069	0.403
MOD_Plk_4	685	691	PF00069	0.582
MOD_ProDKin_1	653	659	PF00069	0.720
MOD_ProDKin_1	79	85	PF00069	0.668
MOD_SUMO_for_1	343	346	PF00179	0.611
MOD_SUMO_for_1	475	478	PF00179	0.580
MOD_SUMO_rev_2	29	37	PF00179	0.651
MOD_SUMO_rev_2	437	446	PF00179	0.615
MOD_SUMO_rev_2	478	484	PF00179	0.614
TRG_DiLeu_BaEn_1	32	37	PF01217	0.736
TRG_DiLeu_BaEn_1	367	372	PF01217	0.611
TRG_DiLeu_BaEn_4	168	174	PF01217	0.695
TRG_DiLeu_BaEn_4	32	38	PF01217	0.694
TRG_DiLeu_BaEn_4	442	448	PF01217	0.607
TRG_DiLeu_BaEn_4	600	606	PF01217	0.728
TRG_ENDOCYTIC_2	206	209	PF00928	0.556
TRG_ENDOCYTIC_2	669	672	PF00928	0.672
TRG_ENDOCYTIC_2	695	698	PF00928	0.679
TRG_ER_diArg_1	170	173	PF00400	0.694
TRG_ER_diArg_1	202	205	PF00400	0.731
TRG_ER_diArg_1	723	726	PF00400	0.690
TRG_ER_diArg_1	745	748	PF00400	0.691
TRG_ER_diArg_1	764	766	PF00400	0.380
TRG_NES_CRM1_1	42	56	PF08389	0.696
TRG_NLS_MonoCore_2	113	118	PF00514	0.706
TRG_NLS_MonoExtC_3	114	120	PF00514	0.705
TRG_NLS_MonoExtN_4	114	119	PF00514	0.708
TRG_Pf-PMV_PEXEL_1	233	238	PF00026	0.610
TRG_Pf-PMV_PEXEL_1	306	310	PF00026	0.573
TRG_Pf-PMV_PEXEL_1	617	621	PF00026	0.618

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H6S7	Leishmania braziliensis	69%	100%
A4HV55	Leishmania infantum	99%	100%
E9ANT8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QGT2	Leishmania major	86%	99%