Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7WR94_LEIDO

TriTrypDb:

LdBPK_100700.1 , LdCL_100013800 , LDHU3_10.1030

Length:

375

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WR94

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WR94

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	154	158	PF00656	0.669
CLV_NRD_NRD_1	112	114	PF00675	0.549
CLV_NRD_NRD_1	117	119	PF00675	0.592
CLV_NRD_NRD_1	169	171	PF00675	0.508
CLV_NRD_NRD_1	181	183	PF00675	0.525
CLV_NRD_NRD_1	191	193	PF00675	0.551
CLV_NRD_NRD_1	254	256	PF00675	0.718
CLV_NRD_NRD_1	305	307	PF00675	0.605
CLV_NRD_NRD_1	313	315	PF00675	0.709
CLV_NRD_NRD_1	78	80	PF00675	0.610
CLV_NRD_NRD_1	81	83	PF00675	0.576
CLV_NRD_NRD_1	84	86	PF00675	0.575
CLV_PCSK_FUR_1	115	119	PF00082	0.600
CLV_PCSK_FUR_1	311	315	PF00082	0.631
CLV_PCSK_FUR_1	79	83	PF00082	0.671
CLV_PCSK_KEX2_1	112	114	PF00082	0.550
CLV_PCSK_KEX2_1	117	119	PF00082	0.593
CLV_PCSK_KEX2_1	181	183	PF00082	0.612
CLV_PCSK_KEX2_1	191	193	PF00082	0.557
CLV_PCSK_KEX2_1	305	307	PF00082	0.592
CLV_PCSK_KEX2_1	313	315	PF00082	0.709
CLV_PCSK_KEX2_1	5	7	PF00082	0.793
CLV_PCSK_KEX2_1	78	80	PF00082	0.610
CLV_PCSK_KEX2_1	81	83	PF00082	0.576
CLV_PCSK_KEX2_1	84	86	PF00082	0.575
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.616
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.793
CLV_PCSK_PC7_1	113	119	PF00082	0.593
CLV_PCSK_SKI1_1	171	175	PF00082	0.634
CLV_PCSK_SKI1_1	182	186	PF00082	0.466
CLV_PCSK_SKI1_1	19	23	PF00082	0.660
CLV_PCSK_SKI1_1	232	236	PF00082	0.794
CLV_PCSK_SKI1_1	25	29	PF00082	0.781
CLV_PCSK_SKI1_1	314	318	PF00082	0.687
CLV_PCSK_SKI1_1	35	39	PF00082	0.642
CLV_PCSK_SKI1_1	64	68	PF00082	0.625
DEG_APCC_DBOX_1	180	188	PF00400	0.544
DEG_Kelch_Keap1_1	207	212	PF01344	0.781
DEG_Nend_Nbox_1	1	3	PF02207	0.807
DOC_CYCLIN_RxL_1	178	186	PF00134	0.588
DOC_CYCLIN_yCln2_LP_2	123	129	PF00134	0.636
DOC_CYCLIN_yCln2_LP_2	371	374	PF00134	0.624
DOC_MAPK_gen_1	178	187	PF00069	0.582
DOC_MAPK_RevD_3	65	79	PF00069	0.699
DOC_PP1_RVXF_1	220	227	PF00149	0.592
DOC_PP1_RVXF_1	330	336	PF00149	0.650
DOC_PP2B_LxvP_1	123	126	PF13499	0.677
DOC_PP2B_LxvP_1	203	206	PF13499	0.668
DOC_PP2B_LxvP_1	21	24	PF13499	0.676
DOC_PP2B_LxvP_1	351	354	PF13499	0.579
DOC_PP2B_LxvP_1	371	374	PF13499	0.374
DOC_PP4_FxxP_1	15	18	PF00568	0.741
DOC_WW_Pin1_4	204	209	PF00397	0.678
DOC_WW_Pin1_4	248	253	PF00397	0.760
DOC_WW_Pin1_4	304	309	PF00397	0.405
LIG_14-3-3_CanoR_1	170	180	PF00244	0.490
LIG_14-3-3_CanoR_1	313	319	PF00244	0.694
LIG_APCC_ABBA_1	358	363	PF00400	0.659
LIG_BIR_III_4	132	136	PF00653	0.621
LIG_CaM_IQ_9	185	200	PF13499	0.631
LIG_deltaCOP1_diTrp_1	363	369	PF00928	0.671
LIG_FHA_1	103	109	PF00498	0.593
LIG_FHA_1	157	163	PF00498	0.620
LIG_FHA_1	208	214	PF00498	0.644
LIG_FHA_1	249	255	PF00498	0.733
LIG_FHA_1	70	76	PF00498	0.549
LIG_FHA_2	315	321	PF00498	0.672
LIG_GBD_Chelix_1	338	346	PF00786	0.663
LIG_LIR_Apic_2	12	18	PF02991	0.744
LIG_LIR_Gen_1	334	342	PF02991	0.666
LIG_LIR_Gen_1	343	352	PF02991	0.498
LIG_LIR_Nem_3	334	338	PF02991	0.677
LIG_LIR_Nem_3	341	347	PF02991	0.542
LIG_LIR_Nem_3	348	353	PF02991	0.410
LIG_LIR_Nem_3	367	372	PF02991	0.418
LIG_MYND_1	14	18	PF01753	0.741
LIG_NRBOX	183	189	PF00104	0.650
LIG_SH2_CRK	221	225	PF00017	0.653
LIG_SH2_NCK_1	344	348	PF00017	0.621
LIG_SH2_STAT3	300	303	PF00017	0.641
LIG_SH2_STAT5	297	300	PF00017	0.478
LIG_SH2_STAT5	350	353	PF00017	0.560
LIG_SUMO_SIM_anti_2	183	190	PF11976	0.570
LIG_SUMO_SIM_par_1	201	207	PF11976	0.664
LIG_SUMO_SIM_par_1	63	70	PF11976	0.625
LIG_TRFH_1	369	373	PF08558	0.696
LIG_TYR_ITIM	342	347	PF00017	0.610
LIG_UBA3_1	162	171	PF00899	0.646
LIG_UBA3_1	184	193	PF00899	0.675
MOD_CDK_SPxxK_3	248	255	PF00069	0.685
MOD_CDK_SPxxK_3	304	311	PF00069	0.408
MOD_CK1_1	141	147	PF00069	0.689
MOD_CK1_1	164	170	PF00069	0.619
MOD_CK1_1	207	213	PF00069	0.681
MOD_CK1_1	90	96	PF00069	0.585
MOD_GlcNHglycan	122	126	PF01048	0.736
MOD_GlcNHglycan	127	130	PF01048	0.716
MOD_GlcNHglycan	140	143	PF01048	0.618
MOD_GlcNHglycan	149	152	PF01048	0.772
MOD_GlcNHglycan	265	269	PF01048	0.762
MOD_GlcNHglycan	279	282	PF01048	0.611
MOD_GlcNHglycan	32	38	PF01048	0.602
MOD_GSK3_1	121	128	PF00069	0.727
MOD_GSK3_1	138	145	PF00069	0.680
MOD_GSK3_1	157	164	PF00069	0.535
MOD_NEK2_1	102	107	PF00069	0.612
MOD_NEK2_1	69	74	PF00069	0.557
MOD_PIKK_1	90	96	PF00454	0.497
MOD_PKA_2	138	144	PF00069	0.683
MOD_PKA_2	90	96	PF00069	0.585
MOD_Plk_1	319	325	PF00069	0.636
MOD_Plk_2-3	319	325	PF00069	0.636
MOD_Plk_4	183	189	PF00069	0.600
MOD_ProDKin_1	204	210	PF00069	0.677
MOD_ProDKin_1	248	254	PF00069	0.761
MOD_ProDKin_1	304	310	PF00069	0.406
TRG_DiLeu_BaEn_1	12	17	PF01217	0.745
TRG_DiLeu_BaEn_1	183	188	PF01217	0.636
TRG_ENDOCYTIC_2	221	224	PF00928	0.597
TRG_ENDOCYTIC_2	344	347	PF00928	0.577
TRG_ENDOCYTIC_2	350	353	PF00928	0.513
TRG_ER_diArg_1	111	113	PF00400	0.558
TRG_ER_diArg_1	114	117	PF00400	0.580
TRG_ER_diArg_1	180	182	PF00400	0.580
TRG_ER_diArg_1	310	313	PF00400	0.658
TRG_ER_diArg_1	78	81	PF00400	0.668
TRG_ER_diArg_1	82	85	PF00400	0.608
TRG_Pf-PMV_PEXEL_1	255	260	PF00026	0.704

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5X7	Leptomonas seymouri	34%	95%
A4H657	Leishmania braziliensis	76%	100%
A4HUH7	Leishmania infantum	99%	100%
E9AN75	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QHF0	Leishmania major	92%	100%