Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7WRC5_LEIDO

TriTrypDb:

LdBPK_101150.1 , LdCL_100018400 , LDHU3_10.1500

Length:

592

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WRC5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WRC5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	113	117	PF00656	0.606
CLV_C14_Caspase3-7	256	260	PF00656	0.644
CLV_C14_Caspase3-7	263	267	PF00656	0.519
CLV_C14_Caspase3-7	570	574	PF00656	0.409
CLV_NRD_NRD_1	124	126	PF00675	0.597
CLV_NRD_NRD_1	160	162	PF00675	0.583
CLV_NRD_NRD_1	270	272	PF00675	0.489
CLV_NRD_NRD_1	290	292	PF00675	0.348
CLV_NRD_NRD_1	299	301	PF00675	0.445
CLV_NRD_NRD_1	330	332	PF00675	0.540
CLV_NRD_NRD_1	425	427	PF00675	0.520
CLV_NRD_NRD_1	472	474	PF00675	0.583
CLV_NRD_NRD_1	52	54	PF00675	0.563
CLV_NRD_NRD_1	555	557	PF00675	0.503
CLV_PCSK_KEX2_1	126	128	PF00082	0.578
CLV_PCSK_KEX2_1	270	272	PF00082	0.489
CLV_PCSK_KEX2_1	290	292	PF00082	0.348
CLV_PCSK_KEX2_1	299	301	PF00082	0.445
CLV_PCSK_KEX2_1	329	331	PF00082	0.544
CLV_PCSK_KEX2_1	423	425	PF00082	0.517
CLV_PCSK_KEX2_1	471	473	PF00082	0.591
CLV_PCSK_KEX2_1	52	54	PF00082	0.563
CLV_PCSK_KEX2_1	555	557	PF00082	0.503
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.563
CLV_PCSK_PC1ET2_1	423	425	PF00082	0.556
CLV_PCSK_PC1ET2_1	471	473	PF00082	0.591
CLV_PCSK_PC7_1	286	292	PF00082	0.496
CLV_PCSK_PC7_1	420	426	PF00082	0.458
CLV_PCSK_SKI1_1	145	149	PF00082	0.574
CLV_PCSK_SKI1_1	194	198	PF00082	0.533
CLV_PCSK_SKI1_1	231	235	PF00082	0.606
CLV_PCSK_SKI1_1	273	277	PF00082	0.474
CLV_PCSK_SKI1_1	291	295	PF00082	0.359
CLV_PCSK_SKI1_1	360	364	PF00082	0.540
CLV_PCSK_SKI1_1	42	46	PF00082	0.520
CLV_PCSK_SKI1_1	437	441	PF00082	0.466
CLV_PCSK_SKI1_1	548	552	PF00082	0.485
CLV_PCSK_SKI1_1	558	562	PF00082	0.387
CLV_Separin_Metazoa	515	519	PF03568	0.510
DEG_APCC_DBOX_1	124	132	PF00400	0.495
DEG_APCC_DBOX_1	144	152	PF00400	0.532
DEG_APCC_DBOX_1	197	205	PF00400	0.465
DEG_APCC_DBOX_1	328	336	PF00400	0.512
DEG_APCC_DBOX_1	436	444	PF00400	0.453
DEG_APCC_DBOX_1	547	555	PF00400	0.495
DEG_MDM2_SWIB_1	142	149	PF02201	0.574
DEG_Nend_Nbox_1	1	3	PF02207	0.638
DEG_SPOP_SBC_1	19	23	PF00917	0.754
DEG_SPOP_SBC_1	54	58	PF00917	0.582
DOC_CKS1_1	81	86	PF01111	0.695
DOC_CYCLIN_RxL_1	270	278	PF00134	0.491
DOC_MAPK_gen_1	270	276	PF00069	0.542
DOC_MAPK_gen_1	546	553	PF00069	0.446
DOC_MAPK_MEF2A_6	174	183	PF00069	0.543
DOC_MIT_MIM_1	304	315	PF04212	0.394
DOC_PP1_RVXF_1	34	41	PF00149	0.536
DOC_USP7_MATH_1	103	107	PF00917	0.575
DOC_USP7_MATH_1	19	23	PF00917	0.715
DOC_USP7_MATH_1	222	226	PF00917	0.602
DOC_USP7_MATH_1	253	257	PF00917	0.676
DOC_USP7_MATH_1	439	443	PF00917	0.509
DOC_USP7_MATH_1	6	10	PF00917	0.603
DOC_WW_Pin1_4	167	172	PF00397	0.673
DOC_WW_Pin1_4	65	70	PF00397	0.772
DOC_WW_Pin1_4	80	85	PF00397	0.699
LIG_14-3-3_CanoR_1	112	119	PF00244	0.603
LIG_14-3-3_CanoR_1	178	182	PF00244	0.585
LIG_14-3-3_CanoR_1	508	512	PF00244	0.453
LIG_14-3-3_CanoR_1	52	59	PF00244	0.567
LIG_14-3-3_CanoR_1	555	565	PF00244	0.500
LIG_14-3-3_CanoR_1	73	81	PF00244	0.576
LIG_Actin_WH2_2	179	196	PF00022	0.433
LIG_Actin_WH2_2	526	543	PF00022	0.509
LIG_FHA_1	171	177	PF00498	0.570
LIG_FHA_1	178	184	PF00498	0.479
LIG_FHA_1	270	276	PF00498	0.542
LIG_FHA_1	292	298	PF00498	0.478
LIG_FHA_2	111	117	PF00498	0.599
LIG_FHA_2	232	238	PF00498	0.555
LIG_FHA_2	320	326	PF00498	0.536
LIG_FHA_2	534	540	PF00498	0.465
LIG_FHA_2	557	563	PF00498	0.504
LIG_LIR_Gen_1	143	151	PF02991	0.570
LIG_LIR_Gen_1	444	455	PF02991	0.449
LIG_LIR_Gen_1	507	517	PF02991	0.455
LIG_LIR_Nem_3	143	149	PF02991	0.498
LIG_LIR_Nem_3	444	450	PF02991	0.440
LIG_LIR_Nem_3	507	512	PF02991	0.460
LIG_MYND_3	516	520	PF01753	0.450
LIG_NRBOX	33	39	PF00104	0.405
LIG_PCNA_yPIPBox_3	518	531	PF02747	0.466
LIG_Pex14_2	142	146	PF04695	0.502
LIG_RPA_C_Fungi	325	337	PF08784	0.485
LIG_SH2_CRK	509	513	PF00017	0.521
LIG_SH2_SRC	447	450	PF00017	0.390
LIG_SH2_STAP1	398	402	PF00017	0.518
LIG_SH2_STAT5	119	122	PF00017	0.540
LIG_SH2_STAT5	509	512	PF00017	0.392
LIG_SH3_3	66	72	PF00018	0.776
LIG_SH3_3	78	84	PF00018	0.659
LIG_SUMO_SIM_anti_2	549	555	PF11976	0.462
LIG_SUMO_SIM_par_1	528	534	PF11976	0.461
LIG_TRAF2_1	322	325	PF00917	0.535
LIG_TRAF2_1	380	383	PF00917	0.469
LIG_TRAF2_1	407	410	PF00917	0.523
LIG_TRAF2_1	526	529	PF00917	0.465
LIG_UBA3_1	156	162	PF00899	0.556
LIG_WW_3	70	74	PF00397	0.569
MOD_CDK_SPK_2	65	70	PF00069	0.772
MOD_CDK_SPxxK_3	167	174	PF00069	0.640
MOD_CK1_1	104	110	PF00069	0.593
MOD_CK1_1	111	117	PF00069	0.562
MOD_CK1_1	13	19	PF00069	0.658
MOD_CK1_1	170	176	PF00069	0.629
MOD_CK1_1	244	250	PF00069	0.640
MOD_CK1_1	260	266	PF00069	0.483
MOD_CK1_1	28	34	PF00069	0.539
MOD_CK1_1	55	61	PF00069	0.675
MOD_CK1_1	567	573	PF00069	0.442
MOD_CK2_1	189	195	PF00069	0.500
MOD_CK2_1	224	230	PF00069	0.622
MOD_CK2_1	231	237	PF00069	0.653
MOD_CK2_1	275	281	PF00069	0.485
MOD_CK2_1	319	325	PF00069	0.461
MOD_CK2_1	523	529	PF00069	0.505
MOD_CK2_1	533	539	PF00069	0.421
MOD_CK2_1	556	562	PF00069	0.508
MOD_GlcNHglycan	103	106	PF01048	0.567
MOD_GlcNHglycan	22	25	PF01048	0.601
MOD_GlcNHglycan	224	227	PF01048	0.579
MOD_GlcNHglycan	255	258	PF01048	0.697
MOD_GlcNHglycan	27	30	PF01048	0.560
MOD_GlcNHglycan	351	354	PF01048	0.536
MOD_GlcNHglycan	479	482	PF01048	0.780
MOD_GlcNHglycan	499	502	PF01048	0.403
MOD_GlcNHglycan	547	551	PF01048	0.467
MOD_GlcNHglycan	76	79	PF01048	0.760
MOD_GlcNHglycan	8	11	PF01048	0.675
MOD_GSK3_1	101	108	PF00069	0.738
MOD_GSK3_1	14	21	PF00069	0.622
MOD_GSK3_1	231	238	PF00069	0.542
MOD_GSK3_1	253	260	PF00069	0.640
MOD_GSK3_1	6	13	PF00069	0.663
MOD_GSK3_1	86	93	PF00069	0.746
MOD_N-GLC_1	349	354	PF02516	0.537
MOD_NEK2_1	101	106	PF00069	0.611
MOD_NEK2_1	110	115	PF00069	0.554
MOD_NEK2_1	235	240	PF00069	0.668
MOD_NEK2_1	275	280	PF00069	0.483
MOD_NEK2_1	496	501	PF00069	0.557
MOD_NEK2_1	74	79	PF00069	0.606
MOD_NEK2_2	189	194	PF00069	0.490
MOD_PIKK_1	583	589	PF00454	0.521
MOD_PKA_1	231	237	PF00069	0.537
MOD_PKA_1	52	58	PF00069	0.701
MOD_PKA_2	111	117	PF00069	0.618
MOD_PKA_2	177	183	PF00069	0.641
MOD_PKA_2	269	275	PF00069	0.540
MOD_PKA_2	419	425	PF00069	0.532
MOD_PKA_2	477	483	PF00069	0.484
MOD_PKA_2	507	513	PF00069	0.399
MOD_PKA_2	52	58	PF00069	0.589
MOD_PKA_2	540	546	PF00069	0.510
MOD_PKA_2	72	78	PF00069	0.614
MOD_Plk_1	189	195	PF00069	0.558
MOD_Plk_1	349	355	PF00069	0.541
MOD_Plk_1	546	552	PF00069	0.473
MOD_Plk_1	90	96	PF00069	0.576
MOD_Plk_2-3	90	96	PF00069	0.552
MOD_Plk_4	231	237	PF00069	0.524
MOD_Plk_4	507	513	PF00069	0.399
MOD_ProDKin_1	167	173	PF00069	0.668
MOD_ProDKin_1	65	71	PF00069	0.768
MOD_ProDKin_1	80	86	PF00069	0.696
MOD_SUMO_rev_2	225	234	PF00179	0.558
MOD_SUMO_rev_2	387	397	PF00179	0.342
TRG_DiLeu_BaEn_4	528	534	PF01217	0.461
TRG_DiLeu_BaLyEn_6	152	157	PF01217	0.564
TRG_DiLeu_BaLyEn_6	270	275	PF01217	0.494
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.542
TRG_ENDOCYTIC_2	447	450	PF00928	0.390
TRG_ENDOCYTIC_2	509	512	PF00928	0.517
TRG_ER_diArg_1	125	128	PF00400	0.502
TRG_ER_diArg_1	269	271	PF00400	0.487
TRG_ER_diArg_1	329	331	PF00400	0.544
TRG_ER_diArg_1	424	426	PF00400	0.547
TRG_ER_diArg_1	472	475	PF00400	0.525
TRG_ER_diArg_1	554	556	PF00400	0.493
TRG_NLS_MonoExtC_3	470	475	PF00514	0.593
TRG_Pf-PMV_PEXEL_1	202	206	PF00026	0.493
TRG_Pf-PMV_PEXEL_1	262	266	PF00026	0.530
TRG_Pf-PMV_PEXEL_1	273	277	PF00026	0.432
TRG_Pf-PMV_PEXEL_1	330	334	PF00026	0.512

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL10	Leptomonas seymouri	34%	100%
A4H695	Leishmania braziliensis	71%	100%
A4HUL8	Leishmania infantum	98%	100%
E9ANB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QHA7	Leishmania major	88%	100%