Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WRP0_LEIDO

TriTrypDb:

LdBPK_110800.1 , LdCL_110013400 , LDHU3_11.1000

Length:

147

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WRP0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WRP0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	51	53	PF00675	0.619
CLV_PCSK_KEX2_1	21	23	PF00082	0.558
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.652
DOC_MAPK_FxFP_2	118	121	PF00069	0.541
DOC_PP4_FxxP_1	118	121	PF00568	0.507
DOC_PP4_FxxP_1	134	137	PF00568	0.616
DOC_USP7_MATH_1	34	38	PF00917	0.492
DOC_USP7_MATH_1	67	71	PF00917	0.617
DOC_USP7_MATH_1	86	90	PF00917	0.347
LIG_14-3-3_CanoR_1	22	30	PF00244	0.542
LIG_14-3-3_CanoR_1	52	61	PF00244	0.538
LIG_FHA_1	7	13	PF00498	0.647
LIG_GBD_Chelix_1	124	132	PF00786	0.488
LIG_LIR_Apic_2	116	121	PF02991	0.502
LIG_LIR_Apic_2	75	81	PF02991	0.463
LIG_LIR_Gen_1	89	98	PF02991	0.496
LIG_LIR_Nem_3	16	20	PF02991	0.498
LIG_LIR_Nem_3	89	94	PF02991	0.480
LIG_LIR_Nem_3	96	102	PF02991	0.372
LIG_LYPXL_L_2	119	128	PF13949	0.481
LIG_SH2_NCK_1	54	58	PF00017	0.621
LIG_SH2_PTP2	91	94	PF00017	0.532
LIG_SH2_STAP1	54	58	PF00017	0.512
LIG_SH2_STAT5	19	22	PF00017	0.591
LIG_SH2_STAT5	47	50	PF00017	0.523
LIG_SH2_STAT5	54	57	PF00017	0.489
LIG_SH2_STAT5	91	94	PF00017	0.532
LIG_SH3_3	39	45	PF00018	0.573
LIG_WRC_WIRS_1	7	12	PF05994	0.509
MOD_CK2_1	136	142	PF00069	0.686
MOD_CK2_1	68	74	PF00069	0.645
MOD_GlcNHglycan	129	132	PF01048	0.595
MOD_GlcNHglycan	36	39	PF01048	0.616
MOD_GlcNHglycan	65	68	PF01048	0.594
MOD_GlcNHglycan	95	98	PF01048	0.488
MOD_GSK3_1	63	70	PF00069	0.560
MOD_NEK2_2	86	91	PF00069	0.538
MOD_PIKK_1	1	7	PF00454	0.558
MOD_PKA_1	52	58	PF00069	0.624
MOD_PKA_2	67	73	PF00069	0.655
MOD_PKB_1	50	58	PF00069	0.621
MOD_Plk_4	6	12	PF00069	0.599
MOD_Plk_4	86	92	PF00069	0.482
TRG_ENDOCYTIC_2	91	94	PF00928	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P635	Leptomonas seymouri	70%	98%
A0A0S4JUP0	Bodo saltans	29%	100%
A0A1X0NV26	Trypanosomatidae	50%	100%
A0A422NQB2	Trypanosoma rangeli	46%	97%
A4H6K4	Leishmania braziliensis	82%	100%
A4HUY9	Leishmania infantum	100%	100%
D0A7G0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9ANM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QGZ9	Leishmania major	95%	100%