Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7WRI4_LEIDO

TriTrypDb:

LdBPK_110290.1 , LdCL_110007800 , LDHU3_11.0350

Length:

463

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WRI4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WRI4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	245	249	PF00656	0.635
CLV_NRD_NRD_1	309	311	PF00675	0.632
CLV_NRD_NRD_1	344	346	PF00675	0.668
CLV_NRD_NRD_1	38	40	PF00675	0.710
CLV_NRD_NRD_1	430	432	PF00675	0.625
CLV_NRD_NRD_1	68	70	PF00675	0.677
CLV_NRD_NRD_1	83	85	PF00675	0.617
CLV_PCSK_FUR_1	352	356	PF00082	0.670
CLV_PCSK_FUR_1	36	40	PF00082	0.694
CLV_PCSK_KEX2_1	309	311	PF00082	0.632
CLV_PCSK_KEX2_1	344	346	PF00082	0.668
CLV_PCSK_KEX2_1	354	356	PF00082	0.716
CLV_PCSK_KEX2_1	38	40	PF00082	0.695
CLV_PCSK_KEX2_1	430	432	PF00082	0.625
CLV_PCSK_KEX2_1	48	50	PF00082	0.566
CLV_PCSK_KEX2_1	68	70	PF00082	0.559
CLV_PCSK_PC1ET2_1	354	356	PF00082	0.716
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.610
CLV_PCSK_PC7_1	340	346	PF00082	0.665
CLV_PCSK_PC7_1	426	432	PF00082	0.637
CLV_PCSK_SKI1_1	27	31	PF00082	0.638
CLV_PCSK_SKI1_1	309	313	PF00082	0.714
CLV_PCSK_SKI1_1	345	349	PF00082	0.698
CLV_PCSK_SKI1_1	84	88	PF00082	0.632
DEG_Nend_Nbox_1	1	3	PF02207	0.543
DEG_SCF_FBW7_1	100	106	PF00400	0.678
DEG_SPOP_SBC_1	116	120	PF00917	0.593
DOC_ANK_TNKS_1	354	361	PF00023	0.690
DOC_CKS1_1	100	105	PF01111	0.633
DOC_CKS1_1	237	242	PF01111	0.719
DOC_CKS1_1	417	422	PF01111	0.602
DOC_CYCLIN_RxL_1	306	315	PF00134	0.697
DOC_MAPK_MEF2A_6	3	12	PF00069	0.555
DOC_PP1_RVXF_1	239	245	PF00149	0.582
DOC_PP2B_LxvP_1	95	98	PF13499	0.711
DOC_PP4_FxxP_1	237	240	PF00568	0.728
DOC_PP4_FxxP_1	347	350	PF00568	0.637
DOC_USP7_MATH_1	107	111	PF00917	0.736
DOC_USP7_MATH_1	134	138	PF00917	0.724
DOC_USP7_MATH_1	146	150	PF00917	0.613
DOC_USP7_MATH_1	164	168	PF00917	0.537
DOC_USP7_MATH_1	29	33	PF00917	0.596
DOC_USP7_MATH_1	437	441	PF00917	0.593
DOC_USP7_MATH_1	53	57	PF00917	0.613
DOC_WW_Pin1_4	103	108	PF00397	0.663
DOC_WW_Pin1_4	130	135	PF00397	0.695
DOC_WW_Pin1_4	142	147	PF00397	0.607
DOC_WW_Pin1_4	181	186	PF00397	0.705
DOC_WW_Pin1_4	236	241	PF00397	0.729
DOC_WW_Pin1_4	292	297	PF00397	0.838
DOC_WW_Pin1_4	30	35	PF00397	0.527
DOC_WW_Pin1_4	416	421	PF00397	0.602
DOC_WW_Pin1_4	96	101	PF00397	0.669
LIG_14-3-3_CanoR_1	214	221	PF00244	0.711
LIG_14-3-3_CanoR_1	84	93	PF00244	0.604
LIG_Clathr_ClatBox_1	311	315	PF01394	0.677
LIG_FHA_1	100	106	PF00498	0.692
LIG_FHA_1	237	243	PF00498	0.668
LIG_FHA_1	397	403	PF00498	0.602
LIG_FHA_1	75	81	PF00498	0.599
LIG_FHA_2	185	191	PF00498	0.589
LIG_FHA_2	436	442	PF00498	0.570
LIG_FHA_2	85	91	PF00498	0.695
LIG_LIR_Apic_2	336	341	PF02991	0.688
LIG_LIR_Gen_1	381	391	PF02991	0.727
LIG_LIR_Gen_1	394	402	PF02991	0.505
LIG_LIR_Nem_3	255	260	PF02991	0.563
LIG_LIR_Nem_3	381	386	PF02991	0.737
LIG_LIR_Nem_3	394	398	PF02991	0.492
LIG_MYND_1	346	350	PF01753	0.686
LIG_SH2_CRK	338	342	PF00017	0.693
LIG_SH2_CRK	383	387	PF00017	0.610
LIG_SH2_NCK_1	338	342	PF00017	0.645
LIG_SH2_STAP1	383	387	PF00017	0.610
LIG_SH2_STAT5	252	255	PF00017	0.684
LIG_SH3_1	414	420	PF00018	0.665
LIG_SH3_3	125	131	PF00018	0.681
LIG_SH3_3	140	146	PF00018	0.567
LIG_SH3_3	290	296	PF00018	0.730
LIG_SH3_3	343	349	PF00018	0.704
LIG_SH3_3	414	420	PF00018	0.786
LIG_SH3_3	97	103	PF00018	0.700
LIG_SUMO_SIM_par_1	251	259	PF11976	0.552
LIG_TRAF2_1	210	213	PF00917	0.595
LIG_TRFH_1	312	316	PF08558	0.675
LIG_WRC_WIRS_1	172	177	PF05994	0.607
LIG_WRC_WIRS_1	445	450	PF05994	0.596
MOD_CDC14_SPxK_1	145	148	PF00782	0.682
MOD_CDC14_SPxK_1	33	36	PF00782	0.546
MOD_CDK_SPK_2	236	241	PF00069	0.681
MOD_CDK_SPxK_1	142	148	PF00069	0.680
MOD_CDK_SPxK_1	30	36	PF00069	0.533
MOD_CDK_SPxxK_3	236	243	PF00069	0.658
MOD_CK1_1	133	139	PF00069	0.703
MOD_CK1_1	151	157	PF00069	0.534
MOD_CK1_1	173	179	PF00069	0.680
MOD_CK1_1	207	213	PF00069	0.617
MOD_CK1_1	215	221	PF00069	0.733
MOD_CK1_1	255	261	PF00069	0.636
MOD_CK1_1	99	105	PF00069	0.732
MOD_CK2_1	207	213	PF00069	0.739
MOD_CK2_1	259	265	PF00069	0.639
MOD_CK2_1	322	328	PF00069	0.741
MOD_CK2_1	368	374	PF00069	0.584
MOD_CK2_1	435	441	PF00069	0.575
MOD_CK2_1	53	59	PF00069	0.702
MOD_Cter_Amidation	66	69	PF01082	0.608
MOD_GlcNHglycan	136	139	PF01048	0.674
MOD_GlcNHglycan	140	143	PF01048	0.694
MOD_GlcNHglycan	148	151	PF01048	0.614
MOD_GlcNHglycan	153	156	PF01048	0.542
MOD_GlcNHglycan	193	196	PF01048	0.630
MOD_GlcNHglycan	324	327	PF01048	0.742
MOD_GlcNHglycan	330	333	PF01048	0.696
MOD_GlcNHglycan	359	363	PF01048	0.683
MOD_GlcNHglycan	435	438	PF01048	0.627
MOD_GlcNHglycan	63	66	PF01048	0.590
MOD_GSK3_1	130	137	PF00069	0.688
MOD_GSK3_1	138	145	PF00069	0.694
MOD_GSK3_1	146	153	PF00069	0.659
MOD_GSK3_1	203	210	PF00069	0.686
MOD_GSK3_1	212	219	PF00069	0.721
MOD_GSK3_1	225	232	PF00069	0.605
MOD_GSK3_1	248	255	PF00069	0.552
MOD_GSK3_1	256	263	PF00069	0.610
MOD_GSK3_1	393	400	PF00069	0.492
MOD_GSK3_1	412	419	PF00069	0.658
MOD_GSK3_1	431	438	PF00069	0.525
MOD_GSK3_1	53	60	PF00069	0.796
MOD_GSK3_1	84	91	PF00069	0.715
MOD_GSK3_1	99	106	PF00069	0.669
MOD_N-GLC_1	108	113	PF02516	0.601
MOD_N-GLC_1	116	121	PF02516	0.542
MOD_NEK2_1	203	208	PF00069	0.709
MOD_NEK2_1	93	98	PF00069	0.690
MOD_NEK2_2	252	257	PF00069	0.547
MOD_PIKK_1	10	16	PF00454	0.562
MOD_PIKK_1	79	85	PF00454	0.697
MOD_PKA_1	84	90	PF00069	0.564
MOD_PKA_2	213	219	PF00069	0.699
MOD_PKA_2	225	231	PF00069	0.649
MOD_PKA_2	425	431	PF00069	0.725
MOD_PKB_1	424	432	PF00069	0.630
MOD_Plk_1	124	130	PF00069	0.668
MOD_Plk_1	170	176	PF00069	0.651
MOD_Plk_1	393	399	PF00069	0.490
MOD_Plk_1	88	94	PF00069	0.602
MOD_Plk_2-3	171	177	PF00069	0.655
MOD_Plk_4	124	130	PF00069	0.620
MOD_Plk_4	164	170	PF00069	0.679
MOD_Plk_4	204	210	PF00069	0.684
MOD_Plk_4	248	254	PF00069	0.633
MOD_Plk_4	397	403	PF00069	0.602
MOD_ProDKin_1	103	109	PF00069	0.665
MOD_ProDKin_1	130	136	PF00069	0.697
MOD_ProDKin_1	142	148	PF00069	0.610
MOD_ProDKin_1	181	187	PF00069	0.706
MOD_ProDKin_1	236	242	PF00069	0.722
MOD_ProDKin_1	292	298	PF00069	0.838
MOD_ProDKin_1	30	36	PF00069	0.533
MOD_ProDKin_1	416	422	PF00069	0.603
MOD_ProDKin_1	96	102	PF00069	0.666
MOD_SUMO_rev_2	457	463	PF00179	0.715
TRG_DiLeu_BaEn_2	373	379	PF01217	0.566
TRG_DiLeu_BaLyEn_6	4	9	PF01217	0.605
TRG_ENDOCYTIC_2	383	386	PF00928	0.621
TRG_ER_diArg_1	309	311	PF00400	0.632
TRG_ER_diArg_1	344	346	PF00400	0.668
TRG_ER_diArg_1	36	39	PF00400	0.693
TRG_Pf-PMV_PEXEL_1	7	11	PF00026	0.596

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H9S9	Leishmania braziliensis	60%	100%
A4HUU0	Leishmania infantum	99%	100%
E9ANH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QH51	Leishmania major	88%	100%