Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3S7WRT9_LEIDO

TriTrypDb:

LdCL_120006500 , LDHU3_12.0210

Length:

454

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005783	endoplasmic reticulum	5	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0070765	gamma-secretase complex	3	1
GO:0098796	membrane protein complex	2	1
GO:0098797	plasma membrane protein complex	3	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A0A3S7WRT9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WRT9

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0016485	protein processing	5	9
GO:0019538	protein metabolic process	3	9
GO:0043085	positive regulation of catalytic activity	4	9
GO:0043170	macromolecule metabolic process	3	9
GO:0044093	positive regulation of molecular function	3	9
GO:0044238	primary metabolic process	2	9
GO:0050790	regulation of catalytic activity	3	9
GO:0051604	protein maturation	4	9
GO:0065007	biological regulation	1	9
GO:0065009	regulation of molecular function	2	9
GO:0071704	organic substance metabolic process	2	9
GO:1901564	organonitrogen compound metabolic process	3	9

Molecular functions
Term	Name	Level	Count
GO:0030674	protein-macromolecule adaptor activity	2	1
GO:0060090	molecular adaptor activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	148	150	PF00675	0.570
CLV_NRD_NRD_1	286	288	PF00675	0.523
CLV_NRD_NRD_1	337	339	PF00675	0.441
CLV_NRD_NRD_1	415	417	PF00675	0.601
CLV_PCSK_KEX2_1	148	150	PF00082	0.570
CLV_PCSK_KEX2_1	286	288	PF00082	0.523
CLV_PCSK_KEX2_1	415	417	PF00082	0.601
CLV_PCSK_SKI1_1	142	146	PF00082	0.590
DEG_APCC_DBOX_1	106	114	PF00400	0.520
DOC_CYCLIN_yCln2_LP_2	26	32	PF00134	0.431
DOC_MAPK_MEF2A_6	105	113	PF00069	0.520
DOC_MAPK_MEF2A_6	82	90	PF00069	0.521
DOC_PP1_RVXF_1	158	164	PF00149	0.321
DOC_PP1_RVXF_1	92	98	PF00149	0.582
DOC_PP2B_LxvP_1	13	16	PF13499	0.384
DOC_USP7_MATH_1	122	126	PF00917	0.365
DOC_USP7_MATH_1	251	255	PF00917	0.693
DOC_USP7_MATH_1	281	285	PF00917	0.679
DOC_USP7_MATH_1	302	306	PF00917	0.696
DOC_USP7_MATH_1	330	334	PF00917	0.735
DOC_USP7_MATH_1	353	357	PF00917	0.649
DOC_USP7_MATH_1	399	403	PF00917	0.411
DOC_USP7_MATH_1	409	413	PF00917	0.471
DOC_USP7_MATH_1	414	418	PF00917	0.423
DOC_WW_Pin1_4	349	354	PF00397	0.693
DOC_WW_Pin1_4	407	412	PF00397	0.350
LIG_14-3-3_CanoR_1	148	156	PF00244	0.476
LIG_14-3-3_CanoR_1	175	185	PF00244	0.348
LIG_14-3-3_CanoR_1	307	315	PF00244	0.666
LIG_14-3-3_CanoR_1	338	345	PF00244	0.713
LIG_14-3-3_CanoR_1	415	422	PF00244	0.421
LIG_14-3-3_CanoR_1	446	452	PF00244	0.633
LIG_Actin_WH2_2	41	59	PF00022	0.364
LIG_BIR_II_1	1	5	PF00653	0.540
LIG_FHA_1	224	230	PF00498	0.795
LIG_FHA_1	257	263	PF00498	0.693
LIG_FHA_1	3	9	PF00498	0.488
LIG_FHA_1	448	454	PF00498	0.637
LIG_FHA_1	47	53	PF00498	0.344
LIG_FHA_1	66	72	PF00498	0.417
LIG_FHA_1	83	89	PF00498	0.515
LIG_LIR_Gen_1	2	10	PF02991	0.600
LIG_LIR_Gen_1	39	48	PF02991	0.345
LIG_LIR_Gen_1	450	454	PF02991	0.658
LIG_LIR_Gen_1	66	76	PF02991	0.603
LIG_LIR_Nem_3	106	111	PF02991	0.611
LIG_LIR_Nem_3	2	6	PF02991	0.602
LIG_LIR_Nem_3	39	43	PF02991	0.311
LIG_LIR_Nem_3	450	454	PF02991	0.658
LIG_LIR_Nem_3	66	72	PF02991	0.596
LIG_NRBOX	172	178	PF00104	0.436
LIG_PCNA_yPIPBox_3	416	430	PF02747	0.248
LIG_Pex14_2	181	185	PF04695	0.356
LIG_SH2_CRK	3	7	PF00017	0.462
LIG_SH2_SRC	14	17	PF00017	0.364
LIG_SH2_STAP1	201	205	PF00017	0.344
LIG_SH2_STAP1	3	7	PF00017	0.485
LIG_SH2_STAT5	314	317	PF00017	0.697
LIG_SH3_3	106	112	PF00018	0.536
LIG_SH3_3	292	298	PF00018	0.625
LIG_SH3_3	388	394	PF00018	0.349
LIG_Sin3_3	381	388	PF02671	0.241
LIG_SUMO_SIM_anti_2	431	437	PF11976	0.329
LIG_SUMO_SIM_anti_2	68	74	PF11976	0.424
LIG_SUMO_SIM_par_1	29	35	PF11976	0.329
LIG_SUMO_SIM_par_1	428	434	PF11976	0.285
LIG_SUMO_SIM_par_1	440	445	PF11976	0.486
LIG_TRAF2_1	265	268	PF00917	0.608
LIG_TRAF2_1	298	301	PF00917	0.775
LIG_TRFH_1	108	112	PF08558	0.506
LIG_TRFH_1	390	394	PF08558	0.384
LIG_WRC_WIRS_1	37	42	PF05994	0.341
MOD_CK1_1	151	157	PF00069	0.443
MOD_CK1_1	2	8	PF00069	0.468
MOD_CK1_1	351	357	PF00069	0.691
MOD_CK1_1	404	410	PF00069	0.444
MOD_CK2_1	251	257	PF00069	0.745
MOD_CK2_1	330	336	PF00069	0.768
MOD_CK2_1	352	358	PF00069	0.676
MOD_GlcNHglycan	166	169	PF01048	0.637
MOD_GlcNHglycan	241	244	PF01048	0.553
MOD_GlcNHglycan	290	293	PF01048	0.482
MOD_GlcNHglycan	310	313	PF01048	0.511
MOD_GlcNHglycan	316	320	PF01048	0.471
MOD_GlcNHglycan	328	331	PF01048	0.526
MOD_GlcNHglycan	342	345	PF01048	0.467
MOD_GlcNHglycan	355	358	PF01048	0.461
MOD_GlcNHglycan	401	404	PF01048	0.595
MOD_GlcNHglycan	412	415	PF01048	0.626
MOD_GSK3_1	144	151	PF00069	0.503
MOD_GSK3_1	277	284	PF00069	0.759
MOD_GSK3_1	315	322	PF00069	0.586
MOD_GSK3_1	32	39	PF00069	0.406
MOD_GSK3_1	326	333	PF00069	0.764
MOD_GSK3_1	347	354	PF00069	0.774
MOD_GSK3_1	401	408	PF00069	0.466
MOD_GSK3_1	410	417	PF00069	0.508
MOD_GSK3_1	78	85	PF00069	0.550
MOD_N-GLC_1	422	427	PF02516	0.283
MOD_N-GLC_1	78	83	PF02516	0.334
MOD_NEK2_1	103	108	PF00069	0.588
MOD_NEK2_1	144	149	PF00069	0.385
MOD_NEK2_1	163	168	PF00069	0.363
MOD_NEK2_1	176	181	PF00069	0.262
MOD_NEK2_1	315	320	PF00069	0.639
MOD_NEK2_1	32	37	PF00069	0.352
MOD_NEK2_1	46	51	PF00069	0.338
MOD_NEK2_2	251	256	PF00069	0.725
MOD_NEK2_2	281	286	PF00069	0.730
MOD_PIKK_1	302	308	PF00454	0.661
MOD_PK_1	149	155	PF00069	0.352
MOD_PKA_1	148	154	PF00069	0.357
MOD_PKA_1	338	344	PF00069	0.618
MOD_PKA_2	148	154	PF00069	0.498
MOD_PKA_2	171	177	PF00069	0.355
MOD_PKA_2	414	420	PF00069	0.445
MOD_Plk_1	251	257	PF00069	0.761
MOD_Plk_1	422	428	PF00069	0.394
MOD_Plk_1	78	84	PF00069	0.580
MOD_Plk_4	122	128	PF00069	0.312
MOD_Plk_4	181	187	PF00069	0.356
MOD_Plk_4	32	38	PF00069	0.371
MOD_Plk_4	364	370	PF00069	0.561
MOD_Plk_4	428	434	PF00069	0.331
MOD_Plk_4	65	71	PF00069	0.433
MOD_ProDKin_1	349	355	PF00069	0.690
MOD_ProDKin_1	407	413	PF00069	0.348
TRG_DiLeu_BaLyEn_6	172	177	PF01217	0.364
TRG_ENDOCYTIC_2	201	204	PF00928	0.364
TRG_ENDOCYTIC_2	3	6	PF00928	0.462
TRG_ENDOCYTIC_2	451	454	PF00928	0.660
TRG_ER_diArg_1	104	107	PF00400	0.622
TRG_ER_diArg_1	285	287	PF00400	0.728

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY04	Leptomonas seymouri	42%	95%
A0A422NUD7	Trypanosoma rangeli	29%	100%
A4H6T0	Leishmania braziliensis	66%	100%
A4HV58	Leishmania infantum	99%	100%
E9ANU1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%
Q4QGS9	Leishmania major	87%	100%
V5BDA4	Trypanosoma cruzi	24%	100%