Methyltransferase domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Methyltransferase domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WRE9_LEIDO

TriTrypDb:

LdCL_100020800 , LDHU3_10.1730

Length:

311

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WRE9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WRE9

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	2
GO:0032259	methylation	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	54	56	PF00675	0.564
CLV_PCSK_KEX2_1	13	15	PF00082	0.585
CLV_PCSK_KEX2_1	148	150	PF00082	0.334
CLV_PCSK_KEX2_1	239	241	PF00082	0.305
CLV_PCSK_KEX2_1	54	56	PF00082	0.564
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.585
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.233
CLV_PCSK_PC1ET2_1	239	241	PF00082	0.305
CLV_PCSK_SKI1_1	104	108	PF00082	0.433
CLV_PCSK_SKI1_1	13	17	PF00082	0.460
DEG_MDM2_SWIB_1	220	227	PF02201	0.470
DOC_CKS1_1	27	32	PF01111	0.461
DOC_CYCLIN_yCln2_LP_2	213	219	PF00134	0.305
DOC_CYCLIN_yCln2_LP_2	35	41	PF00134	0.456
DOC_MAPK_gen_1	225	235	PF00069	0.402
DOC_MAPK_MEF2A_6	228	237	PF00069	0.294
DOC_MAPK_MEF2A_6	72	81	PF00069	0.401
DOC_WW_Pin1_4	147	152	PF00397	0.344
DOC_WW_Pin1_4	26	31	PF00397	0.462
DOC_WW_Pin1_4	34	39	PF00397	0.457
DOC_WW_Pin1_4	73	78	PF00397	0.440
LIG_14-3-3_CanoR_1	285	294	PF00244	0.397
LIG_14-3-3_CanoR_1	33	38	PF00244	0.461
LIG_BRCT_BRCA1_1	22	26	PF00533	0.459
LIG_BRCT_BRCA1_1	35	39	PF00533	0.452
LIG_BRCT_BRCA1_1	96	100	PF00533	0.347
LIG_eIF4E_1	43	49	PF01652	0.455
LIG_FHA_1	205	211	PF00498	0.334
LIG_FHA_1	236	242	PF00498	0.313
LIG_FHA_1	282	288	PF00498	0.405
LIG_FHA_1	43	49	PF00498	0.469
LIG_FHA_2	203	209	PF00498	0.321
LIG_LIR_Gen_1	125	136	PF02991	0.374
LIG_LIR_Gen_1	141	147	PF02991	0.305
LIG_LIR_Gen_1	198	209	PF02991	0.455
LIG_LIR_Gen_1	20	30	PF02991	0.543
LIG_LIR_Gen_1	265	276	PF02991	0.304
LIG_LIR_Gen_1	302	311	PF02991	0.464
LIG_LIR_Gen_1	42	49	PF02991	0.567
LIG_LIR_Nem_3	125	131	PF02991	0.419
LIG_LIR_Nem_3	141	145	PF02991	0.305
LIG_LIR_Nem_3	181	186	PF02991	0.305
LIG_LIR_Nem_3	198	204	PF02991	0.305
LIG_LIR_Nem_3	20	25	PF02991	0.542
LIG_LIR_Nem_3	218	223	PF02991	0.354
LIG_LIR_Nem_3	265	271	PF02991	0.345
LIG_LIR_Nem_3	302	307	PF02991	0.571
LIG_LIR_Nem_3	42	46	PF02991	0.562
LIG_Pex14_2	220	224	PF04695	0.470
LIG_PTB_Apo_2	247	254	PF02174	0.310
LIG_PTB_Phospho_1	247	253	PF10480	0.305
LIG_SH2_CRK	201	205	PF00017	0.305
LIG_SH2_CRK	22	26	PF00017	0.459
LIG_SH2_NCK_1	22	26	PF00017	0.459
LIG_SH2_STAP1	128	132	PF00017	0.378
LIG_SH2_STAP1	176	180	PF00017	0.269
LIG_SH2_STAP1	22	26	PF00017	0.459
LIG_SH2_STAT5	142	145	PF00017	0.325
LIG_SH2_STAT5	187	190	PF00017	0.351
LIG_SH2_STAT5	193	196	PF00017	0.351
LIG_SH2_STAT5	253	256	PF00017	0.341
LIG_SH3_1	148	154	PF00018	0.295
LIG_SH3_3	148	154	PF00018	0.295
LIG_SH3_3	35	41	PF00018	0.456
LIG_SH3_3	96	102	PF00018	0.320
LIG_SH3_5	138	142	PF00018	0.333
LIG_SUMO_SIM_anti_2	290	295	PF11976	0.324
LIG_SUMO_SIM_par_1	232	238	PF11976	0.294
LIG_TRAF2_1	109	112	PF00917	0.418
LIG_TYR_ITSM	18	25	PF00017	0.459
LIG_WRC_WIRS_1	43	48	PF05994	0.461
MOD_CDK_SPK_2	26	31	PF00069	0.462
MOD_CDK_SPxxK_3	26	33	PF00069	0.462
MOD_CK1_1	189	195	PF00069	0.208
MOD_CK1_1	274	280	PF00069	0.417
MOD_CK1_1	42	48	PF00069	0.469
MOD_CK1_1	58	64	PF00069	0.498
MOD_CK2_1	105	111	PF00069	0.427
MOD_CK2_1	202	208	PF00069	0.305
MOD_CK2_1	274	280	PF00069	0.384
MOD_Cter_Amidation	11	14	PF01082	0.458
MOD_Cter_Amidation	52	55	PF01082	0.444
MOD_GlcNHglycan	108	111	PF01048	0.483
MOD_GlcNHglycan	171	174	PF01048	0.294
MOD_GlcNHglycan	287	290	PF01048	0.504
MOD_GlcNHglycan	308	311	PF01048	0.614
MOD_GlcNHglycan	51	54	PF01048	0.471
MOD_GSK3_1	143	150	PF00069	0.284
MOD_GSK3_1	17	24	PF00069	0.450
MOD_GSK3_1	2	9	PF00069	0.459
MOD_GSK3_1	215	222	PF00069	0.404
MOD_GSK3_1	251	258	PF00069	0.343
MOD_GSK3_1	274	281	PF00069	0.424
MOD_GSK3_1	73	80	PF00069	0.400
MOD_N-GLC_2	69	71	PF02516	0.401
MOD_NEK2_1	105	110	PF00069	0.440
MOD_NEK2_1	143	148	PF00069	0.233
MOD_NEK2_1	262	267	PF00069	0.356
MOD_NEK2_1	271	276	PF00069	0.329
MOD_NEK2_1	306	311	PF00069	0.475
MOD_NEK2_1	49	54	PF00069	0.525
MOD_NEK2_1	7	12	PF00069	0.535
MOD_NEK2_2	77	82	PF00069	0.413
MOD_PKB_1	31	39	PF00069	0.462
MOD_Plk_1	189	195	PF00069	0.281
MOD_Plk_1	56	62	PF00069	0.512
MOD_Plk_4	21	27	PF00069	0.503
MOD_Plk_4	215	221	PF00069	0.388
MOD_Plk_4	77	83	PF00069	0.503
MOD_Plk_4	94	100	PF00069	0.337
MOD_ProDKin_1	147	153	PF00069	0.344
MOD_ProDKin_1	26	32	PF00069	0.462
MOD_ProDKin_1	34	40	PF00069	0.455
MOD_ProDKin_1	73	79	PF00069	0.437
MOD_SUMO_rev_2	108	115	PF00179	0.391
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.466
TRG_ENDOCYTIC_2	128	131	PF00928	0.390
TRG_ENDOCYTIC_2	142	145	PF00928	0.305
TRG_ENDOCYTIC_2	201	204	PF00928	0.478
TRG_ENDOCYTIC_2	22	25	PF00928	0.459
TRG_ENDOCYTIC_2	43	46	PF00928	0.588
TRG_ER_diArg_1	30	33	PF00400	0.463
TRG_ER_diArg_1	54	56	PF00400	0.447
TRG_ER_FFAT_2	198	208	PF00635	0.367

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDF1	Leptomonas seymouri	61%	100%
A4H6B4	Leishmania braziliensis	72%	100%
A4HUN7	Leishmania infantum	100%	100%
E9ACR1	Leishmania major	89%	100%
E9AND6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%