Bacterial_transferase_hexapeptide_(Six_repeats)_p utative/Pfam:PF00132

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Bacterial transferase hexapeptide (six repeats), putative

Species:

Leishmania donovani

UniProt:

A0A3S7WRH8_LEIDO

TriTrypDb:

LdBPK_110030.1 , LdCL_110005200 , LDHU3_11.0040

Length:

307

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WRH8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WRH8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016740	transferase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	245	249	PF00656	0.555
CLV_C14_Caspase3-7	288	292	PF00656	0.531
CLV_C14_Caspase3-7	81	85	PF00656	0.428
CLV_NRD_NRD_1	101	103	PF00675	0.370
CLV_NRD_NRD_1	277	279	PF00675	0.526
CLV_NRD_NRD_1	283	285	PF00675	0.515
CLV_PCSK_KEX2_1	28	30	PF00082	0.491
CLV_PCSK_KEX2_1	283	285	PF00082	0.640
CLV_PCSK_KEX2_1	78	80	PF00082	0.437
CLV_PCSK_PC1ET2_1	28	30	PF00082	0.521
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.437
CLV_PCSK_SKI1_1	220	224	PF00082	0.431
CLV_PCSK_SKI1_1	250	254	PF00082	0.617
CLV_PCSK_SKI1_1	38	42	PF00082	0.450
CLV_PCSK_SKI1_1	45	49	PF00082	0.420
CLV_PCSK_SKI1_1	71	75	PF00082	0.419
CLV_Separin_Metazoa	272	276	PF03568	0.528
DEG_Nend_Nbox_1	1	3	PF02207	0.618
DEG_ODPH_VHL_1	88	100	PF01847	0.347
DOC_CDC14_PxL_1	66	74	PF14671	0.456
DOC_MAPK_gen_1	113	122	PF00069	0.339
DOC_MAPK_gen_1	220	230	PF00069	0.381
DOC_MAPK_gen_1	261	270	PF00069	0.541
DOC_MAPK_gen_1	28	36	PF00069	0.482
DOC_MAPK_MEF2A_6	223	230	PF00069	0.374
DOC_MAPK_MEF2A_6	28	36	PF00069	0.492
DOC_MAPK_NFAT4_5	29	37	PF00069	0.520
DOC_PP4_FxxP_1	87	90	PF00568	0.352
DOC_USP7_MATH_1	158	162	PF00917	0.345
DOC_USP7_MATH_1	222	226	PF00917	0.499
DOC_USP7_UBL2_3	74	78	PF12436	0.489
DOC_WW_Pin1_4	282	287	PF00397	0.517
LIG_14-3-3_CanoR_1	29	35	PF00244	0.436
LIG_BH_BH3_1	42	58	PF00452	0.482
LIG_BRCT_BRCA1_1	158	162	PF00533	0.345
LIG_Clathr_ClatBox_1	227	231	PF01394	0.387
LIG_deltaCOP1_diTrp_1	234	240	PF00928	0.437
LIG_eIF4E_1	67	73	PF01652	0.453
LIG_FHA_1	46	52	PF00498	0.556
LIG_FHA_1	93	99	PF00498	0.417
LIG_FHA_2	142	148	PF00498	0.387
LIG_FHA_2	209	215	PF00498	0.433
LIG_FHA_2	237	243	PF00498	0.447
LIG_FHA_2	283	289	PF00498	0.534
LIG_FHA_2	79	85	PF00498	0.472
LIG_LIR_Apic_2	64	70	PF02991	0.480
LIG_LIR_Apic_2	84	90	PF02991	0.190
LIG_LIR_Gen_1	237	245	PF02991	0.458
LIG_LIR_Gen_1	30	36	PF02991	0.515
LIG_LIR_Nem_3	237	243	PF02991	0.445
LIG_LIR_Nem_3	251	256	PF02991	0.449
LIG_LIR_Nem_3	30	34	PF02991	0.520
LIG_Pex14_2	2	6	PF04695	0.643
LIG_SH2_CRK	108	112	PF00017	0.351
LIG_SH2_CRK	67	71	PF00017	0.470
LIG_SH2_SRC	256	259	PF00017	0.602
LIG_SH2_STAT5	105	108	PF00017	0.342
LIG_SH2_STAT5	269	272	PF00017	0.544
LIG_SH2_STAT5	31	34	PF00017	0.480
LIG_SH3_2	273	278	PF14604	0.525
LIG_SH3_3	270	276	PF00018	0.531
LIG_SUMO_SIM_par_1	225	231	PF11976	0.394
LIG_SUMO_SIM_par_1	48	55	PF11976	0.492
LIG_TRAF2_1	239	242	PF00917	0.469
LIG_TRAF2_1	62	65	PF00917	0.562
LIG_TRAF2_2	18	23	PF00917	0.553
LIG_TYR_ITIM	106	111	PF00017	0.346
LIG_WW_3	272	276	PF00397	0.528
MOD_CK1_1	174	180	PF00069	0.468
MOD_CK2_1	141	147	PF00069	0.386
MOD_CK2_1	170	176	PF00069	0.468
MOD_CK2_1	208	214	PF00069	0.424
MOD_CK2_1	236	242	PF00069	0.444
MOD_CK2_1	282	288	PF00069	0.525
MOD_Cter_Amidation	100	103	PF01082	0.359
MOD_Cter_Amidation	281	284	PF01082	0.613
MOD_Cter_Amidation	76	79	PF01082	0.483
MOD_GlcNHglycan	11	14	PF01048	0.632
MOD_GlcNHglycan	153	156	PF01048	0.437
MOD_GlcNHglycan	165	168	PF01048	0.360
MOD_GlcNHglycan	176	179	PF01048	0.325
MOD_GlcNHglycan	188	191	PF01048	0.366
MOD_GlcNHglycan	194	197	PF01048	0.283
MOD_GlcNHglycan	75	78	PF01048	0.472
MOD_GlcNHglycan	90	93	PF01048	0.290
MOD_GSK3_1	132	139	PF00069	0.374
MOD_GSK3_1	170	177	PF00069	0.424
MOD_GSK3_1	182	189	PF00069	0.351
MOD_GSK3_1	232	239	PF00069	0.422
MOD_GSK3_1	88	95	PF00069	0.352
MOD_N-GLC_1	136	141	PF02516	0.449
MOD_NEK2_1	1	6	PF00069	0.595
MOD_NEK2_1	122	127	PF00069	0.371
MOD_NEK2_1	170	175	PF00069	0.465
MOD_NEK2_1	299	304	PF00069	0.566
MOD_NEK2_1	73	78	PF00069	0.513
MOD_PK_1	116	122	PF00069	0.320
MOD_PK_1	171	177	PF00069	0.479
MOD_PKA_1	78	84	PF00069	0.506
MOD_PKA_2	78	84	PF00069	0.413
MOD_Plk_1	136	142	PF00069	0.489
MOD_Plk_1	236	242	PF00069	0.475
MOD_Plk_4	158	164	PF00069	0.339
MOD_Plk_4	182	188	PF00069	0.382
MOD_Plk_4	222	228	PF00069	0.455
MOD_Plk_4	78	84	PF00069	0.416
MOD_ProDKin_1	282	288	PF00069	0.516
MOD_SUMO_for_1	62	65	PF00179	0.568
TRG_DiLeu_BaLyEn_6	68	73	PF01217	0.429
TRG_ENDOCYTIC_2	108	111	PF00928	0.359
TRG_ENDOCYTIC_2	31	34	PF00928	0.519
TRG_ER_diArg_1	2	5	PF00400	0.592
TRG_NLS_MonoExtN_4	275	282	PF00514	0.652

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0A3	Leptomonas seymouri	83%	100%
A0A0N1ICC0	Leptomonas seymouri	27%	100%
A0A0S4JVD5	Bodo saltans	64%	96%
A0A1X0NVC1	Trypanosomatidae	73%	100%
A0A3S7WQ41	Leishmania donovani	29%	100%
A4H585	Leishmania braziliensis	28%	100%
A4H9V5	Leishmania braziliensis	92%	100%
A4HTG9	Leishmania infantum	29%	100%
A4HUR5	Leishmania infantum	100%	100%
C9ZPP8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
D0A7P7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	100%
E9AM97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9ANE9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4QH77	Leishmania major	97%	100%
Q4QIF1	Leishmania major	29%	100%
Q54JC2	Dictyostelium discoideum	30%	100%
Q9C6B3	Arabidopsis thaliana	33%	100%
V5BBY5	Trypanosoma cruzi	75%	100%