Amino_acid_permease/transporter_putative/GeneDB:L mjF.11.0520

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amino acid permease/transporter, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WRN2_LEIDO

TriTrypDb:

LdBPK_110550.1 , LdCL_110010800 , LDHU3_11.0680

Length:

466

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	23
GO:0110165	cellular anatomical entity	1	23
GO:0000323	lytic vacuole	6	1
GO:0005764	lysosome	7	1
GO:0005773	vacuole	5	1
GO:0020022	acidocalcisome	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S7WRN2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WRN2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	23
GO:0015203	polyamine transmembrane transporter activity	3	23
GO:0022857	transmembrane transporter activity	2	23
GO:0003824	catalytic activity	1	5
GO:0016787	hydrolase activity	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	301	303	PF00675	0.224
CLV_NRD_NRD_1	454	456	PF00675	0.482
CLV_PCSK_FUR_1	302	306	PF00082	0.284
CLV_PCSK_KEX2_1	301	303	PF00082	0.291
CLV_PCSK_KEX2_1	304	306	PF00082	0.286
CLV_PCSK_KEX2_1	454	456	PF00082	0.499
CLV_PCSK_PC1ET2_1	304	306	PF00082	0.276
CLV_PCSK_SKI1_1	256	260	PF00082	0.390
CLV_PCSK_SKI1_1	429	433	PF00082	0.409
DEG_Nend_Nbox_1	1	3	PF02207	0.286
DOC_CYCLIN_yClb1_LxF_4	252	258	PF00134	0.182
DOC_CYCLIN_yCln2_LP_2	361	367	PF00134	0.446
DOC_MAPK_gen_1	107	116	PF00069	0.280
DOC_MAPK_MEF2A_6	343	351	PF00069	0.321
DOC_MAPK_MEF2A_6	373	382	PF00069	0.516
DOC_MAPK_MEF2A_6	397	406	PF00069	0.326
DOC_MAPK_MEF2A_6	429	438	PF00069	0.532
DOC_PP1_RVXF_1	427	434	PF00149	0.556
DOC_PP1_RVXF_1	59	65	PF00149	0.339
DOC_PP4_FxxP_1	365	368	PF00568	0.457
DOC_USP7_MATH_1	224	228	PF00917	0.367
DOC_USP7_MATH_1	244	248	PF00917	0.364
DOC_USP7_MATH_1	381	385	PF00917	0.356
DOC_USP7_MATH_1	49	53	PF00917	0.448
DOC_USP7_MATH_1	73	77	PF00917	0.403
DOC_WW_Pin1_4	454	459	PF00397	0.697
LIG_14-3-3_CanoR_1	100	108	PF00244	0.164
LIG_14-3-3_CanoR_1	174	183	PF00244	0.528
LIG_14-3-3_CanoR_1	429	434	PF00244	0.650
LIG_Actin_WH2_2	139	155	PF00022	0.182
LIG_APCC_ABBA_1	391	396	PF00400	0.319
LIG_Clathr_ClatBox_1	332	336	PF01394	0.353
LIG_CtBP_PxDLS_1	232	236	PF00389	0.224
LIG_deltaCOP1_diTrp_1	171	175	PF00928	0.473
LIG_FHA_1	1	7	PF00498	0.347
LIG_FHA_1	115	121	PF00498	0.267
LIG_FHA_1	129	135	PF00498	0.328
LIG_FHA_1	171	177	PF00498	0.538
LIG_FHA_1	276	282	PF00498	0.422
LIG_FHA_1	397	403	PF00498	0.277
LIG_FHA_1	451	457	PF00498	0.742
LIG_FHA_2	189	195	PF00498	0.502
LIG_LIR_Apic_2	217	221	PF02991	0.320
LIG_LIR_Gen_1	169	179	PF02991	0.488
LIG_LIR_Gen_1	240	250	PF02991	0.296
LIG_LIR_Gen_1	312	323	PF02991	0.372
LIG_LIR_Gen_1	414	421	PF02991	0.410
LIG_LIR_Gen_1	432	438	PF02991	0.641
LIG_LIR_Gen_1	76	87	PF02991	0.310
LIG_LIR_Nem_3	169	175	PF02991	0.457
LIG_LIR_Nem_3	240	246	PF02991	0.284
LIG_LIR_Nem_3	312	318	PF02991	0.312
LIG_LIR_Nem_3	320	326	PF02991	0.280
LIG_LIR_Nem_3	350	354	PF02991	0.368
LIG_LIR_Nem_3	414	420	PF02991	0.311
LIG_LIR_Nem_3	432	436	PF02991	0.616
LIG_LIR_Nem_3	76	82	PF02991	0.325
LIG_LIR_Nem_3	89	94	PF02991	0.188
LIG_LYPXL_S_1	357	361	PF13949	0.318
LIG_LYPXL_S_1	86	90	PF13949	0.477
LIG_LYPXL_yS_3	358	361	PF13949	0.442
LIG_LYPXL_yS_3	87	90	PF13949	0.262
LIG_MAD2	429	437	PF02301	0.545
LIG_NRBOX	110	116	PF00104	0.338
LIG_NRBOX	144	150	PF00104	0.375
LIG_Pex14_1	238	242	PF04695	0.262
LIG_Pex14_1	311	315	PF04695	0.404
LIG_Pex14_2	156	160	PF04695	0.465
LIG_Pex14_2	365	369	PF04695	0.476
LIG_Pex14_2	411	415	PF04695	0.330
LIG_PTB_Apo_2	81	88	PF02174	0.250
LIG_PTB_Phospho_1	81	87	PF10480	0.262
LIG_SH2_GRB2like	157	160	PF00017	0.469
LIG_SH2_PTP2	218	221	PF00017	0.320
LIG_SH2_PTP2	79	82	PF00017	0.224
LIG_SH2_SRC	165	168	PF00017	0.498
LIG_SH2_SRC	218	221	PF00017	0.320
LIG_SH2_STAP1	118	122	PF00017	0.308
LIG_SH2_STAP1	2	6	PF00017	0.331
LIG_SH2_STAT3	147	150	PF00017	0.394
LIG_SH2_STAT5	147	150	PF00017	0.468
LIG_SH2_STAT5	157	160	PF00017	0.451
LIG_SH2_STAT5	165	168	PF00017	0.458
LIG_SH2_STAT5	2	5	PF00017	0.319
LIG_SH2_STAT5	218	221	PF00017	0.335
LIG_SH2_STAT5	360	363	PF00017	0.490
LIG_SH2_STAT5	417	420	PF00017	0.380
LIG_SH2_STAT5	69	72	PF00017	0.299
LIG_SH2_STAT5	79	82	PF00017	0.246
LIG_SH2_STAT5	94	97	PF00017	0.225
LIG_SH3_1	455	461	PF00018	0.602
LIG_SH3_3	155	161	PF00018	0.498
LIG_SH3_3	356	362	PF00018	0.460
LIG_SH3_3	431	437	PF00018	0.662
LIG_SH3_3	455	461	PF00018	0.780
LIG_SUMO_SIM_anti_2	24	30	PF11976	0.413
LIG_SUMO_SIM_anti_2	331	336	PF11976	0.340
LIG_SUMO_SIM_anti_2	396	402	PF11976	0.308
LIG_SUMO_SIM_par_1	131	139	PF11976	0.374
LIG_SUMO_SIM_par_1	21	27	PF11976	0.324
LIG_SUMO_SIM_par_1	231	236	PF11976	0.349
LIG_SUMO_SIM_par_1	331	336	PF11976	0.312
LIG_SUMO_SIM_par_1	344	350	PF11976	0.412
LIG_SUMO_SIM_par_1	39	45	PF11976	0.530
LIG_SxIP_EBH_1	201	214	PF03271	0.394
LIG_TYR_ITIM	77	82	PF00017	0.267
LIG_UBA3_1	57	61	PF00899	0.530
LIG_WRC_WIRS_1	1	6	PF05994	0.389
LIG_WRC_WIRS_1	348	353	PF05994	0.399
LIG_WRC_WIRS_1	412	417	PF05994	0.419
LIG_WRC_WIRS_1	430	435	PF05994	0.619
MOD_CK1_1	177	183	PF00069	0.470
MOD_CK1_1	199	205	PF00069	0.566
MOD_CK1_1	439	445	PF00069	0.712
MOD_CK2_1	181	187	PF00069	0.464
MOD_CK2_1	188	194	PF00069	0.432
MOD_GlcNHglycan	183	186	PF01048	0.286
MOD_GlcNHglycan	265	268	PF01048	0.276
MOD_GlcNHglycan	272	275	PF01048	0.236
MOD_GlcNHglycan	282	285	PF01048	0.280
MOD_GlcNHglycan	6	9	PF01048	0.467
MOD_GSK3_1	129	136	PF00069	0.321
MOD_GSK3_1	166	173	PF00069	0.473
MOD_GSK3_1	177	184	PF00069	0.456
MOD_GSK3_1	199	206	PF00069	0.486
MOD_GSK3_1	233	240	PF00069	0.282
MOD_GSK3_1	270	277	PF00069	0.298
MOD_GSK3_1	305	312	PF00069	0.459
MOD_GSK3_1	317	324	PF00069	0.310
MOD_GSK3_1	382	389	PF00069	0.290
MOD_GSK3_1	407	414	PF00069	0.389
MOD_GSK3_1	450	457	PF00069	0.792
MOD_GSK3_1	95	102	PF00069	0.233
MOD_NEK2_1	114	119	PF00069	0.245
MOD_NEK2_1	175	180	PF00069	0.463
MOD_NEK2_1	233	238	PF00069	0.349
MOD_NEK2_1	268	273	PF00069	0.278
MOD_NEK2_1	275	280	PF00069	0.417
MOD_NEK2_1	322	327	PF00069	0.331
MOD_NEK2_1	382	387	PF00069	0.338
MOD_NEK2_1	4	9	PF00069	0.312
MOD_NEK2_1	411	416	PF00069	0.394
MOD_NEK2_1	95	100	PF00069	0.322
MOD_PIKK_1	196	202	PF00454	0.379
MOD_PKA_2	439	445	PF00069	0.720
MOD_PKA_2	99	105	PF00069	0.194
MOD_Plk_1	170	176	PF00069	0.448
MOD_Plk_1	244	250	PF00069	0.314
MOD_Plk_4	129	135	PF00069	0.322
MOD_Plk_4	188	194	PF00069	0.497
MOD_Plk_4	203	209	PF00069	0.440
MOD_Plk_4	21	27	PF00069	0.304
MOD_Plk_4	314	320	PF00069	0.318
MOD_Plk_4	322	328	PF00069	0.317
MOD_Plk_4	386	392	PF00069	0.304
MOD_Plk_4	396	402	PF00069	0.261
MOD_Plk_4	407	413	PF00069	0.321
MOD_Plk_4	429	435	PF00069	0.636
MOD_Plk_4	73	79	PF00069	0.287
MOD_Plk_4	86	92	PF00069	0.257
MOD_ProDKin_1	454	460	PF00069	0.696
TRG_DiLeu_BaLyEn_6	206	211	PF01217	0.317
TRG_ENDOCYTIC_2	358	361	PF00928	0.452
TRG_ENDOCYTIC_2	417	420	PF00928	0.360
TRG_ENDOCYTIC_2	69	72	PF00928	0.290
TRG_ENDOCYTIC_2	79	82	PF00928	0.246
TRG_ENDOCYTIC_2	87	90	PF00928	0.238
TRG_ER_diArg_1	454	456	PF00400	0.689

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2T0	Leptomonas seymouri	69%	80%
A0A0N1PGN1	Leptomonas seymouri	34%	89%
A0A0S4IJF6	Bodo saltans	25%	80%
A0A0S4ISA5	Bodo saltans	23%	81%
A0A0S4JBT0	Bodo saltans	25%	90%
A0A1X0NNQ0	Trypanosomatidae	31%	74%
A0A1X0NV66	Trypanosomatidae	51%	89%
A0A1X0P501	Trypanosomatidae	36%	86%
A0A3R7M6P3	Trypanosoma rangeli	32%	76%
A0A3R7N0T9	Trypanosoma rangeli	52%	92%
A0A3S5IRV3	Trypanosoma rangeli	35%	92%
A0A3S7XA01	Leishmania donovani	35%	90%
A2X8M8	Oryza sativa subsp. indica	28%	88%
A4H6H7	Leishmania braziliensis	84%	100%
A4HNB0	Leishmania braziliensis	36%	100%
A4HUW5	Leishmania infantum	100%	100%
A4IBY1	Leishmania infantum	35%	100%
C9ZYM5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	95%
D0A7J0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	92%
E9AFR8	Leishmania major	35%	100%
E9ANJ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9B6X1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
Q4QH28	Leishmania major	95%	100%
Q6Z8D0	Oryza sativa subsp. japonica	28%	88%
Q9C6S4	Arabidopsis thaliana	27%	97%
Q9C6S5	Arabidopsis thaliana	28%	94%
Q9FFL1	Arabidopsis thaliana	30%	95%
Q9LH39	Arabidopsis thaliana	28%	97%
Q9LHN7	Arabidopsis thaliana	26%	97%
V5BCQ1	Trypanosoma cruzi	37%	100%
V5DDZ5	Trypanosoma cruzi	31%	74%