Major Facilitator Superfamily/Nodulin-like, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

major facilitator superfamily, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WRL4_LEIDO

TriTrypDb:

LdBPK_110680.1 , LdCL_110012200 , LDHU3_11.0880

Length:

622

Annotations

LeishMANIAdb annotations

Nutrient transporter belonging to the Major Facilitator Superfamily (MFS). Probable nutrient transporter. Heavily expanded in all parazitic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 97
NetGPI	no	yes: 0, no: 97

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	92
GO:0110165	cellular anatomical entity	1	92

Expansion

Sequence features

A0A3S7WRL4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WRL4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	43
GO:0022857	transmembrane transporter activity	2	43

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	607	611	PF00656	0.570
CLV_NRD_NRD_1	166	168	PF00675	0.359
CLV_NRD_NRD_1	39	41	PF00675	0.267
CLV_NRD_NRD_1	425	427	PF00675	0.368
CLV_NRD_NRD_1	565	567	PF00675	0.336
CLV_NRD_NRD_1	572	574	PF00675	0.362
CLV_NRD_NRD_1	617	619	PF00675	0.586
CLV_PCSK_KEX2_1	166	168	PF00082	0.374
CLV_PCSK_KEX2_1	39	41	PF00082	0.324
CLV_PCSK_KEX2_1	425	427	PF00082	0.350
CLV_PCSK_KEX2_1	565	567	PF00082	0.333
CLV_PCSK_KEX2_1	571	573	PF00082	0.341
CLV_PCSK_PC1ET2_1	425	427	PF00082	0.371
CLV_PCSK_SKI1_1	284	288	PF00082	0.600
CLV_PCSK_SKI1_1	458	462	PF00082	0.526
CLV_PCSK_SKI1_1	565	569	PF00082	0.344
DEG_APCC_DBOX_1	39	47	PF00400	0.477
DEG_Kelch_Keap1_1	329	334	PF01344	0.729
DEG_MDM2_SWIB_1	498	506	PF02201	0.415
DOC_CKS1_1	194	199	PF01111	0.190
DOC_CYCLIN_yClb5_NLxxxL_5	542	551	PF00134	0.215
DOC_CYCLIN_yCln2_LP_2	194	200	PF00134	0.384
DOC_MAPK_gen_1	166	173	PF00069	0.527
DOC_MAPK_gen_1	39	46	PF00069	0.472
DOC_MAPK_gen_1	425	434	PF00069	0.548
DOC_MAPK_gen_1	520	530	PF00069	0.417
DOC_MAPK_MEF2A_6	258	267	PF00069	0.487
DOC_MAPK_MEF2A_6	427	436	PF00069	0.546
DOC_MAPK_MEF2A_6	532	541	PF00069	0.313
DOC_PP2B_LxvP_1	453	456	PF13499	0.420
DOC_PP4_FxxP_1	438	441	PF00568	0.421
DOC_PP4_FxxP_1	91	94	PF00568	0.324
DOC_SPAK_OSR1_1	136	140	PF12202	0.321
DOC_USP7_MATH_1	274	278	PF00917	0.353
DOC_USP7_MATH_1	456	460	PF00917	0.408
DOC_USP7_MATH_1	465	469	PF00917	0.330
DOC_USP7_MATH_1	54	58	PF00917	0.329
DOC_USP7_MATH_1	580	584	PF00917	0.690
DOC_USP7_MATH_1	601	605	PF00917	0.666
DOC_USP7_UBL2_3	488	492	PF12436	0.477
DOC_WW_Pin1_4	193	198	PF00397	0.337
DOC_WW_Pin1_4	378	383	PF00397	0.419
DOC_WW_Pin1_4	387	392	PF00397	0.393
LIG_14-3-3_CanoR_1	233	241	PF00244	0.546
LIG_14-3-3_CanoR_1	318	324	PF00244	0.586
LIG_14-3-3_CanoR_1	33	41	PF00244	0.550
LIG_14-3-3_CanoR_1	413	419	PF00244	0.306
LIG_14-3-3_CanoR_1	431	437	PF00244	0.417
LIG_14-3-3_CanoR_1	76	84	PF00244	0.334
LIG_Actin_WH2_2	560	577	PF00022	0.623
LIG_BRCT_BRCA1_1	147	151	PF00533	0.413
LIG_BRCT_BRCA1_1	380	384	PF00533	0.385
LIG_BRCT_BRCA1_1	56	60	PF00533	0.370
LIG_FHA_1	274	280	PF00498	0.339
LIG_FHA_1	346	352	PF00498	0.509
LIG_FHA_1	354	360	PF00498	0.493
LIG_FHA_1	388	394	PF00498	0.383
LIG_FHA_1	440	446	PF00498	0.344
LIG_FHA_1	448	454	PF00498	0.334
LIG_FHA_1	476	482	PF00498	0.306
LIG_FHA_1	546	552	PF00498	0.392
LIG_FHA_2	335	341	PF00498	0.517
LIG_FHA_2	95	101	PF00498	0.470
LIG_GBD_Chelix_1	170	178	PF00786	0.430
LIG_GBD_Chelix_1	265	273	PF00786	0.315
LIG_GBD_Chelix_1	503	511	PF00786	0.387
LIG_IRF3_LxIS_1	554	559	PF10401	0.520
LIG_LIR_Apic_2	100	104	PF02991	0.470
LIG_LIR_Apic_2	338	344	PF02991	0.510
LIG_LIR_Apic_2	435	441	PF02991	0.384
LIG_LIR_Gen_1	303	314	PF02991	0.360
LIG_LIR_Gen_1	358	367	PF02991	0.345
LIG_LIR_Gen_1	373	382	PF02991	0.373
LIG_LIR_Gen_1	450	460	PF02991	0.338
LIG_LIR_Gen_1	48	54	PF02991	0.327
LIG_LIR_Gen_1	552	563	PF02991	0.363
LIG_LIR_Gen_1	57	67	PF02991	0.353
LIG_LIR_Gen_1	97	107	PF02991	0.422
LIG_LIR_Nem_3	125	129	PF02991	0.263
LIG_LIR_Nem_3	358	363	PF02991	0.311
LIG_LIR_Nem_3	365	370	PF02991	0.310
LIG_LIR_Nem_3	373	377	PF02991	0.337
LIG_LIR_Nem_3	381	387	PF02991	0.340
LIG_LIR_Nem_3	417	422	PF02991	0.552
LIG_LIR_Nem_3	450	455	PF02991	0.260
LIG_LIR_Nem_3	48	52	PF02991	0.351
LIG_LIR_Nem_3	552	558	PF02991	0.325
LIG_LIR_Nem_3	559	563	PF02991	0.481
LIG_LIR_Nem_3	57	63	PF02991	0.336
LIG_LIR_Nem_3	97	102	PF02991	0.372
LIG_NRBOX	116	122	PF00104	0.285
LIG_NRBOX	507	513	PF00104	0.304
LIG_NRBOX	546	552	PF00104	0.476
LIG_PAM2_1	192	204	PF00658	0.190
LIG_Pex14_2	374	378	PF04695	0.373
LIG_Pex14_2	498	502	PF04695	0.398
LIG_SH2_CRK	41	45	PF00017	0.328
LIG_SH2_CRK	95	99	PF00017	0.329
LIG_SH2_PTP2	341	344	PF00017	0.503
LIG_SH2_SRC	555	558	PF00017	0.476
LIG_SH2_SRC	600	603	PF00017	0.775
LIG_SH2_STAP1	58	62	PF00017	0.358
LIG_SH2_STAT3	249	252	PF00017	0.478
LIG_SH2_STAT5	101	104	PF00017	0.491
LIG_SH2_STAT5	108	111	PF00017	0.331
LIG_SH2_STAT5	200	203	PF00017	0.331
LIG_SH2_STAT5	249	252	PF00017	0.499
LIG_SH2_STAT5	260	263	PF00017	0.316
LIG_SH2_STAT5	272	275	PF00017	0.315
LIG_SH2_STAT5	341	344	PF00017	0.509
LIG_SH2_STAT5	422	425	PF00017	0.555
LIG_SH2_STAT5	555	558	PF00017	0.332
LIG_SH2_STAT5	90	93	PF00017	0.308
LIG_SH3_2	586	591	PF14604	0.770
LIG_SH3_3	268	274	PF00018	0.329
LIG_SH3_3	308	314	PF00018	0.372
LIG_SH3_3	532	538	PF00018	0.327
LIG_SH3_3	583	589	PF00018	0.678
LIG_SUMO_SIM_anti_2	262	267	PF11976	0.378
LIG_SUMO_SIM_anti_2	442	448	PF11976	0.320
LIG_SUMO_SIM_anti_2	476	481	PF11976	0.341
LIG_SUMO_SIM_par_1	142	148	PF11976	0.341
LIG_SUMO_SIM_par_1	206	211	PF11976	0.370
LIG_SUMO_SIM_par_1	42	48	PF11976	0.436
LIG_SUMO_SIM_par_1	442	448	PF11976	0.323
LIG_SUMO_SIM_par_1	478	484	PF11976	0.294
LIG_TRFH_1	90	94	PF08558	0.372
LIG_TYR_ITIM	93	98	PF00017	0.346
LIG_UBA3_1	383	392	PF00899	0.401
LIG_WRC_WIRS_1	46	51	PF05994	0.420
MOD_CDK_SPK_2	387	392	PF00069	0.261
MOD_CK1_1	145	151	PF00069	0.361
MOD_CK1_1	187	193	PF00069	0.385
MOD_CK1_1	232	238	PF00069	0.618
MOD_CK1_1	329	335	PF00069	0.650
MOD_CK1_1	353	359	PF00069	0.511
MOD_CK1_1	385	391	PF00069	0.371
MOD_CK1_1	561	567	PF00069	0.564
MOD_CK1_1	604	610	PF00069	0.761
MOD_CK2_1	15	21	PF00069	0.637
MOD_CK2_1	414	420	PF00069	0.377
MOD_CK2_1	5	11	PF00069	0.624
MOD_GlcNHglycan	181	184	PF01048	0.326
MOD_GlcNHglycan	276	279	PF01048	0.343
MOD_GlcNHglycan	326	331	PF01048	0.479
MOD_GlcNHglycan	384	387	PF01048	0.526
MOD_GlcNHglycan	397	400	PF01048	0.331
MOD_GlcNHglycan	408	411	PF01048	0.283
MOD_GlcNHglycan	603	606	PF01048	0.504
MOD_GlcNHglycan	63	66	PF01048	0.473
MOD_GSK3_1	158	165	PF00069	0.346
MOD_GSK3_1	220	227	PF00069	0.511
MOD_GSK3_1	346	353	PF00069	0.536
MOD_GSK3_1	378	385	PF00069	0.377
MOD_GSK3_1	395	402	PF00069	0.295
MOD_GSK3_1	545	552	PF00069	0.388
MOD_GSK3_1	604	611	PF00069	0.725
MOD_GSK3_1	72	79	PF00069	0.279
MOD_N-GLC_1	378	383	PF02516	0.584
MOD_N-GLC_1	545	550	PF02516	0.292
MOD_NEK2_1	122	127	PF00069	0.302
MOD_NEK2_1	173	178	PF00069	0.395
MOD_NEK2_1	259	264	PF00069	0.355
MOD_NEK2_1	27	32	PF00069	0.579
MOD_NEK2_1	350	355	PF00069	0.508
MOD_NEK2_1	393	398	PF00069	0.358
MOD_NEK2_1	414	419	PF00069	0.383
MOD_NEK2_1	447	452	PF00069	0.301
MOD_NEK2_1	473	478	PF00069	0.338
MOD_NEK2_1	545	550	PF00069	0.339
MOD_NEK2_1	556	561	PF00069	0.331
MOD_NEK2_1	63	68	PF00069	0.276
MOD_NEK2_2	94	99	PF00069	0.487
MOD_PIKK_1	145	151	PF00454	0.415
MOD_PIKK_1	248	254	PF00454	0.541
MOD_PIKK_1	285	291	PF00454	0.359
MOD_PIKK_1	420	426	PF00454	0.532
MOD_PKA_2	232	238	PF00069	0.521
MOD_PKA_2	317	323	PF00069	0.563
MOD_PKA_2	561	567	PF00069	0.499
MOD_Plk_1	393	399	PF00069	0.346
MOD_Plk_1	545	551	PF00069	0.311
MOD_Plk_2-3	334	340	PF00069	0.608
MOD_Plk_2-3	5	11	PF00069	0.492
MOD_Plk_4	130	136	PF00069	0.277
MOD_Plk_4	152	158	PF00069	0.320
MOD_Plk_4	173	179	PF00069	0.365
MOD_Plk_4	346	352	PF00069	0.513
MOD_Plk_4	355	361	PF00069	0.478
MOD_Plk_4	399	405	PF00069	0.316
MOD_Plk_4	414	420	PF00069	0.337
MOD_Plk_4	440	446	PF00069	0.330
MOD_Plk_4	447	453	PF00069	0.321
MOD_Plk_4	94	100	PF00069	0.381
MOD_ProDKin_1	193	199	PF00069	0.337
MOD_ProDKin_1	378	384	PF00069	0.415
MOD_ProDKin_1	387	393	PF00069	0.390
MOD_SUMO_rev_2	232	241	PF00179	0.555
TRG_DiLeu_BaLyEn_6	507	512	PF01217	0.329
TRG_DiLeu_BaLyEn_6	535	540	PF01217	0.319
TRG_ENDOCYTIC_2	200	203	PF00928	0.302
TRG_ENDOCYTIC_2	260	263	PF00928	0.376
TRG_ENDOCYTIC_2	41	44	PF00928	0.296
TRG_ENDOCYTIC_2	555	558	PF00928	0.378
TRG_ENDOCYTIC_2	560	563	PF00928	0.513
TRG_ENDOCYTIC_2	90	93	PF00928	0.317
TRG_ENDOCYTIC_2	95	98	PF00928	0.330
TRG_ENDOCYTIC_2	99	102	PF00928	0.489
TRG_ER_diArg_1	39	41	PF00400	0.441
TRG_ER_diArg_1	565	567	PF00400	0.548
TRG_ER_diArg_1	571	573	PF00400	0.556
TRG_NLS_MonoCore_2	617	622	PF00514	0.581
TRG_Pf-PMV_PEXEL_1	33	37	PF00026	0.412
TRG_Pf-PMV_PEXEL_1	510	515	PF00026	0.414
TRG_Pf-PMV_PEXEL_1	566	570	PF00026	0.357
TRG_Pf-PMV_PEXEL_1	572	576	PF00026	0.385

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6G0	Leptomonas seymouri	38%	98%
A0A0N1HT40	Leptomonas seymouri	74%	100%
A0A0N1HZC2	Leptomonas seymouri	28%	99%
A0A0N1IKC5	Leptomonas seymouri	47%	100%
A0A0N1PB63	Leptomonas seymouri	27%	94%
A0A0S4IIJ4	Bodo saltans	22%	100%
A0A0S4JR45	Bodo saltans	33%	100%
A0A1X0NKK0	Trypanosomatidae	33%	100%
A0A1X0NL32	Trypanosomatidae	34%	99%
A0A1X0NM09	Trypanosomatidae	31%	100%
A0A1X0NRW5	Trypanosomatidae	40%	89%
A0A1X0NV13	Trypanosomatidae	49%	96%
A0A1X0NV19	Trypanosomatidae	48%	100%
A0A1X0NV27	Trypanosomatidae	49%	100%
A0A1X0NVH8	Trypanosomatidae	45%	94%
A0A1X0NVM7	Trypanosomatidae	53%	96%
A0A1X0NWQ1	Trypanosomatidae	44%	97%
A0A1X0NZE6	Trypanosomatidae	33%	100%
A0A1X0NZU2	Trypanosomatidae	28%	96%
A0A1X0NZU5	Trypanosomatidae	34%	100%
A0A1X0NZW1	Trypanosomatidae	29%	100%
A0A1X0P0M7	Trypanosomatidae	32%	100%
A0A3Q8I7Y9	Leishmania donovani	100%	100%
A0A3Q8IF95	Leishmania donovani	29%	100%
A0A3Q8ISY9	Leishmania donovani	38%	100%
A0A3R7JSQ9	Trypanosoma rangeli	29%	100%
A0A3R7KKN8	Trypanosoma rangeli	30%	100%
A0A3R7MAQ7	Trypanosoma rangeli	35%	88%
A0A3R7N415	Trypanosoma rangeli	30%	100%
A0A3R7N921	Trypanosoma rangeli	28%	100%
A0A3R7R443	Trypanosoma rangeli	29%	100%
A0A3S7WRJ4	Leishmania donovani	46%	98%
A0A3S7WRJ5	Leishmania donovani	40%	100%
A0A3S7WSR4	Leishmania donovani	45%	100%
A0A3S7WWU1	Leishmania donovani	28%	94%
A0A3S7XB11	Leishmania donovani	29%	100%
A0A422MSE4	Trypanosoma rangeli	48%	100%
A0A422MSP6	Trypanosoma rangeli	34%	100%
A0A422MST9	Trypanosoma rangeli	29%	100%
A0A422MU68	Trypanosoma rangeli	27%	100%
A4H6J0	Leishmania braziliensis	45%	100%
A4H6J1	Leishmania braziliensis	45%	100%
A4H6J3	Leishmania braziliensis	84%	100%
A4HC19	Leishmania braziliensis	27%	100%
A4HJW3	Leishmania braziliensis	38%	100%
A4HPE2	Leishmania braziliensis	29%	100%
A4HUX5	Leishmania infantum	46%	98%
A4HUX6	Leishmania infantum	41%	100%
A4HUX7	Leishmania infantum	99%	100%
A4HUX8	Leishmania infantum	97%	100%
A4HZF5	Leishmania infantum	29%	100%
A4HZJ4	Leishmania infantum	27%	100%
A4I7C5	Leishmania infantum	38%	100%
A4ICI3	Leishmania infantum	29%	100%
C9ZL97	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
C9ZL98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
C9ZL99	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
C9ZLA0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
C9ZLA1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
C9ZTR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
C9ZTR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
C9ZTR7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
C9ZTR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
C9ZTR9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
C9ZTS1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
C9ZUT6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
D0A7H1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
D0AAQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	91%
E8NHE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AGK5	Leishmania infantum	45%	100%
E9ANL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9ANL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9ANL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9APJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AT53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AVF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AVF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B2B8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
Q4Q1E4	Leishmania major	29%	100%
Q4Q5T8	Leishmania major	37%	100%
Q4QC27	Leishmania major	28%	100%
Q4QC28	Leishmania major	31%	100%
Q4QFY5	Leishmania major	45%	100%
Q4QH10	Leishmania major	96%	100%
Q4QH11	Leishmania major	97%	100%
Q4QH12	Leishmania major	97%	100%
Q4QH13	Leishmania major	97%	100%
Q4QH14	Leishmania major	41%	100%
Q4QH15	Leishmania major	47%	100%
V5B647	Trypanosoma cruzi	46%	99%
V5B983	Trypanosoma cruzi	33%	100%
V5BBB1	Trypanosoma cruzi	45%	100%
V5BFV8	Trypanosoma cruzi	30%	93%
V5BQY6	Trypanosoma cruzi	38%	88%
V5BVP0	Trypanosoma cruzi	47%	100%
V5DT25	Trypanosoma cruzi	57%	100%