Leucine Rich repeat, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WRP9_LEIDO

TriTrypDb:

LdBPK_110890.1 , LdCL_110014400 , LDHU3_11.1110

Length:

1004

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11

Expansion

Sequence features

A0A3S7WRP9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WRP9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	24	28	PF00656	0.668
CLV_C14_Caspase3-7	501	505	PF00656	0.427
CLV_C14_Caspase3-7	559	563	PF00656	0.297
CLV_C14_Caspase3-7	618	622	PF00656	0.561
CLV_C14_Caspase3-7	921	925	PF00656	0.591
CLV_C14_Caspase3-7	926	930	PF00656	0.517
CLV_NRD_NRD_1	625	627	PF00675	0.571
CLV_NRD_NRD_1	640	642	PF00675	0.352
CLV_NRD_NRD_1	653	655	PF00675	0.306
CLV_NRD_NRD_1	879	881	PF00675	0.424
CLV_PCSK_FUR_1	623	627	PF00082	0.593
CLV_PCSK_KEX2_1	623	625	PF00082	0.638
CLV_PCSK_KEX2_1	629	631	PF00082	0.577
CLV_PCSK_KEX2_1	640	642	PF00082	0.337
CLV_PCSK_KEX2_1	653	655	PF00082	0.306
CLV_PCSK_PC1ET2_1	629	631	PF00082	0.519
CLV_PCSK_PC7_1	625	631	PF00082	0.536
CLV_PCSK_SKI1_1	146	150	PF00082	0.576
CLV_PCSK_SKI1_1	391	395	PF00082	0.340
CLV_PCSK_SKI1_1	534	538	PF00082	0.410
CLV_PCSK_SKI1_1	575	579	PF00082	0.353
CLV_PCSK_SKI1_1	625	629	PF00082	0.506
CLV_PCSK_SKI1_1	633	637	PF00082	0.363
CLV_PCSK_SKI1_1	824	828	PF00082	0.492
CLV_PCSK_SKI1_1	990	994	PF00082	0.432
CLV_PCSK_SKI1_1	998	1002	PF00082	0.489
DEG_APCC_DBOX_1	145	153	PF00400	0.573
DEG_APCC_DBOX_1	989	997	PF00400	0.443
DEG_SPOP_SBC_1	951	955	PF00917	0.447
DEG_SPOP_SBC_1	970	974	PF00917	0.420
DEG_SPOP_SBC_1	999	1003	PF00917	0.435
DOC_CDC14_PxL_1	842	850	PF14671	0.442
DOC_CKS1_1	17	22	PF01111	0.728
DOC_CYCLIN_RxL_1	319	327	PF00134	0.352
DOC_CYCLIN_RxL_1	445	457	PF00134	0.434
DOC_CYCLIN_RxL_1	523	533	PF00134	0.362
DOC_CYCLIN_yCln2_LP_2	739	742	PF00134	0.419
DOC_MAPK_gen_1	156	163	PF00069	0.500
DOC_MAPK_gen_1	445	455	PF00069	0.354
DOC_MAPK_gen_1	523	532	PF00069	0.410
DOC_MAPK_gen_1	988	995	PF00069	0.446
DOC_MAPK_MEF2A_6	905	912	PF00069	0.450
DOC_MAPK_MEF2A_6	988	997	PF00069	0.453
DOC_MAPK_NFAT4_5	988	996	PF00069	0.449
DOC_PP1_RVXF_1	278	285	PF00149	0.451
DOC_PP2B_LxvP_1	466	469	PF13499	0.720
DOC_PP2B_LxvP_1	739	742	PF13499	0.419
DOC_USP7_MATH_1	207	211	PF00917	0.534
DOC_USP7_MATH_1	232	236	PF00917	0.627
DOC_USP7_MATH_1	334	338	PF00917	0.488
DOC_USP7_MATH_1	367	371	PF00917	0.508
DOC_USP7_MATH_1	75	79	PF00917	0.635
DOC_USP7_MATH_1	970	974	PF00917	0.614
DOC_USP7_MATH_1	977	981	PF00917	0.572
DOC_USP7_MATH_1	999	1003	PF00917	0.616
DOC_USP7_UBL2_3	391	395	PF12436	0.340
DOC_USP7_UBL2_3	629	633	PF12436	0.643
DOC_WW_Pin1_4	12	17	PF00397	0.696
DOC_WW_Pin1_4	205	210	PF00397	0.511
DOC_WW_Pin1_4	353	358	PF00397	0.407
DOC_WW_Pin1_4	516	521	PF00397	0.449
DOC_WW_Pin1_4	63	68	PF00397	0.722
DOC_WW_Pin1_4	824	829	PF00397	0.536
DOC_WW_Pin1_4	884	889	PF00397	0.580
LIG_14-3-3_CanoR_1	224	228	PF00244	0.355
LIG_14-3-3_CanoR_1	630	639	PF00244	0.528
LIG_14-3-3_CanoR_1	640	649	PF00244	0.448
LIG_14-3-3_CanoR_1	759	763	PF00244	0.503
LIG_14-3-3_CanoR_1	859	866	PF00244	0.367
LIG_BRCT_BRCA1_1	238	242	PF00533	0.588
LIG_BRCT_BRCA1_1	866	870	PF00533	0.380
LIG_Clathr_ClatBox_1	956	960	PF01394	0.490
LIG_deltaCOP1_diTrp_1	507	515	PF00928	0.375
LIG_FHA_1	190	196	PF00498	0.461
LIG_FHA_1	224	230	PF00498	0.379
LIG_FHA_1	392	398	PF00498	0.343
LIG_FHA_1	413	419	PF00498	0.567
LIG_FHA_1	597	603	PF00498	0.352
LIG_FHA_1	885	891	PF00498	0.581
LIG_FHA_1	905	911	PF00498	0.504
LIG_FHA_1	918	924	PF00498	0.663
LIG_FHA_2	247	253	PF00498	0.586
LIG_FHA_2	551	557	PF00498	0.355
LIG_FHA_2	759	765	PF00498	0.582
LIG_FHA_2	779	785	PF00498	0.398
LIG_FHA_2	859	865	PF00498	0.371
LIG_FHA_2	92	98	PF00498	0.573
LIG_Integrin_RGD_1	346	348	PF01839	0.588
LIG_IRF3_LxIS_1	780	786	PF10401	0.424
LIG_IRF3_LxIS_1	848	854	PF10401	0.427
LIG_LIR_Apic_2	15	20	PF02991	0.750
LIG_LIR_Apic_2	660	664	PF02991	0.484
LIG_LIR_Gen_1	325	336	PF02991	0.351
LIG_LIR_Gen_1	370	381	PF02991	0.489
LIG_LIR_Gen_1	507	517	PF02991	0.363
LIG_LIR_Gen_1	784	794	PF02991	0.482
LIG_LIR_Gen_1	938	946	PF02991	0.518
LIG_LIR_Nem_3	215	221	PF02991	0.533
LIG_LIR_Nem_3	288	293	PF02991	0.497
LIG_LIR_Nem_3	325	331	PF02991	0.351
LIG_LIR_Nem_3	370	376	PF02991	0.493
LIG_LIR_Nem_3	432	437	PF02991	0.453
LIG_LIR_Nem_3	507	512	PF02991	0.423
LIG_LIR_Nem_3	665	669	PF02991	0.540
LIG_LIR_Nem_3	784	790	PF02991	0.478
LIG_LIR_Nem_3	938	942	PF02991	0.525
LIG_MLH1_MIPbox_1	866	870	PF16413	0.380
LIG_MYND_3	845	849	PF01753	0.394
LIG_NRBOX	705	711	PF00104	0.388
LIG_NRBOX	768	774	PF00104	0.435
LIG_NRBOX	894	900	PF00104	0.567
LIG_PCNA_yPIPBox_3	594	603	PF02747	0.446
LIG_Pex14_1	214	218	PF04695	0.542
LIG_SH2_CRK	225	229	PF00017	0.372
LIG_SH2_CRK	328	332	PF00017	0.355
LIG_SH2_CRK	524	528	PF00017	0.279
LIG_SH2_CRK	567	571	PF00017	0.410
LIG_SH2_CRK	787	791	PF00017	0.415
LIG_SH2_GRB2like	373	376	PF00017	0.487
LIG_SH2_NCK_1	328	332	PF00017	0.306
LIG_SH2_NCK_1	787	791	PF00017	0.404
LIG_SH2_PTP2	17	20	PF00017	0.639
LIG_SH2_STAP1	272	276	PF00017	0.459
LIG_SH2_STAP1	285	289	PF00017	0.300
LIG_SH2_STAT3	522	525	PF00017	0.450
LIG_SH2_STAT3	711	714	PF00017	0.495
LIG_SH2_STAT5	17	20	PF00017	0.688
LIG_SH2_STAT5	225	228	PF00017	0.357
LIG_SH2_STAT5	296	299	PF00017	0.490
LIG_SH2_STAT5	373	376	PF00017	0.469
LIG_SH2_STAT5	576	579	PF00017	0.386
LIG_SH2_STAT5	661	664	PF00017	0.351
LIG_SH2_STAT5	901	904	PF00017	0.464
LIG_SH3_1	885	891	PF00018	0.553
LIG_SH3_3	133	139	PF00018	0.467
LIG_SH3_3	154	160	PF00018	0.559
LIG_SH3_3	197	203	PF00018	0.532
LIG_SH3_3	2	8	PF00018	0.748
LIG_SH3_3	415	421	PF00018	0.578
LIG_SH3_3	422	428	PF00018	0.570
LIG_SH3_3	743	749	PF00018	0.474
LIG_SH3_3	885	891	PF00018	0.553
LIG_SUMO_SIM_anti_2	553	559	PF11976	0.327
LIG_SUMO_SIM_par_1	322	327	PF11976	0.357
LIG_SUMO_SIM_par_1	556	562	PF11976	0.279
LIG_SUMO_SIM_par_1	849	854	PF11976	0.466
LIG_SUMO_SIM_par_1	953	960	PF11976	0.494
LIG_TRAF2_1	470	473	PF00917	0.721
LIG_TRAF2_1	478	481	PF00917	0.697
LIG_TRAF2_1	482	485	PF00917	0.686
LIG_TRAF2_1	679	682	PF00917	0.350
LIG_TRAF2_1	702	705	PF00917	0.428
LIG_TRAF2_1	829	832	PF00917	0.483
LIG_TYR_ITIM	326	331	PF00017	0.355
LIG_TYR_ITIM	371	376	PF00017	0.495
LIG_TYR_ITIM	565	570	PF00017	0.410
LIG_TYR_ITIM	785	790	PF00017	0.426
LIG_UBA3_1	992	998	PF00899	0.507
LIG_WW_3	717	721	PF00397	0.420
MOD_CDC14_SPxK_1	356	359	PF00782	0.383
MOD_CDK_SPxK_1	353	359	PF00069	0.399
MOD_CDK_SPxxK_3	16	23	PF00069	0.732
MOD_CDK_SPxxK_3	516	523	PF00069	0.464
MOD_CK1_1	208	214	PF00069	0.606
MOD_CK1_1	236	242	PF00069	0.635
MOD_CK1_1	550	556	PF00069	0.397
MOD_CK1_1	871	877	PF00069	0.482
MOD_CK1_1	904	910	PF00069	0.543
MOD_CK1_1	978	984	PF00069	0.641
MOD_CK2_1	246	252	PF00069	0.615
MOD_CK2_1	550	556	PF00069	0.355
MOD_CK2_1	641	647	PF00069	0.518
MOD_CK2_1	802	808	PF00069	0.348
MOD_CK2_1	858	864	PF00069	0.409
MOD_CK2_1	952	958	PF00069	0.453
MOD_GlcNHglycan	113	116	PF01048	0.515
MOD_GlcNHglycan	146	149	PF01048	0.507
MOD_GlcNHglycan	187	190	PF01048	0.647
MOD_GlcNHglycan	235	238	PF01048	0.712
MOD_GlcNHglycan	403	407	PF01048	0.491
MOD_GlcNHglycan	587	590	PF01048	0.546
MOD_GlcNHglycan	594	597	PF01048	0.334
MOD_GlcNHglycan	617	620	PF01048	0.613
MOD_GlcNHglycan	633	636	PF01048	0.414
MOD_GlcNHglycan	643	646	PF01048	0.431
MOD_GlcNHglycan	666	669	PF01048	0.227
MOD_GlcNHglycan	866	869	PF01048	0.467
MOD_GlcNHglycan	980	983	PF01048	0.660
MOD_GSK3_1	12	19	PF00069	0.698
MOD_GSK3_1	185	192	PF00069	0.661
MOD_GSK3_1	232	239	PF00069	0.652
MOD_GSK3_1	547	554	PF00069	0.448
MOD_GSK3_1	592	599	PF00069	0.543
MOD_GSK3_1	788	795	PF00069	0.329
MOD_GSK3_1	864	871	PF00069	0.533
MOD_GSK3_1	971	978	PF00069	0.627
MOD_N-GLC_1	367	372	PF02516	0.366
MOD_N-GLC_1	551	556	PF02516	0.279
MOD_N-GLC_1	729	734	PF02516	0.475
MOD_N-GLC_1	788	793	PF02516	0.433
MOD_N-GLC_1	809	814	PF02516	0.373
MOD_N-GLC_1	871	876	PF02516	0.375
MOD_N-GLC_1	930	935	PF02516	0.488
MOD_N-GLC_1	951	956	PF02516	0.326
MOD_NEK2_1	194	199	PF00069	0.484
MOD_NEK2_1	324	329	PF00069	0.355
MOD_NEK2_1	37	42	PF00069	0.563
MOD_NEK2_1	498	503	PF00069	0.431
MOD_NEK2_1	530	535	PF00069	0.322
MOD_NEK2_1	657	662	PF00069	0.399
MOD_NEK2_1	670	675	PF00069	0.280
MOD_NEK2_1	698	703	PF00069	0.450
MOD_NEK2_1	783	788	PF00069	0.425
MOD_NEK2_1	809	814	PF00069	0.279
MOD_NEK2_1	851	856	PF00069	0.434
MOD_NEK2_1	870	875	PF00069	0.584
MOD_NEK2_1	911	916	PF00069	0.432
MOD_NEK2_2	285	290	PF00069	0.378
MOD_NEK2_2	367	372	PF00069	0.384
MOD_PIKK_1	246	252	PF00454	0.737
MOD_PIKK_1	73	79	PF00454	0.715
MOD_PIKK_1	767	773	PF00454	0.411
MOD_PKA_1	625	631	PF00069	0.538
MOD_PKA_2	223	229	PF00069	0.566
MOD_PKA_2	625	631	PF00069	0.591
MOD_PKA_2	758	764	PF00069	0.503
MOD_PKA_2	858	864	PF00069	0.371
MOD_PKA_2	904	910	PF00069	0.512
MOD_PKB_1	623	631	PF00069	0.571
MOD_Plk_1	285	291	PF00069	0.379
MOD_Plk_1	324	330	PF00069	0.355
MOD_Plk_1	367	373	PF00069	0.368
MOD_Plk_1	551	557	PF00069	0.279
MOD_Plk_1	783	789	PF00069	0.441
MOD_Plk_1	871	877	PF00069	0.482
MOD_Plk_1	930	936	PF00069	0.647
MOD_Plk_1	951	957	PF00069	0.323
MOD_Plk_1	975	981	PF00069	0.576
MOD_Plk_2-3	480	486	PF00069	0.612
MOD_Plk_4	285	291	PF00069	0.379
MOD_Plk_4	596	602	PF00069	0.362
MOD_Plk_4	657	663	PF00069	0.481
MOD_Plk_4	792	798	PF00069	0.479
MOD_Plk_4	894	900	PF00069	0.518
MOD_Plk_4	911	917	PF00069	0.312
MOD_Plk_4	938	944	PF00069	0.386
MOD_Plk_4	952	958	PF00069	0.460
MOD_ProDKin_1	12	18	PF00069	0.695
MOD_ProDKin_1	205	211	PF00069	0.514
MOD_ProDKin_1	353	359	PF00069	0.404
MOD_ProDKin_1	516	522	PF00069	0.454
MOD_ProDKin_1	63	69	PF00069	0.722
MOD_ProDKin_1	824	830	PF00069	0.531
MOD_ProDKin_1	884	890	PF00069	0.574
TRG_DiLeu_BaEn_1	705	710	PF01217	0.433
TRG_DiLeu_BaLyEn_6	288	293	PF01217	0.469
TRG_DiLeu_BaLyEn_6	987	992	PF01217	0.432
TRG_ENDOCYTIC_2	218	221	PF00928	0.522
TRG_ENDOCYTIC_2	31	34	PF00928	0.496
TRG_ENDOCYTIC_2	328	331	PF00928	0.355
TRG_ENDOCYTIC_2	373	376	PF00928	0.487
TRG_ENDOCYTIC_2	434	437	PF00928	0.424
TRG_ENDOCYTIC_2	524	527	PF00928	0.358
TRG_ENDOCYTIC_2	567	570	PF00928	0.410
TRG_ENDOCYTIC_2	787	790	PF00928	0.417
TRG_ER_diArg_1	623	626	PF00400	0.641
TRG_ER_diArg_1	639	641	PF00400	0.353
TRG_ER_diArg_1	652	654	PF00400	0.313
TRG_NES_CRM1_1	844	857	PF08389	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCE6	Leptomonas seymouri	53%	96%
A0A1X0NWD9	Trypanosomatidae	33%	100%
A0A422MZT7	Trypanosoma rangeli	32%	100%
A4H6L5	Leishmania braziliensis	83%	100%
A4HUZ8	Leishmania infantum	99%	100%
D0A7F0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9ANN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QGZ0	Leishmania major	92%	100%
V5C1B4	Trypanosoma cruzi	33%	100%