Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WRU4_LEIDO

TriTrypDb:

LdBPK_111290.1 , LdCL_110018800 , LDHU3_11.1600

Length:

186

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WRU4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WRU4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	125	127	PF00675	0.574
CLV_NRD_NRD_1	166	168	PF00675	0.508
CLV_NRD_NRD_1	40	42	PF00675	0.580
CLV_NRD_NRD_1	51	53	PF00675	0.546
CLV_NRD_NRD_1	62	64	PF00675	0.498
CLV_PCSK_KEX2_1	125	127	PF00082	0.574
CLV_PCSK_KEX2_1	40	42	PF00082	0.584
CLV_PCSK_KEX2_1	50	52	PF00082	0.562
CLV_PCSK_KEX2_1	61	63	PF00082	0.488
CLV_PCSK_KEX2_1	87	89	PF00082	0.633
CLV_PCSK_PC1ET2_1	61	63	PF00082	0.412
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.633
CLV_PCSK_SKI1_1	147	151	PF00082	0.603
CLV_PCSK_SKI1_1	58	62	PF00082	0.382
DEG_Nend_UBRbox_3	1	3	PF02207	0.512
DOC_ANK_TNKS_1	42	49	PF00023	0.581
DOC_MAPK_gen_1	112	120	PF00069	0.535
DOC_WW_Pin1_4	181	186	PF00397	0.616
DOC_WW_Pin1_4	75	80	PF00397	0.552
LIG_14-3-3_CanoR_1	139	145	PF00244	0.548
LIG_14-3-3_CanoR_1	147	153	PF00244	0.621
LIG_14-3-3_CanoR_1	31	39	PF00244	0.576
LIG_BRCT_BRCA1_1	52	56	PF00533	0.573
LIG_BRCT_BRCA1_2	52	58	PF00533	0.568
LIG_EVH1_2	145	149	PF00568	0.496
LIG_FHA_1	17	23	PF00498	0.589
LIG_FHA_1	81	87	PF00498	0.619
LIG_FHA_2	149	155	PF00498	0.485
LIG_FHA_2	79	85	PF00498	0.657
LIG_FHA_2	8	14	PF00498	0.648
LIG_WW_3	144	148	PF00397	0.543
MOD_CK1_1	34	40	PF00069	0.641
MOD_CK1_1	80	86	PF00069	0.672
MOD_CK1_1	96	102	PF00069	0.695
MOD_CK2_1	130	136	PF00069	0.529
MOD_CK2_1	148	154	PF00069	0.495
MOD_CK2_1	15	21	PF00069	0.654
MOD_CK2_1	7	13	PF00069	0.651
MOD_CK2_1	78	84	PF00069	0.719
MOD_GlcNHglycan	181	184	PF01048	0.582
MOD_GSK3_1	148	155	PF00069	0.513
MOD_GSK3_1	27	34	PF00069	0.714
MOD_GSK3_1	71	78	PF00069	0.707
MOD_GSK3_1	96	103	PF00069	0.640
MOD_N-GLC_1	100	105	PF02516	0.727
MOD_NEK2_1	148	153	PF00069	0.644
MOD_NEK2_1	95	100	PF00069	0.644
MOD_PIKK_1	31	37	PF00454	0.595
MOD_PIKK_1	50	56	PF00454	0.448
MOD_PKA_1	50	56	PF00069	0.645
MOD_PKA_2	179	185	PF00069	0.611
MOD_PKA_2	27	33	PF00069	0.565
MOD_PKA_2	50	56	PF00069	0.534
MOD_Plk_1	120	126	PF00069	0.627
MOD_Plk_4	34	40	PF00069	0.586
MOD_ProDKin_1	75	81	PF00069	0.548
TRG_DiLeu_BaLyEn_6	28	33	PF01217	0.529
TRG_ENDOCYTIC_2	128	131	PF00928	0.624
TRG_ER_diArg_1	124	126	PF00400	0.566
TRG_ER_diArg_1	39	41	PF00400	0.614
TRG_ER_diArg_1	49	52	PF00400	0.512
TRG_ER_diArg_1	62	65	PF00400	0.623
TRG_NLS_Bipartite_1	50	65	PF00514	0.368
TRG_NLS_MonoExtC_3	60	65	PF00514	0.382
TRG_NLS_MonoExtN_4	58	65	PF00514	0.376
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.550
TRG_Pf-PMV_PEXEL_1	160	165	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	31	35	PF00026	0.600
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2F7	Leptomonas seymouri	60%	98%
A0A1X0NWA0	Trypanosomatidae	36%	95%
A0A422N1X3	Trypanosoma rangeli	34%	91%
A4H6Q1	Leishmania braziliensis	74%	100%
A4HV36	Leishmania infantum	99%	100%
D0A7B5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	98%
E9ANR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QGV2	Leishmania major	91%	100%