Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WRF3_LEIDO

TriTrypDb:

LdBPK_110010.1 , LdCL_110005000 , LDHU3_11.0020

Length:

170

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WRF3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WRF3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	23	25	PF00675	0.658
CLV_NRD_NRD_1	56	58	PF00675	0.585
CLV_NRD_NRD_1	71	73	PF00675	0.404
CLV_NRD_NRD_1	92	94	PF00675	0.546
CLV_PCSK_FUR_1	72	76	PF00082	0.566
CLV_PCSK_KEX2_1	23	25	PF00082	0.658
CLV_PCSK_KEX2_1	71	73	PF00082	0.604
CLV_PCSK_KEX2_1	74	76	PF00082	0.569
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.568
CLV_PCSK_SKI1_1	85	89	PF00082	0.489
CLV_PCSK_SKI1_1	96	100	PF00082	0.502
CLV_Separin_Metazoa	86	90	PF03568	0.453
DEG_APCC_DBOX_1	95	103	PF00400	0.597
DEG_APCC_KENBOX_2	43	47	PF00400	0.454
DEG_Nend_UBRbox_2	1	3	PF02207	0.738
DOC_CYCLIN_RxL_1	82	92	PF00134	0.519
DOC_CYCLIN_RxL_1	93	101	PF00134	0.527
DOC_MAPK_gen_1	54	63	PF00069	0.586
DOC_MAPK_gen_1	93	102	PF00069	0.607
DOC_MAPK_MEF2A_6	93	102	PF00069	0.598
DOC_USP7_MATH_1	149	153	PF00917	0.568
DOC_USP7_MATH_1	18	22	PF00917	0.752
LIG_14-3-3_CanoR_1	123	129	PF00244	0.580
LIG_14-3-3_CanoR_1	23	29	PF00244	0.632
LIG_FHA_1	23	29	PF00498	0.570
LIG_LIR_Gen_1	115	122	PF02991	0.611
LIG_LIR_Nem_3	115	121	PF02991	0.615
LIG_NRBOX	83	89	PF00104	0.460
LIG_PCNA_PIPBox_1	126	135	PF02747	0.552
LIG_PCNA_PIPBox_1	141	150	PF02747	0.407
LIG_PCNA_yPIPBox_3	123	133	PF02747	0.553
LIG_PCNA_yPIPBox_3	136	148	PF02747	0.429
LIG_SH2_NCK_1	148	152	PF00017	0.572
LIG_SH2_SRC	148	151	PF00017	0.575
LIG_SH2_STAP1	133	137	PF00017	0.589
LIG_SUMO_SIM_anti_2	59	64	PF11976	0.584
LIG_UBA3_1	161	166	PF00899	0.589
MOD_CK2_1	113	119	PF00069	0.477
MOD_Cter_Amidation	21	24	PF01082	0.601
MOD_GlcNHglycan	12	16	PF01048	0.740
MOD_GlcNHglycan	151	154	PF01048	0.587
MOD_GlcNHglycan	19	23	PF01048	0.754
MOD_GSK3_1	18	25	PF00069	0.603
MOD_NEK2_1	11	16	PF00069	0.798
MOD_NEK2_1	98	103	PF00069	0.558
MOD_PIKK_1	122	128	PF00454	0.581
MOD_PKA_1	23	29	PF00069	0.570
MOD_PKA_2	122	128	PF00069	0.581
MOD_PKA_2	22	28	PF00069	0.579
MOD_PKA_2	88	94	PF00069	0.487
MOD_Plk_1	77	83	PF00069	0.600
MOD_Plk_2-3	77	83	PF00069	0.600
MOD_SUMO_for_1	165	168	PF00179	0.582
TRG_DiLeu_BaEn_1	45	50	PF01217	0.451
TRG_DiLeu_BaEn_1	95	100	PF01217	0.558
TRG_ER_diArg_1	70	72	PF00400	0.606
TRG_Pf-PMV_PEXEL_1	33	37	PF00026	0.618
TRG_Pf-PMV_PEXEL_1	54	59	PF00026	0.588
TRG_Pf-PMV_PEXEL_1	85	90	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HUR3	Leishmania infantum	99%	100%
E9ANE7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QH79	Leishmania major	88%	100%