LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7WRW4_LEIDO
TriTrypDb:
LdBPK_120090.1 * , LdCL_120006000 , LDHU3_12.0130
Length:
481

Annotations

LeishMANIAdb annotations

Consists of a solenoid domain with LRR-like helical repeats. Certainly not TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A0A3S7WRW4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WRW4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 223 225 PF00675 0.343
CLV_NRD_NRD_1 332 334 PF00675 0.449
CLV_PCSK_KEX2_1 223 225 PF00082 0.472
CLV_PCSK_SKI1_1 2 6 PF00082 0.521
DEG_APCC_DBOX_1 151 159 PF00400 0.410
DEG_Nend_UBRbox_1 1 4 PF02207 0.481
DOC_MAPK_MEF2A_6 378 387 PF00069 0.409
DOC_PP1_RVXF_1 159 166 PF00149 0.439
DOC_PP2B_LxvP_1 24 27 PF13499 0.473
DOC_PP2B_LxvP_1 389 392 PF13499 0.390
DOC_USP7_MATH_1 168 172 PF00917 0.473
DOC_USP7_MATH_2 468 474 PF00917 0.491
DOC_WW_Pin1_4 287 292 PF00397 0.472
DOC_WW_Pin1_4 424 429 PF00397 0.507
DOC_WW_Pin1_4 445 450 PF00397 0.468
LIG_14-3-3_CanoR_1 2 11 PF00244 0.484
LIG_Actin_WH2_2 347 362 PF00022 0.433
LIG_Actin_WH2_2 57 72 PF00022 0.490
LIG_Clathr_ClatBox_1 10 14 PF01394 0.478
LIG_CtBP_PxDLS_1 320 325 PF00389 0.378
LIG_FHA_1 104 110 PF00498 0.503
LIG_FHA_1 288 294 PF00498 0.392
LIG_FHA_1 296 302 PF00498 0.309
LIG_FHA_1 3 9 PF00498 0.481
LIG_FHA_1 409 415 PF00498 0.379
LIG_FHA_1 55 61 PF00498 0.520
LIG_FHA_2 138 144 PF00498 0.644
LIG_FHA_2 377 383 PF00498 0.371
LIG_LIR_Gen_1 12 20 PF02991 0.428
LIG_LIR_Gen_1 382 392 PF02991 0.411
LIG_LIR_Gen_1 416 426 PF02991 0.439
LIG_LIR_Gen_1 472 481 PF02991 0.467
LIG_LIR_Nem_3 12 16 PF02991 0.404
LIG_LIR_Nem_3 208 212 PF02991 0.326
LIG_LIR_Nem_3 382 387 PF02991 0.497
LIG_LIR_Nem_3 416 421 PF02991 0.481
LIG_LIR_Nem_3 472 477 PF02991 0.454
LIG_NRBOX 399 405 PF00104 0.395
LIG_RPA_C_Fungi 108 120 PF08784 0.314
LIG_SH2_STAP1 296 300 PF00017 0.345
LIG_SH2_STAT3 296 299 PF00017 0.329
LIG_SH2_STAT3 92 95 PF00017 0.384
LIG_SH2_STAT5 437 440 PF00017 0.352
LIG_SH2_STAT5 92 95 PF00017 0.491
LIG_SH3_3 20 26 PF00018 0.539
LIG_SUMO_SIM_anti_2 189 196 PF11976 0.423
LIG_SUMO_SIM_anti_2 245 250 PF11976 0.421
LIG_SUMO_SIM_anti_2 448 454 PF11976 0.393
LIG_TRAF2_1 37 40 PF00917 0.545
LIG_TRAF2_1 379 382 PF00917 0.412
LIG_TRFH_1 357 361 PF08558 0.425
LIG_WRC_WIRS_1 10 15 PF05994 0.557
MOD_CK1_1 101 107 PF00069 0.476
MOD_CK1_1 136 142 PF00069 0.707
MOD_CK1_1 373 379 PF00069 0.390
MOD_CK1_1 43 49 PF00069 0.464
MOD_CK2_1 376 382 PF00069 0.500
MOD_GlcNHglycan 135 138 PF01048 0.605
MOD_GlcNHglycan 235 238 PF01048 0.336
MOD_GlcNHglycan 306 309 PF01048 0.447
MOD_GlcNHglycan 370 373 PF01048 0.551
MOD_GlcNHglycan 441 444 PF01048 0.354
MOD_GlcNHglycan 47 50 PF01048 0.598
MOD_GSK3_1 132 139 PF00069 0.657
MOD_GSK3_1 40 47 PF00069 0.539
MOD_GSK3_1 50 57 PF00069 0.529
MOD_N-GLC_1 376 381 PF02516 0.307
MOD_NEK2_1 100 105 PF00069 0.442
MOD_NEK2_1 132 137 PF00069 0.603
MOD_NEK2_1 173 178 PF00069 0.360
MOD_NEK2_1 232 237 PF00069 0.335
MOD_NEK2_1 343 348 PF00069 0.416
MOD_NEK2_1 403 408 PF00069 0.341
MOD_NEK2_1 54 59 PF00069 0.403
MOD_PIKK_1 295 301 PF00454 0.453
MOD_PIKK_1 40 46 PF00454 0.554
MOD_PK_1 242 248 PF00069 0.371
MOD_Plk_1 143 149 PF00069 0.531
MOD_Plk_1 200 206 PF00069 0.502
MOD_Plk_1 376 382 PF00069 0.415
MOD_Plk_2-3 144 150 PF00069 0.371
MOD_Plk_4 119 125 PF00069 0.448
MOD_Plk_4 12 18 PF00069 0.440
MOD_Plk_4 168 174 PF00069 0.342
MOD_Plk_4 289 295 PF00069 0.394
MOD_Plk_4 470 476 PF00069 0.540
MOD_Plk_4 50 56 PF00069 0.496
MOD_ProDKin_1 287 293 PF00069 0.467
MOD_ProDKin_1 424 430 PF00069 0.502
MOD_ProDKin_1 445 451 PF00069 0.465
MOD_SUMO_for_1 37 40 PF00179 0.430
TRG_DiLeu_BaEn_1 396 401 PF01217 0.416
TRG_DiLeu_BaEn_2 352 358 PF01217 0.475
TRG_ENDOCYTIC_2 418 421 PF00928 0.482
TRG_ER_diArg_1 222 224 PF00400 0.477
TRG_Pf-PMV_PEXEL_1 333 338 PF00026 0.362
TRG_Pf-PMV_PEXEL_1 378 382 PF00026 0.544

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IKK8 Leptomonas seymouri 53% 99%
A0A1X0NM47 Trypanosomatidae 27% 100%
A0A3S5IQL9 Trypanosoma rangeli 30% 100%
A4H6S5 Leishmania braziliensis 82% 100%
A4HV53 Leishmania infantum 100% 100%
C9ZQD2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
E9ANT6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4QGT4 Leishmania major 93% 100%
V5BDA8 Trypanosoma cruzi 30% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS