Skp1 family, dimerization domain protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SKP1-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7WRR3_LEIDO

TriTrypDb:

LdBPK_111200.1 , LdCL_110017900 , LDHU3_11.1450

Length:

183

Annotations

Annotations by Jardim et al.

Protein kinase, S-phase kinase-associated

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A0A3S7WRR3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WRR3

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006511	ubiquitin-dependent protein catabolic process	7	12
GO:0006793	phosphorus metabolic process	3	9
GO:0006796	phosphate-containing compound metabolic process	4	9
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0009987	cellular process	1	12
GO:0010498	proteasomal protein catabolic process	5	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0016301	kinase activity	4	9
GO:0016740	transferase activity	2	9
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	9
GO:0097602	cullin family protein binding	3	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	133	137	PF00082	0.259
CLV_PCSK_SKI1_1	156	160	PF00082	0.217
CLV_PCSK_SKI1_1	43	47	PF00082	0.226
CLV_PCSK_SKI1_1	67	71	PF00082	0.269
CLV_PCSK_SKI1_1	86	90	PF00082	0.309
DEG_APCC_DBOX_1	66	74	PF00400	0.483
DOC_CYCLIN_RxL_1	150	162	PF00134	0.417
DOC_MAPK_MEF2A_6	115	123	PF00069	0.363
DOC_USP7_MATH_1	36	40	PF00917	0.417
DOC_USP7_MATH_1	59	63	PF00917	0.428

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSC5	Leptomonas seymouri	95%	100%
A0A0N1I7P1	Leptomonas seymouri	23%	77%
A0A0S4IX54	Bodo saltans	33%	97%
A0A0S4J0Y1	Bodo saltans	33%	100%
A0A0S4J983	Bodo saltans	30%	71%
A0A0S4JSD6	Bodo saltans	32%	74%
A0A0S4KKL0	Bodo saltans	74%	100%
A0A1X0NIG1	Trypanosomatidae	26%	100%
A0A1X0NUV8	Trypanosomatidae	76%	100%
A0A422NRM4	Trypanosoma rangeli	75%	100%

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