LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7WRT8_LEIDO
TriTrypDb:
LdBPK_120155.1 , LdCL_120006800 , LDHU3_12.0250
Length:
400

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WRT8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WRT8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 297 299 PF00675 0.729
CLV_NRD_NRD_1 73 75 PF00675 0.639
CLV_NRD_NRD_1 87 89 PF00675 0.607
CLV_PCSK_KEX2_1 297 299 PF00082 0.729
CLV_PCSK_KEX2_1 72 74 PF00082 0.647
CLV_PCSK_KEX2_1 87 89 PF00082 0.598
CLV_PCSK_SKI1_1 239 243 PF00082 0.557
CLV_PCSK_SKI1_1 300 304 PF00082 0.712
CLV_PCSK_SKI1_1 73 77 PF00082 0.614
DEG_APCC_DBOX_1 299 307 PF00400 0.613
DEG_Nend_UBRbox_4 1 3 PF02207 0.608
DEG_SPOP_SBC_1 157 161 PF00917 0.614
DEG_SPOP_SBC_1 312 316 PF00917 0.727
DEG_SPOP_SBC_1 32 36 PF00917 0.626
DOC_CYCLIN_RxL_1 70 78 PF00134 0.604
DOC_MAPK_RevD_3 283 298 PF00069 0.720
DOC_PP4_FxxP_1 344 347 PF00568 0.466
DOC_USP7_MATH_1 103 107 PF00917 0.681
DOC_USP7_MATH_1 157 161 PF00917 0.689
DOC_USP7_MATH_1 174 178 PF00917 0.714
DOC_USP7_MATH_1 23 27 PF00917 0.741
DOC_USP7_MATH_1 32 36 PF00917 0.612
DOC_WW_Pin1_4 105 110 PF00397 0.571
DOC_WW_Pin1_4 141 146 PF00397 0.618
DOC_WW_Pin1_4 8 13 PF00397 0.711
LIG_14-3-3_CanoR_1 87 96 PF00244 0.727
LIG_BRCT_BRCA1_1 340 344 PF00533 0.429
LIG_eIF4E_1 142 148 PF01652 0.496
LIG_eIF4E_1 70 76 PF01652 0.683
LIG_FHA_1 170 176 PF00498 0.775
LIG_FHA_1 264 270 PF00498 0.593
LIG_FHA_1 332 338 PF00498 0.545
LIG_FHA_2 316 322 PF00498 0.584
LIG_FHA_2 380 386 PF00498 0.622
LIG_FHA_2 9 15 PF00498 0.677
LIG_LIR_Apic_2 341 347 PF02991 0.448
LIG_LIR_Gen_1 206 213 PF02991 0.746
LIG_LIR_Gen_1 48 59 PF02991 0.657
LIG_LIR_Nem_3 206 212 PF02991 0.745
LIG_LIR_Nem_3 48 54 PF02991 0.632
LIG_PDZ_Class_3 395 400 PF00595 0.553
LIG_SH2_STAP1 55 59 PF00017 0.602
LIG_SH2_STAP1 61 65 PF00017 0.566
LIG_SH2_STAT5 142 145 PF00017 0.716
LIG_SH2_STAT5 230 233 PF00017 0.731
LIG_SH2_STAT5 376 379 PF00017 0.591
LIG_SH2_STAT5 388 391 PF00017 0.397
LIG_SH2_STAT5 70 73 PF00017 0.620
LIG_SH3_1 180 186 PF00018 0.741
LIG_SH3_3 178 184 PF00018 0.688
LIG_SH3_3 283 289 PF00018 0.700
LIG_SH3_3 9 15 PF00018 0.618
LIG_SUMO_SIM_anti_2 279 287 PF11976 0.762
LIG_TRAF2_1 277 280 PF00917 0.571
LIG_TRAF2_1 45 48 PF00917 0.683
MOD_CK1_1 158 164 PF00069 0.707
MOD_CK1_1 24 30 PF00069 0.738
MOD_CK1_1 308 314 PF00069 0.733
MOD_CK1_1 31 37 PF00069 0.672
MOD_CK1_1 315 321 PF00069 0.636
MOD_CK1_1 380 386 PF00069 0.602
MOD_CK1_1 49 55 PF00069 0.694
MOD_CK1_1 90 96 PF00069 0.574
MOD_CK2_1 189 195 PF00069 0.628
MOD_CK2_1 315 321 PF00069 0.606
MOD_CK2_1 8 14 PF00069 0.676
MOD_DYRK1A_RPxSP_1 105 109 PF00069 0.570
MOD_GlcNHglycan 115 118 PF01048 0.740
MOD_GlcNHglycan 130 133 PF01048 0.654
MOD_GlcNHglycan 160 163 PF01048 0.805
MOD_GlcNHglycan 172 175 PF01048 0.700
MOD_GlcNHglycan 23 26 PF01048 0.724
MOD_GlcNHglycan 30 33 PF01048 0.709
MOD_GlcNHglycan 315 318 PF01048 0.607
MOD_GlcNHglycan 339 343 PF01048 0.575
MOD_GlcNHglycan 379 382 PF01048 0.588
MOD_GlcNHglycan 62 65 PF01048 0.695
MOD_GSK3_1 103 110 PF00069 0.665
MOD_GSK3_1 151 158 PF00069 0.591
MOD_GSK3_1 17 24 PF00069 0.781
MOD_GSK3_1 170 177 PF00069 0.740
MOD_GSK3_1 28 35 PF00069 0.648
MOD_GSK3_1 308 315 PF00069 0.822
MOD_GSK3_1 327 334 PF00069 0.417
MOD_GSK3_1 379 386 PF00069 0.629
MOD_N-GLC_1 226 231 PF02516 0.528
MOD_N-GLC_1 271 276 PF02516 0.806
MOD_N-GLC_1 68 73 PF02516 0.591
MOD_NEK2_1 128 133 PF00069 0.665
MOD_NEK2_1 372 377 PF00069 0.608
MOD_PIKK_1 151 157 PF00454 0.641
MOD_PIKK_1 87 93 PF00454 0.726
MOD_PKA_1 87 93 PF00069 0.512
MOD_PKA_2 327 333 PF00069 0.685
MOD_PKA_2 49 55 PF00069 0.686
MOD_PKA_2 87 93 PF00069 0.512
MOD_Plk_1 119 125 PF00069 0.685
MOD_Plk_1 17 23 PF00069 0.702
MOD_Plk_1 189 195 PF00069 0.731
MOD_Plk_1 226 232 PF00069 0.526
MOD_Plk_1 271 277 PF00069 0.706
MOD_Plk_1 281 287 PF00069 0.653
MOD_Plk_1 319 325 PF00069 0.682
MOD_Plk_1 46 52 PF00069 0.700
MOD_ProDKin_1 105 111 PF00069 0.571
MOD_ProDKin_1 141 147 PF00069 0.617
MOD_ProDKin_1 8 14 PF00069 0.714
TRG_DiLeu_BaLyEn_6 123 128 PF01217 0.584
TRG_DiLeu_BaLyEn_6 71 76 PF01217 0.601
TRG_ENDOCYTIC_2 209 212 PF00928 0.800
TRG_ENDOCYTIC_2 55 58 PF00928 0.574
TRG_ER_diArg_1 296 298 PF00400 0.719
TRG_ER_diArg_1 72 74 PF00400 0.647
TRG_ER_diArg_1 97 100 PF00400 0.618
TRG_Pf-PMV_PEXEL_1 126 130 PF00026 0.580
TRG_Pf-PMV_PEXEL_1 300 304 PF00026 0.605
TRG_Pf-PMV_PEXEL_1 73 77 PF00026 0.713
TRG_Pf-PMV_PEXEL_1 95 99 PF00026 0.595

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PD33 Leptomonas seymouri 29% 85%
A4H6T2 Leishmania braziliensis 62% 100%
E9AGA6 Leishmania infantum 99% 100%
E9ANU4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 75% 98%
Q4QGS6 Leishmania major 81% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS