PUB domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Short C-terminal domain/PUB domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WRQ6_LEIDO

TriTrypDb:

LdBPK_110920.1 , LdCL_110014700 , LDHU3_11.1140

Length:

620

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WRQ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WRQ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.642
CLV_C14_Caspase3-7	370	374	PF00656	0.532
CLV_NRD_NRD_1	19	21	PF00675	0.532
CLV_NRD_NRD_1	200	202	PF00675	0.345
CLV_NRD_NRD_1	287	289	PF00675	0.477
CLV_NRD_NRD_1	496	498	PF00675	0.536
CLV_NRD_NRD_1	528	530	PF00675	0.577
CLV_NRD_NRD_1	553	555	PF00675	0.619
CLV_NRD_NRD_1	557	559	PF00675	0.656
CLV_NRD_NRD_1	564	566	PF00675	0.723
CLV_PCSK_FUR_1	494	498	PF00082	0.534
CLV_PCSK_FUR_1	526	530	PF00082	0.593
CLV_PCSK_KEX2_1	19	21	PF00082	0.538
CLV_PCSK_KEX2_1	200	202	PF00082	0.294
CLV_PCSK_KEX2_1	287	289	PF00082	0.477
CLV_PCSK_KEX2_1	496	498	PF00082	0.474
CLV_PCSK_KEX2_1	523	525	PF00082	0.529
CLV_PCSK_KEX2_1	528	530	PF00082	0.555
CLV_PCSK_KEX2_1	552	554	PF00082	0.642
CLV_PCSK_KEX2_1	557	559	PF00082	0.699
CLV_PCSK_KEX2_1	564	566	PF00082	0.768
CLV_PCSK_PC1ET2_1	523	525	PF00082	0.576
CLV_PCSK_PC7_1	519	525	PF00082	0.577
CLV_PCSK_PC7_1	549	555	PF00082	0.611
CLV_PCSK_PC7_1	560	566	PF00082	0.576
CLV_PCSK_SKI1_1	13	17	PF00082	0.605
CLV_PCSK_SKI1_1	159	163	PF00082	0.544
CLV_PCSK_SKI1_1	25	29	PF00082	0.537
CLV_PCSK_SKI1_1	59	63	PF00082	0.453
CLV_PCSK_SKI1_1	64	68	PF00082	0.478
DEG_SCF_FBW7_1	475	482	PF00400	0.585
DEG_SPOP_SBC_1	29	33	PF00917	0.505
DEG_SPOP_SBC_1	456	460	PF00917	0.568
DEG_SPOP_SBC_1	571	575	PF00917	0.671
DEG_SPOP_SBC_1	614	618	PF00917	0.712
DOC_MAPK_MEF2A_6	296	304	PF00069	0.551
DOC_MAPK_MEF2A_6	422	429	PF00069	0.443
DOC_PP2B_LxvP_1	120	123	PF13499	0.705
DOC_PP4_FxxP_1	436	439	PF00568	0.601
DOC_USP7_MATH_1	103	107	PF00917	0.546
DOC_USP7_MATH_1	125	129	PF00917	0.821
DOC_USP7_MATH_1	138	142	PF00917	0.473
DOC_USP7_MATH_1	154	158	PF00917	0.511
DOC_USP7_MATH_1	161	165	PF00917	0.612
DOC_USP7_MATH_1	217	221	PF00917	0.395
DOC_USP7_MATH_1	238	242	PF00917	0.568
DOC_USP7_MATH_1	29	33	PF00917	0.505
DOC_USP7_MATH_1	343	347	PF00917	0.651
DOC_USP7_MATH_1	400	404	PF00917	0.532
DOC_USP7_MATH_1	449	453	PF00917	0.661
DOC_USP7_MATH_1	456	460	PF00917	0.564
DOC_USP7_MATH_1	479	483	PF00917	0.575
DOC_USP7_MATH_1	514	518	PF00917	0.513
DOC_USP7_MATH_1	566	570	PF00917	0.725
DOC_USP7_MATH_1	571	575	PF00917	0.660
DOC_USP7_MATH_1	80	84	PF00917	0.599
DOC_USP7_MATH_1	91	95	PF00917	0.620
DOC_WW_Pin1_4	121	126	PF00397	0.625
DOC_WW_Pin1_4	127	132	PF00397	0.637
DOC_WW_Pin1_4	240	245	PF00397	0.539
DOC_WW_Pin1_4	312	317	PF00397	0.687
DOC_WW_Pin1_4	350	355	PF00397	0.643
DOC_WW_Pin1_4	457	462	PF00397	0.545
DOC_WW_Pin1_4	475	480	PF00397	0.645
DOC_WW_Pin1_4	567	572	PF00397	0.556
DOC_WW_Pin1_4	604	609	PF00397	0.619
DOC_WW_Pin1_4	615	620	PF00397	0.628
DOC_WW_Pin1_4	87	92	PF00397	0.614
DOC_WW_Pin1_4	94	99	PF00397	0.591
LIG_14-3-3_CanoR_1	13	18	PF00244	0.602
LIG_14-3-3_CanoR_1	140	145	PF00244	0.612
LIG_14-3-3_CanoR_1	565	571	PF00244	0.559
LIG_14-3-3_CanoR_1	592	602	PF00244	0.621
LIG_BIR_III_4	115	119	PF00653	0.634
LIG_BRCT_BRCA1_1	140	144	PF00533	0.564
LIG_CaM_IQ_9	489	505	PF13499	0.492
LIG_deltaCOP1_diTrp_1	145	151	PF00928	0.425
LIG_EVH1_2	169	173	PF00568	0.523
LIG_FHA_1	151	157	PF00498	0.527
LIG_FHA_1	409	415	PF00498	0.540
LIG_FHA_1	441	447	PF00498	0.672
LIG_FHA_1	468	474	PF00498	0.585
LIG_FHA_1	594	600	PF00498	0.624
LIG_FHA_2	110	116	PF00498	0.659
LIG_FHA_2	141	147	PF00498	0.560
LIG_FHA_2	365	371	PF00498	0.461
LIG_FHA_2	463	469	PF00498	0.724
LIG_FHA_2	49	55	PF00498	0.493
LIG_LIR_Gen_1	108	116	PF02991	0.561
LIG_LIR_Gen_1	249	258	PF02991	0.366
LIG_LIR_Gen_1	373	382	PF02991	0.499
LIG_LIR_Nem_3	145	150	PF02991	0.446
LIG_LIR_Nem_3	196	202	PF02991	0.423
LIG_LIR_Nem_3	225	229	PF02991	0.419
LIG_LIR_Nem_3	249	253	PF02991	0.334
LIG_LIR_Nem_3	373	379	PF02991	0.574
LIG_LIR_Nem_3	413	418	PF02991	0.536
LIG_NRBOX	182	188	PF00104	0.395
LIG_SH2_CRK	199	203	PF00017	0.315
LIG_SH2_CRK	415	419	PF00017	0.467
LIG_SH2_NCK_1	389	393	PF00017	0.531
LIG_SH2_SRC	389	392	PF00017	0.479
LIG_SH2_STAP1	389	393	PF00017	0.531
LIG_SH2_STAP1	469	473	PF00017	0.586
LIG_SH2_STAT3	289	292	PF00017	0.583
LIG_SH2_STAT3	469	472	PF00017	0.594
LIG_SH2_STAT5	111	114	PF00017	0.655
LIG_SH2_STAT5	250	253	PF00017	0.397
LIG_SH2_STAT5	280	283	PF00017	0.488
LIG_SH2_STAT5	361	364	PF00017	0.500
LIG_SH2_STAT5	366	369	PF00017	0.458
LIG_SH2_STAT5	469	472	PF00017	0.537
LIG_SH3_1	119	125	PF00018	0.564
LIG_SH3_3	119	125	PF00018	0.627
LIG_SH3_3	191	197	PF00018	0.395
LIG_SH3_3	349	355	PF00018	0.600
LIG_SUMO_SIM_anti_2	596	603	PF11976	0.582
LIG_TRAF2_1	143	146	PF00917	0.457
LIG_TRAF2_1	51	54	PF00917	0.506
LIG_WRC_WIRS_1	223	228	PF05994	0.370
LIG_WRC_WIRS_1	63	68	PF05994	0.473
MOD_CDK_SPxK_1	94	100	PF00069	0.598
MOD_CK1_1	105	111	PF00069	0.614
MOD_CK1_1	132	138	PF00069	0.585
MOD_CK1_1	157	163	PF00069	0.613
MOD_CK1_1	164	170	PF00069	0.552
MOD_CK1_1	346	352	PF00069	0.671
MOD_CK1_1	4	10	PF00069	0.556
MOD_CK1_1	404	410	PF00069	0.509
MOD_CK1_1	569	575	PF00069	0.637
MOD_CK1_1	577	583	PF00069	0.671
MOD_CK1_1	607	613	PF00069	0.629
MOD_CK1_1	65	71	PF00069	0.491
MOD_CK1_1	83	89	PF00069	0.691
MOD_CK1_1	94	100	PF00069	0.799
MOD_CK2_1	140	146	PF00069	0.485
MOD_CK2_1	212	218	PF00069	0.395
MOD_CK2_1	364	370	PF00069	0.453
MOD_CK2_1	48	54	PF00069	0.507
MOD_CK2_1	83	89	PF00069	0.692
MOD_Cter_Amidation	17	20	PF01082	0.493
MOD_Cter_Amidation	603	606	PF01082	0.564
MOD_GlcNHglycan	104	108	PF01048	0.665
MOD_GlcNHglycan	127	130	PF01048	0.666
MOD_GlcNHglycan	166	169	PF01048	0.784
MOD_GlcNHglycan	218	222	PF01048	0.313
MOD_GlcNHglycan	235	241	PF01048	0.323
MOD_GlcNHglycan	312	315	PF01048	0.550
MOD_GlcNHglycan	319	323	PF01048	0.593
MOD_GlcNHglycan	345	348	PF01048	0.692
MOD_GlcNHglycan	534	537	PF01048	0.632
MOD_GlcNHglycan	574	577	PF01048	0.647
MOD_GlcNHglycan	75	78	PF01048	0.616
MOD_GlcNHglycan	83	86	PF01048	0.581
MOD_GSK3_1	105	112	PF00069	0.599
MOD_GSK3_1	121	128	PF00069	0.608
MOD_GSK3_1	132	139	PF00069	0.553
MOD_GSK3_1	150	157	PF00069	0.467
MOD_GSK3_1	236	243	PF00069	0.650
MOD_GSK3_1	346	353	PF00069	0.657
MOD_GSK3_1	400	407	PF00069	0.576
MOD_GSK3_1	456	463	PF00069	0.599
MOD_GSK3_1	475	482	PF00069	0.585
MOD_GSK3_1	566	573	PF00069	0.686
MOD_GSK3_1	574	581	PF00069	0.756
MOD_GSK3_1	604	611	PF00069	0.634
MOD_GSK3_1	613	620	PF00069	0.630
MOD_GSK3_1	81	88	PF00069	0.793
MOD_LATS_1	550	556	PF00433	0.677
MOD_N-GLC_1	125	130	PF02516	0.628
MOD_N-GLC_1	479	484	PF02516	0.377
MOD_NEK2_1	1	6	PF00069	0.564
MOD_NEK2_1	150	155	PF00069	0.515
MOD_NEK2_1	28	33	PF00069	0.626
MOD_NEK2_1	294	299	PF00069	0.540
MOD_NEK2_1	375	380	PF00069	0.511
MOD_NEK2_1	447	452	PF00069	0.614
MOD_NEK2_2	514	519	PF00069	0.494
MOD_PIKK_1	19	25	PF00454	0.525
MOD_PIKK_1	440	446	PF00454	0.617
MOD_PIKK_1	48	54	PF00454	0.588
MOD_PIKK_1	543	549	PF00454	0.562
MOD_PKA_1	19	25	PF00069	0.512
MOD_PKA_1	552	558	PF00069	0.690
MOD_PKA_2	19	25	PF00069	0.512
MOD_PKA_2	202	208	PF00069	0.390
MOD_PKA_2	552	558	PF00069	0.646
MOD_Plk_1	467	473	PF00069	0.600
MOD_Plk_1	514	520	PF00069	0.494
MOD_Plk_2-3	212	218	PF00069	0.395
MOD_Plk_2-3	364	370	PF00069	0.453
MOD_Plk_4	357	363	PF00069	0.634
MOD_Plk_4	404	410	PF00069	0.534
MOD_Plk_4	450	456	PF00069	0.605
MOD_ProDKin_1	121	127	PF00069	0.626
MOD_ProDKin_1	240	246	PF00069	0.535
MOD_ProDKin_1	312	318	PF00069	0.691
MOD_ProDKin_1	350	356	PF00069	0.635
MOD_ProDKin_1	457	463	PF00069	0.543
MOD_ProDKin_1	475	481	PF00069	0.587
MOD_ProDKin_1	567	573	PF00069	0.555
MOD_ProDKin_1	604	610	PF00069	0.623
MOD_ProDKin_1	87	93	PF00069	0.616
MOD_ProDKin_1	94	100	PF00069	0.591
MOD_SUMO_for_1	522	525	PF00179	0.574
MOD_SUMO_rev_2	113	121	PF00179	0.555
MOD_SUMO_rev_2	141	150	PF00179	0.476
MOD_SUMO_rev_2	53	61	PF00179	0.567
TRG_DiLeu_BaEn_4	145	151	PF01217	0.404
TRG_DiLeu_BaLyEn_6	182	187	PF01217	0.395
TRG_DiLeu_BaLyEn_6	487	492	PF01217	0.509
TRG_ENDOCYTIC_2	111	114	PF00928	0.563
TRG_ENDOCYTIC_2	199	202	PF00928	0.335
TRG_ENDOCYTIC_2	250	253	PF00928	0.382
TRG_ENDOCYTIC_2	415	418	PF00928	0.513
TRG_ER_diArg_1	199	201	PF00400	0.345
TRG_ER_diArg_1	287	289	PF00400	0.477
TRG_ER_diArg_1	494	497	PF00400	0.529
TRG_ER_diArg_1	526	529	PF00400	0.566
TRG_ER_diArg_1	552	554	PF00400	0.620
TRG_ER_diArg_1	557	560	PF00400	0.662
TRG_NES_CRM1_1	292	305	PF08389	0.514
TRG_Pf-PMV_PEXEL_1	200	204	PF00026	0.345

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEJ9	Leptomonas seymouri	43%	100%
A4H6L8	Leishmania braziliensis	70%	100%
A4HV01	Leishmania infantum	99%	100%
E9ANN6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QGY7	Leishmania major	90%	100%