LeishMANIAdb
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Membrane-associated protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Membrane-associated protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania donovani
UniProt:
A0A3S7WRU5_LEIDO
TriTrypDb:
LdBPK_120220.1 * , LdCL_120007500 , LDHU3_12.0330
Length:
698

Annotations

LeishMANIAdb annotations

This membrane protein has considerable similarity to beta-lactamases found in Streptomyces species. A protein family found in a single copy in parazitic species, while multiple paralogs exist in B.saltans.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 4, no: 6
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

A0A3S7WRU5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WRU5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 152 156 PF00656 0.357
CLV_C14_Caspase3-7 671 675 PF00656 0.807
CLV_NRD_NRD_1 640 642 PF00675 0.609
CLV_NRD_NRD_1 648 650 PF00675 0.635
CLV_NRD_NRD_1 684 686 PF00675 0.468
CLV_PCSK_FUR_1 644 648 PF00082 0.528
CLV_PCSK_KEX2_1 125 127 PF00082 0.731
CLV_PCSK_KEX2_1 639 641 PF00082 0.610
CLV_PCSK_KEX2_1 644 646 PF00082 0.620
CLV_PCSK_KEX2_1 647 649 PF00082 0.632
CLV_PCSK_KEX2_1 684 686 PF00082 0.468
CLV_PCSK_PC1ET2_1 125 127 PF00082 0.731
CLV_PCSK_PC7_1 640 646 PF00082 0.615
CLV_PCSK_SKI1_1 326 330 PF00082 0.662
CLV_PCSK_SKI1_1 689 693 PF00082 0.579
CLV_PCSK_SKI1_1 75 79 PF00082 0.623
DEG_APCC_DBOX_1 24 32 PF00400 0.676
DEG_SCF_FBW7_1 512 519 PF00400 0.370
DEG_SPOP_SBC_1 86 90 PF00917 0.426
DOC_CYCLIN_RxL_1 72 81 PF00134 0.392
DOC_MAPK_DCC_7 23 33 PF00069 0.615
DOC_PP4_FxxP_1 180 183 PF00568 0.352
DOC_USP7_MATH_1 164 168 PF00917 0.443
DOC_USP7_MATH_1 224 228 PF00917 0.412
DOC_USP7_MATH_1 311 315 PF00917 0.523
DOC_USP7_MATH_1 433 437 PF00917 0.460
DOC_USP7_MATH_1 459 463 PF00917 0.375
DOC_USP7_MATH_1 496 500 PF00917 0.325
DOC_USP7_MATH_1 584 588 PF00917 0.798
DOC_USP7_MATH_1 632 636 PF00917 0.749
DOC_WW_Pin1_4 26 31 PF00397 0.666
DOC_WW_Pin1_4 481 486 PF00397 0.516
DOC_WW_Pin1_4 512 517 PF00397 0.489
DOC_WW_Pin1_4 54 59 PF00397 0.543
DOC_WW_Pin1_4 593 598 PF00397 0.762
DOC_WW_Pin1_4 619 624 PF00397 0.776
DOC_WW_Pin1_4 684 689 PF00397 0.745
LIG_14-3-3_CanoR_1 126 134 PF00244 0.426
LIG_14-3-3_CanoR_1 313 321 PF00244 0.511
LIG_14-3-3_CanoR_1 376 382 PF00244 0.393
LIG_14-3-3_CanoR_1 633 639 PF00244 0.809
LIG_14-3-3_CanoR_1 678 686 PF00244 0.788
LIG_BIR_II_1 1 5 PF00653 0.712
LIG_BIR_III_2 10 14 PF00653 0.538
LIG_BIR_III_2 155 159 PF00653 0.357
LIG_BRCT_BRCA1_1 226 230 PF00533 0.376
LIG_BRCT_BRCA1_1 293 297 PF00533 0.368
LIG_Clathr_ClatBox_1 148 152 PF01394 0.404
LIG_eIF4E_1 544 550 PF01652 0.581
LIG_FHA_1 152 158 PF00498 0.379
LIG_FHA_1 160 166 PF00498 0.367
LIG_FHA_1 185 191 PF00498 0.372
LIG_FHA_1 232 238 PF00498 0.437
LIG_FHA_1 294 300 PF00498 0.337
LIG_FHA_1 332 338 PF00498 0.475
LIG_FHA_1 383 389 PF00498 0.319
LIG_FHA_1 398 404 PF00498 0.353
LIG_FHA_1 448 454 PF00498 0.448
LIG_FHA_1 533 539 PF00498 0.356
LIG_FHA_1 544 550 PF00498 0.557
LIG_FHA_1 55 61 PF00498 0.508
LIG_FHA_1 620 626 PF00498 0.781
LIG_FHA_1 87 93 PF00498 0.394
LIG_FHA_2 203 209 PF00498 0.489
LIG_FHA_2 353 359 PF00498 0.330
LIG_FHA_2 432 438 PF00498 0.461
LIG_FHA_2 61 67 PF00498 0.535
LIG_GBD_Chelix_1 541 549 PF00786 0.583
LIG_Integrin_isoDGR_2 603 605 PF01839 0.545
LIG_LIR_Apic_2 179 183 PF02991 0.345
LIG_LIR_Gen_1 270 279 PF02991 0.414
LIG_LIR_Gen_1 281 291 PF02991 0.394
LIG_LIR_Gen_1 348 357 PF02991 0.379
LIG_LIR_Gen_1 35 43 PF02991 0.449
LIG_LIR_Gen_1 413 421 PF02991 0.431
LIG_LIR_Gen_1 464 475 PF02991 0.376
LIG_LIR_LC3C_4 535 538 PF02991 0.480
LIG_LIR_Nem_3 184 188 PF02991 0.450
LIG_LIR_Nem_3 270 276 PF02991 0.416
LIG_LIR_Nem_3 281 287 PF02991 0.367
LIG_LIR_Nem_3 345 350 PF02991 0.336
LIG_LIR_Nem_3 35 41 PF02991 0.443
LIG_LIR_Nem_3 413 419 PF02991 0.400
LIG_LIR_Nem_3 464 470 PF02991 0.376
LIG_LIR_Nem_3 71 77 PF02991 0.393
LIG_LYPXL_yS_3 99 102 PF13949 0.470
LIG_NRBOX 191 197 PF00104 0.321
LIG_PALB2_WD40_1 522 530 PF16756 0.330
LIG_Pex14_2 523 527 PF04695 0.330
LIG_PTB_Apo_2 179 186 PF02174 0.333
LIG_SH2_CRK 24 28 PF00017 0.501
LIG_SH2_CRK 273 277 PF00017 0.421
LIG_SH2_CRK 416 420 PF00017 0.414
LIG_SH2_CRK 74 78 PF00017 0.394
LIG_SH2_NCK_1 251 255 PF00017 0.391
LIG_SH2_NCK_1 416 420 PF00017 0.437
LIG_SH2_NCK_1 430 434 PF00017 0.289
LIG_SH2_SRC 150 153 PF00017 0.393
LIG_SH2_SRC 169 172 PF00017 0.415
LIG_SH2_STAT3 421 424 PF00017 0.325
LIG_SH2_STAT3 548 551 PF00017 0.660
LIG_SH2_STAT5 150 153 PF00017 0.332
LIG_SH2_STAT5 169 172 PF00017 0.252
LIG_SH2_STAT5 174 177 PF00017 0.395
LIG_SH2_STAT5 249 252 PF00017 0.353
LIG_SH2_STAT5 261 264 PF00017 0.273
LIG_SH2_STAT5 346 349 PF00017 0.352
LIG_SH2_STAT5 395 398 PF00017 0.388
LIG_SH2_STAT5 427 430 PF00017 0.433
LIG_SH2_STAT5 544 547 PF00017 0.592
LIG_SH2_STAT5 548 551 PF00017 0.639
LIG_SH2_STAT5 624 627 PF00017 0.790
LIG_SH3_1 109 115 PF00018 0.528
LIG_SH3_1 24 30 PF00018 0.409
LIG_SH3_2 552 557 PF14604 0.739
LIG_SH3_3 109 115 PF00018 0.453
LIG_SH3_3 180 186 PF00018 0.334
LIG_SH3_3 24 30 PF00018 0.409
LIG_SH3_3 283 289 PF00018 0.433
LIG_SH3_3 363 369 PF00018 0.384
LIG_SH3_3 453 459 PF00018 0.412
LIG_SH3_3 506 512 PF00018 0.464
LIG_SH3_3 549 555 PF00018 0.679
LIG_SH3_3 94 100 PF00018 0.488
LIG_SUMO_SIM_anti_2 450 457 PF11976 0.396
LIG_SUMO_SIM_anti_2 535 541 PF11976 0.379
LIG_SUMO_SIM_par_1 385 392 PF11976 0.417
LIG_SUMO_SIM_par_1 537 543 PF11976 0.372
LIG_TYR_ITIM 97 102 PF00017 0.475
LIG_TYR_ITSM 412 419 PF00017 0.398
LIG_UBA3_1 59 67 PF00899 0.536
MOD_CDK_SPK_2 684 689 PF00069 0.661
MOD_CK1_1 184 190 PF00069 0.380
MOD_CK1_1 200 206 PF00069 0.327
MOD_CK1_1 220 226 PF00069 0.363
MOD_CK1_1 228 234 PF00069 0.392
MOD_CK1_1 274 280 PF00069 0.359
MOD_CK1_1 314 320 PF00069 0.465
MOD_CK1_1 331 337 PF00069 0.390
MOD_CK1_1 345 351 PF00069 0.346
MOD_CK1_1 481 487 PF00069 0.489
MOD_CK1_1 543 549 PF00069 0.648
MOD_CK1_1 658 664 PF00069 0.790
MOD_CK1_1 680 686 PF00069 0.790
MOD_CK2_1 198 204 PF00069 0.313
MOD_CK2_1 431 437 PF00069 0.402
MOD_CK2_1 466 472 PF00069 0.335
MOD_GlcNHglycan 121 124 PF01048 0.756
MOD_GlcNHglycan 215 218 PF01048 0.689
MOD_GlcNHglycan 222 225 PF01048 0.599
MOD_GlcNHglycan 238 241 PF01048 0.638
MOD_GlcNHglycan 273 276 PF01048 0.601
MOD_GlcNHglycan 313 316 PF01048 0.707
MOD_GlcNHglycan 338 341 PF01048 0.686
MOD_GlcNHglycan 355 358 PF01048 0.553
MOD_GlcNHglycan 406 409 PF01048 0.617
MOD_GlcNHglycan 421 424 PF01048 0.588
MOD_GlcNHglycan 431 434 PF01048 0.639
MOD_GlcNHglycan 437 440 PF01048 0.647
MOD_GlcNHglycan 475 478 PF01048 0.636
MOD_GlcNHglycan 570 573 PF01048 0.560
MOD_GlcNHglycan 613 616 PF01048 0.587
MOD_GlcNHglycan 627 630 PF01048 0.523
MOD_GlcNHglycan 663 666 PF01048 0.606
MOD_GSK3_1 172 179 PF00069 0.455
MOD_GSK3_1 184 191 PF00069 0.327
MOD_GSK3_1 198 205 PF00069 0.297
MOD_GSK3_1 213 220 PF00069 0.471
MOD_GSK3_1 224 231 PF00069 0.364
MOD_GSK3_1 232 239 PF00069 0.374
MOD_GSK3_1 243 250 PF00069 0.326
MOD_GSK3_1 267 274 PF00069 0.395
MOD_GSK3_1 313 320 PF00069 0.493
MOD_GSK3_1 389 396 PF00069 0.421
MOD_GSK3_1 429 436 PF00069 0.438
MOD_GSK3_1 459 466 PF00069 0.362
MOD_GSK3_1 471 478 PF00069 0.314
MOD_GSK3_1 512 519 PF00069 0.543
MOD_GSK3_1 680 687 PF00069 0.808
MOD_GSK3_1 76 83 PF00069 0.402
MOD_GSK3_1 86 93 PF00069 0.377
MOD_N-GLC_1 271 276 PF02516 0.642
MOD_N-GLC_1 60 65 PF02516 0.739
MOD_NEK2_1 119 124 PF00069 0.520
MOD_NEK2_1 159 164 PF00069 0.401
MOD_NEK2_1 202 207 PF00069 0.366
MOD_NEK2_1 225 230 PF00069 0.344
MOD_NEK2_1 238 243 PF00069 0.386
MOD_NEK2_1 245 250 PF00069 0.325
MOD_NEK2_1 267 272 PF00069 0.403
MOD_NEK2_1 282 287 PF00069 0.255
MOD_NEK2_1 291 296 PF00069 0.335
MOD_NEK2_1 32 37 PF00069 0.592
MOD_NEK2_1 351 356 PF00069 0.322
MOD_NEK2_1 377 382 PF00069 0.354
MOD_NEK2_1 404 409 PF00069 0.400
MOD_NEK2_1 411 416 PF00069 0.371
MOD_NEK2_1 42 47 PF00069 0.645
MOD_NEK2_1 444 449 PF00069 0.409
MOD_NEK2_1 473 478 PF00069 0.420
MOD_NEK2_1 60 65 PF00069 0.375
MOD_NEK2_1 85 90 PF00069 0.359
MOD_NEK2_2 634 639 PF00069 0.767
MOD_PIKK_1 238 244 PF00454 0.427
MOD_PIKK_1 76 82 PF00454 0.399
MOD_PKA_2 331 337 PF00069 0.474
MOD_PKA_2 393 399 PF00069 0.382
MOD_PKA_2 632 638 PF00069 0.756
MOD_PKA_2 672 678 PF00069 0.793
MOD_PKB_1 631 639 PF00069 0.661
MOD_Plk_1 271 277 PF00069 0.439
MOD_Plk_1 342 348 PF00069 0.331
MOD_Plk_1 471 477 PF00069 0.332
MOD_Plk_1 52 58 PF00069 0.641
MOD_Plk_1 80 86 PF00069 0.399
MOD_Plk_2-3 672 678 PF00069 0.821
MOD_Plk_4 165 171 PF00069 0.403
MOD_Plk_4 176 182 PF00069 0.386
MOD_Plk_4 225 231 PF00069 0.351
MOD_Plk_4 233 239 PF00069 0.417
MOD_Plk_4 293 299 PF00069 0.373
MOD_Plk_4 32 38 PF00069 0.575
MOD_Plk_4 342 348 PF00069 0.366
MOD_Plk_4 377 383 PF00069 0.407
MOD_Plk_4 411 417 PF00069 0.396
MOD_Plk_4 532 538 PF00069 0.369
MOD_Plk_4 540 546 PF00069 0.378
MOD_Plk_4 80 86 PF00069 0.395
MOD_Plk_4 87 93 PF00069 0.362
MOD_ProDKin_1 26 32 PF00069 0.662
MOD_ProDKin_1 481 487 PF00069 0.513
MOD_ProDKin_1 512 518 PF00069 0.486
MOD_ProDKin_1 54 60 PF00069 0.548
MOD_ProDKin_1 593 599 PF00069 0.762
MOD_ProDKin_1 619 625 PF00069 0.779
MOD_ProDKin_1 684 690 PF00069 0.743
TRG_DiLeu_BaLyEn_6 27 32 PF01217 0.640
TRG_DiLeu_BaLyEn_6 55 60 PF01217 0.548
TRG_ENDOCYTIC_2 273 276 PF00928 0.413
TRG_ENDOCYTIC_2 350 353 PF00928 0.389
TRG_ENDOCYTIC_2 416 419 PF00928 0.405
TRG_ENDOCYTIC_2 73 76 PF00928 0.392
TRG_ENDOCYTIC_2 99 102 PF00928 0.451
TRG_ER_diArg_1 638 641 PF00400 0.797
TRG_ER_diArg_1 643 646 PF00400 0.786
TRG_ER_diArg_1 647 649 PF00400 0.799
TRG_ER_diArg_1 684 686 PF00400 0.668
TRG_NES_CRM1_1 137 152 PF08389 0.367

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZA5 Leptomonas seymouri 43% 99%
A0A0S4JQ75 Bodo saltans 28% 100%
A0A1X0NMU7 Trypanosomatidae 31% 100%
A0A422NUF1 Trypanosoma rangeli 30% 100%
A4H6T9 Leishmania braziliensis 64% 100%
E9AGB3 Leishmania infantum 99% 100%
E9ANV1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
Q4QGR9 Leishmania major 89% 100%
V5BD98 Trypanosoma cruzi 30% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS