Archaic_translocase_of_outer_membrane_12_kDa_subu nit_putative/GeneDB:LmjF.10.0945

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Archaic translocase of outer membrane 12 kDa subunit, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WR90_LEIDO

TriTrypDb:

LdBPK_101020.1 , LdCL_100017100 , LDHU3_10.1360

Length:

107

Annotations

LeishMANIAdb annotations

A very simple single-pass membrane protein restricted to Kinetoplastids. Might be mitochondrial.. A transit peptide cannot be excluded in the sequence.. Localization: Mitochondrial (by feature)

Annotations by Jardim et al.

Mitochondrial protein, outer mitochondrial membrane proteome 40 (ATOM12) Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0005741	mitochondrial outer membrane	5	1
GO:0005742	mitochondrial outer membrane translocase complex	4	1
GO:0016020	membrane	2	4
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098799	outer mitochondrial membrane protein complex	3	1
GO:0110165	cellular anatomical entity	1	4

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S7WR90

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WR90

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	1
GO:0006626	protein targeting to mitochondrion	5	1
GO:0006810	transport	3	1
GO:0006839	mitochondrial transport	4	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0030150	protein import into mitochondrial matrix	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0044743	protein transmembrane import into intracellular organelle	4	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0055085	transmembrane transport	2	1
GO:0065002	intracellular protein transmembrane transport	4	1
GO:0070585	protein localization to mitochondrion	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071806	protein transmembrane transport	3	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072655	establishment of protein localization to mitochondrion	5	1
GO:1990542	mitochondrial transmembrane transport	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	8	12	PF00656	0.645
CLV_NRD_NRD_1	18	20	PF00675	0.397
CLV_NRD_NRD_1	92	94	PF00675	0.561
CLV_PCSK_KEX2_1	18	20	PF00082	0.395
CLV_PCSK_KEX2_1	91	93	PF00082	0.548
DEG_APCC_DBOX_1	58	66	PF00400	0.322
DEG_Nend_Nbox_1	1	3	PF02207	0.646
DOC_PP4_FxxP_1	38	41	PF00568	0.274
DOC_USP7_UBL2_3	25	29	PF12436	0.587
LIG_14-3-3_CanoR_1	91	100	PF00244	0.413
LIG_BRCT_BRCA1_1	56	60	PF00533	0.419
LIG_LIR_Apic_2	37	41	PF02991	0.274
LIG_LIR_Nem_3	77	83	PF02991	0.397
LIG_Pex14_2	60	64	PF04695	0.322
LIG_RPA_C_Fungi	88	100	PF08784	0.546
LIG_SH2_NCK_1	102	106	PF00017	0.540
LIG_SH2_SRC	83	86	PF00017	0.475
LIG_SH2_STAT5	27	30	PF00017	0.421
LIG_SH2_STAT5	35	38	PF00017	0.233
LIG_SH2_STAT5	66	69	PF00017	0.514
MOD_CK2_1	95	101	PF00069	0.543
MOD_GlcNHglycan	14	17	PF01048	0.471
MOD_GlcNHglycan	86	89	PF01048	0.447
MOD_GlcNHglycan	97	100	PF01048	0.475
MOD_GSK3_1	79	86	PF00069	0.569
MOD_GSK3_1	91	98	PF00069	0.481
MOD_NEK2_1	23	28	PF00069	0.426
MOD_NEK2_1	65	70	PF00069	0.476
MOD_NEK2_2	66	71	PF00069	0.510
MOD_PKA_1	91	97	PF00069	0.511
MOD_PKA_2	91	97	PF00069	0.550
MOD_Plk_4	23	29	PF00069	0.495
MOD_SUMO_rev_2	72	81	PF00179	0.440
TRG_DiLeu_BaLyEn_6	38	43	PF01217	0.386
TRG_ENDOCYTIC_2	35	38	PF00928	0.274
TRG_ER_diArg_1	18	20	PF00400	0.520
TRG_ER_diArg_1	91	93	PF00400	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVG0	Leptomonas seymouri	74%	100%
A0A0S4JL52	Bodo saltans	39%	100%
A0A1X0NS16	Trypanosomatidae	46%	100%
A0A422NCR7	Trypanosoma rangeli	53%	100%
A4HUK7	Leishmania infantum	100%	100%
C9ZVN4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9ANA4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4QHC0	Leishmania major	95%	100%