Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7WRB9_LEIDO

TriTrypDb:

LdBPK_101060.1 , LdCL_100017500 , LDHU3_10.1410

Length:

616

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WRB9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WRB9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.696
CLV_C14_Caspase3-7	387	391	PF00656	0.479
CLV_NRD_NRD_1	114	116	PF00675	0.730
CLV_NRD_NRD_1	487	489	PF00675	0.773
CLV_NRD_NRD_1	494	496	PF00675	0.582
CLV_NRD_NRD_1	564	566	PF00675	0.672
CLV_PCSK_KEX2_1	114	116	PF00082	0.730
CLV_PCSK_KEX2_1	428	430	PF00082	0.722
CLV_PCSK_KEX2_1	48	50	PF00082	0.563
CLV_PCSK_KEX2_1	494	496	PF00082	0.587
CLV_PCSK_PC1ET2_1	428	430	PF00082	0.722
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.563
CLV_PCSK_SKI1_1	177	181	PF00082	0.531
CLV_PCSK_SKI1_1	372	376	PF00082	0.583
CLV_PCSK_SKI1_1	386	390	PF00082	0.595
CLV_PCSK_SKI1_1	448	452	PF00082	0.643
CLV_PCSK_SKI1_1	606	610	PF00082	0.695
DEG_Nend_UBRbox_3	1	3	PF02207	0.593
DEG_SPOP_SBC_1	356	360	PF00917	0.567
DEG_SPOP_SBC_1	585	589	PF00917	0.542
DOC_MAPK_gen_1	494	500	PF00069	0.521
DOC_MAPK_MEF2A_6	196	203	PF00069	0.585
DOC_PP1_RVXF_1	198	204	PF00149	0.478
DOC_PP1_RVXF_1	446	453	PF00149	0.643
DOC_PP1_RVXF_1	604	610	PF00149	0.688
DOC_USP7_MATH_1	117	121	PF00917	0.719
DOC_USP7_MATH_1	239	243	PF00917	0.677
DOC_USP7_MATH_1	258	262	PF00917	0.494
DOC_USP7_MATH_1	274	278	PF00917	0.540
DOC_USP7_MATH_1	356	360	PF00917	0.633
DOC_USP7_MATH_1	384	388	PF00917	0.454
DOC_USP7_MATH_1	433	437	PF00917	0.778
DOC_USP7_MATH_1	479	483	PF00917	0.616
DOC_USP7_MATH_1	585	589	PF00917	0.638
DOC_USP7_MATH_1	6	10	PF00917	0.731
DOC_USP7_MATH_1	610	614	PF00917	0.616
DOC_WW_Pin1_4	140	145	PF00397	0.754
DOC_WW_Pin1_4	185	190	PF00397	0.649
DOC_WW_Pin1_4	260	265	PF00397	0.734
DOC_WW_Pin1_4	297	302	PF00397	0.688
DOC_WW_Pin1_4	550	555	PF00397	0.737
DOC_WW_Pin1_4	569	574	PF00397	0.477
DOC_WW_Pin1_4	577	582	PF00397	0.609
LIG_14-3-3_CanoR_1	246	252	PF00244	0.667
LIG_14-3-3_CanoR_1	448	453	PF00244	0.644
LIG_14-3-3_CanoR_1	522	531	PF00244	0.601
LIG_APCC_ABBA_1	199	204	PF00400	0.485
LIG_eIF4E_1	373	379	PF01652	0.668
LIG_FHA_1	155	161	PF00498	0.566
LIG_FHA_1	319	325	PF00498	0.592
LIG_FHA_1	478	484	PF00498	0.682
LIG_FHA_1	491	497	PF00498	0.522
LIG_FHA_1	502	508	PF00498	0.534
LIG_FHA_1	531	537	PF00498	0.797
LIG_FHA_2	146	152	PF00498	0.771
LIG_FHA_2	164	170	PF00498	0.390
LIG_FHA_2	212	218	PF00498	0.607
LIG_FHA_2	261	267	PF00498	0.701
LIG_FHA_2	463	469	PF00498	0.674
LIG_FHA_2	587	593	PF00498	0.649
LIG_GBD_Chelix_1	446	454	PF00786	0.637
LIG_HCF-1_HBM_1	16	19	PF13415	0.664
LIG_LIR_Gen_1	16	25	PF02991	0.640
LIG_LIR_Gen_1	451	460	PF02991	0.625
LIG_LIR_Nem_3	16	22	PF02991	0.652
LIG_LIR_Nem_3	220	224	PF02991	0.678
LIG_LIR_Nem_3	390	396	PF02991	0.552
LIG_LIR_Nem_3	453	459	PF02991	0.529
LIG_Pex14_2	333	337	PF04695	0.499
LIG_Pex14_2	452	456	PF04695	0.514
LIG_SH2_SRC	19	22	PF00017	0.632
LIG_SH2_STAT5	373	376	PF00017	0.569
LIG_SH2_STAT5	464	467	PF00017	0.654
LIG_SH3_3	268	274	PF00018	0.791
LIG_SH3_3	321	327	PF00018	0.585
LIG_SH3_3	335	341	PF00018	0.651
LIG_SH3_3	567	573	PF00018	0.720
LIG_SH3_3	575	581	PF00018	0.646
LIG_SH3_3	604	610	PF00018	0.688
LIG_SUMO_SIM_anti_2	250	255	PF11976	0.721
LIG_SUMO_SIM_anti_2	575	580	PF11976	0.658
LIG_TYR_ITIM	374	379	PF00017	0.742
LIG_WRC_WIRS_1	385	390	PF05994	0.483
LIG_WRC_WIRS_1	449	454	PF05994	0.593
LIG_WRC_WIRS_1	561	566	PF05994	0.642
MOD_CDK_SPxxK_3	140	147	PF00069	0.634
MOD_CK1_1	233	239	PF00069	0.618
MOD_CK1_1	297	303	PF00069	0.644
MOD_CK1_1	358	364	PF00069	0.710
MOD_CK1_1	511	517	PF00069	0.585
MOD_CK1_1	525	531	PF00069	0.562
MOD_CK1_1	572	578	PF00069	0.688
MOD_CK2_1	163	169	PF00069	0.576
MOD_CK2_1	211	217	PF00069	0.603
MOD_CK2_1	260	266	PF00069	0.651
MOD_CK2_1	374	380	PF00069	0.553
MOD_CK2_1	462	468	PF00069	0.560
MOD_DYRK1A_RPxSP_1	569	573	PF00069	0.678
MOD_GlcNHglycan	119	122	PF01048	0.720
MOD_GlcNHglycan	126	129	PF01048	0.649
MOD_GlcNHglycan	234	238	PF01048	0.712
MOD_GlcNHglycan	241	244	PF01048	0.661
MOD_GlcNHglycan	255	259	PF01048	0.633
MOD_GlcNHglycan	260	263	PF01048	0.497
MOD_GlcNHglycan	289	292	PF01048	0.679
MOD_GlcNHglycan	296	299	PF01048	0.584
MOD_GlcNHglycan	362	365	PF01048	0.712
MOD_GlcNHglycan	417	420	PF01048	0.630
MOD_GlcNHglycan	435	438	PF01048	0.513
MOD_GlcNHglycan	508	511	PF01048	0.699
MOD_GlcNHglycan	515	518	PF01048	0.635
MOD_GlcNHglycan	554	557	PF01048	0.615
MOD_GlcNHglycan	8	11	PF01048	0.690
MOD_GSK3_1	254	261	PF00069	0.704
MOD_GSK3_1	352	359	PF00069	0.729
MOD_GSK3_1	473	480	PF00069	0.679
MOD_GSK3_1	502	509	PF00069	0.675
MOD_GSK3_1	511	518	PF00069	0.606
MOD_GSK3_1	521	528	PF00069	0.583
MOD_GSK3_1	548	555	PF00069	0.659
MOD_NEK2_1	163	168	PF00069	0.463
MOD_NEK2_1	180	185	PF00069	0.545
MOD_NEK2_1	318	323	PF00069	0.473
MOD_NEK2_1	331	336	PF00069	0.530
MOD_NEK2_1	349	354	PF00069	0.635
MOD_NEK2_1	396	401	PF00069	0.621
MOD_NEK2_1	455	460	PF00069	0.612
MOD_NEK2_1	473	478	PF00069	0.570
MOD_NEK2_1	501	506	PF00069	0.728
MOD_NEK2_1	508	513	PF00069	0.659
MOD_NEK2_1	523	528	PF00069	0.545
MOD_NEK2_1	586	591	PF00069	0.550
MOD_PIKK_1	27	33	PF00454	0.512
MOD_PKA_2	401	407	PF00069	0.669
MOD_PKA_2	521	527	PF00069	0.661
MOD_PKA_2	53	59	PF00069	0.729
MOD_Plk_1	396	402	PF00069	0.597
MOD_Plk_1	473	479	PF00069	0.670
MOD_Plk_1	537	543	PF00069	0.633
MOD_Plk_4	249	255	PF00069	0.721
MOD_Plk_4	309	315	PF00069	0.597
MOD_Plk_4	363	369	PF00069	0.779
MOD_Plk_4	374	380	PF00069	0.462
MOD_Plk_4	384	390	PF00069	0.431
MOD_Plk_4	455	461	PF00069	0.531
MOD_ProDKin_1	140	146	PF00069	0.751
MOD_ProDKin_1	185	191	PF00069	0.647
MOD_ProDKin_1	260	266	PF00069	0.738
MOD_ProDKin_1	297	303	PF00069	0.691
MOD_ProDKin_1	550	556	PF00069	0.737
MOD_ProDKin_1	569	575	PF00069	0.478
MOD_ProDKin_1	577	583	PF00069	0.609
MOD_SUMO_rev_2	56	60	PF00179	0.729
TRG_DiLeu_BaLyEn_6	445	450	PF01217	0.562
TRG_ENDOCYTIC_2	19	22	PF00928	0.526
TRG_ENDOCYTIC_2	376	379	PF00928	0.735
TRG_ER_diArg_1	113	115	PF00400	0.736
TRG_ER_diArg_1	174	177	PF00400	0.564
TRG_ER_diArg_1	494	496	PF00400	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSV0	Leptomonas seymouri	35%	100%
A4HUL1	Leishmania infantum	99%	100%
E9ANA8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QHB6	Leishmania major	89%	100%