A_deaminase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WR98_LEIDO

TriTrypDb:

LdBPK_100890.1 , LdCL_100015700 , LDHU3_10.1250

Length:

732

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WR98

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WR98

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006152	purine nucleoside catabolic process	6	1
GO:0006154	adenosine catabolic process	8	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009058	biosynthetic process	2	1
GO:0009116	nucleoside metabolic process	4	1
GO:0009119	ribonucleoside metabolic process	5	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004000	adenosine deaminase activity	4	1
GO:0016787	hydrolase activity	2	11
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	1
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	4	1
GO:0019239	deaminase activity	3	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.515
CLV_C14_Caspase3-7	410	414	PF00656	0.529
CLV_C14_Caspase3-7	554	558	PF00656	0.577
CLV_C14_Caspase3-7	609	613	PF00656	0.603
CLV_NRD_NRD_1	173	175	PF00675	0.478
CLV_NRD_NRD_1	177	179	PF00675	0.502
CLV_NRD_NRD_1	275	277	PF00675	0.510
CLV_NRD_NRD_1	342	344	PF00675	0.568
CLV_NRD_NRD_1	372	374	PF00675	0.392
CLV_NRD_NRD_1	405	407	PF00675	0.460

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6F9	Leptomonas seymouri	49%	98%
A0A1X0NRU3	Trypanosomatidae	32%	100%
A0A3S5IS54	Trypanosoma rangeli	36%	100%
A4H672	Leishmania braziliensis	74%	99%
A4HUJ6	Leishmania infantum	99%	100%
C9ZVM1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AN94	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	98%
Q4QHD0	Leishmania major	92%	99%
V5BTS5	Trypanosoma cruzi	36%	100%

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