LeishMANIAdb
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Nodulin-like, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Nodulin-like, putative
Gene product:
Nodulin-like/Major Facilitator Superfamily, putative
Species:
Leishmania donovani
UniProt:
A0A3S7WRS3_LEIDO
TriTrypDb:
LdBPK_111330.1 , LdCL_110019200 , LDHU3_11.1640
Length:
627

Annotations

LeishMANIAdb annotations

Nutrient transporter belonging to the Major Facilitator Superfamily (MFS). Probable nutrient transporter. Heavily expanded in all parazitic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 36
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 84
NetGPI no yes: 0, no: 84
Cellular components
Term Name Level Count
GO:0016020 membrane 2 78
GO:0110165 cellular anatomical entity 1 78
GO:0005737 cytoplasm 2 3

Expansion

Sequence features

A0A3S7WRS3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WRS3

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 36
GO:0022857 transmembrane transporter activity 2 36

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 355 359 PF00656 0.804
CLV_NRD_NRD_1 305 307 PF00675 0.446
CLV_NRD_NRD_1 489 491 PF00675 0.362
CLV_NRD_NRD_1 88 90 PF00675 0.331
CLV_PCSK_KEX2_1 304 306 PF00082 0.467
CLV_PCSK_KEX2_1 489 491 PF00082 0.357
CLV_PCSK_PC7_1 485 491 PF00082 0.419
CLV_PCSK_SKI1_1 157 161 PF00082 0.308
CLV_PCSK_SKI1_1 360 364 PF00082 0.383
CLV_PCSK_SKI1_1 517 521 PF00082 0.517
CLV_PCSK_SKI1_1 621 625 PF00082 0.364
DEG_SCF_FBW7_1 212 218 PF00400 0.374
DEG_SCF_FBW7_2 294 301 PF00400 0.486
DEG_SPOP_SBC_1 376 380 PF00917 0.588
DEG_SPOP_SBC_1 544 548 PF00917 0.429
DOC_CDC14_PxL_1 497 505 PF14671 0.284
DOC_CKS1_1 212 217 PF01111 0.569
DOC_CKS1_1 295 300 PF01111 0.357
DOC_CYCLIN_yCln2_LP_2 329 332 PF00134 0.717
DOC_CYCLIN_yCln2_LP_2 519 525 PF00134 0.281
DOC_PP1_RVXF_1 515 521 PF00149 0.240
DOC_PP1_RVXF_1 586 592 PF00149 0.457
DOC_PP2B_LxvP_1 210 213 PF13499 0.298
DOC_PP2B_LxvP_1 329 332 PF13499 0.717
DOC_PP2B_LxvP_1 498 501 PF13499 0.322
DOC_PP2B_LxvP_1 519 522 PF13499 0.280
DOC_PP4_FxxP_1 240 243 PF00568 0.458
DOC_PP4_FxxP_1 295 298 PF00568 0.442
DOC_PP4_FxxP_1 79 82 PF00568 0.330
DOC_USP7_MATH_1 215 219 PF00917 0.574
DOC_USP7_MATH_1 452 456 PF00917 0.402
DOC_USP7_MATH_1 612 616 PF00917 0.389
DOC_WW_Pin1_4 211 216 PF00397 0.577
DOC_WW_Pin1_4 294 299 PF00397 0.358
DOC_WW_Pin1_4 48 53 PF00397 0.259
DOC_WW_Pin1_4 561 566 PF00397 0.277
LIG_14-3-3_CanoR_1 349 357 PF00244 0.596
LIG_14-3-3_CanoR_1 453 459 PF00244 0.404
LIG_14-3-3_CanoR_1 60 66 PF00244 0.379
LIG_BIR_II_1 1 5 PF00653 0.693
LIG_BIR_III_2 366 370 PF00653 0.576
LIG_BIR_III_4 358 362 PF00653 0.724
LIG_BRCT_BRCA1_1 134 138 PF00533 0.329
LIG_BRCT_BRCA1_1 253 257 PF00533 0.373
LIG_deltaCOP1_diTrp_1 24 31 PF00928 0.450
LIG_deltaCOP1_diTrp_1 422 431 PF00928 0.362
LIG_EH1_1 30 38 PF00400 0.259
LIG_FHA_1 139 145 PF00498 0.295
LIG_FHA_1 202 208 PF00498 0.393
LIG_FHA_1 215 221 PF00498 0.529
LIG_FHA_1 246 252 PF00498 0.306
LIG_FHA_1 259 265 PF00498 0.337
LIG_FHA_1 281 287 PF00498 0.368
LIG_FHA_1 289 295 PF00498 0.379
LIG_FHA_1 378 384 PF00498 0.717
LIG_FHA_1 460 466 PF00498 0.337
LIG_FHA_1 597 603 PF00498 0.321
LIG_FHA_1 69 75 PF00498 0.378
LIG_FHA_1 81 87 PF00498 0.336
LIG_FHA_1 91 97 PF00498 0.430
LIG_GBD_Chelix_1 123 131 PF00786 0.382
LIG_GBD_Chelix_1 255 263 PF00786 0.294
LIG_GBD_Chelix_1 470 478 PF00786 0.194
LIG_LIR_Apic_2 265 270 PF02991 0.337
LIG_LIR_Apic_2 77 82 PF02991 0.330
LIG_LIR_Gen_1 197 205 PF02991 0.360
LIG_LIR_Gen_1 254 264 PF02991 0.383
LIG_LIR_Gen_1 289 298 PF02991 0.321
LIG_LIR_Gen_1 445 456 PF02991 0.314
LIG_LIR_Gen_1 462 471 PF02991 0.312
LIG_LIR_Nem_3 150 154 PF02991 0.491
LIG_LIR_Nem_3 164 168 PF02991 0.383
LIG_LIR_Nem_3 182 188 PF02991 0.258
LIG_LIR_Nem_3 197 201 PF02991 0.336
LIG_LIR_Nem_3 254 260 PF02991 0.327
LIG_LIR_Nem_3 445 451 PF02991 0.308
LIG_LIR_Nem_3 462 467 PF02991 0.327
LIG_LIR_Nem_3 48 53 PF02991 0.307
LIG_LIR_Nem_3 615 620 PF02991 0.339
LIG_LYPXL_S_1 482 486 PF13949 0.229
LIG_LYPXL_yS_3 483 486 PF13949 0.427
LIG_MAD2 476 484 PF02301 0.198
LIG_MYND_1 388 392 PF01753 0.594
LIG_Pex14_1 107 111 PF04695 0.304
LIG_Pex14_1 27 31 PF04695 0.463
LIG_Pex14_1 424 428 PF04695 0.341
LIG_Pex14_2 181 185 PF04695 0.263
LIG_Pex14_2 240 244 PF04695 0.496
LIG_Pex14_2 253 257 PF04695 0.351
LIG_Pex14_2 520 524 PF04695 0.344
LIG_REV1ctd_RIR_1 178 187 PF16727 0.359
LIG_RPA_C_Fungi 485 497 PF08784 0.241
LIG_SH2_CRK 448 452 PF00017 0.372
LIG_SH2_CRK 554 558 PF00017 0.259
LIG_SH2_CRK 620 624 PF00017 0.385
LIG_SH2_PTP2 267 270 PF00017 0.365
LIG_SH2_SRC 267 270 PF00017 0.435
LIG_SH2_STAP1 198 202 PF00017 0.262
LIG_SH2_STAP1 554 558 PF00017 0.301
LIG_SH2_STAT5 111 114 PF00017 0.347
LIG_SH2_STAT5 177 180 PF00017 0.341
LIG_SH2_STAT5 209 212 PF00017 0.342
LIG_SH2_STAT5 21 24 PF00017 0.460
LIG_SH2_STAT5 267 270 PF00017 0.343
LIG_SH2_STAT5 558 561 PF00017 0.375
LIG_SH2_STAT5 78 81 PF00017 0.325
LIG_SH3_3 325 331 PF00018 0.743
LIG_SH3_3 382 388 PF00018 0.675
LIG_SH3_3 389 395 PF00018 0.638
LIG_SUMO_SIM_par_1 536 543 PF11976 0.259
LIG_SUMO_SIM_par_1 93 100 PF11976 0.357
LIG_TYR_ITIM 207 212 PF00017 0.397
LIG_UBA3_1 144 149 PF00899 0.314
LIG_WRC_WIRS_1 148 153 PF05994 0.394
MOD_CDK_SPxxK_3 48 55 PF00069 0.302
MOD_CK1_1 132 138 PF00069 0.333
MOD_CK1_1 143 149 PF00069 0.364
MOD_CK1_1 377 383 PF00069 0.755
MOD_CK1_1 435 441 PF00069 0.309
MOD_CK1_1 442 448 PF00069 0.362
MOD_CK1_1 48 54 PF00069 0.333
MOD_CK1_1 533 539 PF00069 0.319
MOD_CK1_1 543 549 PF00069 0.400
MOD_CK1_1 77 83 PF00069 0.325
MOD_CK2_1 134 140 PF00069 0.338
MOD_CK2_1 259 265 PF00069 0.287
MOD_CK2_1 59 65 PF00069 0.352
MOD_CMANNOS 424 427 PF00535 0.370
MOD_GlcNHglycan 120 123 PF01048 0.422
MOD_GlcNHglycan 134 137 PF01048 0.342
MOD_GlcNHglycan 185 188 PF01048 0.299
MOD_GlcNHglycan 198 201 PF01048 0.324
MOD_GlcNHglycan 325 328 PF01048 0.614
MOD_GlcNHglycan 350 353 PF01048 0.666
MOD_GlcNHglycan 434 437 PF01048 0.292
MOD_GlcNHglycan 471 474 PF01048 0.329
MOD_GlcNHglycan 614 617 PF01048 0.379
MOD_GSK3_1 112 119 PF00069 0.360
MOD_GSK3_1 134 141 PF00069 0.349
MOD_GSK3_1 143 150 PF00069 0.336
MOD_GSK3_1 211 218 PF00069 0.262
MOD_GSK3_1 371 378 PF00069 0.727
MOD_GSK3_1 435 442 PF00069 0.367
MOD_GSK3_1 452 459 PF00069 0.473
MOD_GSK3_1 530 537 PF00069 0.355
MOD_GSK3_1 539 546 PF00069 0.388
MOD_GSK3_1 552 559 PF00069 0.346
MOD_N-GLC_1 102 107 PF02516 0.408
MOD_N-GLC_1 442 447 PF02516 0.420
MOD_NEK2_1 118 123 PF00069 0.276
MOD_NEK2_1 134 139 PF00069 0.332
MOD_NEK2_1 168 173 PF00069 0.367
MOD_NEK2_1 181 186 PF00069 0.372
MOD_NEK2_1 194 199 PF00069 0.315
MOD_NEK2_1 201 206 PF00069 0.316
MOD_NEK2_1 251 256 PF00069 0.375
MOD_NEK2_1 259 264 PF00069 0.328
MOD_NEK2_1 286 291 PF00069 0.369
MOD_NEK2_1 293 298 PF00069 0.368
MOD_NEK2_1 323 328 PF00069 0.654
MOD_NEK2_1 45 50 PF00069 0.347
MOD_NEK2_1 456 461 PF00069 0.419
MOD_NEK2_1 539 544 PF00069 0.389
MOD_NEK2_1 545 550 PF00069 0.422
MOD_NEK2_1 556 561 PF00069 0.337
MOD_NEK2_1 59 64 PF00069 0.338
MOD_NEK2_1 97 102 PF00069 0.280
MOD_PIKK_1 129 135 PF00454 0.290
MOD_PIKK_1 399 405 PF00454 0.781
MOD_PIKK_1 59 65 PF00454 0.316
MOD_PKA_2 348 354 PF00069 0.730
MOD_PKA_2 452 458 PF00069 0.489
MOD_PKA_2 59 65 PF00069 0.410
MOD_Plk_1 181 187 PF00069 0.352
MOD_Plk_1 19 25 PF00069 0.559
MOD_Plk_1 442 448 PF00069 0.386
MOD_Plk_4 134 140 PF00069 0.336
MOD_Plk_4 161 167 PF00069 0.340
MOD_Plk_4 168 174 PF00069 0.364
MOD_Plk_4 246 252 PF00069 0.347
MOD_Plk_4 259 265 PF00069 0.333
MOD_Plk_4 435 441 PF00069 0.332
MOD_Plk_4 459 465 PF00069 0.327
MOD_Plk_4 534 540 PF00069 0.315
MOD_Plk_4 552 558 PF00069 0.349
MOD_Plk_4 74 80 PF00069 0.349
MOD_Plk_4 92 98 PF00069 0.304
MOD_ProDKin_1 211 217 PF00069 0.462
MOD_ProDKin_1 294 300 PF00069 0.361
MOD_ProDKin_1 48 54 PF00069 0.296
MOD_ProDKin_1 561 567 PF00069 0.277
MOD_SUMO_for_1 54 57 PF00179 0.198
TRG_DiLeu_BaLyEn_6 498 503 PF01217 0.233
TRG_DiLeu_BaLyEn_6 598 603 PF01217 0.374
TRG_ENDOCYTIC_2 111 114 PF00928 0.395
TRG_ENDOCYTIC_2 177 180 PF00928 0.325
TRG_ENDOCYTIC_2 198 201 PF00928 0.328
TRG_ENDOCYTIC_2 209 212 PF00928 0.342
TRG_ENDOCYTIC_2 448 451 PF00928 0.347
TRG_ENDOCYTIC_2 483 486 PF00928 0.388
TRG_ENDOCYTIC_2 554 557 PF00928 0.319
TRG_ENDOCYTIC_2 61 64 PF00928 0.364
TRG_ENDOCYTIC_2 620 623 PF00928 0.384
TRG_ENDOCYTIC_2 78 81 PF00928 0.317
TRG_ER_diArg_1 304 306 PF00400 0.618
TRG_ER_diArg_1 489 491 PF00400 0.426
TRG_Pf-PMV_PEXEL_1 412 416 PF00026 0.295
TRG_PTS1 624 627 PF00515 0.301

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6G0 Leptomonas seymouri 22% 99%
A0A0N1HZC2 Leptomonas seymouri 27% 100%
A0A0N1IKC5 Leptomonas seymouri 25% 100%
A0A0N1PB63 Leptomonas seymouri 23% 95%
A0A0N1PD04 Leptomonas seymouri 63% 98%
A0A0N1PFR4 Leptomonas seymouri 25% 95%
A0A1X0NKK0 Trypanosomatidae 24% 100%
A0A1X0NM09 Trypanosomatidae 24% 100%
A0A1X0NRW5 Trypanosomatidae 24% 90%
A0A1X0NVF9 Trypanosomatidae 46% 94%
A0A1X0NVM7 Trypanosomatidae 24% 97%
A0A1X0NZU2 Trypanosomatidae 26% 97%
A0A1X0NZU5 Trypanosomatidae 23% 100%
A0A381MMW5 Leishmania infantum 24% 100%
A0A3Q8IEC4 Leishmania donovani 24% 100%
A0A3Q8IF95 Leishmania donovani 23% 100%
A0A3Q8IIT5 Leishmania donovani 25% 100%
A0A3Q8ISY9 Leishmania donovani 23% 100%
A0A3R7JSQ9 Trypanosoma rangeli 25% 100%
A0A3R7KKN8 Trypanosoma rangeli 25% 100%
A0A3R7MAQ7 Trypanosoma rangeli 22% 89%
A0A3R7N3S6 Trypanosoma rangeli 48% 97%
A0A3R7N415 Trypanosoma rangeli 25% 100%
A0A3R7R443 Trypanosoma rangeli 24% 100%
A0A3S7WRJ4 Leishmania donovani 24% 100%
A0A3S7WRJ5 Leishmania donovani 25% 100%
A0A3S7WSR4 Leishmania donovani 23% 100%
A0A3S7WWU1 Leishmania donovani 22% 94%
A0A3S7X2G0 Leishmania donovani 25% 96%
A0A3S7X2K5 Leishmania donovani 25% 100%
A0A3S7XB11 Leishmania donovani 26% 100%
A0A422MSP6 Trypanosoma rangeli 21% 100%
A0A422MU68 Trypanosoma rangeli 25% 100%
A4H6J0 Leishmania braziliensis 25% 100%
A4H6J1 Leishmania braziliensis 25% 100%
A4H6Q5 Leishmania braziliensis 71% 100%
A4HC19 Leishmania braziliensis 22% 100%
A4HHG2 Leishmania braziliensis 25% 100%
A4HHG3 Leishmania braziliensis 25% 100%
A4HHG4 Leishmania braziliensis 26% 100%
A4HJW3 Leishmania braziliensis 24% 100%
A4HPE2 Leishmania braziliensis 26% 100%
A4HUX5 Leishmania infantum 24% 100%
A4HUX6 Leishmania infantum 24% 100%
A4HV40 Leishmania infantum 100% 100%
A4HZF5 Leishmania infantum 23% 100%
A4HZJ4 Leishmania infantum 22% 100%
A4I4L2 Leishmania infantum 25% 100%
A4I7C5 Leishmania infantum 23% 100%
A4ICI3 Leishmania infantum 26% 100%
C9ZTS1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 100%
C9ZUT6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 23% 100%
D0A7B1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 98%
E8NHE1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
E9AE01 Leishmania major 24% 100%
E9AE09 Leishmania major 25% 100%
E9AE10 Leishmania major 24% 100%
E9AE11 Leishmania major 25% 100%
E9AGK5 Leishmania infantum 23% 100%
E9AHJ0 Leishmania infantum 24% 100%
E9AHJ1 Leishmania infantum 25% 100%
E9ALS2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9ALS3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
E9ANL0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
E9ANL1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
E9ANS1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
E9APJ3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9AT53 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 98%
E9AVF1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 21% 100%
E9AVF2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 22% 100%
E9B2B8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 100%
Q4Q1E4 Leishmania major 26% 99%
Q4Q5T8 Leishmania major 23% 100%
Q4QC27 Leishmania major 22% 100%
Q4QC28 Leishmania major 24% 100%
Q4QFY5 Leishmania major 24% 100%
Q4QGU8 Leishmania major 90% 100%
Q4QH14 Leishmania major 25% 100%
Q4QH15 Leishmania major 24% 100%
V5B647 Trypanosoma cruzi 22% 99%
V5BQY6 Trypanosoma cruzi 24% 89%
V5BVP0 Trypanosoma cruzi 24% 100%
V5DT25 Trypanosoma cruzi 23% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS