Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WRS2_LEIDO

TriTrypDb:

LdBPK_111300.1 , LdCL_110018900 , LDHU3_11.1610

Length:

402

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WRS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WRS2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	278	280	PF00675	0.494
CLV_NRD_NRD_1	61	63	PF00675	0.457
CLV_NRD_NRD_1	7	9	PF00675	0.522
CLV_PCSK_KEX2_1	278	280	PF00082	0.502
CLV_PCSK_KEX2_1	6	8	PF00082	0.530
CLV_PCSK_KEX2_1	61	63	PF00082	0.443
CLV_PCSK_KEX2_1	86	88	PF00082	0.497
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.519
CLV_PCSK_SKI1_1	133	137	PF00082	0.565
CLV_PCSK_SKI1_1	180	184	PF00082	0.437
CLV_PCSK_SKI1_1	227	231	PF00082	0.411
CLV_PCSK_SKI1_1	29	33	PF00082	0.516
CLV_PCSK_SKI1_1	341	345	PF00082	0.406
CLV_PCSK_SKI1_1	393	397	PF00082	0.549
CLV_PCSK_SKI1_1	62	66	PF00082	0.498
DEG_APCC_DBOX_1	340	348	PF00400	0.398
DEG_APCC_DBOX_1	364	372	PF00400	0.480
DEG_Nend_Nbox_1	1	3	PF02207	0.533
DOC_CDC14_PxL_1	96	104	PF14671	0.499
DOC_CYCLIN_RxL_1	127	140	PF00134	0.541
DOC_CYCLIN_RxL_1	224	234	PF00134	0.454
DOC_CYCLIN_RxL_1	59	67	PF00134	0.538
DOC_MAPK_gen_1	115	124	PF00069	0.402
DOC_MAPK_HePTP_8	114	126	PF00069	0.473
DOC_MAPK_MEF2A_6	115	124	PF00069	0.460
DOC_MAPK_NFAT4_5	117	125	PF00069	0.490
DOC_WW_Pin1_4	154	159	PF00397	0.564
DOC_WW_Pin1_4	41	46	PF00397	0.582
LIG_14-3-3_CanoR_1	152	156	PF00244	0.453
LIG_14-3-3_CanoR_1	361	365	PF00244	0.508
LIG_Actin_WH2_2	225	243	PF00022	0.532
LIG_APCC_ABBA_1	80	85	PF00400	0.521
LIG_FHA_1	129	135	PF00498	0.480
LIG_FHA_1	155	161	PF00498	0.569
LIG_FHA_1	193	199	PF00498	0.378
LIG_FHA_1	212	218	PF00498	0.442
LIG_FHA_1	224	230	PF00498	0.366
LIG_FHA_1	247	253	PF00498	0.357
LIG_FHA_1	298	304	PF00498	0.413
LIG_FHA_1	357	363	PF00498	0.526
LIG_FHA_1	394	400	PF00498	0.481
LIG_FHA_2	311	317	PF00498	0.393
LIG_FHA_2	361	367	PF00498	0.504
LIG_GBD_Chelix_1	175	183	PF00786	0.472
LIG_LIR_Gen_1	143	150	PF02991	0.694
LIG_LIR_Gen_1	54	65	PF02991	0.425
LIG_LIR_Gen_1	93	103	PF02991	0.498
LIG_LIR_Nem_3	143	149	PF02991	0.522
LIG_LIR_Nem_3	49	55	PF02991	0.430
LIG_LIR_Nem_3	93	99	PF02991	0.398
LIG_MAD2	393	401	PF02301	0.592
LIG_PDZ_Class_2	397	402	PF00595	0.644
LIG_SH2_CRK	42	46	PF00017	0.536
LIG_SH2_CRK	57	61	PF00017	0.474
LIG_SH2_CRK	96	100	PF00017	0.505
LIG_SH2_NCK_1	306	310	PF00017	0.486
LIG_SH2_NCK_1	352	356	PF00017	0.488
LIG_SH2_NCK_1	42	46	PF00017	0.383
LIG_SH2_STAP1	306	310	PF00017	0.486
LIG_SH2_STAT3	327	330	PF00017	0.544
LIG_SH2_STAT5	42	45	PF00017	0.606
LIG_SH3_3	322	328	PF00018	0.530
LIG_SH3_3	35	41	PF00018	0.515
LIG_Sin3_3	257	264	PF02671	0.470
LIG_SUMO_SIM_anti_2	256	263	PF11976	0.516
LIG_SUMO_SIM_par_1	99	105	PF11976	0.500
LIG_TYR_ITIM	94	99	PF00017	0.403
LIG_UBA3_1	102	108	PF00899	0.533
MOD_CK1_1	213	219	PF00069	0.537
MOD_CK2_1	101	107	PF00069	0.521
MOD_CK2_1	310	316	PF00069	0.383
MOD_CK2_1	360	366	PF00069	0.522
MOD_Cter_Amidation	276	279	PF01082	0.413
MOD_GlcNHglycan	109	113	PF01048	0.498
MOD_GlcNHglycan	223	226	PF01048	0.356
MOD_GlcNHglycan	24	27	PF01048	0.614
MOD_GlcNHglycan	306	309	PF01048	0.460
MOD_GSK3_1	211	218	PF00069	0.505
MOD_GSK3_1	244	251	PF00069	0.414
MOD_GSK3_1	356	363	PF00069	0.540
MOD_N-GLC_1	297	302	PF02516	0.513
MOD_NEK2_1	192	197	PF00069	0.437
MOD_NEK2_1	210	215	PF00069	0.504
MOD_NEK2_1	248	253	PF00069	0.445
MOD_NEK2_1	386	391	PF00069	0.447
MOD_NEK2_2	297	302	PF00069	0.491
MOD_NEK2_2	360	365	PF00069	0.526
MOD_PIKK_1	128	134	PF00454	0.516
MOD_PIKK_1	215	221	PF00454	0.486
MOD_PIKK_1	386	392	PF00454	0.452
MOD_PKA_2	151	157	PF00069	0.645
MOD_PKA_2	360	366	PF00069	0.534
MOD_Plk_1	297	303	PF00069	0.510
MOD_Plk_4	248	254	PF00069	0.474
MOD_Plk_4	266	272	PF00069	0.465
MOD_Plk_4	286	292	PF00069	0.189
MOD_ProDKin_1	154	160	PF00069	0.552
MOD_ProDKin_1	41	47	PF00069	0.579
MOD_SUMO_for_1	253	256	PF00179	0.448
TRG_DiLeu_BaEn_1	256	261	PF01217	0.478
TRG_DiLeu_BaEn_1	266	271	PF01217	0.431
TRG_DiLeu_BaEn_1	340	345	PF01217	0.372
TRG_DiLeu_BaLyEn_6	130	135	PF01217	0.553
TRG_DiLeu_BaLyEn_6	346	351	PF01217	0.479
TRG_ENDOCYTIC_2	52	55	PF00928	0.446
TRG_ENDOCYTIC_2	57	60	PF00928	0.347
TRG_ENDOCYTIC_2	96	99	PF00928	0.394
TRG_ER_diArg_1	5	8	PF00400	0.526
TRG_ER_diArg_1	60	62	PF00400	0.465
TRG_NES_CRM1_1	366	381	PF08389	0.481
TRG_Pf-PMV_PEXEL_1	227	231	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	62	66	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVS3	Leptomonas seymouri	64%	99%
A0A0S4KKN0	Bodo saltans	32%	100%
A0A1X0NUU6	Trypanosomatidae	36%	100%
A0A3R7M4V0	Trypanosoma rangeli	35%	100%
A4H6Q2	Leishmania braziliensis	80%	100%
A4HV37	Leishmania infantum	100%	100%
D0A7B4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	76%
E9ANR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QGV1	Leishmania major	95%	100%
V5BWJ3	Trypanosoma cruzi	35%	100%