Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WRK9_LEIDO

TriTrypDb:

LdBPK_110790.1 , LdCL_110013300 , LDHU3_11.0990

Length:

256

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WRK9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WRK9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	83	85	PF00675	0.649
CLV_PCSK_KEX2_1	82	84	PF00082	0.543
CLV_PCSK_SKI1_1	177	181	PF00082	0.348
CLV_PCSK_SKI1_1	193	197	PF00082	0.308
CLV_PCSK_SKI1_1	221	225	PF00082	0.457
CLV_PCSK_SKI1_1	52	56	PF00082	0.486
DEG_APCC_DBOX_1	180	188	PF00400	0.284
DEG_SPOP_SBC_1	222	226	PF00917	0.461
DOC_CKS1_1	10	15	PF01111	0.555
DOC_USP7_MATH_1	122	126	PF00917	0.440
DOC_USP7_MATH_1	14	18	PF00917	0.519
DOC_USP7_MATH_1	248	252	PF00917	0.532
DOC_USP7_UBL2_3	110	114	PF12436	0.418
DOC_USP7_UBL2_3	249	253	PF12436	0.616
DOC_WW_Pin1_4	166	171	PF00397	0.449
DOC_WW_Pin1_4	9	14	PF00397	0.563
LIG_14-3-3_CanoR_1	117	124	PF00244	0.374
LIG_APCC_ABBA_1	21	26	PF00400	0.579
LIG_FHA_1	70	76	PF00498	0.377
LIG_FHA_2	222	228	PF00498	0.514
LIG_FHA_2	71	77	PF00498	0.497
LIG_LIR_Nem_3	173	179	PF02991	0.420
LIG_LIR_Nem_3	201	207	PF02991	0.414
LIG_SH2_CRK	176	180	PF00017	0.326
LIG_SH2_SRC	245	248	PF00017	0.619
LIG_SH2_STAP1	71	75	PF00017	0.310
LIG_SH2_STAT5	123	126	PF00017	0.353
LIG_SH2_STAT5	219	222	PF00017	0.523
LIG_SH2_STAT5	245	248	PF00017	0.553
LIG_SH2_STAT5	62	65	PF00017	0.404
LIG_SH2_STAT5	71	74	PF00017	0.366
LIG_TRAF2_1	45	48	PF00917	0.467
LIG_TRFH_1	244	248	PF08558	0.526
LIG_TYR_ITIM	63	68	PF00017	0.343
MOD_CDK_SPxK_1	9	15	PF00069	0.563
MOD_CK1_1	125	131	PF00069	0.436
MOD_CK1_1	17	23	PF00069	0.450
MOD_CK1_1	98	104	PF00069	0.644
MOD_CK2_1	221	227	PF00069	0.484
MOD_CK2_1	70	76	PF00069	0.492
MOD_CK2_1	98	104	PF00069	0.596
MOD_GlcNHglycan	138	141	PF01048	0.400
MOD_GSK3_1	122	129	PF00069	0.408
MOD_GSK3_1	160	167	PF00069	0.477
MOD_GSK3_1	95	102	PF00069	0.644
MOD_PIKK_1	126	132	PF00454	0.423
MOD_PIKK_1	14	20	PF00454	0.450
MOD_PIKK_1	248	254	PF00454	0.470
MOD_PKA_2	116	122	PF00069	0.340
MOD_PKA_2	69	75	PF00069	0.431
MOD_ProDKin_1	166	172	PF00069	0.436
MOD_ProDKin_1	9	15	PF00069	0.563
MOD_SUMO_rev_2	22	29	PF00179	0.522
MOD_SUMO_rev_2	76	81	PF00179	0.489
TRG_DiLeu_BaEn_1	76	81	PF01217	0.428
TRG_ENDOCYTIC_2	176	179	PF00928	0.335
TRG_ENDOCYTIC_2	65	68	PF00928	0.354
TRG_ER_diArg_1	81	84	PF00400	0.582

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKT7	Leptomonas seymouri	76%	100%
A0A0S4JTR3	Bodo saltans	50%	100%
A0A1X0NV10	Trypanosomatidae	52%	100%
A4H6K3	Leishmania braziliensis	88%	100%
A4HUY8	Leishmania infantum	100%	100%
D0A7G3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9ANM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QH00	Leishmania major	96%	100%
V5C1A3	Trypanosoma cruzi	52%	100%