Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WRA2_LEIDO

TriTrypDb:

LdBPK_101140.1 , LdCL_100018300 , LDHU3_10.1490

Length:

322

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WRA2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WRA2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.654
CLV_NRD_NRD_1	146	148	PF00675	0.605
CLV_PCSK_KEX2_1	146	148	PF00082	0.605
CLV_PCSK_KEX2_1	228	230	PF00082	0.543
CLV_PCSK_PC1ET2_1	228	230	PF00082	0.543
CLV_PCSK_SKI1_1	214	218	PF00082	0.568
DEG_Nend_UBRbox_1	1	4	PF02207	0.542
DOC_MAPK_gen_1	195	204	PF00069	0.519
DOC_MAPK_RevD_3	215	229	PF00069	0.555
DOC_PP4_FxxP_1	21	24	PF00568	0.699
DOC_USP7_MATH_1	141	145	PF00917	0.503
DOC_USP7_MATH_1	86	90	PF00917	0.618
DOC_WW_Pin1_4	126	131	PF00397	0.560
DOC_WW_Pin1_4	20	25	PF00397	0.771
DOC_WW_Pin1_4	57	62	PF00397	0.548
LIG_14-3-3_CanoR_1	229	235	PF00244	0.613
LIG_Actin_WH2_2	215	230	PF00022	0.522
LIG_Clathr_ClatBox_1	312	316	PF01394	0.466
LIG_EH1_1	312	320	PF00400	0.558
LIG_EVH1_2	160	164	PF00568	0.550
LIG_FHA_1	197	203	PF00498	0.602
LIG_FHA_1	231	237	PF00498	0.646
LIG_FHA_1	58	64	PF00498	0.616
LIG_FHA_1	92	98	PF00498	0.575
LIG_FHA_2	24	30	PF00498	0.630
LIG_FHA_2	249	255	PF00498	0.688
LIG_LIR_Gen_1	129	138	PF02991	0.602
LIG_LIR_Gen_1	174	182	PF02991	0.409
LIG_LIR_Nem_3	129	134	PF02991	0.600
LIG_LIR_Nem_3	174	178	PF02991	0.402
LIG_PDZ_Class_1	317	322	PF00595	0.500
LIG_Pex14_2	134	138	PF04695	0.428
LIG_Pex14_2	309	313	PF04695	0.576
LIG_PTB_Apo_2	132	139	PF02174	0.583
LIG_SH2_GRB2like	133	136	PF00017	0.591
LIG_SH2_STAT3	181	184	PF00017	0.539
LIG_SH2_STAT5	133	136	PF00017	0.515
LIG_SH2_STAT5	163	166	PF00017	0.402
LIG_SH2_STAT5	177	180	PF00017	0.399
LIG_SUMO_SIM_par_1	50	56	PF11976	0.554
LIG_TRAF2_1	241	244	PF00917	0.700
LIG_WRC_WIRS_1	172	177	PF05994	0.417
LIG_WW_1	160	163	PF00397	0.561
MOD_CK1_1	136	142	PF00069	0.556
MOD_CK1_1	23	29	PF00069	0.634
MOD_CK1_1	230	236	PF00069	0.600
MOD_CK1_1	275	281	PF00069	0.739
MOD_CK1_1	294	300	PF00069	0.493
MOD_CK1_1	56	62	PF00069	0.420
MOD_CK1_1	91	97	PF00069	0.532
MOD_CK2_1	134	140	PF00069	0.503
MOD_CK2_1	23	29	PF00069	0.684
MOD_CK2_1	86	92	PF00069	0.655
MOD_GlcNHglycan	104	107	PF01048	0.607
MOD_GlcNHglycan	229	232	PF01048	0.513
MOD_GlcNHglycan	277	280	PF01048	0.697
MOD_GlcNHglycan	291	294	PF01048	0.550
MOD_GlcNHglycan	55	58	PF01048	0.410
MOD_GlcNHglycan	77	80	PF01048	0.651
MOD_GlcNHglycan	9	13	PF01048	0.609
MOD_GSK3_1	167	174	PF00069	0.512
MOD_GSK3_1	19	26	PF00069	0.630
MOD_GSK3_1	53	60	PF00069	0.417
MOD_N-GLC_1	134	139	PF02516	0.571
MOD_NEK2_1	134	139	PF00069	0.533
MOD_NEK2_1	227	232	PF00069	0.548
MOD_NEK2_1	53	58	PF00069	0.433
MOD_NEK2_2	141	146	PF00069	0.518
MOD_NEK2_2	40	45	PF00069	0.433
MOD_PIKK_1	28	34	PF00454	0.631
MOD_PIKK_1	91	97	PF00454	0.598
MOD_PK_1	291	297	PF00069	0.645
MOD_PKA_2	196	202	PF00069	0.629
MOD_PKA_2	272	278	PF00069	0.486
MOD_Plk_1	134	140	PF00069	0.568
MOD_Plk_1	141	147	PF00069	0.461
MOD_Plk_1	86	92	PF00069	0.702
MOD_Plk_2-3	171	177	PF00069	0.458
MOD_Plk_4	272	278	PF00069	0.486
MOD_Plk_4	294	300	PF00069	0.617
MOD_ProDKin_1	126	132	PF00069	0.561
MOD_ProDKin_1	20	26	PF00069	0.762
MOD_ProDKin_1	57	63	PF00069	0.563
TRG_ENDOCYTIC_2	118	121	PF00928	0.588
TRG_ENDOCYTIC_2	131	134	PF00928	0.399
TRG_ENDOCYTIC_2	163	166	PF00928	0.402
TRG_ER_diArg_1	145	147	PF00400	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5X0	Leptomonas seymouri	48%	95%
A0A1X0NS26	Trypanosomatidae	31%	100%
A0A422NGN0	Trypanosoma rangeli	33%	100%
A4H694	Leishmania braziliensis	81%	99%
A4HUL7	Leishmania infantum	99%	100%
C9ZVP4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9ANB6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QHA8	Leishmania major	91%	100%
V5DKP6	Trypanosoma cruzi	34%	100%