NIF3 (NGG1p interacting factor 3) family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NGG1 interacting factor 3-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7WRI8_LEIDO

TriTrypDb:

LdBPK_110130.1 , LdCL_110006200 , LDHU3_11.0150

Length:

279

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WRI8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WRI8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0003933	GTP cyclohydrolase activity	6	1
GO:0003934	GTP cyclohydrolase I activity	7	1
GO:0016787	hydrolase activity	2	1
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	1
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	4	1
GO:0019238	cyclohydrolase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.444
CLV_PCSK_KEX2_1	76	78	PF00082	0.246
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.247
CLV_PCSK_SKI1_1	152	156	PF00082	0.294
CLV_PCSK_SKI1_1	179	183	PF00082	0.328
CLV_PCSK_SKI1_1	246	250	PF00082	0.302
CLV_PCSK_SKI1_1	73	77	PF00082	0.250
CLV_PCSK_SKI1_1	86	90	PF00082	0.207
DEG_APCC_DBOX_1	245	253	PF00400	0.500
DOC_CYCLIN_RxL_1	73	82	PF00134	0.447
DOC_CYCLIN_yCln2_LP_2	209	215	PF00134	0.533
DOC_MAPK_gen_1	152	162	PF00069	0.550
DOC_MAPK_gen_1	207	217	PF00069	0.460
DOC_MAPK_MEF2A_6	207	215	PF00069	0.455
DOC_MAPK_MEF2A_6	38	46	PF00069	0.503
DOC_PP2B_LxvP_1	209	212	PF13499	0.533
DOC_USP7_MATH_1	101	105	PF00917	0.423
DOC_USP7_MATH_1	133	137	PF00917	0.507
DOC_USP7_MATH_1	20	24	PF00917	0.454
DOC_USP7_MATH_1	36	40	PF00917	0.454
DOC_USP7_MATH_1	94	98	PF00917	0.461
DOC_WW_Pin1_4	126	131	PF00397	0.493
DOC_WW_Pin1_4	30	35	PF00397	0.446
DOC_WW_Pin1_4	46	51	PF00397	0.363
LIG_14-3-3_CanoR_1	77	81	PF00244	0.464
LIG_BIR_II_1	1	5	PF00653	0.434
LIG_CtBP_PxDLS_1	16	20	PF00389	0.530
LIG_FHA_1	175	181	PF00498	0.443
LIG_FHA_1	262	268	PF00498	0.476
LIG_FHA_1	43	49	PF00498	0.432
LIG_FHA_2	101	107	PF00498	0.442
LIG_FHA_2	240	246	PF00498	0.447
LIG_FHA_2	77	83	PF00498	0.477
LIG_LIR_Gen_1	159	169	PF02991	0.519
LIG_LIR_Gen_1	21	31	PF02991	0.435
LIG_LIR_Nem_3	203	209	PF02991	0.419
LIG_LIR_Nem_3	21	27	PF02991	0.435
LIG_SH2_CRK	67	71	PF00017	0.435
LIG_SH2_SRC	99	102	PF00017	0.533
LIG_SH2_STAT5	126	129	PF00017	0.530
LIG_SH3_3	127	133	PF00018	0.447
LIG_SH3_3	177	183	PF00018	0.435
LIG_SUMO_SIM_par_1	15	21	PF11976	0.500
LIG_SUMO_SIM_par_1	264	270	PF11976	0.495
LIG_SUMO_SIM_par_1	42	47	PF11976	0.441
MOD_CK1_1	201	207	PF00069	0.504
MOD_CK2_1	239	245	PF00069	0.435
MOD_GlcNHglycan	200	203	PF01048	0.261
MOD_GlcNHglycan	217	220	PF01048	0.249
MOD_GlcNHglycan	92	95	PF01048	0.361
MOD_GSK3_1	161	168	PF00069	0.467
MOD_GSK3_1	182	189	PF00069	0.464
MOD_GSK3_1	215	222	PF00069	0.557
MOD_GSK3_1	262	269	PF00069	0.484
MOD_GSK3_1	42	49	PF00069	0.439
MOD_GSK3_1	90	97	PF00069	0.464
MOD_N-GLC_1	36	41	PF02516	0.261
MOD_NEK2_1	165	170	PF00069	0.530
MOD_NEK2_1	227	232	PF00069	0.533
MOD_NEK2_1	253	258	PF00069	0.544
MOD_NEK2_1	261	266	PF00069	0.471
MOD_NEK2_2	174	179	PF00069	0.553
MOD_NEK2_2	94	99	PF00069	0.500
MOD_PK_1	191	197	PF00069	0.530
MOD_PKA_1	76	82	PF00069	0.461
MOD_PKA_2	76	82	PF00069	0.463
MOD_Plk_1	20	26	PF00069	0.435
MOD_Plk_4	115	121	PF00069	0.436
MOD_Plk_4	161	167	PF00069	0.462
MOD_Plk_4	201	207	PF00069	0.465
MOD_Plk_4	262	268	PF00069	0.506
MOD_Plk_4	94	100	PF00069	0.435
MOD_ProDKin_1	126	132	PF00069	0.493
MOD_ProDKin_1	30	36	PF00069	0.446
MOD_ProDKin_1	46	52	PF00069	0.363
MOD_SUMO_for_1	156	159	PF00179	0.533
MOD_SUMO_for_1	259	262	PF00179	0.483
TRG_DiLeu_BaLyEn_6	204	209	PF01217	0.530
TRG_Pf-PMV_PEXEL_1	86	90	PF00026	0.312

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I283	Leptomonas seymouri	76%	100%
A0A0S4JZ92	Bodo saltans	54%	100%
A0A1X0NVI4	Trypanosomatidae	57%	100%
A0A3R7LAW5	Trypanosoma rangeli	56%	98%
A4H9U5	Leishmania braziliensis	91%	100%
A4HUS5	Leishmania infantum	100%	100%
D0A7N9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	99%
E9ANF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
O94404	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	43%	100%
P53081	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	97%
Q4QH67	Leishmania major	99%	100%
Q8XIV9	Clostridium perfringens (strain 13 / Type A)	27%	100%
Q8YS75	Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)	25%	100%
Q97JI0	Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)	27%	100%
Q9CGM3	Lactococcus lactis subsp. lactis (strain IL1403)	25%	100%
Q9L012	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	24%	98%
Q9NK57	Drosophila melanogaster	37%	96%
V5BRI2	Trypanosoma cruzi	58%	98%