DUF1861 family protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1861), putative

Species:

Leishmania donovani

UniProt:

A0A3S7WRD5_LEIDO

TriTrypDb:

LdBPK_101400.1 , LdCL_100021200 , LDHU3_10.1790

Length:

315

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 42

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 42
NetGPI	no	yes: 0, no: 42

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WRD5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WRD5

PDB structure(s): 2b4w_A , 6q4w_A , 6q4w_B , 6q4x_A , 6q4x_B , 6q4y_A , 6q4y_B , 6q4z_A , 6q4z_B , 6q50_A

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	100	102	PF00675	0.466
CLV_PCSK_KEX2_1	12	14	PF00082	0.514
CLV_PCSK_KEX2_1	51	53	PF00082	0.487
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.570
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.480
CLV_PCSK_SKI1_1	123	127	PF00082	0.417
CLV_PCSK_SKI1_1	2	6	PF00082	0.551
DEG_Nend_UBRbox_1	1	4	PF02207	0.560
DOC_CDC14_PxL_1	175	183	PF14671	0.519
DOC_MAPK_FxFP_2	307	310	PF00069	0.358
DOC_MAPK_gen_1	12	20	PF00069	0.533
DOC_MAPK_MEF2A_6	13	22	PF00069	0.550
DOC_PP4_FxxP_1	148	151	PF00568	0.464
DOC_PP4_FxxP_1	307	310	PF00568	0.442
DOC_USP7_MATH_1	310	314	PF00917	0.442
DOC_WW_Pin1_4	115	120	PF00397	0.439
LIG_APCC_ABBA_1	60	65	PF00400	0.448
LIG_BRCT_BRCA1_1	157	161	PF00533	0.405
LIG_BRCT_BRCA1_1	33	37	PF00533	0.464
LIG_FHA_2	116	122	PF00498	0.480
LIG_FHA_2	125	131	PF00498	0.477
LIG_FHA_2	64	70	PF00498	0.464
LIG_LIR_Apic_2	306	310	PF02991	0.442
LIG_LIR_Gen_1	158	167	PF02991	0.443
LIG_LIR_Gen_1	69	79	PF02991	0.481
LIG_LIR_Nem_3	108	114	PF02991	0.464
LIG_LIR_Nem_3	158	164	PF02991	0.446
LIG_LIR_Nem_3	186	192	PF02991	0.460
LIG_LIR_Nem_3	21	25	PF02991	0.477
LIG_LIR_Nem_3	222	227	PF02991	0.462
LIG_LIR_Nem_3	26	31	PF02991	0.475
LIG_LIR_Nem_3	278	283	PF02991	0.452
LIG_LIR_Nem_3	43	49	PF02991	0.478
LIG_LIR_Nem_3	69	74	PF02991	0.472
LIG_PDZ_Class_1	310	315	PF00595	0.597
LIG_PTB_Apo_2	223	230	PF02174	0.464
LIG_SH2_CRK	227	231	PF00017	0.464
LIG_SH2_CRK	280	284	PF00017	0.464
LIG_SH2_GRB2like	224	227	PF00017	0.464
LIG_SH2_STAP1	15	19	PF00017	0.473
LIG_SH2_STAP1	227	231	PF00017	0.463
LIG_SH2_STAT5	113	116	PF00017	0.464
LIG_SH2_STAT5	124	127	PF00017	0.432
LIG_SH2_STAT5	196	199	PF00017	0.474
LIG_SH2_STAT5	224	227	PF00017	0.446
LIG_SH2_STAT5	78	81	PF00017	0.460
LIG_SH3_3	227	233	PF00018	0.464
LIG_SH3_3	249	255	PF00018	0.448
LIG_TRFH_1	229	233	PF08558	0.464
LIG_TYR_ITIM	225	230	PF00017	0.464
LIG_WRC_WIRS_1	19	24	PF05994	0.477
MOD_CK2_1	115	121	PF00069	0.444
MOD_CK2_1	163	169	PF00069	0.496
MOD_GlcNHglycan	106	110	PF01048	0.536
MOD_GlcNHglycan	199	202	PF01048	0.456
MOD_GlcNHglycan	266	269	PF01048	0.452
MOD_GlcNHglycan	280	283	PF01048	0.452
MOD_GSK3_1	14	21	PF00069	0.458
MOD_GSK3_1	207	214	PF00069	0.320
MOD_GSK3_1	31	38	PF00069	0.473
MOD_N-GLC_1	225	230	PF02516	0.463
MOD_N-GLC_1	31	36	PF02516	0.468
MOD_NEK2_1	197	202	PF00069	0.479
MOD_NEK2_1	63	68	PF00069	0.455
MOD_NEK2_1	95	100	PF00069	0.457
MOD_NEK2_2	245	250	PF00069	0.426
MOD_PKA_2	289	295	PF00069	0.473
MOD_Plk_1	105	111	PF00069	0.529
MOD_Plk_1	225	231	PF00069	0.447
MOD_Plk_1	31	37	PF00069	0.437
MOD_Plk_1	69	75	PF00069	0.480
MOD_Plk_4	14	20	PF00069	0.532
MOD_Plk_4	219	225	PF00069	0.458
MOD_Plk_4	299	305	PF00069	0.548
MOD_ProDKin_1	115	121	PF00069	0.439
MOD_SUMO_rev_2	120	125	PF00179	0.556
MOD_SUMO_rev_2	235	244	PF00179	0.424
MOD_SUMO_rev_2	248	258	PF00179	0.414
TRG_DiLeu_BaLyEn_6	255	260	PF01217	0.338
TRG_ENDOCYTIC_2	111	114	PF00928	0.481
TRG_ENDOCYTIC_2	15	18	PF00928	0.507
TRG_ENDOCYTIC_2	227	230	PF00928	0.493
TRG_ENDOCYTIC_2	280	283	PF00928	0.464
TRG_ENDOCYTIC_2	46	49	PF00928	0.491
TRG_ENDOCYTIC_2	78	81	PF00928	0.540
TRG_ER_diArg_1	150	153	PF00400	0.522
TRG_NES_CRM1_1	130	142	PF08389	0.448
TRG_Pf-PMV_PEXEL_1	136	141	PF00026	0.444
TRG_Pf-PMV_PEXEL_1	236	240	PF00026	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5W3	Leptomonas seymouri	61%	100%
A0A0N1HYU8	Leptomonas seymouri	62%	99%
A0A0N1I429	Leptomonas seymouri	52%	96%
A0A0N1I5D6	Leptomonas seymouri	79%	100%
A0A0N1I720	Leptomonas seymouri	56%	100%
A0A0N1IL04	Leptomonas seymouri	64%	100%
A0A0N1PCE9	Leptomonas seymouri	51%	98%
A0A0R6XPC0	Leishmania donovani	60%	100%
A0A3Q8IHB3	Leishmania donovani	50%	100%
A0A3S5H6H4	Leishmania donovani	52%	100%
A0A3S5H6H5	Leishmania donovani	53%	100%
A0A3S7WRC9	Leishmania donovani	63%	100%
A0A3S7WRE8	Leishmania donovani	69%	100%
A4H6B5	Leishmania braziliensis	50%	100%
A4H6B6	Leishmania braziliensis	48%	100%
A4H6B7	Leishmania braziliensis	61%	100%
A4H6B8	Leishmania braziliensis	82%	100%
A4H6B9	Leishmania braziliensis	55%	100%
A4H6C0	Leishmania braziliensis	61%	100%
A4H6C1	Leishmania braziliensis	65%	100%
A4HUN8	Leishmania infantum	52%	100%
A4HUN9	Leishmania infantum	50%	100%
A4HUP0	Leishmania infantum	60%	100%
A4HUP1	Leishmania infantum	100%	100%
A4HUP2	Leishmania infantum	53%	100%
A4HUP3	Leishmania infantum	63%	100%
A4HUP4	Leishmania infantum	69%	100%
E9AND7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
E9AND8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E9AND9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
E9ANE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9ANE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%
E9ANE2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	100%
E9ANE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4QH83	Leishmania major	71%	100%
Q4QH84	Leishmania major	63%	100%
Q4QH85	Leishmania major	53%	100%
Q4QH86	Leishmania major	92%	100%
Q4QH87	Leishmania major	61%	100%
Q4QH88	Leishmania major	50%	100%
Q4QH89	Leishmania major	53%	100%