Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WRE4_LEIDO

TriTrypDb:

LdBPK_110160.1 , LdCL_110006500 , LDHU3_11.0190

Length:

1027

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000145	exocyst	3	1
GO:0032991	protein-containing complex	1	1
GO:0099023	vesicle tethering complex	2	1

Expansion

Sequence features

A0A3S7WRE4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WRE4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0016043	cellular component organization	3	12
GO:0033036	macromolecule localization	2	12
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0090522	vesicle tethering involved in exocytosis	3	12
GO:0099022	vesicle tethering	4	12
GO:0140029	exocytic process	2	12
GO:0006887	exocytosis	4	1
GO:0006892	post-Golgi vesicle-mediated transport	6	1
GO:0006893	Golgi to plasma membrane transport	5	1
GO:0016192	vesicle-mediated transport	4	1
GO:0032940	secretion by cell	3	1
GO:0046903	secretion	4	1
GO:0048193	Golgi vesicle transport	5	1
GO:0051668	localization within membrane	3	1
GO:0098876	vesicle-mediated transport to the plasma membrane	4	1
GO:0140352	export from cell	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.668
CLV_C14_Caspase3-7	170	174	PF00656	0.768
CLV_C14_Caspase3-7	175	179	PF00656	0.710
CLV_C14_Caspase3-7	225	229	PF00656	0.506
CLV_C14_Caspase3-7	286	290	PF00656	0.523
CLV_C14_Caspase3-7	323	327	PF00656	0.558
CLV_NRD_NRD_1	11	13	PF00675	0.613
CLV_NRD_NRD_1	203	205	PF00675	0.760
CLV_NRD_NRD_1	852	854	PF00675	0.534
CLV_NRD_NRD_1	943	945	PF00675	0.495
CLV_PCSK_KEX2_1	11	13	PF00082	0.613
CLV_PCSK_KEX2_1	852	854	PF00082	0.551
CLV_PCSK_KEX2_1	943	945	PF00082	0.473
CLV_PCSK_SKI1_1	118	122	PF00082	0.618
CLV_PCSK_SKI1_1	25	29	PF00082	0.562
CLV_PCSK_SKI1_1	312	316	PF00082	0.517
CLV_PCSK_SKI1_1	332	336	PF00082	0.255
CLV_PCSK_SKI1_1	60	64	PF00082	0.491
CLV_PCSK_SKI1_1	735	739	PF00082	0.499
CLV_PCSK_SKI1_1	758	762	PF00082	0.452
CLV_PCSK_SKI1_1	811	815	PF00082	0.524
CLV_PCSK_SKI1_1	90	94	PF00082	0.707
DEG_APCC_DBOX_1	324	332	PF00400	0.509
DEG_APCC_DBOX_1	80	88	PF00400	0.493
DEG_APCC_KENBOX_2	257	261	PF00400	0.576
DEG_Nend_UBRbox_2	1	3	PF02207	0.651
DEG_SCF_TRCP1_1	178	183	PF00400	0.650
DOC_CDC14_PxL_1	871	879	PF14671	0.409
DOC_CYCLIN_RxL_1	20	32	PF00134	0.587
DOC_CYCLIN_RxL_1	329	336	PF00134	0.545
DOC_CYCLIN_RxL_1	811	822	PF00134	0.538
DOC_CYCLIN_yCln2_LP_2	507	513	PF00134	0.509
DOC_CYCLIN_yCln2_LP_2	687	693	PF00134	0.515
DOC_MAPK_gen_1	312	320	PF00069	0.489
DOC_MAPK_gen_1	551	559	PF00069	0.517
DOC_MAPK_HePTP_8	755	767	PF00069	0.413
DOC_MAPK_MEF2A_6	20	28	PF00069	0.620
DOC_MAPK_MEF2A_6	670	678	PF00069	0.426
DOC_MAPK_MEF2A_6	758	767	PF00069	0.426
DOC_MAPK_NFAT4_5	758	766	PF00069	0.429
DOC_PP1_RVXF_1	23	29	PF00149	0.585
DOC_PP2B_LxvP_1	370	373	PF13499	0.526
DOC_PP2B_LxvP_1	676	679	PF13499	0.406
DOC_PP2B_LxvP_1	687	690	PF13499	0.387
DOC_USP7_MATH_1	1014	1018	PF00917	0.750
DOC_USP7_MATH_1	222	226	PF00917	0.495
DOC_USP7_MATH_1	314	318	PF00917	0.532
DOC_USP7_MATH_1	440	444	PF00917	0.528
DOC_USP7_MATH_1	580	584	PF00917	0.498
DOC_USP7_MATH_1	681	685	PF00917	0.492
DOC_USP7_MATH_1	838	842	PF00917	0.567
DOC_USP7_MATH_1	862	866	PF00917	0.501
DOC_USP7_MATH_2	518	524	PF00917	0.518
DOC_USP7_UBL2_3	118	122	PF12436	0.540
DOC_USP7_UBL2_3	811	815	PF12436	0.448
DOC_USP7_UBL2_3	999	1003	PF12436	0.642
DOC_WW_Pin1_4	20	25	PF00397	0.478
DOC_WW_Pin1_4	514	519	PF00397	0.532
DOC_WW_Pin1_4	544	549	PF00397	0.533
DOC_WW_Pin1_4	92	97	PF00397	0.712
LIG_14-3-3_CanoR_1	1015	1019	PF00244	0.755
LIG_14-3-3_CanoR_1	25	35	PF00244	0.558
LIG_14-3-3_CanoR_1	432	439	PF00244	0.478
LIG_14-3-3_CanoR_1	670	675	PF00244	0.474
LIG_14-3-3_CanoR_1	71	76	PF00244	0.471
LIG_14-3-3_CanoR_1	81	89	PF00244	0.509
LIG_14-3-3_CanoR_1	823	832	PF00244	0.515
LIG_Actin_WH2_2	106	124	PF00022	0.537
LIG_APCC_ABBA_1	459	464	PF00400	0.584
LIG_APCC_ABBA_1	482	487	PF00400	0.524
LIG_BIR_III_2	3	7	PF00653	0.682
LIG_BRCT_BRCA1_1	58	62	PF00533	0.582
LIG_BRCT_BRCA1_1	644	648	PF00533	0.522
LIG_CaM_IQ_9	1002	1017	PF13499	0.741
LIG_Clathr_ClatBox_1	752	756	PF01394	0.553
LIG_deltaCOP1_diTrp_1	444	452	PF00928	0.530
LIG_DLG_GKlike_1	670	678	PF00625	0.480
LIG_FHA_1	110	116	PF00498	0.533
LIG_FHA_1	138	144	PF00498	0.526
LIG_FHA_1	21	27	PF00498	0.614
LIG_FHA_1	222	228	PF00498	0.559
LIG_FHA_1	299	305	PF00498	0.583
LIG_FHA_1	313	319	PF00498	0.572
LIG_FHA_1	390	396	PF00498	0.410
LIG_FHA_1	52	58	PF00498	0.495
LIG_FHA_1	715	721	PF00498	0.620
LIG_FHA_1	795	801	PF00498	0.461
LIG_FHA_1	812	818	PF00498	0.433
LIG_FHA_1	933	939	PF00498	0.462
LIG_FHA_2	361	367	PF00498	0.499
LIG_FHA_2	5	11	PF00498	0.649
LIG_FHA_2	620	626	PF00498	0.505
LIG_FHA_2	670	676	PF00498	0.498
LIG_FHA_2	741	747	PF00498	0.424
LIG_FHA_2	83	89	PF00498	0.554
LIG_HCF-1_HBM_1	269	272	PF13415	0.642
LIG_LIR_Gen_1	109	115	PF02991	0.473
LIG_LIR_Gen_1	218	227	PF02991	0.517
LIG_LIR_Gen_1	233	242	PF02991	0.527
LIG_LIR_Gen_1	41	52	PF02991	0.457
LIG_LIR_Gen_1	688	698	PF02991	0.402
LIG_LIR_Gen_1	707	714	PF02991	0.510
LIG_LIR_Nem_3	109	113	PF02991	0.459
LIG_LIR_Nem_3	218	223	PF02991	0.522
LIG_LIR_Nem_3	228	234	PF02991	0.426
LIG_LIR_Nem_3	269	275	PF02991	0.526
LIG_LIR_Nem_3	41	47	PF02991	0.426
LIG_LIR_Nem_3	49	55	PF02991	0.391
LIG_LIR_Nem_3	523	528	PF02991	0.483
LIG_LIR_Nem_3	59	65	PF02991	0.403
LIG_LIR_Nem_3	688	694	PF02991	0.440
LIG_LIR_Nem_3	707	713	PF02991	0.530
LIG_LIR_Nem_3	738	744	PF02991	0.407
LIG_LYPXL_yS_3	272	275	PF13949	0.619
LIG_MAD2	25	33	PF02301	0.569
LIG_MAD2	408	416	PF02301	0.510
LIG_NRBOX	574	580	PF00104	0.521
LIG_PCNA_yPIPBox_3	811	825	PF02747	0.434
LIG_Pex14_1	788	792	PF04695	0.523
LIG_REV1ctd_RIR_1	810	819	PF16727	0.512
LIG_RPA_C_Fungi	66	78	PF08784	0.560
LIG_SH2_CRK	14	18	PF00017	0.563
LIG_SH2_CRK	234	238	PF00017	0.529
LIG_SH2_CRK	691	695	PF00017	0.461
LIG_SH2_CRK	710	714	PF00017	0.430
LIG_SH2_PTP2	220	223	PF00017	0.581
LIG_SH2_PTP2	44	47	PF00017	0.476
LIG_SH2_SRC	377	380	PF00017	0.492
LIG_SH2_SRC	913	916	PF00017	0.611
LIG_SH2_STAP1	53	57	PF00017	0.456
LIG_SH2_STAP1	65	69	PF00017	0.440
LIG_SH2_STAP1	659	663	PF00017	0.449
LIG_SH2_STAP1	691	695	PF00017	0.344
LIG_SH2_STAP1	710	714	PF00017	0.392
LIG_SH2_STAT3	398	401	PF00017	0.500
LIG_SH2_STAT3	930	933	PF00017	0.560
LIG_SH2_STAT5	132	135	PF00017	0.546
LIG_SH2_STAT5	158	161	PF00017	0.696
LIG_SH2_STAT5	220	223	PF00017	0.496
LIG_SH2_STAT5	234	237	PF00017	0.537
LIG_SH2_STAT5	344	347	PF00017	0.516
LIG_SH2_STAT5	382	385	PF00017	0.413
LIG_SH2_STAT5	44	47	PF00017	0.434
LIG_SH2_STAT5	489	492	PF00017	0.453
LIG_SH2_STAT5	494	497	PF00017	0.423
LIG_SH2_STAT5	528	531	PF00017	0.364
LIG_SH2_STAT5	53	56	PF00017	0.348
LIG_SH2_STAT5	667	670	PF00017	0.394
LIG_SH2_STAT5	682	685	PF00017	0.509
LIG_SH2_STAT5	736	739	PF00017	0.362
LIG_SH2_STAT5	766	769	PF00017	0.410
LIG_SH2_STAT5	869	872	PF00017	0.413
LIG_SH3_3	383	389	PF00018	0.474
LIG_Sin3_3	300	307	PF02671	0.533
LIG_Sin3_3	757	764	PF02671	0.505
LIG_SUMO_SIM_anti_2	29	38	PF11976	0.573
LIG_SUMO_SIM_par_1	111	117	PF11976	0.581
LIG_SUMO_SIM_par_1	773	778	PF11976	0.433
LIG_TRAF2_1	926	929	PF00917	0.516
LIG_TRAF2_1	965	968	PF00917	0.583
LIG_TYR_ITIM	689	694	PF00017	0.465
LIG_TYR_ITIM	734	739	PF00017	0.395
LIG_UBA3_1	249	258	PF00899	0.584
LIG_UBA3_1	824	830	PF00899	0.529
LIG_UBA3_1	870	876	PF00899	0.449
LIG_UBA3_1	990	999	PF00899	0.701
MOD_CDK_SPK_2	20	25	PF00069	0.554
MOD_CDK_SPxxK_3	544	551	PF00069	0.521
MOD_CK1_1	111	117	PF00069	0.529
MOD_CK1_1	168	174	PF00069	0.693
MOD_CK1_1	179	185	PF00069	0.618
MOD_CK1_1	298	304	PF00069	0.539
MOD_CK1_1	321	327	PF00069	0.544
MOD_CK1_1	333	339	PF00069	0.481
MOD_CK1_1	583	589	PF00069	0.493
MOD_CK1_1	677	683	PF00069	0.529
MOD_CK1_1	904	910	PF00069	0.497
MOD_CK1_1	932	938	PF00069	0.522
MOD_CK2_1	169	175	PF00069	0.706
MOD_CK2_1	281	287	PF00069	0.556
MOD_CK2_1	360	366	PF00069	0.492
MOD_CK2_1	514	520	PF00069	0.500
MOD_CK2_1	549	555	PF00069	0.410
MOD_CK2_1	669	675	PF00069	0.497
MOD_CK2_1	740	746	PF00069	0.389
MOD_CK2_1	775	781	PF00069	0.347
MOD_CK2_1	862	868	PF00069	0.504
MOD_CK2_1	95	101	PF00069	0.776
MOD_Cter_Amidation	202	205	PF01082	0.703
MOD_GlcNHglycan	118	121	PF01048	0.501
MOD_GlcNHglycan	135	138	PF01048	0.397
MOD_GlcNHglycan	167	170	PF01048	0.705
MOD_GlcNHglycan	178	181	PF01048	0.695
MOD_GlcNHglycan	184	187	PF01048	0.567
MOD_GlcNHglycan	189	192	PF01048	0.708
MOD_GlcNHglycan	295	300	PF01048	0.524
MOD_GlcNHglycan	563	566	PF01048	0.516
MOD_GlcNHglycan	679	682	PF01048	0.426
MOD_GlcNHglycan	683	686	PF01048	0.437
MOD_GlcNHglycan	691	694	PF01048	0.360
MOD_GlcNHglycan	825	828	PF01048	0.522
MOD_GlcNHglycan	952	955	PF01048	0.561
MOD_GSK3_1	133	140	PF00069	0.544
MOD_GSK3_1	165	172	PF00069	0.711
MOD_GSK3_1	176	183	PF00069	0.700
MOD_GSK3_1	314	321	PF00069	0.552
MOD_GSK3_1	47	54	PF00069	0.516
MOD_GSK3_1	670	677	PF00069	0.470
MOD_GSK3_1	681	688	PF00069	0.403
MOD_GSK3_1	704	711	PF00069	0.419
MOD_GSK3_1	712	719	PF00069	0.474
MOD_GSK3_1	740	747	PF00069	0.439
MOD_GSK3_1	76	83	PF00069	0.494
MOD_GSK3_1	876	883	PF00069	0.418
MOD_GSK3_1	885	892	PF00069	0.358
MOD_GSK3_1	900	907	PF00069	0.513
MOD_GSK3_1	95	102	PF00069	0.748
MOD_N-GLC_1	514	519	PF02516	0.534
MOD_NEK2_1	133	138	PF00069	0.523
MOD_NEK2_1	303	308	PF00069	0.476
MOD_NEK2_1	318	323	PF00069	0.398
MOD_NEK2_1	46	51	PF00069	0.467
MOD_NEK2_1	559	564	PF00069	0.471
MOD_NEK2_1	56	61	PF00069	0.481
MOD_NEK2_1	627	632	PF00069	0.458
MOD_NEK2_1	644	649	PF00069	0.315
MOD_NEK2_1	674	679	PF00069	0.475
MOD_NEK2_1	73	78	PF00069	0.305
MOD_NEK2_1	740	745	PF00069	0.370
MOD_NEK2_1	813	818	PF00069	0.414
MOD_NEK2_1	881	886	PF00069	0.421
MOD_NEK2_1	900	905	PF00069	0.408
MOD_NEK2_2	1014	1019	PF00069	0.675
MOD_NEK2_2	360	365	PF00069	0.405
MOD_PIKK_1	347	353	PF00454	0.536
MOD_PIKK_1	389	395	PF00454	0.423
MOD_PIKK_1	704	710	PF00454	0.463
MOD_PIKK_1	794	800	PF00454	0.549
MOD_PIKK_1	929	935	PF00454	0.559
MOD_PIKK_1	983	989	PF00454	0.679
MOD_PK_1	71	77	PF00069	0.498
MOD_PK_1	876	882	PF00069	0.536
MOD_PK_1	918	924	PF00069	0.554
MOD_PKA_1	206	212	PF00069	0.706
MOD_PKA_1	312	318	PF00069	0.558
MOD_PKA_2	1014	1020	PF00069	0.761
MOD_PKA_2	321	327	PF00069	0.512
MOD_PKA_2	431	437	PF00069	0.486
MOD_PKA_2	669	675	PF00069	0.497
MOD_PKA_2	80	86	PF00069	0.560
MOD_Plk_1	108	114	PF00069	0.510
MOD_Plk_1	232	238	PF00069	0.528
MOD_Plk_1	674	680	PF00069	0.482
MOD_Plk_1	715	721	PF00069	0.529
MOD_Plk_1	918	924	PF00069	0.446
MOD_Plk_4	1014	1020	PF00069	0.729
MOD_Plk_4	184	190	PF00069	0.549
MOD_Plk_4	222	228	PF00069	0.560
MOD_Plk_4	314	320	PF00069	0.503
MOD_Plk_4	51	57	PF00069	0.481
MOD_Plk_4	594	600	PF00069	0.454
MOD_Plk_4	627	633	PF00069	0.438
MOD_Plk_4	709	715	PF00069	0.453
MOD_Plk_4	716	722	PF00069	0.511
MOD_Plk_4	735	741	PF00069	0.281
MOD_Plk_4	768	774	PF00069	0.392
MOD_Plk_4	840	846	PF00069	0.539
MOD_Plk_4	869	875	PF00069	0.441
MOD_Plk_4	876	882	PF00069	0.399
MOD_ProDKin_1	20	26	PF00069	0.469
MOD_ProDKin_1	514	520	PF00069	0.531
MOD_ProDKin_1	544	550	PF00069	0.526
MOD_ProDKin_1	92	98	PF00069	0.714
MOD_SUMO_rev_2	111	120	PF00179	0.582
TRG_DiLeu_BaEn_1	245	250	PF01217	0.540
TRG_DiLeu_BaEn_4	245	251	PF01217	0.562
TRG_DiLeu_BaLyEn_6	820	825	PF01217	0.458
TRG_ENDOCYTIC_2	14	17	PF00928	0.557
TRG_ENDOCYTIC_2	220	223	PF00928	0.496
TRG_ENDOCYTIC_2	234	237	PF00928	0.526
TRG_ENDOCYTIC_2	272	275	PF00928	0.490
TRG_ENDOCYTIC_2	44	47	PF00928	0.446
TRG_ENDOCYTIC_2	53	56	PF00928	0.380
TRG_ENDOCYTIC_2	659	662	PF00928	0.512
TRG_ENDOCYTIC_2	691	694	PF00928	0.369
TRG_ENDOCYTIC_2	710	713	PF00928	0.410
TRG_ENDOCYTIC_2	736	739	PF00928	0.385
TRG_ER_diArg_1	11	13	PF00400	0.613
TRG_ER_diArg_1	550	553	PF00400	0.512
TRG_ER_diArg_1	943	945	PF00400	0.477
TRG_NES_CRM1_1	822	837	PF08389	0.325
TRG_NLS_MonoCore_2	203	208	PF00514	0.740
TRG_NLS_MonoExtC_3	204	210	PF00514	0.738
TRG_NLS_MonoExtN_4	204	209	PF00514	0.739
TRG_Pf-PMV_PEXEL_1	157	161	PF00026	0.775
TRG_Pf-PMV_PEXEL_1	408	412	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	943	947	PF00026	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3J5	Leptomonas seymouri	74%	100%
A0A0S4JSF8	Bodo saltans	30%	91%
A0A1X0NVP2	Trypanosomatidae	42%	99%
A0A422NYQ9	Trypanosoma rangeli	44%	99%
A4H9U2	Leishmania braziliensis	88%	100%
A4HUS8	Leishmania infantum	100%	100%
D0A7N6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9ANG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QH64	Leishmania major	96%	100%
V5BW65	Trypanosoma cruzi	45%	99%