60Kd inner membrane protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60Kd inner membrane protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WRQ0_LEIDO

TriTrypDb:

LdBPK_111170.1 , LdCL_110017600 , LDHU3_11.1400

Length:

441

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A0A3S7WRQ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WRQ0

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006839	mitochondrial transport	4	1
GO:0006886	intracellular protein transport	4	1
GO:0006996	organelle organization	4	1
GO:0007005	mitochondrion organization	5	1
GO:0007006	mitochondrial membrane organization	5	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0032978	protein insertion into membrane from inner side	6	1
GO:0032979	protein insertion into mitochondrial inner membrane from matrix	5	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051205	protein insertion into membrane	5	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0061024	membrane organization	4	1
GO:0070585	protein localization to mitochondrion	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072655	establishment of protein localization to mitochondrion	5	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:0090151	establishment of protein localization to mitochondrial membrane	4	1

Molecular functions
Term	Name	Level	Count
GO:0032977	membrane insertase activity	3	12
GO:0140104	molecular carrier activity	1	12
GO:0140597	protein carrier chaperone	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	258	260	PF00675	0.466
CLV_NRD_NRD_1	36	38	PF00675	0.734
CLV_NRD_NRD_1	405	407	PF00675	0.416
CLV_NRD_NRD_1	70	72	PF00675	0.713
CLV_PCSK_KEX2_1	215	217	PF00082	0.271
CLV_PCSK_KEX2_1	258	260	PF00082	0.466
CLV_PCSK_KEX2_1	36	38	PF00082	0.734
CLV_PCSK_KEX2_1	70	72	PF00082	0.713
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.271
CLV_PCSK_SKI1_1	115	119	PF00082	0.583
CLV_PCSK_SKI1_1	170	174	PF00082	0.364
CLV_PCSK_SKI1_1	216	220	PF00082	0.276
CLV_PCSK_SKI1_1	226	230	PF00082	0.267
CLV_PCSK_SKI1_1	239	243	PF00082	0.264
CLV_PCSK_SKI1_1	276	280	PF00082	0.499
CLV_PCSK_SKI1_1	363	367	PF00082	0.352
CLV_Separin_Metazoa	140	144	PF03568	0.367
DEG_Nend_Nbox_1	1	3	PF02207	0.536
DOC_CDC14_PxL_1	172	180	PF14671	0.386
DOC_CDC14_PxL_1	267	275	PF14671	0.283
DOC_CKS1_1	245	250	PF01111	0.386
DOC_CKS1_1	25	30	PF01111	0.464
DOC_CYCLIN_RxL_1	167	177	PF00134	0.449
DOC_CYCLIN_yCln2_LP_2	351	357	PF00134	0.344
DOC_MAPK_FxFP_2	366	369	PF00069	0.562
DOC_MAPK_gen_1	143	153	PF00069	0.383
DOC_MAPK_gen_1	307	317	PF00069	0.476
DOC_MAPK_gen_1	53	63	PF00069	0.503
DOC_MAPK_MEF2A_6	322	331	PF00069	0.386
DOC_MAPK_MEF2A_6	56	65	PF00069	0.501
DOC_PP1_RVXF_1	68	75	PF00149	0.437
DOC_PP2B_LxvP_1	278	281	PF13499	0.276
DOC_PP4_FxxP_1	131	134	PF00568	0.362
DOC_PP4_FxxP_1	245	248	PF00568	0.406
DOC_PP4_FxxP_1	366	369	PF00568	0.550
DOC_USP7_MATH_1	113	117	PF00917	0.387
DOC_USP7_MATH_1	12	16	PF00917	0.540
DOC_USP7_MATH_1	374	378	PF00917	0.649
DOC_USP7_UBL2_3	215	219	PF12436	0.476
DOC_WW_Pin1_4	24	29	PF00397	0.531
DOC_WW_Pin1_4	244	249	PF00397	0.386
LIG_14-3-3_CanoR_1	170	175	PF00244	0.329
LIG_14-3-3_CanoR_1	182	186	PF00244	0.476
LIG_14-3-3_CanoR_1	208	218	PF00244	0.490
LIG_14-3-3_CanoR_1	307	317	PF00244	0.476
LIG_14-3-3_CanoR_1	322	327	PF00244	0.329
LIG_14-3-3_CanoR_1	410	418	PF00244	0.694
LIG_14-3-3_CanoR_1	56	63	PF00244	0.526
LIG_14-3-3_CanoR_1	70	75	PF00244	0.388
LIG_AP2alpha_1	362	366	PF02296	0.565
LIG_BRCT_BRCA1_1	336	340	PF00533	0.287
LIG_Clathr_ClatBox_1	296	300	PF01394	0.363
LIG_deltaCOP1_diTrp_1	122	131	PF00928	0.354
LIG_EVH1_1	368	372	PF00568	0.555
LIG_FHA_1	15	21	PF00498	0.558
LIG_FHA_1	244	250	PF00498	0.322
LIG_FHA_1	282	288	PF00498	0.276
LIG_FHA_1	346	352	PF00498	0.344
LIG_FHA_2	263	269	PF00498	0.294
LIG_FHA_2	277	283	PF00498	0.225
LIG_FHA_2	393	399	PF00498	0.652
LIG_FHA_2	418	424	PF00498	0.700
LIG_LIR_Apic_2	108	113	PF02991	0.412
LIG_LIR_Apic_2	130	134	PF02991	0.372
LIG_LIR_Apic_2	243	248	PF02991	0.406
LIG_LIR_Apic_2	282	288	PF02991	0.275
LIG_LIR_Apic_2	364	369	PF02991	0.566
LIG_LIR_Gen_1	116	124	PF02991	0.360
LIG_LIR_Gen_1	148	155	PF02991	0.463
LIG_LIR_Gen_1	220	229	PF02991	0.487
LIG_LIR_Gen_1	252	262	PF02991	0.367
LIG_LIR_Gen_1	387	394	PF02991	0.688
LIG_LIR_Gen_1	42	47	PF02991	0.572
LIG_LIR_Gen_1	422	432	PF02991	0.681
LIG_LIR_Nem_3	116	121	PF02991	0.357
LIG_LIR_Nem_3	148	153	PF02991	0.418
LIG_LIR_Nem_3	236	241	PF02991	0.539
LIG_LIR_Nem_3	252	257	PF02991	0.228
LIG_LIR_Nem_3	364	368	PF02991	0.563
LIG_LIR_Nem_3	387	392	PF02991	0.693
LIG_LIR_Nem_3	42	46	PF02991	0.499
LIG_LIR_Nem_3	422	427	PF02991	0.648
LIG_LIR_Nem_3	73	77	PF02991	0.505
LIG_NRP_CendR_1	440	441	PF00754	0.611
LIG_Pex14_1	127	131	PF04695	0.379
LIG_Pex14_1	158	162	PF04695	0.276
LIG_Pex14_2	241	245	PF04695	0.406
LIG_Pex14_2	295	299	PF04695	0.329
LIG_Pex14_2	362	366	PF04695	0.540
LIG_SH2_CRK	285	289	PF00017	0.363
LIG_SH2_NCK_1	285	289	PF00017	0.476
LIG_SH2_NCK_1	424	428	PF00017	0.715
LIG_SH2_PTP2	110	113	PF00017	0.476
LIG_SH2_STAP1	263	267	PF00017	0.276
LIG_SH2_STAP1	389	393	PF00017	0.696
LIG_SH2_STAP1	424	428	PF00017	0.653
LIG_SH2_STAT5	110	113	PF00017	0.476
LIG_SH2_STAT5	316	319	PF00017	0.476
LIG_SH2_STAT5	330	333	PF00017	0.328
LIG_SH3_3	22	28	PF00018	0.463
LIG_SH3_3	366	372	PF00018	0.560
LIG_SUMO_SIM_par_1	103	109	PF11976	0.461
LIG_SxIP_EBH_1	168	182	PF03271	0.363
LIG_TRAF2_1	394	397	PF00917	0.572
LIG_UBA3_1	379	384	PF00899	0.670
LIG_WRC_WIRS_1	150	155	PF05994	0.400
LIG_WRC_WIRS_1	242	247	PF05994	0.292
MOD_CDK_SPxxK_3	24	31	PF00069	0.467
MOD_CK1_1	177	183	PF00069	0.476
MOD_CK1_1	195	201	PF00069	0.397
MOD_CK1_1	240	246	PF00069	0.347
MOD_CK2_1	113	119	PF00069	0.381
MOD_CK2_1	208	214	PF00069	0.476
MOD_CK2_1	262	268	PF00069	0.278
MOD_CK2_1	384	390	PF00069	0.611
MOD_CK2_1	392	398	PF00069	0.594
MOD_GlcNHglycan	14	17	PF01048	0.698
MOD_GlcNHglycan	211	214	PF01048	0.317
MOD_GlcNHglycan	251	254	PF01048	0.329
MOD_GlcNHglycan	310	313	PF01048	0.305
MOD_GlcNHglycan	336	339	PF01048	0.490
MOD_GlcNHglycan	413	416	PF01048	0.497
MOD_GlcNHglycan	436	439	PF01048	0.563
MOD_GlcNHglycan	58	61	PF01048	0.703
MOD_GSK3_1	170	177	PF00069	0.329
MOD_GSK3_1	233	240	PF00069	0.522
MOD_GSK3_1	243	250	PF00069	0.276
MOD_GSK3_1	374	381	PF00069	0.639
MOD_N-GLC_1	233	238	PF02516	0.289
MOD_NEK2_1	19	24	PF00069	0.541
MOD_NEK2_1	2	7	PF00069	0.532
MOD_NEK2_1	241	246	PF00069	0.384
MOD_NEK2_2	113	118	PF00069	0.396
MOD_NEK2_2	253	258	PF00069	0.329
MOD_PIKK_1	233	239	PF00454	0.516
MOD_PIKK_1	392	398	PF00454	0.624
MOD_PK_1	31	37	PF00069	0.414
MOD_PK_1	322	328	PF00069	0.406
MOD_PKA_1	70	76	PF00069	0.426
MOD_PKA_2	181	187	PF00069	0.513
MOD_PKA_2	321	327	PF00069	0.414
MOD_PKA_2	55	61	PF00069	0.539
MOD_PKA_2	70	76	PF00069	0.488
MOD_PKA_2	85	91	PF00069	0.436
MOD_Plk_1	113	119	PF00069	0.381
MOD_Plk_1	206	212	PF00069	0.476
MOD_Plk_1	233	239	PF00069	0.489
MOD_Plk_1	276	282	PF00069	0.281
MOD_Plk_1	397	403	PF00069	0.682
MOD_Plk_4	113	119	PF00069	0.392
MOD_Plk_4	127	133	PF00069	0.382
MOD_Plk_4	170	176	PF00069	0.335
MOD_Plk_4	237	243	PF00069	0.489
MOD_Plk_4	322	328	PF00069	0.362
MOD_Plk_4	384	390	PF00069	0.617
MOD_ProDKin_1	24	30	PF00069	0.533
MOD_ProDKin_1	244	250	PF00069	0.386
MOD_SUMO_rev_2	377	386	PF00179	0.672
TRG_DiLeu_BaEn_2	267	273	PF01217	0.276
TRG_DiLeu_BaEn_4	397	403	PF01217	0.665
TRG_DiLeu_BaLyEn_6	28	33	PF01217	0.448
TRG_ENDOCYTIC_2	222	225	PF00928	0.487
TRG_ENDOCYTIC_2	389	392	PF00928	0.697
TRG_ENDOCYTIC_2	424	427	PF00928	0.652
TRG_ER_diArg_1	257	259	PF00400	0.267
TRG_ER_diArg_1	35	37	PF00400	0.568
TRG_ER_diArg_1	70	72	PF00400	0.531
TRG_Pf-PMV_PEXEL_1	115	119	PF00026	0.657
TRG_Pf-PMV_PEXEL_1	143	148	PF00026	0.572
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.287

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Y9	Leptomonas seymouri	84%	98%
A0A0S4IZY1	Bodo saltans	62%	100%
A0A1X0NWK5	Trypanosomatidae	70%	100%
A0A3R7NUU3	Trypanosoma rangeli	71%	99%
A4H6P4	Leishmania braziliensis	90%	100%
A4HV25	Leishmania infantum	100%	100%
D0A7C4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9ANQ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QGW4	Leishmania major	97%	100%
V5C1D0	Trypanosoma cruzi	67%	100%