LeishMANIAdb
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tRNA pseudouridine synthase D (TruD), putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
tRNA pseudouridine synthase D (TruD), putative
Gene product:
tRNA pseudouridine synthase D (TruD), putative
Species:
Leishmania donovani
UniProt:
A0A3S7WRT6_LEIDO
TriTrypDb:
LdBPK_111360.1 , LdCL_110019500 , LDHU3_11.1690
Length:
618

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A0A3S7WRT6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WRT6

PDB structure(s): 7am2_CA

Function

Biological processes
Term Name Level Count
GO:0001522 pseudouridine synthesis 6 12
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009451 RNA modification 5 12
GO:0009987 cellular process 1 12
GO:0016070 RNA metabolic process 5 12
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0043170 macromolecule metabolic process 3 12
GO:0043412 macromolecule modification 4 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0046483 heterocycle metabolic process 3 12
GO:0071704 organic substance metabolic process 2 12
GO:0090304 nucleic acid metabolic process 4 12
GO:1901360 organic cyclic compound metabolic process 3 12
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 12
GO:0003723 RNA binding 4 12
GO:0003824 catalytic activity 1 12
GO:0005488 binding 1 12
GO:0009982 pseudouridine synthase activity 4 12
GO:0016853 isomerase activity 2 12
GO:0016866 intramolecular transferase activity 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:1901363 heterocyclic compound binding 2 12
GO:0106029 tRNA pseudouridine synthase activity 5 1
GO:0140098 catalytic activity, acting on RNA 3 1
GO:0140101 catalytic activity, acting on a tRNA 4 1
GO:0140640 catalytic activity, acting on a nucleic acid 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 439 443 PF00656 0.435
CLV_C14_Caspase3-7 492 496 PF00656 0.448
CLV_NRD_NRD_1 106 108 PF00675 0.402
CLV_NRD_NRD_1 143 145 PF00675 0.496
CLV_NRD_NRD_1 299 301 PF00675 0.388
CLV_NRD_NRD_1 359 361 PF00675 0.524
CLV_NRD_NRD_1 44 46 PF00675 0.480
CLV_NRD_NRD_1 481 483 PF00675 0.281
CLV_NRD_NRD_1 508 510 PF00675 0.476
CLV_NRD_NRD_1 553 555 PF00675 0.365
CLV_NRD_NRD_1 574 576 PF00675 0.511
CLV_NRD_NRD_1 577 579 PF00675 0.517
CLV_PCSK_FUR_1 575 579 PF00082 0.401
CLV_PCSK_KEX2_1 143 145 PF00082 0.546
CLV_PCSK_KEX2_1 299 301 PF00082 0.388
CLV_PCSK_KEX2_1 44 46 PF00082 0.480
CLV_PCSK_KEX2_1 508 510 PF00082 0.476
CLV_PCSK_KEX2_1 553 555 PF00082 0.383
CLV_PCSK_KEX2_1 576 578 PF00082 0.428
CLV_PCSK_PC1ET2_1 576 578 PF00082 0.398
CLV_PCSK_SKI1_1 113 117 PF00082 0.453
CLV_PCSK_SKI1_1 152 156 PF00082 0.464
CLV_PCSK_SKI1_1 249 253 PF00082 0.275
CLV_PCSK_SKI1_1 356 360 PF00082 0.390
CLV_PCSK_SKI1_1 416 420 PF00082 0.425
CLV_PCSK_SKI1_1 601 605 PF00082 0.313
CLV_Separin_Metazoa 235 239 PF03568 0.504
CLV_Separin_Metazoa 357 361 PF03568 0.391
DEG_APCC_DBOX_1 248 256 PF00400 0.280
DEG_APCC_DBOX_1 355 363 PF00400 0.391
DEG_Nend_UBRbox_1 1 4 PF02207 0.407
DEG_SCF_TRCP1_1 491 497 PF00400 0.435
DEG_SPOP_SBC_1 375 379 PF00917 0.392
DOC_CDC14_PxL_1 233 241 PF14671 0.466
DOC_CYCLIN_RxL_1 107 120 PF00134 0.435
DOC_MAPK_gen_1 107 117 PF00069 0.400
DOC_MAPK_gen_1 170 179 PF00069 0.397
DOC_MAPK_gen_1 482 488 PF00069 0.495
DOC_PP1_RVXF_1 407 414 PF00149 0.393
DOC_PP2B_LxvP_1 453 456 PF13499 0.328
DOC_PP4_FxxP_1 124 127 PF00568 0.392
DOC_PP4_FxxP_1 588 591 PF00568 0.436
DOC_USP7_MATH_1 127 131 PF00917 0.431
DOC_USP7_MATH_1 18 22 PF00917 0.520
DOC_USP7_MATH_1 190 194 PF00917 0.372
DOC_USP7_MATH_1 212 216 PF00917 0.330
DOC_USP7_MATH_1 295 299 PF00917 0.372
DOC_USP7_MATH_1 302 306 PF00917 0.531
DOC_USP7_MATH_1 330 334 PF00917 0.380
DOC_USP7_MATH_1 404 408 PF00917 0.296
DOC_USP7_MATH_1 468 472 PF00917 0.458
DOC_USP7_MATH_1 530 534 PF00917 0.420
DOC_USP7_MATH_1 591 595 PF00917 0.377
DOC_USP7_MATH_2 543 549 PF00917 0.488
DOC_WW_Pin1_4 119 124 PF00397 0.442
DOC_WW_Pin1_4 129 134 PF00397 0.346
DOC_WW_Pin1_4 314 319 PF00397 0.470
DOC_WW_Pin1_4 494 499 PF00397 0.603
DOC_WW_Pin1_4 592 597 PF00397 0.337
DOC_WW_Pin1_4 62 67 PF00397 0.676
LIG_14-3-3_CanoR_1 111 116 PF00244 0.423
LIG_14-3-3_CanoR_1 134 139 PF00244 0.401
LIG_14-3-3_CanoR_1 238 246 PF00244 0.505
LIG_14-3-3_CanoR_1 267 275 PF00244 0.410
LIG_14-3-3_CanoR_1 409 414 PF00244 0.452
LIG_14-3-3_CanoR_1 482 487 PF00244 0.421
LIG_14-3-3_CanoR_1 499 507 PF00244 0.479
LIG_14-3-3_CanoR_1 51 56 PF00244 0.529
LIG_14-3-3_CanoR_1 78 86 PF00244 0.476
LIG_Actin_WH2_2 141 158 PF00022 0.364
LIG_APCC_ABBA_1 157 162 PF00400 0.292
LIG_APCC_ABBAyCdc20_2 156 162 PF00400 0.310
LIG_BIR_III_4 90 94 PF00653 0.419
LIG_BRCT_BRCA1_1 270 274 PF00533 0.448
LIG_BRCT_BRCA1_1 484 488 PF00533 0.330
LIG_BRCT_BRCA1_1 532 536 PF00533 0.417
LIG_BRCT_BRCA1_1 563 567 PF00533 0.369
LIG_DLG_GKlike_1 482 489 PF00625 0.278
LIG_EH1_1 217 225 PF00400 0.348
LIG_eIF4E_1 218 224 PF01652 0.350
LIG_eIF4E_1 246 252 PF01652 0.337
LIG_FHA_1 112 118 PF00498 0.384
LIG_FHA_1 338 344 PF00498 0.434
LIG_FHA_1 353 359 PF00498 0.445
LIG_FHA_1 467 473 PF00498 0.534
LIG_FHA_2 287 293 PF00498 0.465
LIG_FHA_2 310 316 PF00498 0.452
LIG_FHA_2 376 382 PF00498 0.364
LIG_FHA_2 445 451 PF00498 0.422
LIG_FHA_2 608 614 PF00498 0.441
LIG_HP1_1 596 600 PF01393 0.349
LIG_LIR_Apic_2 122 127 PF02991 0.388
LIG_LIR_Gen_1 193 202 PF02991 0.455
LIG_LIR_Gen_1 227 237 PF02991 0.437
LIG_LIR_Gen_1 340 349 PF02991 0.401
LIG_LIR_Gen_1 399 410 PF02991 0.290
LIG_LIR_Gen_1 594 604 PF02991 0.319
LIG_LIR_Gen_1 610 617 PF02991 0.276
LIG_LIR_Nem_3 137 141 PF02991 0.372
LIG_LIR_Nem_3 193 197 PF02991 0.335
LIG_LIR_Nem_3 227 233 PF02991 0.416
LIG_LIR_Nem_3 271 277 PF02991 0.341
LIG_LIR_Nem_3 340 345 PF02991 0.391
LIG_LIR_Nem_3 474 480 PF02991 0.430
LIG_LIR_Nem_3 506 510 PF02991 0.379
LIG_LIR_Nem_3 594 600 PF02991 0.316
LIG_LIR_Nem_3 610 614 PF02991 0.271
LIG_Pex14_1 547 551 PF04695 0.515
LIG_Pex14_2 274 278 PF04695 0.323
LIG_Pex14_2 476 480 PF04695 0.348
LIG_Rb_pABgroove_1 484 492 PF01858 0.416
LIG_REV1ctd_RIR_1 474 482 PF16727 0.280
LIG_SH2_CRK 507 511 PF00017 0.364
LIG_SH2_GRB2like 327 330 PF00017 0.354
LIG_SH2_NCK_1 327 331 PF00017 0.495
LIG_SH2_SRC 175 178 PF00017 0.476
LIG_SH2_SRC 327 330 PF00017 0.354
LIG_SH2_STAT5 141 144 PF00017 0.431
LIG_SH2_STAT5 185 188 PF00017 0.474
LIG_SH2_STAT5 246 249 PF00017 0.487
LIG_SH2_STAT5 277 280 PF00017 0.284
LIG_SH2_STAT5 309 312 PF00017 0.355
LIG_SH2_STAT5 324 327 PF00017 0.262
LIG_SH2_STAT5 446 449 PF00017 0.478
LIG_SH3_3 448 454 PF00018 0.317
LIG_SH3_3 495 501 PF00018 0.572
LIG_SH3_3 508 514 PF00018 0.410
LIG_SH3_3 552 558 PF00018 0.373
LIG_SUMO_SIM_par_1 112 120 PF11976 0.396
LIG_TRAF2_1 40 43 PF00917 0.368
LIG_TYR_ITIM 275 280 PF00017 0.284
LIG_WRC_WIRS_1 280 285 PF05994 0.329
LIG_WRC_WIRS_1 410 415 PF05994 0.413
LIG_WRC_WIRS_1 608 613 PF05994 0.391
MOD_CDK_SPK_2 129 134 PF00069 0.362
MOD_CDK_SPK_2 494 499 PF00069 0.538
MOD_CK1_1 165 171 PF00069 0.322
MOD_CK1_1 396 402 PF00069 0.430
MOD_CK1_1 412 418 PF00069 0.549
MOD_CK1_1 444 450 PF00069 0.416
MOD_CK2_1 122 128 PF00069 0.454
MOD_CK2_1 134 140 PF00069 0.373
MOD_CK2_1 295 301 PF00069 0.530
MOD_CK2_1 309 315 PF00069 0.422
MOD_CK2_1 37 43 PF00069 0.403
MOD_CK2_1 375 381 PF00069 0.551
MOD_CK2_1 468 474 PF00069 0.391
MOD_Cter_Amidation 551 554 PF01082 0.341
MOD_GlcNHglycan 20 23 PF01048 0.535
MOD_GlcNHglycan 239 242 PF01048 0.439
MOD_GlcNHglycan 38 42 PF01048 0.398
MOD_GlcNHglycan 394 398 PF01048 0.341
MOD_GlcNHglycan 491 494 PF01048 0.550
MOD_GSK3_1 107 114 PF00069 0.446
MOD_GSK3_1 47 54 PF00069 0.453
MOD_GSK3_1 489 496 PF00069 0.601
MOD_GSK3_1 541 548 PF00069 0.448
MOD_GSK3_1 576 583 PF00069 0.357
MOD_N-GLC_1 561 566 PF02516 0.378
MOD_NEK2_1 12 17 PF00069 0.580
MOD_NEK2_1 489 494 PF00069 0.560
MOD_NEK2_1 55 60 PF00069 0.511
MOD_NEK2_2 286 291 PF00069 0.441
MOD_PIKK_1 195 201 PF00454 0.298
MOD_PIKK_1 365 371 PF00454 0.528
MOD_PIKK_1 404 410 PF00454 0.337
MOD_PIKK_1 441 447 PF00454 0.573
MOD_PIKK_1 500 506 PF00454 0.460
MOD_PKA_1 107 113 PF00069 0.399
MOD_PKA_1 482 488 PF00069 0.354
MOD_PKA_1 576 582 PF00069 0.305
MOD_PKA_2 237 243 PF00069 0.504
MOD_PKA_2 569 575 PF00069 0.486
MOD_PKA_2 576 582 PF00069 0.454
MOD_PKB_1 105 113 PF00069 0.530
MOD_PKB_1 265 273 PF00069 0.388
MOD_PKB_1 554 562 PF00069 0.482
MOD_Plk_1 127 133 PF00069 0.499
MOD_Plk_1 226 232 PF00069 0.384
MOD_Plk_1 330 336 PF00069 0.398
MOD_Plk_1 441 447 PF00069 0.523
MOD_Plk_1 580 586 PF00069 0.458
MOD_Plk_2-3 162 168 PF00069 0.461
MOD_Plk_2-3 436 442 PF00069 0.517
MOD_Plk_2-3 545 551 PF00069 0.516
MOD_Plk_4 111 117 PF00069 0.406
MOD_Plk_4 286 292 PF00069 0.446
MOD_Plk_4 396 402 PF00069 0.302
MOD_Plk_4 484 490 PF00069 0.340
MOD_ProDKin_1 119 125 PF00069 0.444
MOD_ProDKin_1 129 135 PF00069 0.345
MOD_ProDKin_1 314 320 PF00069 0.467
MOD_ProDKin_1 494 500 PF00069 0.603
MOD_ProDKin_1 592 598 PF00069 0.336
MOD_ProDKin_1 62 68 PF00069 0.672
TRG_DiLeu_BaLyEn_6 406 411 PF01217 0.312
TRG_DiLeu_LyEn_5 150 155 PF01217 0.435
TRG_ENDOCYTIC_2 230 233 PF00928 0.438
TRG_ENDOCYTIC_2 277 280 PF00928 0.279
TRG_ENDOCYTIC_2 507 510 PF00928 0.361
TRG_ENDOCYTIC_2 608 611 PF00928 0.326
TRG_ER_diArg_1 142 144 PF00400 0.529
TRG_ER_diArg_1 169 172 PF00400 0.419
TRG_ER_diArg_1 507 509 PF00400 0.472
TRG_ER_diArg_1 553 556 PF00400 0.432
TRG_ER_diArg_1 574 577 PF00400 0.519
TRG_NLS_MonoCore_2 574 579 PF00514 0.391
TRG_NLS_MonoExtC_3 575 581 PF00514 0.388
TRG_NLS_MonoExtN_4 575 580 PF00514 0.389

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P414 Leptomonas seymouri 62% 98%
A0A0S4JV05 Bodo saltans 40% 94%
A0A1X0NUT8 Trypanosomatidae 43% 100%
A0A422N563 Trypanosoma rangeli 46% 100%
A4H6R0 Leishmania braziliensis 80% 100%
A4HV43 Leishmania infantum 100% 100%
D0A7A5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 99%
E9ANS4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4QGU5 Leishmania major 92% 100%
V5BBF7 Trypanosoma cruzi 43% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS