Inorganic diphosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acidocalcisomal pyrophosphatase

Species:

Leishmania donovani

UniProt:

A0A3S7WRH5_LEIDO

TriTrypDb:

LdBPK_110210.1 , LdCL_110007000 , LDHU3_11.0240

Length:

443

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	16
GO:0110165	cellular anatomical entity	1	16
GO:0005829	cytosol	2	1

Expansion

Sequence features

A0A3S7WRH5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WRH5

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	16
GO:0006796	phosphate-containing compound metabolic process	4	16
GO:0008152	metabolic process	1	16
GO:0009987	cellular process	1	16
GO:0044237	cellular metabolic process	2	16

Molecular functions
Term	Name	Level	Count
GO:0000287	magnesium ion binding	5	16
GO:0003824	catalytic activity	1	16
GO:0004427	inorganic diphosphate phosphatase activity	6	16
GO:0005488	binding	1	16
GO:0016462	pyrophosphatase activity	5	16
GO:0016787	hydrolase activity	2	16
GO:0016817	hydrolase activity, acting on acid anhydrides	3	16
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	16
GO:0043167	ion binding	2	16
GO:0043169	cation binding	3	16
GO:0046872	metal ion binding	4	16
GO:0005509	calcium ion binding	5	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	223	229	PF00089	0.397
CLV_NRD_NRD_1	11	13	PF00675	0.729
CLV_NRD_NRD_1	225	227	PF00675	0.499
CLV_NRD_NRD_1	434	436	PF00675	0.371
CLV_PCSK_KEX2_1	106	108	PF00082	0.432
CLV_PCSK_KEX2_1	224	226	PF00082	0.518
CLV_PCSK_PC1ET2_1	106	108	PF00082	0.409
CLV_PCSK_SKI1_1	407	411	PF00082	0.259
CLV_PCSK_SKI1_1	435	439	PF00082	0.548
DOC_CKS1_1	205	210	PF01111	0.340
DOC_MAPK_DCC_7	335	344	PF00069	0.547
DOC_MAPK_gen_1	12	19	PF00069	0.729
DOC_MAPK_gen_1	128	136	PF00069	0.511
DOC_MAPK_gen_1	415	423	PF00069	0.443
DOC_MAPK_MEF2A_6	128	136	PF00069	0.412
DOC_PP4_FxxP_1	188	191	PF00568	0.405
DOC_USP7_UBL2_3	213	217	PF12436	0.469
DOC_USP7_UBL2_3	279	283	PF12436	0.435
DOC_USP7_UBL2_3	436	440	PF12436	0.427
DOC_WW_Pin1_4	204	209	PF00397	0.350
DOC_WW_Pin1_4	225	230	PF00397	0.319
DOC_WW_Pin1_4	41	46	PF00397	0.563
LIG_14-3-3_CanoR_1	111	118	PF00244	0.373
LIG_BIR_II_1	1	5	PF00653	0.638
LIG_BRCT_BRCA1_1	109	113	PF00533	0.431
LIG_BRCT_BRCA1_1	184	188	PF00533	0.403
LIG_deltaCOP1_diTrp_1	162	168	PF00928	0.337
LIG_deltaCOP1_diTrp_1	294	302	PF00928	0.478
LIG_FHA_1	158	164	PF00498	0.495
LIG_FHA_1	178	184	PF00498	0.600
LIG_FHA_1	307	313	PF00498	0.436
LIG_FHA_1	44	50	PF00498	0.660
LIG_FHA_1	67	73	PF00498	0.700
LIG_FHA_1	82	88	PF00498	0.578
LIG_FHA_1	99	105	PF00498	0.500
LIG_FHA_2	168	174	PF00498	0.543
LIG_FHA_2	241	247	PF00498	0.425
LIG_LIR_Apic_2	185	191	PF02991	0.401
LIG_LIR_Apic_2	5	10	PF02991	0.712
LIG_LIR_Gen_1	110	121	PF02991	0.448
LIG_LIR_Gen_1	146	155	PF02991	0.578
LIG_LIR_Gen_1	179	188	PF02991	0.495
LIG_LIR_Gen_1	228	237	PF02991	0.339
LIG_LIR_Nem_3	110	116	PF02991	0.439
LIG_LIR_Nem_3	146	152	PF02991	0.551
LIG_LIR_Nem_3	160	164	PF02991	0.222
LIG_LIR_Nem_3	179	184	PF02991	0.505
LIG_LIR_Nem_3	228	233	PF02991	0.350
LIG_LIR_Nem_3	273	278	PF02991	0.438
LIG_LIR_Nem_3	32	36	PF02991	0.609
LIG_LIR_Nem_3	357	361	PF02991	0.430
LIG_LIR_Nem_3	392	397	PF02991	0.456
LIG_PCNA_yPIPBox_3	359	373	PF02747	0.444
LIG_PDZ_Class_3	438	443	PF00595	0.490
LIG_Pex14_1	167	171	PF04695	0.411
LIG_Pex14_1	393	397	PF04695	0.448
LIG_Pex14_2	161	165	PF04695	0.320
LIG_Pex14_2	302	306	PF04695	0.494
LIG_PTAP_UEV_1	50	55	PF05743	0.527
LIG_SH2_CRK	253	257	PF00017	0.246
LIG_SH2_CRK	7	11	PF00017	0.710
LIG_SH2_SRC	123	126	PF00017	0.460
LIG_SH2_STAP1	419	423	PF00017	0.499
LIG_SH2_STAT3	192	195	PF00017	0.363
LIG_SH2_STAT5	123	126	PF00017	0.359
LIG_SH2_STAT5	135	138	PF00017	0.377
LIG_SH2_STAT5	215	218	PF00017	0.351
LIG_SH2_STAT5	236	239	PF00017	0.387
LIG_SH3_2	274	279	PF14604	0.485
LIG_SH3_3	234	240	PF00018	0.536
LIG_SH3_3	271	277	PF00018	0.474
LIG_SH3_3	362	368	PF00018	0.547
LIG_SH3_3	39	45	PF00018	0.650
LIG_SH3_3	48	54	PF00018	0.680
LIG_TRAF2_1	73	76	PF00917	0.675
LIG_TYR_ITIM	121	126	PF00017	0.477
LIG_UBA3_1	148	153	PF00899	0.545
MOD_CDK_SPxxK_3	204	211	PF00069	0.333
MOD_CK1_1	182	188	PF00069	0.442
MOD_CK1_1	2	8	PF00069	0.615
MOD_CK1_1	35	41	PF00069	0.599
MOD_CK2_1	240	246	PF00069	0.415
MOD_CMANNOS	165	168	PF00535	0.333
MOD_GlcNHglycan	113	116	PF01048	0.352
MOD_GlcNHglycan	184	187	PF01048	0.438
MOD_GlcNHglycan	317	320	PF01048	0.301
MOD_GlcNHglycan	51	54	PF01048	0.598
MOD_GSK3_1	107	114	PF00069	0.461
MOD_GSK3_1	138	145	PF00069	0.542
MOD_GSK3_1	167	174	PF00069	0.460
MOD_GSK3_1	182	189	PF00069	0.360
MOD_GSK3_1	302	309	PF00069	0.428
MOD_GSK3_1	54	61	PF00069	0.505
MOD_LATS_1	105	111	PF00433	0.427
MOD_N-GLC_1	138	143	PF02516	0.490
MOD_NEK2_1	100	105	PF00069	0.457
MOD_NEK2_1	116	121	PF00069	0.373
MOD_NEK2_1	19	24	PF00069	0.707
MOD_NEK2_1	65	70	PF00069	0.610
MOD_PIKK_1	116	122	PF00454	0.392
MOD_PIKK_1	138	144	PF00454	0.555
MOD_PIKK_1	98	104	PF00454	0.480
MOD_Plk_1	116	122	PF00069	0.408
MOD_Plk_1	186	192	PF00069	0.450
MOD_Plk_1	415	421	PF00069	0.463
MOD_Plk_1	424	430	PF00069	0.426
MOD_Plk_2-3	76	82	PF00069	0.746
MOD_ProDKin_1	204	210	PF00069	0.341
MOD_ProDKin_1	225	231	PF00069	0.320
MOD_ProDKin_1	41	47	PF00069	0.561
MOD_SUMO_for_1	199	202	PF00179	0.529
MOD_SUMO_for_1	265	268	PF00179	0.462
MOD_SUMO_rev_2	145	155	PF00179	0.516
MOD_SUMO_rev_2	22	32	PF00179	0.549
MOD_SUMO_rev_2	352	361	PF00179	0.448
MOD_SUMO_rev_2	44	52	PF00179	0.659
TRG_ENDOCYTIC_2	123	126	PF00928	0.484
TRG_ENDOCYTIC_2	253	256	PF00928	0.279
TRG_ENDOCYTIC_2	299	302	PF00928	0.442
TRG_ER_diArg_1	223	226	PF00400	0.525
TRG_ER_diLys_1	438	443	PF00400	0.536
TRG_NES_CRM1_1	355	367	PF08389	0.547
TRG_NLS_MonoExtC_3	434	439	PF00514	0.437
TRG_Pf-PMV_PEXEL_1	371	375	PF00026	0.244

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDG0	Leptomonas seymouri	81%	99%
A0A0S4JW75	Bodo saltans	61%	100%
A0A1X0NVA1	Trypanosomatidae	67%	100%
A0A1X0NVH4	Trypanosomatidae	72%	100%
A0A1X0NWW9	Trypanosomatidae	67%	100%
A0A3R7KMZ3	Trypanosoma rangeli	64%	100%
A4H3Q3	Leishmania braziliensis	38%	100%
A4H9T7	Leishmania braziliensis	94%	100%
A4HUT3	Leishmania infantum	100%	100%
D0A7N0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
D0A7N2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9ANG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4QH59	Leishmania major	98%	100%
V5BB26	Trypanosoma cruzi	65%	100%